Hasil untuk "Human anatomy"

S. Jbabdi, H. Johansen-Berg

C. Ecker, S. Bookheimer, D. Murphy

J. Duyn, P. van Gelderen, Tie-Qiang Li et al.

Kailin R. Mesa

The Thieme Atlas of Anatomy: General Anatomy and Musculoskeletal System, second edition, is an exceptional resource for anyone studying anatomy with an emphasis on the musculoskeletal system. The Thieme Atlas of Anatomy, unlike many other anatomical atlases, combines illustrations with descriptive text and tables and clinical applications. Thus, this text not only functions as a clinically focused atlas, but also a standalone anatomical textbook. The authors approach the study of anatomy in a manner that builds complexity, starting with basic human embryology and development, then moving onto surface anatomy, bones, joints, muscles, vessels, and innervation, followed by an in-depth study of the trunk wall, upper limb, and lower limb. Each chapter notably emphasizes the important relationship between anatomic structure and function as well as introduces clinical applications. The most remarkable feature of this atlas is the set of extraordinarily realistic illustrations created for the first edition, in an attempt to provide both students and providers with a fresh approach to the subject matter. New to the second edition are 30 two-page spreads devoted to clinical pathology that include osteoarthritis of the hip joint, compression syndromes of peripheral nerves, conduction anesthesia of peripheral nerves, shoulder arthroscopy and degenerative changes of the shoulder joint, functions of individual muscles and the symptoms associated with weakening of these muscles, and diagnostic imaging of the large joints. The second edition also contains clinically important imaging for plain film, CT, and MRI scans related to musculoskeletal anatomy and pathology that are presented in parallel with the anatomical illustrations. This edition also comes with access to WinkingSkull.com PLUS, an online resource that contains more than 500 full-color illustrations and radiographs not contained in the text. In addition to the image bank that can be studied with labels-on and labels-off, this online resource can be used by students to self-assess their understanding of the material by taking timed tests with instant results. This book is an ideal text not only for students of various disciplines studying anatomy for the first time, but it also serves as a valuable resource for faculty and providers. The well-organized summary tables are ideal for readers who are interested in a quick anatomical review.

M. O'Toole

Fabio Galbusera

Gabrielle A. Hartley, Mariam Okhovat, Savannah J. Hoyt et al.

Summary: Great apes have maintained a stable karyotype with few large-scale rearrangements; in contrast, gibbons have undergone a high rate of chromosomal rearrangements coincident with rapid centromere turnover. Here, we characterize fully assembled centromeres in the eastern hoolock gibbon, Hoolock leuconedys (HLE), finding a diverse group of transposable elements (TEs) that differ from the canonical alpha-satellites found across centromeres of other apes. We find that HLE centromeres contain a CpG methylation centromere dip region, providing evidence that this epigenetic feature is conserved in the absence of satellite arrays. We uncovered a variety of atypical centromeric features, including protein-coding genes and mismatched replication timing. Further, we identify duplications and deletions in HLE centromeres that distinguish them from other gibbons. Finally, we observed differentially methylated TEs, topologically associated domain boundaries, and segmental duplications at chromosomal breakpoints, and thus propose that a combination of multiple genomic attributes with propensities for chromosome instability shaped gibbon centromere evolution.

Jinsong Wu, Zixian Wang, Fengjiao Li et al.

Abstract Background Protein expression asymmetry between brain hemispheres is hypothesized to influence functional connectivity, yet its role in language‐related networks remains poorly understood. Additionally, how such molecular differences relate to brain reorganization in glioma requires further exploration. Methods We performed label‐free tandem mass spectrometry on 13 left‐hemispheric language‐related Brodmann areas (BAs) and their right‐hemispheric counterparts from 10 donor brains, identifying protein signatures across 6 language‐related functional modules. We then compared these proteomic profiles with resting‐state structural and functional connectivity data from 26 BAs across 90 subjects from the Human Connectome Project (HCP). Finally, we examined functional compensation in 13 glioma patients with tumors in Wernicke's area, correlating gray matter volume in contralateral homologs with linguistic performance. Results Protein expression heterogeneity was greater within hemispheres than between homologous contralateral BAs. Hierarchical clustering revealed interactions between core language areas (Broca's, Wernicke's, Geschwind's) and auditory/motor regions. Functional connectivity strength correlated with protein expression similarity, particularly in symmetric BA4 (primary motor cortex). Excitatory/inhibitory (E/I) neuronal markers (GRIA1/GRIA4) showed a left‐positive, right‐negative correlation with connectivity, suggesting hemispheric differences in synaptic regulation. Glioma patients exhibited right‐hemispheric compensation, with gray matter volume in Wernicke's homolog correlating with linguistic function. Conclusion Our findings support the hypothesis of a homophilic mixing effect between protein expression similarity and connectome architecture, and help explain brain rearrangement in glioma patients. Key points Protein expression differs more within hemispheres than across homologous regions, with distinct signatures in language‐related brain areas. Functional connectivity strength correlates with protein expression similarity, showing left‐right asymmetry in excitatory/inhibitory synaptic regulation (GRIA1/GRIA4). Right‐hemispheric homologs compensate for left‐hemispheric language‐area damage in glioma patients, linking molecular profiles to functional reorganization.

K. Oishi, K. Zilles, K. Amunts et al.

Julio Lara-Riegos, Hugo Azcorra, Juan Carlos Salazar-Rendón et al.

Background Knowledge about the influence of early developmental factors on cardiometabolic health in the Maya is limited.Aim To analyse the relationship between birthweight (BW) and cardiometabolic parameters in a sample of rural Maya children from Yucatan, Mexico.Subjects and methods We took anthropometric measurements and obtained data on BW and fasting blood samples in a sample of 75 children aged 5–14 years. Dependent variables were: fat mass index (FMI), body mass index (BMI), glucose (G), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), LDL/HDL and TC/HDL ratios and metabolic index (TGxG/HDL2). Outcomes were transformed to y = 100 log(e)x and the resulting estimates are interpreted as symmetrical percentage differences. The main independent variable was BW z-score. Multiple linear regression analyses were used to assess the relationship between BW and outcomes.Results An increase of one standard deviation in BW predicted 6.6% (95% CI [–11.6, −1.6]) decrease in HDL and 11% (95% CI [3.7, 18.4]), 7.8% (95% CI [2.3, 13.2]) and 19.6% (95% CI [3.1, 36]) increases in LDL/HDL, TC/HDL and metabolic index, respectively.Conclusion Higher birthweights were associated with adverse levels of biochemical parameters in this sample of rural Maya children.

Edward J. Hardy, Joseph J. Bass, Thomas B. Inns et al.

Abstract Background Skeletal muscle is a highly plastic tissue crucial for many functions associated with whole‐body health across the life course. Magnetic resonance imaging (MRI) is the current gold standard for measuring skeletal muscle size. However, MRI is expensive, and access to facilities is often limited. B‐mode ultrasonography (U/S) has been proposed as a potential alternative to MRI for the assessment of muscle size. However, to date, no work has explored the utility of U/S to assess disuse muscle atrophy (DMA) across muscles with different atrophy susceptibility profiles, an omission which may limit the clinical application of previous work. Methods To address this significant knowledge gap, 10 young men (22 ±  years, 24.1 ± 2.3 kg/m2) underwent 15‐day unilateral leg immobilization using a knee‐brace and air boot. Cross‐sectional area (CSA) and muscle thickness (MT) of the tibialis anterior (TA) and medial gastrocnemius (MG) were assessed via U/S before and after immobilization, with CSA and muscle volume assessed via MRI. Results With both muscles combined, there were good correlations between each U/S and MRI measure, both before (e.g., CSAMRI vs. MTU/S and CSAU/S: r = 0.88 and 0.94, respectively, both P < 0.0001) and after (e.g., VOLMRI vs. MTU/S and CSAU/S: r = 0.90 and 0.96, respectively, both P < 0.0001) immobilization. The relationship between the methods was notably stronger for MG than TA at each time‐point (e.g., CSAMRI vs. MTU/S: MG, r = 0.70, P = 0.0006; TA, r = 0.37, P = 0.10). There was no relationship between the degree of DMA determined by the two methods in either muscle (e.g., TA pre‐ vs. post‐immobilization, VOLMRI: 136 ± 6 vs. 133 ± 5, P = 0.08; CSAU/S: 6.05 ± 0.3 vs. 5.92 ± 0.4, P = 0.70; relationship between methods: r = 0.12, P = 0.75). Conclusions Both MTU/S and CSAU/S provide comparable static measures of lower leg muscle size compared with MRI, albeit with weaker agreement in TA compared to MG. Although both MTU/S and CSAU/S can discern differences in DMA susceptibility between muscles, neither can reliably assess degree of DMA. Based on the growing recognition of heterogeneous atrophy profiles between muscles, and the topical importance of less commonly studied muscles (i.e., TA for falls prevention in older adults), future research should aim to optimize accessible methods to determine muscle losses across the body.

Tomokazu Kawashima, Norihiro Sudou, Makoto Sakai et al.

Angelica Perna, Eleonora Hay, Paolo De Blasiis et al.

During pregnancy, SARS-CoV-2 infection is associated with several adverse outcomes, including an increased risk of pre-eclampsia, preterm delivery, hypertensive disorders, gestational diabetes, and fetal growth restriction related to the development of placenta vascular abnormalities. We analyzed human placenta from full-term, uncomplicated pregnancies with SARS-CoV-2 infection during the first, second, or third trimesters of gestation. We studied, by the immunohistochemistry technique, the expression of CD34 and podoplanin (PDPN) as markers of vasculogenesis to find any differences. As secondary outcomes, we correlated maternal symptoms with placental histological alterations, including fibrin deposits, lymphocyte infiltration in the villi, edema, and thrombi. Our results showed a PDPN expression around the villous stroma as a plexiform network around the villous nucleus of fetal vessels; significant down-regulation was observed in the villous stroma of women infected during the third trimester. CD34 showed no changes in expression levels. During SARS-CoV-2 infection, the most common maternal symptoms were fever, anosmia, ageusia and asthenia, and the majority were treated with paracetamol, corticosteroids and azithromycin. Patients that required multiple symptomatic treatments evidenced a large amount of fibrin deposition in the villi. Certainly, PDPN plays a key role in healthy placental vasculogenesis and thus in its proper physiology, and SARS-CoV-2 surely alters its normal expression. Further studies are necessary to understand what mechanisms are being altered to try to avoid possible complications for both the mother and fetus in terms of the contagions that will still occur.

A Ali, K Awad

Abstract Introduction Telegram has become one of the most popular messaging applications. Its multiple features enable its use for different educational purposes. This study aimed to explore the role of a Telegram’s channel in Anatomical education. Method A Telegram channel was created and shared to first year medical students of University of Khartoum. Subscription to the channel was optional. The Thorax module was covered through different types of daily online posts and quizzes which were posted over one month, in line with the formal practical sessions. At the end of the module, an online test shared to both subscribers and non-subscribers, a feedback questionnaire and focus group discussion were used to assess the effects of the channel and students’ reflection on it. Results 336 students subscribed to the channel by the time of the test. There was a significant association between subscription status and test score (p = 0.01, t = 2.79). Frequency of viewing did not affect test score. Students reported that written posts with images and quizzes were the two most helpful types of posts. Students reported that the channel made it easier for them to understand anatomy (86.4%), aided retention of information (92%) and encouraged engagement (81.6%). Continuation of the channel was recommended by 95.2% of students. Conclusions The channel provided concise and structured material that acted as a blueprint for students during studying and exam preparations. It proved itself as a useful complementary tool for students in the anatomy module. We recommend formal integration of Telegram channels in anatomy curricula.

I.

Nienke M. van Atteveldt, E. Formisano, R. Goebel et al.

G. Christensen, S. Joshi, M. Miller

Brendan Portengen, Marnix Naber, Demi Jansen et al.

The assessment of visual field sensitivities in young children continues to be a challenge. Children often do not sit still, fail to fixate stimuli for longer durations, and have limited verbal capacity to report visibility. We investigated the use of a head-mounted VR display, gaze-contingent flicker pupil perimetry (gcFPP), and three fixation stimulus conditions to determine best practices for optimal fixation and pupil response quality. A total of twenty children (3-11y) passively fixated a dot, counted the repeated appearance of an animated character, and watched an animated movie in separate trials of 80s each. We presented large flickering patches at different eccentricities and angles in the periphery to evoke pupillary oscillations (20 locations, 4s per location). The results showed that gaze precision and accuracy did not differ significantly across the fixation conditions but pupil amplitudes were strongest for the dot and count task. We recommend the use of the fixation counting task for pupil perimetry because children enjoyed it the most and it achieved strongest pupil responses. The VR set-up appears to be an ideal apparatus for children to allow free range of movement, an engaging visual task, and reliable eye measurements.

Alessandra Banzato, Antonella Cerchiari, Sofia Pezzola et al.

Background: Functional Chewing Training (FuCT) was designed as a holistic approach to improve chewing function by providing postural alignment, sensory and motor training, and food and environmental adjustments. The aim of this systematic review was to evaluate the effectiveness of FuCT in improving chewing function and the severity of tongue thrust and drooling in children with cerebral palsy as compared with standard treatment. Methods: We conducted a systematic review of randomized controlled trials. The search was performed between October 2021 and January 2022 using the following databases: PubMed, Scopus, Web of Science, and CINAHL. The review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: The initial search yielded 56 articles. After reading the studies in full, 3 articles were chosen based on the inclusion criteria. Included participants were people with PCI; the studies reported a sample size ranging from 40–80 individuals, one study was on a pediatric population, while the others on adults. The selected studies were then evaluated using Jadad and PEDro scales. Conclusion: Our study confirmed the value of FuCT in improving chewing function and the severity of tongue thrust and drooling. Our results may be useful in optimizing appropriate therapeutic management.

Hiwotie Getaneh Ayalew, Alemneh Mekuriaw Liyew, Zemenu Tadesse Tessema et al.

Abstract Background Unintended pregnancy predisposes women to unsafe abortion, malnutrition, mental illness, and even death. Though adolescent girls and young women are at higher risk of unintended pregnancy, there is a paucity of evidence in its burden and associated factors in sub-Saharan Africa. Therefore, this study aimed to assess the prevalence and factors associated with unintended pregnancy among adolescent girls and young women in sub-Saharan Africa. Method This study was a secondary data analysis of 36 sub-Saharan African countries with a total weighted sample of 17,797 adolescent girls and young women. A multilevel logistic regression model was fitted and, the Adjusted Odds Ratio (AOR) with a 95% Confidence Interval (CI) was reported to assess the association between the independent variables and unintended pregnancy in Sub-Saharan Africa. Result The pooled prevalence of unintended pregnancy in sub-Saharan Africa was 30.01 with 95% CI (29.38–30.74). In multivariable multilevel logistic regression analysis, adolescent girls, and young women with higher education (AOR = 0.71 95%CI 0.52–0.97), those who know modern contraceptive methods (AOR = 0.86 95%CI 0.75–0.98), and traditional contraceptive methods (AOR = 0.90, 95%CI 0.59–0.95), married (AOR = 0.80, 95%CI 0.73–0.88), those from female-headed households (AOR = 0.86,95%CI 0.78–0.94), had lower odds of unintended pregnancy. Whereas adolescent girls and young women from Central Africa (AOR = 2.09,95%CI 1.23–3.55), southern Africa (AOR = 5.23, 95%CI 2.71–10.09), and Eastern Africa (AOR = 1.07,95%CI 1.07–2.66) had higher odds of unintended pregnancy. Conclusion Prevalence of unintended pregnancy in Sub-Saharan Africa is high. Therefore, educating adolescent girls and young women, and improving their knowledge about family planning services is vital. It is also better for the government of countries in sub-Saharan Africa and other global and local stakeholders to work hard to ensure universal access to sexual and reproductive healthcare services, including family planning, education, and the integration of reproductive health into national strategies and programs to reduce unintended pregnancy.