Hasil untuk "math.AP"

Clara Masriera-Esquerra

Stefano Costa, Francesco Ripanti

As an orchestra or a rock star, archaeologists have their audience too. This paper wants to highlight an integrated approach between fieldwork, its account and its dissemination to the public in different ways, including social media. This potential integration has come to life in the 2011 excavation of the Roman mansio of Vignale (Italy) and it has been named “Excava(c)tion”. It doesn’t mean a new way of digging but another way of approaching the excavation, an approach integrated toward and with the public, both on site and on the social Web. “Excava(c)tion” conceives the site as a stage and digging as a performance, through a continuous dialogue between archaeologists and the public. Archaeologists share their work in the form of guided tours (live, theatrical-like performances), communicative diaries and videos (edited, motion-picture performances) and on a blog (www.uominiecoseavignale.it). They receive back comments and oral accounts from the local community about the main themes of common interest. “Excava(c)tion” means engagement both of archaeologists and the public in the pursuit of a global multivocality during archaeological excavation.

Rhianna C. Rogers, Menoukha Case

R. Gow

Hui Zhang, Jackelyn Raymundo, Kathleen E. Daly et al.

ABSTRACT AP-2 transcription factors regulate ectodermal development but their roles for epidermal homeostasis in the adult skin are unknown. We find that AP-2α is the predominant AP-2 family member in adult epidermis, followed by AP-2β. Through inactivation of AP-2α, AP-2β, or both in keratinocytes we assessed the effects of a gradient of epidermal AP-2 activity on skin function. We find that (1) loss of AP-2β in keratinocytes is compensated for by AP-2α, (2) loss of AP-2α impairs terminal keratinocyte differentiation and hair morphogenesis, and (3) the combined loss of AP-2α/AP-2β results in more severe skin and hair abnormalities. Keratinocyte differentiation defects precede a progressive neutrophilic skin inflammation. Inducible inactivation of AP-2α/AP-2β in the adult phenocopies these manifestations. Transcriptomic analyses of epidermis lacking AP-2α or AP-2α/AP-2β in keratinocytes demonstrate a terminal keratinocyte differentiation defect with upregulation of alarmin keratins and of several immune pathway regulators. Moreover, our analyses suggest a key role of loss of AP-2α-dependent gene expression of CXCL14 and KRT15 as an early pathogenic event towards the manifestation of skin inflammation. Thus, AP-2α/AP-2β are critical regulators of epidermal homeostasis in the adult skin.

Damian Kolat, Żaneta Kałuzińska, Andrzej K. Bednarek et al.

National Cancer Institute

National Cancer Institute

Samir Benoudina

Shashikala Bhat, AP Ashwini, AP Suma et al.

Asso.Prof of Medicine, Kamineni Medical College, Narketpally, Telangana., Crps Krishna, Y Srinivas et al.

Narayana Medical College & Hospital, Nellore, AP, Ramamohan D, GSCNV Prasad et al.

Ian Bickle

Ian Bickle