L04 Chinese 1070 Ampersand: Encountering China: A Performative Perspective on Chinese Culture and Identity This course examines the diversified and rich history of Chinese visual and performance cultures from the Chinese mainland, Taiwan, Hong Kong, and throughout the Chinese diaspora. A collaboration between the East Asian Languages and Cultures and Performing Arts departments, this course explores Chinese cultural narratives in relation to how they have been performed — on stage in traditional forms of dance-drama, on screen in film, and as lived in the practice of everyday life — from the late Imperial period to the present. It includes a practice component that introduces the students to movement disciplines such as Tai' Chi and opera, and it allows students to pursue creative assignments such as interview, stage plays, and filmmaking that demonstrate their developing knowledge of historical and contemporary Chinese culture. Building bridges of understanding between the United States and the Republic of China in Taiwan, the course will culminate in a spring break trip to Taiwan. This course is only for first-year, non-transfer students in the Ampersand: Encountering China program. Same as L61 FYP 107 Credit 3 units. A&S: AMP A&S IQ: LCD, SC BU: HUM, IS EN: H
Summary Background We aimed to accurately estimate the frequency of a hexanucleotide repeat expansion in C9orf72 that has been associated with a large proportion of cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Methods We screened 4448 patients diagnosed with ALS (El Escorial criteria) and 1425 patients with FTD (Lund-Manchester criteria) from 17 regions worldwide for the GGGGCC hexanucleotide expansion using a repeat-primed PCR assay. We assessed familial disease status on the basis of self-reported family history of similar neurodegenerative diseases at the time of sample collection. We compared haplotype data for 262 patients carrying the expansion with the known Finnish founder risk haplotype across the chromosomal locus. We calculated age-related penetrance using the Kaplan-Meier method with data for 603 individuals with the expansion. Findings In patients with sporadic ALS, we identified the repeat expansion in 236 (7·0%) of 3377 white individuals from the USA, Europe, and Australia, two (4·1%) of 49 black individuals from the USA, and six (8·3%) of 72 Hispanic individuals from the USA. The mutation was present in 217 (39·3%) of 552 white individuals with familial ALS from Europe and the USA. 59 (6·0%) of 981 white Europeans with sporadic FTD had the mutation, as did 99 (24·8%) of 400 white Europeans with familial FTD. Data for other ethnic groups were sparse, but we identified one Asian patient with familial ALS (from 20 assessed) and two with familial FTD (from three assessed) who carried the mutation. The mutation was not carried by the three Native Americans or 360 patients from Asia or the Pacific Islands with sporadic ALS who were tested, or by 41 Asian patients with sporadic FTD. All patients with the repeat expansion had (partly or fully) the founder haplotype, suggesting a one-off expansion occurring about 1500 years ago. The pathogenic expansion was non-penetrant in individuals younger than 35 years, 50% penetrant by 58 years, and almost fully penetrant by 80 years. Interpretation A common Mendelian genetic lesion in C9orf72 is implicated in many cases of sporadic and familial ALS and FTD. Testing for this pathogenic expansion should be considered in the management and genetic counselling of patients with these fatal neurodegenerative diseases. Funding Full funding sources listed at end of paper (see Acknowledgments).
The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is determined partly by the number of generations since the common ancestor: offspring of cousin marriages have long runs of homozygosity (ROH), while the numerous shorter tracts relate to shared ancestry tens and hundreds of generations ago. Human populations have experienced a wide range of demographic histories and hold diverse cultural attitudes to consanguinity. In a global population dataset, genome-wide analysis of long and shorter ROH allows categorisation of the mainly indigenous populations sampled here into four major groups in which the majority of the population are inferred to have: (a) recent parental relatedness (south and west Asians); (b) shared parental ancestry arising hundreds to thousands of years ago through long term isolation and restricted effective population size (Ne), but little recent inbreeding (Oceanians); (c) both ancient and recent parental relatedness (Native Americans); and (d) only the background level of shared ancestry relating to continental Ne (predominantly urban Europeans and East Asians; lowest of all in sub-Saharan African agriculturalists), and the occasional cryptically inbred individual. Moreover, individuals can be positioned along axes representing this demographic historic space. Long runs of homozygosity are therefore a globally widespread and under-appreciated characteristic of our genomes, which record past consanguinity and population isolation and provide a distinctive record of the demographic history of an individual's ancestors. Individual ROH measures will also allow quantification of the disease risk arising from polygenic recessive effects.
Hewa Babarandage Chathurika Harshani, Janaki I Abeynayake
Japanese encephalitis (JE) which is caused by Japanese encephalitis virus (JEV) is a significant public health concern in Asia. The JEV is mainly transmitted by Culex mosquitoes breeding in flooded rice fields. The disease can range from mild flu-like symptoms to severe encephalitis and long-term neurological effects with potentially fatal outcomes with a 30% mortality rate. This review aims to gather information on JE’s public health importance, JE epidemiology, history, vaccination strategies, and public health interventions in Asian countries. A systematic literature search was conducted across various databases, PubMed, Scopus, Web of Science, and Google Scholar, including publications up till 2024. Search terms included “Japanese encephalitis”, “epidemiology”, “outbreaks”, “prevalence” and “prevention & control”. This review highlights the importance of comprehensive vaccination strategies and integrated vector management. Continued efforts are essential to enhance vaccination coverage and strengthen public health infrastructure to mitigate the burden of JE in Asia.
Background: Natural products are increasingly gaining interest as potential new drug candidates for cancer treatment. Herbal formula, which are combinations of several herbs, are primarily used in East Asia and have a long history of use that continues today. Recently, research exploring the combination of herbal formulas and chemotherapy for cancer treatment has been on the rise. Methods: This study reviewed research on the co-administration of herbal formulas and chemotherapy for cancer treatment. The databases PubMed, Embase, and Cochrane Library were used for article searches. The following keywords were employed: “Antineoplastic agents,” “Chemotherapy,” “Phytotherapy,” “Herbal medicine,” “Drug synergism,” and “Synergistic effect.” The selection process focused on studies that investigated the synergistic interaction between herbal formulas and chemotherapeutic agents. Results: Among the 30 studies included, 25 herbal formulas and 7 chemotherapies were used. The chemotherapy agents co-administered included cisplatin, 5-fluorouracil, docetaxel, doxorubicin, oxaliplatin, irinotecan, and gemcitabine. The types of cancer most frequently studied were lung, breast, and colon cancers. Most studies evaluating the anticancer efficacy of combined herbal formula and chemotherapy treatment were conducted in vitro or in vivo. Discussion: Most studies reported synergistic effects on cytotoxicity, apoptosis, and tumor growth inhibition. These effects were found to be associated with cell cycle arrest, anti-angiogenesis, and gene expression regulation. Further studies leading to clinical trials are required. Clinical experiences in East Asian countries could provide insights for future research.
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
The article examines the topic of development and implementation of generative artificial intelligence (AI) in Vietnam, one of the rapidly developing countries in East Asia. The Vietnamese government, stimulated by its economic success, is paying more and more attention to the development and financing of the AI industry every year. The government's national strategy aims to transform Vietnam into one of the leaders in the field of artificial intelligence in the region and even in the whole world. The work on creation and application of AI is gradually becoming a national concern in Vietnam. As an example, the author considers Vietnam Artificial Intelligence Day on the topic “Artificial Intelligence: The Power of Life” – a major event to promote AI technologies, which was held in September 2023 in Ho Chi Minh City, the main economic center of the country. The activities of the Joint Russian-Vietnamese Tropical Research and Technology Center are also outlined in the context of its contribution to solving the AI problem.
South Asia. Southeast Asia. East Asia, Bibliography. Library science. Information resources