Hasil untuk "q-bio.TO"

F. H. Jackson

Arun Rai, Ilgaz Arikan, J. Pye et al.

M. El-Tawil, S. N. Huseen

U. Brandt, B. Trumpower

Himanshu Joshi, H. Sigmarsson, Sungwook Moon et al.

K. Chandran, D. Aggarwal, R. Migrino et al.

Doxorubicin (DOX) is used for treating various cancers. Its clinical use is, however, limited by its dose-limiting cardiomyopathy. The exact mechanism of DOX-induced cardiomyopathy still remains unknown. The goals were to investigate the molecular mechanism of DOX-induced cardiomyopathy and cardioprotection by mitoquinone (Mito-Q), a triphenylphosphonium-conjugated analog of coenzyme Q, using a rat model. Rats were treated with DOX, Mito-Q, and DOX plus Mito-Q for 12 weeks. The left ventricular function as measured by two-dimensional echocardiography decreased in DOX-treated rats but was preserved during Mito-Q plus DOX treatment. Using low-temperature ex vivo electron paramagnetic resonance (EPR), a time-dependent decrease in heme signal was detected in heart tissues isolated from rats administered with a cumulative dose of DOX. DOX attenuated the EPR signals characteristic of the exchange interaction between cytochrome c oxidase (CcO)-Fe(III) heme a3 and CuB. DOX and Mito-Q together restored these EPR signals and the CcO activity in heart tissues. DOX strongly downregulated the stable expression of the CcO subunits II and Va and had a slight inhibitory effect on CcO subunit I gene expression. Mito-Q restored CcO subunit II and Va expressions in DOX-treated rats. These results suggest a novel cardioprotection mechanism by Mito-Q during DOX-induced cardiomyopathy involving CcO.

D. Frankel, H. Richet, A. Renvoisé et al.

To assess Q fever in France, we analyzed data for 1985–2009 from the French National Reference Center. A total of 179,794 serum samples were analyzed; 3,723 patients (one third female patients) had acute Q fever. Yearly distribution of acute Q fever showed a continuous increase. Periodic variations were observed in monthly distribution during January 2000–December 2009; cases peaked during April–September. Q fever was diagnosed more often in patients in southeastern France, where our laboratory is situated, than in other areas. Reevaluation of the current positive predictive value of serologic analysis for endocarditis was performed. We propose a change in the phase I (virulent bacteria) immunoglobulin G cutoff titer to >1,600. Annual incidences of acute Q fever and endocarditis were 2.5/100,000 persons and 0.1/100,000 persons, respectively. Cases and outbreaks of Q fever have increased in France.

I. T. Ellingsen, I. Størksen, P. Stephens

D. Vernooy, A. Furusawa, N. Georgiades et al.

C. Quesenberry

N. Akhtar-Danesh, A. Baumann, L. Cordingley

H. Gidding, Cate Wallace, G. Lawrence et al.

Dachun Yang, Wen Yuan

P. Mehta, Sean P. Meyn

G. Lenaz, R. Fato, G. Formiggini et al.

Pnina Shinebourne

In this paper the author outlines the features of Q method and assesses its suitability as a qualitative research method. She discusses the process of using the method and its particular approach to researching the range and diversity of subjective understandings, beliefs, and experiences. Q method is particularly suitable for identifying commonality and diversity and has a powerful capacity for thematic identification and analysis. In the author's view, Q method makes a contribution to expanding the repertoire of qualitative research methods.

Arild Palmström, E. Broch