Hasil untuk "q-bio.PE"

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S2 Open Access 2004
The CMS trigger system

U. Bhawandeep, V. Khachatryan, A. Sirunyan et al.

The CMS trigger system must reduce an input data rate from the LHC bunch-crossing frequency of 40 MHz to a rate which will be written to permanent storage. A detailed study has recently been made of the performance of this system. This paper presents key elements of the results obtained and gives details of a draft “trigger table” for the Level-1 Trigger and the High-Level Trigger selection at a “start-up” luminosity of 2× 1033 cm – 2s – 1. High efficiencies for most physics objects are attainable with a selection that remains inclusive and avoids detailed topological or other requirements on the event.

1196 sitasi en Physics, Computer Science
S2 Open Access 1998
Discovery potential for supersymmetry in CMS

A. Sirunyan, A. Tumasyan, W. Adam et al.

This work summarizes and puts in an overall perspective studies done within the compact muon solenoid (CMS) concerning the discovery potential for squarks and gluinos, sleptons, charginos and neutralinos, supersymmetric (SUSY) dark matter, lightest Higgs, sparticle mass determination methods and the detector design optimization in view of SUSY searches. It represents the status of our understanding of these subjects as of summer 1997. As a benchmark we used the minimal supergravity-inspired supersymmetric standard model (mSUGRA) with a stable lightest supersymmetric particle (LSP). Discovery of supersymmetry at the large hadron collider should be relatively straightforward. It may occur through the observation of large excesses of events in missing ET plus jets, or with one or more isolated leptons. An excess of trilepton events or isolated dileptons with missing ET, exhibiting a characteristic signature in the l+l− invariant mass distribution, could also be the first manifestation of SUSY production. Squarks and gluinos can be discovered for masses in excess of 2 TeV. Charginos and neutralinos can be discovered from an excess of events in dilepton or trilepton final states. Inclusive searches can give early indications from their copious production in squark and gluino cascade decays. Indirect evidence for sleptons can also be obtained from inclusive dilepton studies. Isolation requirements and a jet veto would allow detection of both the direct chargino/neutralino production and the directly produced sleptons. Squark and gluino production may also represent a copious source of Higgs bosons through cascade decays. The lightest SUSY Higgs h → b may be reconstructed with a signal/background ratio of order 1 thanks to hard cuts on ETmiss justified by escaping LSPs. The LSP of SUSY models with conserved R-parity represents a very good candidate for cosmological dark matter. The region of parameter space where this is true is well covered by our searches, at least for tanβ = 2. If supersymmetry exists at the electroweak scale, it could hardly escape detection in CMS and the study of supersymmetry will form a central part of our physics program.

966 sitasi en Physics
S2 Open Access 2019
Extraction and validation of a new set of CMS pythia8 tunes from underlying-event measurements

A. Sirunyan, A. Tumasyan, W. Adam et al.

New sets of CMS underlying-event parameters (“tunes”) are presented for the pythia8 event generator. These tunes use the NNPDF3.1 parton distribution functions (PDFs) at leading (LO), next-to-leading (NLO), or next-to-next-to-leading (NNLO) orders in perturbative quantum chromodynamics, and the strong coupling evolution at LO or NLO. Measurements of charged-particle multiplicity and transverse momentum densities at various hadron collision energies are fit simultaneously to determine the parameters of the tunes. Comparisons of the predictions of the new tunes are provided for observables sensitive to the event shapes at LEP, global underlying event, soft multiparton interactions, and double-parton scattering contributions. In addition, comparisons are made for observables measured in various specific processes, such as multijet, Drell–Yan, and top quark-antiquark pair production including jet substructure observables. The simulation of the underlying event provided by the new tunes is interfaced to a higher-order matrix-element calculation. For the first time, predictions from pythia8 obtained with tunes based on NLO or NNLO PDFs are shown to reliably describe minimum-bias and underlying-event data with a similar level of agreement to predictions from tunes using LO PDF sets.

489 sitasi en Physics
S2 Open Access 2011
Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer*

Annette Michalski, Eugen Damoc, J. Hauschild et al.

Mass spectrometry-based proteomics has greatly benefitted from enormous advances in high resolution instrumentation in recent years. In particular, the combination of a linear ion trap with the Orbitrap analyzer has proven to be a popular instrument configuration. Complementing this hybrid trap-trap instrument, as well as the standalone Orbitrap analyzer termed Exactive, we here present coupling of a quadrupole mass filter to an Orbitrap analyzer. This “Q Exactive” instrument features high ion currents because of an S-lens, and fast high-energy collision-induced dissociation peptide fragmentation because of parallel filling and detection modes. The image current from the detector is processed by an “enhanced Fourier Transformation” algorithm, doubling mass spectrometric resolution. Together with almost instantaneous isolation and fragmentation, the instrument achieves overall cycle times of 1 s for a top10 higher energy collisional dissociation method. More than 2500 proteins can be identified in standard 90-min gradients of tryptic digests of mammalian cell lysate— a significant improvement over previous Orbitrap mass spectrometers. Furthermore, the quadrupole Orbitrap analyzer combination enables multiplexed operation at the MS and tandem MS levels. This is demonstrated in a multiplexed single ion monitoring mode, in which the quadrupole rapidly switches among different narrow mass ranges that are analyzed in a single composite MS spectrum. Similarly, the quadrupole allows fragmentation of different precursor masses in rapid succession, followed by joint analysis of the higher energy collisional dissociation fragment ions in the Orbitrap analyzer. High performance in a robust benchtop format together with the ability to perform complex multiplexed scan modes make the Q Exactive an exciting new instrument for the proteomics and general analytical communities.

748 sitasi en Chemistry, Medicine
S2 Open Access 2018
Continuous reinforcement learning of energy management with deep Q network for a power split hybrid electric bus

Jingda Wu, Hongwen He, Jiankun Peng et al.

Abstract Reinforcement learning is a new research hotspot in the artificial intelligence community. Q learning as a famous reinforcement learning algorithm can achieve satisfactory control performance without need to clarify the complex internal factors in controlled objects. However, discretization state is necessary which limits the application of Q learning in energy management for hybrid electric bus (HEB). In this paper the deep Q learning (DQL) is adopted for energy management issue and the strategy is proposed and verified. Firstly, the system modeling of bus configuration are described. Then, the energy management strategy based on deep Q learning is put forward. Deep neural network is employed and well trained to approximate the action value function (Q function). Furthermore, the Q learning strategy based on the same model is mentioned and applied to compare with deep Q learning. Finally, a part of trained decision network is analyzed separately to verify the effectiveness and rationality of the DQL-based strategy. The training results indicate that DQL-based strategy makes a better performance than that of Q learning in training time consuming and convergence rate. Results also demonstrate the fuel economy of proposed strategy under the unknown driving condition achieves 89% of dynamic programming-based method. In addition, the technique can finally learn to the target state of charge under different initial conditions. The main contribution of this study is to explore a novel reinforcement learning methodology into energy management for HEB which solve the curse of state variable dimensionality, and the techniques can be adopted to solve similar problems.

361 sitasi en Computer Science
S2 Open Access 2023
Q-Transformer: Scalable Offline Reinforcement Learning via Autoregressive Q-Functions

Yevgen Chebotar, Q. Vuong, A. Irpan et al.

In this work, we present a scalable reinforcement learning method for training multi-task policies from large offline datasets that can leverage both human demonstrations and autonomously collected data. Our method uses a Transformer to provide a scalable representation for Q-functions trained via offline temporal difference backups. We therefore refer to the method as Q-Transformer. By discretizing each action dimension and representing the Q-value of each action dimension as separate tokens, we can apply effective high-capacity sequence modeling techniques for Q-learning. We present several design decisions that enable good performance with offline RL training, and show that Q-Transformer outperforms prior offline RL algorithms and imitation learning techniques on a large diverse real-world robotic manipulation task suite. The project's website and videos can be found at https://qtransformer.github.io

145 sitasi en Computer Science
S2 Open Access 2016
Coherent Φ-OTDR based on I/Q demodulation and homodyne detection.

Zinan Wang, Li Zhang, Song Wang et al.

We demonstrate a novel distributed acoustic sensing (DAS) system based on phase-sensitive optical time-domain reflectometry (Φ-OTDR). Both the phase and the amplitude of the Rayleigh scattering (RS) light can be demodulated in real-time. The technique is based on I/Q demodulation and homodyne detection using a 90° optical hybrid. The theoretical analysis is given, and as a proof of the concept, the dynamic strain sensing is experimentally demonstrated, with a sensing range of 12.566 km and a spatial resolution of 10 m.

376 sitasi en Medicine, Physics
S2 Open Access 2016
Antiproton Flux, Antiproton-to-Proton Flux Ratio, and Properties of Elementary Particle Fluxes in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station.

M. Aguilar, L. Ali Cavasonza, B. Alpat et al.

A precision measurement by AMS of the antiproton flux and the antiproton-to-proton flux ratio in primary cosmic rays in the absolute rigidity range from 1 to 450 GV is presented based on 3.49×10^{5} antiproton events and 2.42×10^{9} proton events. The fluxes and flux ratios of charged elementary particles in cosmic rays are also presented. In the absolute rigidity range ∼60 to ∼500  GV, the antiproton p[over ¯], proton p, and positron e^{+} fluxes are found to have nearly identical rigidity dependence and the electron e^{-} flux exhibits a different rigidity dependence. Below 60 GV, the (p[over ¯]/p), (p[over ¯]/e^{+}), and (p/e^{+}) flux ratios each reaches a maximum. From ∼60 to ∼500  GV, the (p[over ¯]/p), (p[over ¯]/e^{+}), and (p/e^{+}) flux ratios show no rigidity dependence. These are new observations of the properties of elementary particles in the cosmos.

371 sitasi en Physics, Medicine
CrossRef Open Access 2024
COVID-19 and pregnancy: A European study on pre- and post-infection medication use

Eimir Hurley, Benjamin P. Geisler, Angela Lupattelli et al.

Abstract Purpose The COVID-19 pandemic has impacted medication needs and prescribing practices, including those affecting pregnant women. Our goal was to investigate patterns of medication use among pregnant women with COVID-19, focusing on variations by trimester of infection and location. Methods We conducted an observational study using six electronic healthcare databases from six European regions (Aragon/Spain; France; Norway; Tuscany, Italy; Valencia/Spain; and Wales/UK). The prevalence of primary care prescribing or dispensing was compared in the 30-day periods before and after a positive COVID-19 test or diagnosis. Results The study included 294,126 pregnant women, of whom 8943 (3.0%) tested positive for, or were diagnosed with, COVID-19 during their pregnancy. A significantly higher use of antithrombotic medications was observed particularly after COVID-19 infection in the second and third trimesters. The highest increase was observed in the Valencia region where use of antithrombotic medications in the third trimester increased from 3.8% before COVID-19 to 61.9% after the infection. Increases in other countries were lower; for example, in Norway, the prevalence of antithrombotic medication use changed from around 1–2% before to around 6% after COVID-19 in the third trimester. Smaller and less consistent increases were observed in the use of other drug classes, such as antimicrobials and systemic corticosteroids. Conclusion Our findings highlight the substantial impact of COVID-19 on primary care medication use among pregnant women, with a marked increase in the use of antithrombotic medications post-COVID-19. These results underscore the need for further research to understand the broader implications of these patterns on maternal and neonatal/fetal health outcomes.

6 sitasi en
S2 Open Access 2011
Deterministic design of wavelength scale, ultra-high Q photonic crystal nanobeam cavities.

Q. Quan, M. Lončar

Photonic crystal nanobeam cavities are versatile platforms of interest for optical communications, optomechanics, optofluidics, cavity QED, etc. In a previous work [Appl. Phys. Lett. 96, 203102 (2010)], we proposed a deterministic method to achieve ultrahigh Q cavities. This follow-up work provides systematic analysis and verifications of the deterministic design recipe and further extends the discussion to air-mode cavities. We demonstrate designs of dielectric-mode and air-mode cavities with Q > 10⁹, as well as dielectric-mode nanobeam cavities with both ultrahigh-Q (> 10⁷) and ultrahigh on-resonance transmissions (T > 95%).

431 sitasi en Physics, Medicine
S2 Open Access 2019
Congruences on sums of q-binomial coefficients

Ji-Cai Liu, F. Petrov

We establish a $q$-analogue of Sun--Zhao's congruence on harmonic sums. Based on this $q$-congruence and a $q$-series identity, we prove a congruence conjecture on sums of central $q$-binomial coefficients, which was recently proposed by Guo. We also deduce a $q$-analogue of a congruence due to Apagodu and Zeilberger from Guo's $q$-congruence.

113 sitasi en Mathematics, Computer Science
S2 Open Access 2014
Integrated waveguide coupled Si_3N_4 resonators in the ultrahigh-Q regime

D. Spencer, J. Bauters, M. Heck et al.

The vast majority of work on waveguide-coupled resonators focuses on decreasing losses in the waveguide and coupling region. Here we present fully integrated resonators based on an ultralow-loss Si3N4 waveguide platform. By tailoring the directional coupler excitation to the resonators, we are able to achieve lower loss single-mode coupling to multimode waveguide widths compared to straight bus waveguide directional couplers. This allows us to demonstrate record-high integrated waveguide coupled intrinsic quality factor (Qint) values of 81 million at a 9.65 mm bend radius, with a future direction to both stronger and lower loss waveguide–resonator coupling. This result opens up integration possibilities for narrow linewidth integrated diode lasers, low noise feedback systems, microwave photonic research, and the ultrastable timing reference community.

239 sitasi en Materials Science

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