Hasil untuk "Religions of the world"

S. Alam, F. D. Albareti, C. Prieto et al.

The third generation of the Sloan Digital Sky Survey (SDSS-III) took data from 2008 to 2014 using the original SDSS wide-field imager, the original and an upgraded multi-object fiber-fed optical spectrograph, a new near-infrared high-resolution spectrograph, and a novel optical interferometer. All of the data from SDSS-III are now made public. In particular, this paper describes Data Release 11 (DR11) including all data acquired through 2013 July, and Data Release 12 (DR12) adding data acquired through 2014 July (including all data included in previous data releases), marking the end of SDSS-III observing. Relative to our previous public release (DR10), DR12 adds one million new spectra of galaxies and quasars from the Baryon Oscillation Spectroscopic Survey (BOSS) over an additional 3000 deg2 of sky, more than triples the number of H-band spectra of stars as part of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE), and includes repeated accurate radial velocity measurements of 5500 stars from the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS). The APOGEE outputs now include the measured abundances of 15 different elements for each star. In total, SDSS-III added 5200 deg2 of ugriz imaging; 155,520 spectra of 138,099 stars as part of the Sloan Exploration of Galactic Understanding and Evolution 2 (SEGUE-2) survey; 2,497,484 BOSS spectra of 1,372,737 galaxies, 294,512 quasars, and 247,216 stars over 9376 deg2; 618,080 APOGEE spectra of 156,593 stars; and 197,040 MARVELS spectra of 5513 stars. Since its first light in 1998, SDSS has imaged over 1/3 of the Celestial sphere in five bands and obtained over five million astronomical spectra.

N. Batalha, J. Rowe, S. Bryson et al.

New transiting planet candidates are identified in 16 months (2009 May–2010 September) of data from the Kepler spacecraft. Nearly 5000 periodic transit-like signals are vetted against astrophysical and instrumental false positives yielding 1108 viable new planet candidates, bringing the total count up to over 2300. Improved vetting metrics are employed, contributing to higher catalog reliability. Most notable is the noise-weighted robust averaging of multi-quarter photo-center offsets derived from difference image analysis that identifies likely background eclipsing binaries. Twenty-two months of photometry are used for the purpose of characterizing each of the candidates. Ephemerides (transit epoch, T0, and orbital period, P) are tabulated as well as the products of light curve modeling: reduced radius (RP/R⋆), reduced semimajor axis (d/R⋆), and impact parameter (b). The largest fractional increases are seen for the smallest planet candidates (201% for candidates smaller than 2 R⊕ compared to 53% for candidates larger than 2 R⊕) and those at longer orbital periods (124% for candidates outside of 50 day orbits versus 86% for candidates inside of 50 day orbits). The gains are larger than expected from increasing the observing window from 13 months (Quarters 1–5) to 16 months (Quarters 1–6) even in regions of parameter space where one would have expected the previous catalogs to be complete. Analyses of planet frequencies based on previous catalogs will be affected by such incompleteness. The fraction of all planet candidate host stars with multiple candidates has grown from 17% to 20%, and the paucity of short-period giant planets in multiple systems is still evident. The progression toward smaller planets at longer orbital periods with each new catalog release suggests that Earth-size planets in the habitable zone are forthcoming if, indeed, such planets are abundant.

T. Kraemer, M. Mark, P. Waldburger et al.

Systems of three interacting particles are notorious for their complex physical behaviour. A landmark theoretical result in few-body quantum physics is Efimov's prediction of a universal set of bound trimer states appearing for three identical bosons with a resonant two-body interaction. Counterintuitively, these states even exist in the absence of a corresponding two-body bound state. Since the formulation of Efimov's problem in the context of nuclear physics 35 years ago, it has attracted great interest in many areas of physics. However, the observation of Efimov quantum states has remained an elusive goal. Here we report the observation of an Efimov resonance in an ultracold gas of caesium atoms. The resonance occurs in the range of large negative two-body scattering lengths, arising from the coupling of three free atoms to an Efimov trimer. Experimentally, we observe its signature as a giant three-body recombination loss when the strength of the two-body interaction is varied. We also detect a minimum in the recombination loss for positive scattering lengths, indicating destructive interference of decay pathways. Our results confirm central theoretical predictions of Efimov physics and represent a starting point with which to explore the universal properties of resonantly interacting few-body systems. While Feshbach resonances have provided the key to control quantum-mechanical interactions on the two-body level, Efimov resonances connect ultracold matter to the world of few-body quantum phenomena.

H. Katai, T. Ishikawa, K. Akazawa et al.

J. Hansen, M. Sato, L. Simons et al.

Improved knowledge of glacial-to-interglacial global temperature change yields Charney (fast-feedback) equilibrium climate sensitivity 1.2 ± 0.3°C (2σ) per W/m2, which is 4.8°C ± 1.2°C for doubled CO2. Consistent analysis of temperature over the full Cenozoic era—including ‘slow’ feedbacks by ice sheets and trace gases—supports this sensitivity and implies that CO2 was 300–350 ppm in the Pliocene and about 450 ppm at transition to a nearly ice-free planet, exposing unrealistic lethargy of ice sheet models. Equilibrium global warming for today’s GHG amount is 10°C, which is reduced to 8°C by today’s human-made aerosols. Equilibrium warming is not ‘committed’ warming; rapid phaseout of GHG emissions would prevent most equilibrium warming from occurring. However, decline of aerosol emissions since 2010 should increase the 1970–2010 global warming rate of 0.18°C per decade to a post-2010 rate of at least 0.27°C per decade. Thus, under the present geopolitical approach to GHG emissions, global warming will exceed 1.5°C in the 2020s and 2°C before 2050. Impacts on people and nature will accelerate as global warming increases hydrologic (weather) extremes. The enormity of consequences demands a return to Holocene-level global temperature. Required actions include: (1) a global increasing price on GHG emissions accompanied by development of abundant, affordable, dispatchable clean energy, (2) East-West cooperation in a way that accommodates developing world needs, and (3) intervention with Earth’s radiation imbalance to phase down today’s massive human-made ‘geo-transformation’ of Earth’s climate. Current political crises present an opportunity for reset, especially if young people can grasp their situation.

Fakultas and Intensive, Kedokteran Prananda Surya Afrita Amalia Laitupa the COVID-19, Fkum Surabaya Care of Rsud Dr. Kartika Prahasanti et al.

Suicide remains a largely hidden public health concern in Indonesia, shaped by pervasive underreporting and religion-based stigma that frequently frames psychological suffering as a manifestation of weak faith. This narrative review critically examines the dual role of religion in suicide prevention, acknowledging its capacity to function both as a protective resource and, under certain interpretive conditions, as a factor that may exacerbate risk through stigma and social exclusion. Rather than aggregating empirical evidence, this review adopts an interpretive and theory-building approach, synthesizing interdisciplinary literature from public health, psychiatry, neurobiology, and Islamic theology to develop a conceptual framework for narrative reconstruction. The analysis highlights that religious teachings can foster hope, meaning, and social belonging, while rigid or judgmental interpretations may intensify shame and hinder help-seeking. Building on this synthesis, the article proposes a normative framework that integrates scientific understandings of psychological pain and neurobiological vulnerability with compassionate theological concepts, such as divine mercy and hope, and with the reinterpretation of ikhtiar and tawakal as supportive of professional mental health care. As a practical illustration, a culturally resonant psychological first aid model—Ask, Listen, Accompany (ALA)—is presented as a community-oriented approach aligned with established global principles, without claiming empirical validation. The framework is intended as a heuristic guide rather than an evidentiary model, and its applicability will vary across Indonesia’s diverse socioreligious contexts. By repositioning religion as complementary to clinical care, this review aims to inform dialogue, guide future empirical research, and support culturally sensitive suicide prevention efforts.

Ershat Onggar , Nurlan Kairbekov, Shamshadin Kerim

The aim of this study was to identify the mechanisms of religious transformation and cultural continuity in the countries of Central Asia through the analysis of Islamic discourse in texts and architecture. This study specifically addresses the research question: how does Islamic discourse influence both religious transformation and cultural continuity across different Central Asian contexts? The methodological framework included content analysis of religious sources (treatises, fatwas, sermons), discourse analysis of normative documents from the Soviet period, and thematic analysis of architectural forms. The empirical material encompassed Kazakhstan, Uzbekistan, Tajikistan, Turkmenistan, and Kyrgyzstan, enabling a comparative examination of religious dynamics across the region. The research established that the Islamic tradition in the region maintained stable semantic and conceptual cores – such as dhikr, tariqa, akhlaq, umma, and iman – while their interpretations varied according to local cultural codes. In Kazakhstan, Uzbekistan, and Kyrgyzstan, Hanafi and Sufi rhetoric predominated; Tajikistan demonstrated the presence of philosophical-Shī‘a elements; in Turkmenistan, religious knowledge was interwoven into oral tradition and folklore. The Soviet period exhibited a profound transformation of the religious infrastructure: institutional continuity was disrupted, the language of religious discourse was altered, and sacred space was curtailed. At the same time, epic and poetic genres ensured the partial preservation of Islamic symbolism. Post-Soviet religious rhetoric assumed a regulatory character, reflecting the imperatives of nation-building. Contemporary fatwas and khutbas were dominated by themes of moderation, morality, social responsibility, and cultural identity. The architecture of sacred sites recorded the evolution of Islamic identity: from medieval mausoleums to contemporary mosques reflecting a synthesis of religious and state strategies. The original contribution of this study lies in providing a comprehensive comparative analysis of Islamic discourse across multiple Central Asian countries, integrating textual and architectural evidence to trace both continuity and transformation. A possible avenue for future research could explore the impact of digital media and online religious platforms on contemporary Islamic discourse and identity formation in the region.

Aidos Sailaubay, Zhusipov Bakhyt, Zhomart Simtikov et al.

Terrorism persists not simply because of its violence or ideology but because the networks that sustain it are embedded in the everyday relations of markets, politics and faith. This article analyzes the social logic of terrorism financing by integrating sociological theory with recent research on the misuse of charity, informal value transfer systems and digital currencies. Empirical evidence from Kazakhstan and Central Asia is combined with international examples of hawala systems, crowdfunding platforms and cryptocurrency campaigns. The study highlights three levels of analysis: micro-level interpersonal trust and kinship ties, meso-level religious and ethnic communities, and macro-level transnational networks supported by states and ideologues. The findings underscore the need for counterterrorism policies that address social and theological drivers alongside financial controls. Religious literacy, interfaith dialogue and inclusive economic development are identified as critical components of sustainable prevention. This study reconceptualizes terrorism financing as a morally legitimized social process by showing how religious obligation and social capital translate trust into transnational resource flows.

Yanxin Si, Bayu Jayawardhana, J. N. Kutz et al.

Experimental Modal Analysis (EMA) has been widely used to identify structural dynamic properties, including natural frequencies, damping ratios, and mode shapes, for structural integrity assessment. The Poly-reference Least Squares Complex Frequency (pLSCF) method is one of the most widely adopted approaches for EMA because of its strong ability to separate closely spaced modes and its robustness to measurement noise. However, pLSCF-based EMA is generally limited to low-dimensional cases with a small number of measurement points, as its computational cost increases rapidly for high-dimensional or continuous structural measurements, particularly with increasing model order. To overcome this limitation, this paper develops a high-dimensional EMA framework based on Dynamic Mode Decomposition with control (DMDc), a powerful data-driven technique originally developed in fluid dynamics, for modal identification under high-dimensional measurement scenarios. Specifically, the relationship between pLSCF and time-delay DMDc is clarified through the discrete state-space representation of the auto-regressive with exogenous inputs (ARX) model for linear systems. By showing that both methods describe the same physical dynamics of the structure, this study provides a physics-based rationale for applying time-delay DMDc to EMA. The capability and advantages of time-delay DMDc for modal parameter identification in both low- and high-dimensional measurements are validated through numerical simulations of a 6-DOF system and experiments on a cantilever beam using a digital camera. The results demonstrate that time-delay DMDc enables robust and reliable modal parameter identification, effectively addressing high-dimensional EMA problems that are difficult for conventional pLSCF and highlighting its potential for real-world structural dynamics applications.

L. Moccia, Francesca Bardi, M. B. Anesini et al.

Background/Objectives: While positive symptoms of schizophrenia are often satisfactorily controlled, negative symptoms are difficult to treat, persisting despite treatment. Different strategies have been devised to deal with this problem. We aimed to review drug treatment for negative symptoms of schizophrenia in controlled trials of marketed drugs. Methods: We searched the PubMed database and the resulting records’ reference lists to identify eligible trials using schizophrenia[ti] AND “negative symptom*”[ti] as a search strategy. We determined eligibility through Delphi rounds among all authors. Results: On 11 February 2025, we identified 1485 records on PubMed and 3 more from reference lists. Eligible were 95 records. Most studies were double-blind, randomized controlled trials, carried-out in add-on in patients stabilized with antipsychotics. Other antipsychotics were the most frequent comparators, followed by antidepressants, and recently, antioxidants are gaining importance in trials. Many trials, especially those conducted in the Western world, found no significant effects compared to placebo, while most Iranian studies were positive, although not with a strong effect size. Conclusions: Current research has contributed little to progress in the treatment of the negative symptoms of schizophrenia. The reason might reside in the absence of knowledge of the mechanisms whereby these symptoms are generated, which prevents us from designing possibly effective treatment strategies, and/or to the chronicity of negative symptoms, as they are the first to be established even when they do not become fully apparent.

Goodluck Tamarameiye LAYEFA, Ngozi EZENAGU, Olumide OLUGBEMI-GABRIEL et al.

Truth-telling is a cherished religious value in most African societies as opposed to lying. Thus, African indigenous religion upholds the virtue of truth-telling and abhors the vice of lying. This accepted religious virtue is promoted through various means, including film. The film, A Little White-Lie pictures a chaste working-class lady who deceitfully arranges for marriage, a pseudo-spouse under intense parental pressure. As the plot gradually unfolds, the truth is revealed that the fiancé is a true exemplification of ‘a little white lie’. Nevertheless, the film ends in a happy marital union contrary to the punishment for vices from the Afrocentric baseline as the film seems to endorse the vice of lying. The paper examines the art of lying and its verisimilitude in Nigerian society by employing a qualitative survey as the research methodology. Data were collected using focus group discussions. Most participants affirm that any form of lying is wrong and unnecessary from a religious perspective; others contend that lying though wrong is justifiable under some existential conditions. More so, some participants hold that the film reflects the culture and traditions of the Nigerian society. In contrast, a few others view the film as a negation of the religious values of the society it portrays. The study recommends that Nigerian film producers should endeavour to run storylines that align with the normative values of society.

Mokh. Sya’roni, Moh. Nor Ichwan, Muhammad Yusuf Pratama et al.

This study aims to re-examine the teachings of Prophet Muhammad SAW related to the environment in hadith literature, as well as to assess their relevance in addressing the global ecological crisis challenges of the 21st century. The main research question raised is: How can the environmental ethical principles in the Prophet’s hadiths be contextualized to form an Islamic response to the current climate crisis? This study uses a qualitative approach based on library research with thematic analysis methods applied to hadiths related to nature protection, water conservation, animal preservation, and the prohibition of destruction (fasād) on Earth. Additionally, contextual analysis is conducted to understand the relevance of these teachings within contemporary environmental ethics discourse and sustainability policies. The research findings indicate that there is a strong ethical foundation in the Prophet’s hadiths to build an Islamic ecotheological paradigm that emphasizes human responsibility as khalīfah in maintaining ecological balance. This study recommends the integration of prophetic values into public policy and environmental education, as well as underlines Islam’s unique contribution to global environmental ethics.

The Executive Board of Docomomo Deutschland e.V.

In June, Berthold Burkhardt, one of the supporters of the first hours of Docomomo, passed away. He was involved in the organization of the International Docomomo Conference at Bauhaus Dessau (1992), and actively participating in the “restart” of Docomomo Germany in 2006.He studied architecture and civil engineering in Stuttgart (1960-1965). As an architect and engineer in Frei Otto’s office, he was involved in iconic buildings such as the German Pavilion at Expo 67 in Montreal and the roof structures for the 1972 Olympic Games in Munich. As a staff member of Institute for Lightweight Structures at the University (ILEK) in Stuttgart and in research projects, he devoted himself scientifically to the topic that occupied him throughout his entire professional life: lightweight structures.In 1984 he was appointed as professor and Head of the Institute for Structural Design at TU Braunschweig. He was able to combine his research with architectural teaching and his work as an independent architect, from 1993 together with Martin Schumacher in the Burkhardt + Schumacher office. Conservation and renovation projects became increasingly important, e.g. the employment agengy in Dessau by Walter Gropius and the Chancellor’s Bungalow in Bonn by Sep Ruf.Next to his active involvement in Docomomo, he was a member of ICOMOS, Europa Nostra, the Alvar Aalto Society, the Koldewey Society for Historical Building Research and the Society for the History of Building Technology, and served several years as head of the monitoring group for the German World Heritage Sites. As an expert and advisor, he supported the Wüstenrot Foundation and the Bauhaus Dessau Foundation, and played a key role in setting the course for the general refurbishment of the Bauhaus building from 1996 onwards.We will miss him as an architect, engineer, scientist, mentor and friend.

Euclid Collaboration N. E. P. Lines, T. Collett, P. Holloway et al.

In the era of large-scale surveys like Euclid, machine learning has become an essential tool for identifying rare yet scientifically valuable objects, such as strong gravitational lenses. However, supervised machine-learning approaches require large quantities of labelled examples to train on, and the limited number of known strong lenses has lead to a reliance on simulations for training. A well-known challenge is that machine-learning models trained on one data domain often underperform when applied to a different domain: in the context of lens finding, this means that strong performance on simulated lenses does not necessarily translate into equally good performance on real observations. In Euclid's Quick Data Release 1 (Q1), covering 63 deg2, 500 strong lens candidates were discovered through a synergy of machine learning, citizen science, and expert visual inspection. These discoveries now allow us to quantify this performance gap and investigate the impact of training on real data. We find that a network trained only on simulations recovers up to 92% of simulated lenses with 100% purity, but only achieves 50% completeness with 24% purity on real Euclid data. By augmenting training data with real Euclid lenses and non-lenses, completeness improves by 25-30% in terms of the expected yield of discoverable lenses in Euclid DR1 and the full Euclid Wide Survey. Roughly 20% of this improvement comes from the inclusion of real lenses in the training data, while 5-10% comes from exposure to a more diverse set of non-lenses and false-positives from Q1. We show that the most effective lens-finding strategy for real-world performance combines the diversity of simulations with the fidelity of real lenses. This hybrid approach establishes a clear methodology for maximising lens discoveries in future data releases from Euclid, and will likely also be applicable to other surveys such as LSST.

Anbin Wu, Zhiyong Feng, Ruitao Feng et al.

RESTful APIs facilitate data exchange between applications, but they also expose sensitive resources to potential exploitation. Broken Object Level Authorization (BOLA) is the top vulnerability in the OWASP API Security Top 10, exemplifies a critical access control flaw where attackers manipulate API parameters to gain unauthorized access. To address this, we propose BOLAZ, a defense framework grounded in zero trust principles. BOLAZ analyzes the data flow of resource IDs, pinpointing BOLA attack injection points and determining the associated authorization intervals to prevent horizontal privilege escalation. Our approach leverages static taint tracking to categorize APIs into producers and consumers based on how they handle resource IDs. By mapping the propagation paths of resource IDs, BOLAZ captures the context in which these IDs are produced and consumed, allowing for precise identification of authorization boundaries. Unlike defense methods based on common authorization models, BOLAZ is the first authorization-guided method that adapts defense rules based on the system's best-practice authorization logic. We validate BOLAZ through empirical research on 10 GitHub projects. The results demonstrate BOLAZ's effectiveness in defending against vulnerabilities collected from CVE and discovering 35 new BOLA vulnerabilities in the wild, demonstrating its practicality in real-world deployments.

F. Rull, Sylvestre Maurice, I. Hutchinson et al.

The Raman Laser Spectrometer (RLS) on board the ESA/Roscosmos ExoMars 2020 mission will provide precise identification of the mineral phases and the possibility to detect organics on the Red Planet. The RLS will work on the powdered samples prepared inside the Pasteur analytical suite and collected on the surface and subsurface by a drill system. Raman spectroscopy is a well-known analytical technique based on the inelastic scattering by matter of incident monochromatic light (the Raman effect) that has many applications in laboratory and industry, yet to be used in space applications. Raman spectrometers will be included in two Mars rovers scheduled to be launched in 2020. The Raman instrument for ExoMars 2020 consists of three main units: (1) a transmission spectrograph coupled to a CCD detector; (2) an electronics box, including the excitation laser that controls the instrument functions; and (3) an optical head with an autofocus mechanism illuminating and collecting the scattered light from the spot under investigation. The optical head is connected to the excitation laser and the spectrometer by optical fibers. The instrument also has two targets positioned inside the rover analytical laboratory for onboard Raman spectral calibration. The aim of this article was to present a detailed description of the RLS instrument, including its operation on Mars. To verify RLS operation before launch and to prepare science scenarios for the mission, a simulator of the sample analysis chain has been developed by the team. The results obtained are also discussed. Finally, the potential of the Raman instrument for use in field conditions is addressed. By using a ruggedized prototype, also developed by our team, a wide range of terrestrial analog sites across the world have been studied. These investigations allowed preparing a large collection of real, in situ spectra of samples from different geological processes and periods of Earth evolution. On this basis, we are working to develop models for interpreting analog processes on Mars during the mission. Key Words: Raman spectroscopy—ExoMars mission—Instruments and techniques—Planetary sciences—Mars mineralogy and geochemistry—Search for life on Mars. Astrobiology 17, 627–654.

Sarah Tuttle, Mark M. Matsumura, David R. Ardila et al.

We present here the current state of a collection of promising ultraviolet technologies in preparation for the Habitable Worlds Observatory. Working with experts representing a significant number of groups working in the ultraviolet, we summarize some of the leading science drivers, present an argument for a 100 nm blue wavelength cutoff, and gather current state of the art of UV technologies. We present the state of the art of contamination control, a crucial piece of the UV instrument plan. We explore next steps with individual technologies, as well as present paths forward with systems level testing and development.

Mariela Guevara, F. Rodrigues-Soares, Carla González de la Cruz et al.

Background/Objectives: Research on pharmacogenetic variability in response to prescribed drugs and across ethnic groups is essential for personalized medicine, particularly in admixed and unstudied populations. For the first time, this study examines CYP2D6, CYP2C9, and CYP2C19 alleles and genotypes in 197 healthy volunteers from the Dominican Republic, as part of the RIBEF-CEIBA collaborative network. Methods: The analysis focuses on the participants’ tri-hybrid genomic ancestry, with CYP alleles determined by real-time PCR and molecular ancestry inferred using 90 AIMs. Linear regression was used to associate ancestry components with CYP frequencies. Results: The average ancestry was 23.8% European, 42.6% Native American, and 33.6% African, the latter being higher than in most Latin American populations. Native American ancestry was also higher than expected. Predicted phenotype frequencies based on genotypes were 4.2% poor metabolizers (gPMs) and 3.6% ultrarapid metabolizers (gUMs) for CYP2D6, as well as 3% gPMs, 22.8% rapid metabolizers (gRMs), and 1.5% gUMs for CYP2C19. No gPM individuals were observed for CYP2C9. Certain alleles associated with decreased CYP2D6 activity (*17 and *29) and increased CYP2C19 activity (*17 and gUMs) were positively linked with African ancestry and negatively with Native American ancestry. Rare CYP2C9 alleles (*5 and *6) with clinical relevance were additionally found. Conclusions: These findings build on previous results from the RIBEF-CEIBA collaborative network, demonstrating differences in allele frequencies of CYP2D6, CYP2C9, and CYP2C19 in relation to genomic ancestry. In summary, ethnicity must be considered in the development of pharmacogenetic guidelines for clinical application, research, and regulation to avoid widening the biotechnology gap and to allow Personalized Medicine to reach the entire world population.

Georg Schelling, P. Heesen, Boris Tautermann et al.

Simple Summary Sarcomas are rare cancers that are complex to treat and can be expensive to manage, especially when considering surgery costs. This research investigates how much sarcoma surgeries cost across three different hospitals in Switzerland and examines what factors might cause these costs to vary. By consistently using the same surgeon for all procedures, the study ensures that differences in surgical expertise do not affect the results, allowing a clear focus on hospital practices and the complexity of tumor impact costs. The findings aim to help hospitals better plan and manage resources, potentially leading to more cost-effective treatments. This study could influence how healthcare systems approach the financial aspects of treating complex cancers, encouraging a shift towards more standardized and economically sustainable practices. Abstract Background: Sarcomas present a unique challenge within healthcare systems due to their rarity and complex treatment requirements. This study explores the economic impact of sarcoma surgeries across three Swiss tertiary healthcare institutions, utilizing a consistent surgical approach by a single surgeon to eliminate variability in surgical expertise as a confounding factor. Methods: By analyzing data from 356 surgeries recorded in a real-world-time data warehouse, this study assesses surgical and hospital costs relative to institutional characteristics and surgical complexity. Results: Our findings reveal significant cost variations driven more by institutional resource management and pricing strategies than by surgical techniques. Surgical and total hospitalization costs were analyzed in relation to tumor dignity and complexity scores, showing that higher complexity and malignancy significantly increase costs. Interestingly, it was found that surgical costs accounted for only one-third of the total hospitalization costs, highlighting the substantial impact of non-surgical factors on the overall cost of care. Conclusions: The study underscores the need for standardized cost assessment practices and highlights the potential of predictive models in enhancing resource allocation and surgical planning. By advocating for value-based healthcare models and standardized treatment guidelines, this research contributes to more equitable and sustainable healthcare delivery for sarcoma patients. These insights affirm the necessity of including a full spectrum of care costs in value-based models to truly optimize healthcare delivery. These insights prompt a reevaluation of current policies and encourage further research across diverse geographical settings to refine cost management strategies in sarcoma treatment.

Y. Yoon, Jae-Hwan Lee, Wonmook Hwang et al.

BACKGROUND Endovascular therapy (EVT) has become the preferred treatment modality for femoropopliteal disease. However, there is limited evidence regarding its procedural and clinical outcomes according to the affected area. AIMS The aim of this study is to investigate clinical outcomes and device effectiveness according to treatment extent in the superficial femoral artery (SFA), popliteal artery (PA), or both. METHODS In this study, we analysed EVT for SFA (2,404 limbs), PA (155 limbs), SFA/PA (383 limbs) using the population in the K-VIS ELLA (Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Diseases) registry. The primary endpoint was target lesion revascularisation (TLR) at 2 years. RESULTS The SFA/PA group exhibited a higher prevalence of anatomical complexity, characterised by long lesions, moderate to severe calcification, and total occlusion. The procedures were successful in 97.2% of SFA, 92.9% of PA, and 95.6% of SFA/PA EVTs. The 2-year TLR rates were 21.1%, 18.6%, and 32.7% in the SFA, PA, and SFA/PA groups, respectively. SFA/PA EVT was associated with a significantly increased risk for TLR compared to the SFA group (adjusted hazard ratio [HR] 1.48 [1.09-2.00]; p=0.008) and a trend towards an increased risk compared to the PA group (adjusted HR 1.80 [1.00-3.27]; p=0.052). After overlap weighting, the use of a drug-coated balloon (DCB) was shown to be beneficial, with the lowest TLR rate after SFA and SFA/PA EVT. CONCLUSIONS In this large real-world registry, SFA/PA EVT was associated with an increased risk for TLR at 2 years compared to the SFA or PA EVT groups, with favourable outcomes when using a DCB or drug-eluting stent in the SFA/PA EVT group.