Hasil untuk "math.AP"

Sarah De Nardi

Do we need a roadmap to the future? Or do we ‘wing it’, making it up as we go along? Big questions, but never more important than now, in this current time of uncertainty.Let’s start small, and refocus the question on our professional and scholarly area of interest and activities. While the future of the world of work certainly looks different – will robots do digging, recording and interpretation work in 2030?-  I think that the key to prepare suitable strategies for going forward is to be clear about our purpose(s). For what, and for whom, are we and will we be doing research and knowledge sharing? With whom will we operate and work in our capacity as scholars, practitioners, teachers? Even asking why do archaeology may seem straightforward now, but it isn’t. At least, it shouldn’t be.

Kasey Stokdyk, Alexandra Berroyer, Zacharia A. Grami et al.

ABSTRACT Yeast Apn2 is an AP endonuclease and DNA 3’-diesterase that belongs to the Exo III family with homology to the E. coli exonuclease III, Schizosaccharomyces pombe eth1, and human AP endonucleases APEX1 and APEX2. In the absence of Apn1, the major AP endonuclease in yeast, Apn2 can cleave the DNA backbone at an AP lesion initiating the base excision repair pathway. In order to study the role and relative contribution of Apn2, we took advantage of a reporter system that was previously used to delineate how uracil-derived AP sites are repaired. At this reporter, disruption of the Apn1-initiated base excision repair pathway led to a significant elevation of A:T to C:G transversions. Here we show that such highly elevated A:T to C:G transversion mutations associated with uracil residues in DNA are abolished when apn1 Δ yeast cells are grown in glucose as the primary carbon source. We also show that the disruption of Apn2, either by the complete gene deletion or by the mutation of a catalytic residue, results in a similarly reduced rate of the uracil-associated mutations. Overall, our results indicate that Apn2 activity is regulated by the glucose repression pathway in yeast.

Jaime Almansa Sánchez

Do you watch porn? Most people lie when answering this question.The pornographic industry would not be as big as it is if nobodyconsumed it. As with other cultural expressions, archaeology andthe past are also represented in porn movies, affecting the publicimage of our discipline as it does advertising, literature, or cinema.This paper explores and analyses the multiple references to thepast and our profession found within the context of pornographicmovies and other erotic products, highlighting the potential ofpornography as another tool for informal education.

George Goussetis

İlke TAŞDEMİR, Marella BODUR ÜN, Sevgi BALKAN ŞAHİN

National Cancer Institute

Ian Bickle

Ian Bickle

M.L. DEXTER

S. Nakagawa, T. Takeuchi, M. Naoe