Hasil untuk "Dermatology"

E. Samaniego González, E. Pérez Díez, M. Cuesta Lasso et al.

Dany Alkurdi, Lara Shqair, Saniya Tariq et al.

Abstract Equitable access to clinical studies is essential to ensuring that research findings are generalizable, inclusive, and reflective of all populations. When specific demographic or geographic groups are excluded from participation, the external validity of clinical research is undermined and inequities in treatment access are perpetuated. Autoimmune skin disorders are uncommon and often affect patients living far from major research centers, yet no comprehensive analysis of national clinical study accessibility for these conditions has been conducted. We conducted a retrospective, population-level analysis of study accessibility for autoimmune skin disorders in the United States from 2005 to 2024 using ClinicalTrials.gov and U.S. Census data. Population centers were defined as geographic centroids of ZIP codes, and the distance from each population center to the nearest study site was calculated. Trend analyses assessed changes in accessibility over time and differences across racial and urban–rural categories. Although the number of studies has increased over time (approximately six additional studies annually), travel distances to the nearest study site remain substantial. The average distance has decreased modestly by about 3.4 km per year, but 40% of Americans still live more than 200 km from the closest study site, with the greatest distances observed among rural and American Indian populations. Expanding population coverage requires rapidly increasing travel distances. These findings highlight persistent disparities in access to clinical studies. While decentralization and virtual study models may help reduce these gaps, further research is needed to determine whether such strategies effectively improve participation and representation.

Adina-Mihaela Lupulescu, Alexandra Petruța Savu, Ştefana Bucur et al.

Hard-to-treat areas in psoriasis vulgaris, i.e., the scalp, nails, genital area, palms, and soles, are less commonly diagnosed and treated. Our understanding of the complex etiopathogenesis and treatment of psoriasis vulgaris has advanced considerably in recent years. After performing an English literature search, the present article is a comprehensive review based on several relevant articles. The articles included met the following criteria: they mentioned the “hard-to-treat areas, special sites, difficult-to-treat areas” or the specific body location of psoriasis, and they reported the psoriasis prevalence and/or patients’ quality of life. Despite the extensive information about psoriasis, there are still many limitations and challenges regarding the appropriate approach to psoriasis in these special locations. But emerging directions such as precise severity scores, new biomarkers for disease monitoring, and treatment decisions or forthcoming therapies represent solutions to improve the lives of those affected. Although they affect a small area, the impact on the quality of everyday life is significant, causing physical and mental disability. In this review, we try to highlight the need for more information about hard-to-treat areas, including their prevalence, a more rapid diagnosis, and a correct classification based on their real severity and their specific treatment before a significant impact on patients’ quality of life occurs. By presenting these challenges, we hope to contribute to efforts at improving disease control.

LIU Yinghui, CHEN Yangxia, XIE Zhenmou et al.

Objective To evaluate the pathogenicity of Exophiala dermatitidis melanin in Galleria mellonella infection model. Methods Melanin of albino strain of Exophiala dermatitidis was restored by co-culture with E. dermatitidis (mel3). The G. mellonella were infected with albino, melanized strtain, and melanin restored albino strain. Survival rate, macromorphological and histopathological changes of larvae were observed under the optimal infection concentration. Results The melanin production was restored in albino strain of Exophiala dermatitidis, and conidia at a concentration of 1×107/mL was the optimal infection concentration. At the end of observation, the albino strain displayed lower survival rate compared to both the melanized stain (χ2=6.11，P=0.013) and melanin restored albino strain (χ2=6.37, P=0.010). However, the survival rates did not differ significantly between melanized and melanin restored albino strain (χ2=0.01，P=0.940). Histopathological examination revealed that the melanized strain and melanin restored albino strain attracted aggregation of more Galleria mellonella hemocytes, forming larger infectious nodules in comparison to albino strains. Conclusions In the infection model of Galleria mellonella, the albino strain shows stronger pathogenicity than the melanized strain. Restoration of melanin of albino strain can reverse the pathogenicity.

Jose Reeshma, Olasseri Kalathingal Reena Mariyath, KTP Dayal Narayan et al.

Background: Chronic spontaneous urticaria (CSU) is a dermatosis with a significant psychological component. Only a few studies have assessed the quality of life (QoL) and perceived stress in CSU patients. Objectives: To evaluate the QoL and perceived stress in patients with CSU. Materials and Methods: A cross-sectional study was done on 54 patients of CSU attending the Urticaria clinic of the Dermatology department in a tertiary care postgraduate teaching hospital in North Kerala. QoL in chronic urticaria was assessed using the Chronic Urticaria-Quality of Life (CU-QoL) questionnaire and perceived stress was assessed using the Perceived Stress Scale (PSS). Results: The mean scores of CU-QoL and PSS were 55.78 and 16.31, respectively. Out of 54 patients, 26 (48.1%) had mild impairment, 26 (48.1%) had moderate impairment, and 2 (3.7%) had severe impairment of QoL. Low stress was seen in 20 (37%) patients, moderate stress in 28 (51.9%), and six (11.1%) patients had high stress. Conclusion: This study shows that more than half of the patients with CSU had moderate to severe impairment of QoL and had moderate to severe stress.

C. Schut, F. Dalgard, A. Bewley et al.

Body dysmorphic disorder (BDD) is a common psychiatric disorder associated with high costs for healthcare systems as patients may repeatedly ask for different, often not effective, interventions. BDD symptoms are more prevalent in patients with dermatological conditions than in the general population, but there are no large sample studies comparing the prevalence of BDD symptoms between patients with dermatological conditions and healthy skin controls.

C. Goh, Yan Wu, B. Welsh et al.

Treatment, cleansing, moisturizing, and photoprotection are four major components of holistic skin care for dermatological conditions. While treatment (T) is recognized as a key component in the management of dermatological conditions, there is a lack of practical guidance on the adjunctive role of cleansing, moisturizing, and photoprotection (“CMP”). Limited patient knowledge, confusion over product selection, and lack of guidance on how to choose and use CMP skin care products (in conjunction with pharmacological therapy) are the main barriers to establishing a holistic skin care routine for dermatological conditions.

Pushkar Aggarwal, MD, MBA, Emily S. Gorell, DO, MS, Kelsey S. Flood, MD et al.

Brigitte Dreno, V. Bettoli, E. Araviiskaia et al.

Acne vulgaris is one of the main reasons for dermatological consultations. Severity and response to treatment may be impacted by various external factors or exposome.

G. Yosipovitch, A. Devore, A. Dawn

Anne N Fenton, E. Elliott, Ashkan Shahbandi et al.

rate and the fact that each participant did not serve as his/her own control. Our study showed that medical students were less accurate in diagnosing squamous cell carcinoma, atopic dermatitis, and urticaria in patients with SoC but were more accurate in diagnosing tinea versicolor in SoC. These findings highlight the need to present all dermatologic conditions in both light skin and SoC as part of a comprehensive dermatology curriculum.

Fatemeh Mohaghegh, Parvaneh Hatami, Zeinab Aryanian et al.

Acute generalized exanthematous pustulosis (AGEP) is an exanthematous condition, predominantly occurring as a result of drug reactions. We, hereby, present the first case of AGEP following treatment with remdesivir in a patient with COVID-19, without hydroxychloroquine use, which serves as a reminder to consider remdesivir as a possible causative agent when dealing with AGEP presentation in COVID patients.

Simo Huang, Sylvia Hsu, Kiran Motaparthi

A diverse range of inflammatory dermatoses are characterized by vesicles or bullae [...]

P. Gisondi, G. Altomare, F. Ayala et al.

Chan Mi Lee, S. Jin, E. Doh et al.

Vol. 31, No. 3, 2019 349 Received September 20, 2017, Revised April 23, 2018, Accepted for publication May 31, 2018 Corresponding author: Dong Hun Lee, Department of Dermatology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel: 82-2-2072-2417, Fax: 82-2-742-7344, E-mail: ivymed27@snu.ac.kr ORCID: https://orcid.org/0000-0002-2925-3074 Jin Ho Chung, Department of Dermatology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel: 82-2-20722410, Fax: 82-2-742-7344, E-mail: jhchung@snu.ac.kr ORCID: https://orcid.org/0000-0002-0582-6392 *These authors contributed equally to this work. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology https://doi.org/10.5021/ad.2019.31.3.349

A. Onderdijk, H. J. V. Zee, S. Esmann et al.

Dawid Groth, Izabela Poplawska, Marlena Tynecka et al.

The management of hard-to-heal wounds is a significant clinical challenge. Acellular dermal matrices (ADMs) have been successfully introduced to enhance the healing process. Here, we aimed to develop protocol for the preparation of novel ADMs from abdominoplasty skin. We used three different decellularization protocols for skin processing, namely, 1M NaCl and sodium dodecyl sulfate (SDS, in ADM1); 2M NaCl and sodium dodecyl sulfate (SDS, in ADM1); and a combination of recombinant trypsin and Triton X-100 (in hADM 3). We assessed the effectiveness of decellularization and ADM’s structure by using histochemical and immunochemical staining. In addition, we evaluated the therapeutic potential of novel ADMs in a murine model of wound healing. Furthermore, targeted transcriptomic profiling of genes associated with wound healing was performed. First, we found that all three proposed methods of decellularization effectively removed cellular components from abdominoplasty skin. We showed, however, significant differences in the presence of class I human leukocyte antigen (HLA class I ABC), Talin 1/2, and chondroitin sulfate proteoglycan (NG2). In addition, we found that protocols, when utilized differentially, influenced the preservation of types I, III, IV, and VII collagens. Finally, we showed that abdominoplasty skin-derived ADMs might serve as an effective and safe option for deep wound treatment. More importantly, our novel dressing (ADM1) improves the kinetics of wound closure and scar maturation in the proliferative and remodeling phases of wound healing. In conclusion, we developed a protocol for abdominoplasty skin decellularization suitable for the preparation of biological dressings. We showed that different decellularization methods affect the purity, structure, and therapeutic properties of ADMs.

Anisha Kunwar, Palistha Shrestha, Saraswati Shrestha et al.

Background: Pseudomonas aeruginosa is an opportunistic bacterium that rapidly colonised on the exacerbated skin surface after the burn injury. Along with inherent resistance to many antibiotics, it is also a good biofilm producer that aggravates the condition of burns patients by slow or non-responsive to antibiotics. Therefore, immediate attention must be taken otherwise the condition of patients may become life-threatening. Hence, this cross-sectional study was conducted to know the current scenario of antimicrobial profile and biofilm properties of Pseudomonas aeruginosa isolated from burn patients in Nepal Cleft and Burn Centre, Kirtipur Hospital. Methods: Wound swab or pus samples were taken from 344 patients through the Levine technique or syringe, respectively. The standard laboratory protocol was followed for the identification of Pseudomonas aeruginosa. The antibiotic susceptibility test of isolates was performed by using the Kirby-Bauer disc diffusion method as per the CLSI 2018 guidelines. Biofilm production was accessed through the tube method and microtiter plate assay. Results: All together 60 Pseudomonas aeruginosa were isolated from a total of 275 isolates. The antibiotic susceptibility profile showed that more than 50% of isolates were non-susceptible among the tested antibiotics and shifting of antibiotic choice to piperacillin-tazobactam from traditional amikacin, ciprofloxacin and imipenem. The weak agreement of Kappa statistics indicates that biofilm procurement from the tube method and microtiter plate assay was insignificant. Approximately 25% of P. aeruginosa isolates were biofilm producers and there was no relation between biofilm production and antibiotic susceptibility patterns (χ2 = 0.587). Conclusion: Pseudomonas aeruginosa is a common isolate from burn wound infections. There is a shifting in antibiotic choice and more than half of the isolates were antibiotic resistant; however, no relation between biofilm formation and multidrug resistant profile of isolates was found.

Hélio Amante Miot, Mayra Ianhez, Paulo Müller Ramos

Abstract Background: The Anais Brasileiros de Dermatologia (Anais Brasileiros de Dermatologia) is the official journal of the Brazilian Society of Dermatology, which has been published since 1925, with free, bilingual access. There are several bibliometric indicators that estimate aspects of a journal’s scientific influence. Its analysis, based especially on the evolutionary trend, allows identifying the journal’s strengths and weaknesses, in addition to guiding editorial policies. Objectives: To evaluate the trends of the main bibliometric indicators of Anais Brasileiros de Dermatologia, in the decade of 2010–2019. Methods: Methodological study that proposed the analysis of bibliometric indicators published by Journal Citation Reports, SCImago, and Scopus, for the journal Anais Brasileiros de Dermatologia, from 2010 to 2019. The following aspects were evaluated: Impact factor, Immediacy index, SJR (SCImago), in addition to the number of citations, citable items, Cite Score, percentage of external citations, percentage of cited articles, percentage of citable articles, and the article influence score. Results: There was an increase in the main bibliometric indicators in the last decade: impact factor (0.337 to 1.121), immediacy index (0.054 to 0.204),Eigenfactor (0.00025 to 0.00394), SJR (0.176 to 0.453). The percentage of external citations (48.4% to 94.1%) and cited articles (24.7% to 51.4%) also increased. The increase in the impact factors of Anais Brasileiros de Dermatologia in the period was more significant than that of the dermatology journals (1,667 to 2,118) and the Brazilian journals (1,247 to 1,408), indexed in the Journal Citation Reports. Study limitations: Failure in the classification and registration of the databases. Conclusions: There has been a consistent increase in the scientific influence of Anais Brasileiros de Dermatologia in the last decade.

Alice Chen, A. Setser, M. Anadkat et al.