Hasil untuk "physics.atm-clus"

P. Das, H. Kapoor

Convolutional/Deep Neural Networks (CNNs/DNNs) are rapidly growing workloads for the emerging AI-based systems. The gap between the processing speed and the memory-access latency in multi-core systems affects the performance and energy efficiency of the CNN/DNN tasks. This article aims to alleviate this gap by providing a simple and yet efficient near-memory accelerator-based system that expedites the CNN inference. Towards this goal, we first design an efficient parallel algorithm to accelerate CNN/DNN tasks. The data is partitioned across the multiple memory channels (vaults) to assist in the execution of the parallel algorithm. Second, we design a hardware unit, namely the convolutional logic unit (CLU), which implements the parallel algorithm. To optimize the inference, the CLU is designed, and it works in three phases for layer-wise processing of data. Last, to harness the benefits of near-memory processing (NMP), we integrate homogeneous CLUs on the logic layer of the 3D memory, specifically the Hybrid Memory Cube (HMC). The combined effect of these results in a high-performing and energy-efficient system for CNNs/DNNs. The proposed system achieves a substantial gain in the performance and energy reduction compared to multi-core CPU- and GPU-based systems with a minimal area overhead of 2.37%.

Sanjib Thapa, Lok Pant, Briana Vamosi et al.

The lifetime of the $E^3Π_g(v=3)$ state of molecular iodine was measured in the gas phase at room temperature. The $E^3Π_g$ state was selectively populated by two sequential nanosecond pulse laser excitation. Resolved molecular fluorescence for the $B^3Π_u^+\leftarrow E^3Π_g$ was analyzed and the lifetime of the $E(v=3)$ state, measured using a time-correlated single photon counting technique, is to be $τ=21 (2)$ ns.

Iryna Doroshenko, Laziz Meyliev, Bahrom Kuyliev

Conformational analysis of the experimentally recorded IR absorption spectra of propanol in a gaseous state and in a low-temperature argon matrix at 20 K and at 35 K was carried out for different spectral ranges. It showed that the conformational composition of the samples in gas and in matrix isolation is different. In gaseous propanol, Gt conformers predominate, while in matrix isolation the most energetically favorable form is Tg conformer, which prevails in percentage at both considered temperatures of an Ar matrix.

Lorenz S. Cederbaum

It is shown that a molecule can dissociate by the energy transferred from a remote neighbor. This neighbor can be an excited neutral or ionic atom or molecule. If it is an atom, the transferred energy is, of course, electronic and in the case of molecules it can also be vibrational. Explicit examples are given which demonstrate that the transfer can be highly efficient at distances where there is no bonding between the transmitter and the dissociating molecule.

Kamboh Mi, F. Y. Demirci, Xingbin Wang et al.

In addition to apolipoprotein E (APOE), recent large genome-wide association studies (GWASs) have identified nine other genes/loci (CR1, BIN1, CLU, PICALM, MS4A4/MS4A6E, CD2AP, CD33, EPHA1 and ABCA7) for late-onset Alzheimer's disease (LOAD). However, the genetic effect attributable to known loci is about 50%, indicating that additional risk genes for LOAD remain to be identified. In this study, we have used a new GWAS data set from the University of Pittsburgh (1291 cases and 938 controls) to examine in detail the recently implicated nine new regions with Alzheimer's disease (AD) risk, and also performed a meta-analysis utilizing the top 1% GWAS single-nucleotide polymorphisms (SNPs) with P<0.01 along with four independent data sets (2727 cases and 3336 controls) for these SNPs in an effort to identify new AD loci. The new GWAS data were generated on the Illumina Omni1-Quad chip and imputed at ∼2.5 million markers. As expected, several markers in the APOE regions showed genome-wide significant associations in the Pittsburg sample. While we observed nominal significant associations (P<0.05) either within or adjacent to five genes (PICALM, BIN1, ABCA7, MS4A4/MS4A6E and EPHA1), significant signals were observed 69–180 kb outside of the remaining four genes (CD33, CLU, CD2AP and CR1). Meta-analysis on the top 1% SNPs revealed a suggestive novel association in the PPP1R3B gene (top SNP rs3848140 with P=3.05E–07). The association of this SNP with AD risk was consistent in all five samples with a meta-analysis odds ratio of 2.43. This is a potential candidate gene for AD as this is expressed in the brain and is involved in lipid metabolism. These findings need to be confirmed in additional samples.

Angela B. Schmider, Melissa Vaught, Nicholas C. Bauer et al.

The initial steps in the synthesis of leukotrienes are the translocation of 5-lipoxygenase (5-LO) to the nuclear envelope and its subsequent association with its scaffold protein 5-lipoxygenase-activating protein (FLAP). A major gap in our understanding of this process is the knowledge of how the organization of 5-LO and FLAP on the nuclear envelope regulates leukotriene synthesis. We combined single molecule localization microscopy with Clus-DoC cluster analysis, and also a novel unbiased cluster analysis to analyze changes in the relationships between 5-LO and FLAP in response to activation of RBL-2H3 cells to generate leukotriene C4. We identified the time-dependent reorganization of both 5-LO and FLAP into higher-order assemblies or clusters in response to cell activation via the IgE receptor. Clus-DoC analysis identified a subset of these clusters with a high degree of interaction between 5-LO and FLAP that specifically correlates with the time course of LTC4 synthesis, strongly suggesting their role in the initiation of leukotriene biosynthesis.

I. García-Magariño, C. Medrano, A. Lombas et al.

Amal Rekik, Salma Jamoussi

Wei-Wei Li, Pingtao Yi, Yajun Guo

In the process of aggregation, it is necessary, especially for group decision‐making (GDM) problems, to consider distributed characteristic hidden in aggregates. In this case, clustering has been a common way for discovering the implicit distributed structures. This paper mainly investigates the characteristic of majority clusters, rather than majority elements and develops a new class of aggregation operators denominated majority clusters density‐ordered weighting averaging (MC‐DOWA) operators. Furthermore, we discuss properties of these operators and calculate the associated weights. Finally, a numerical example is provided to illustrate the application of the MC‐DOWA operators, and the aggregations are compared with those of the other three aggregation operators: majority additive‐OWA (MA‐OWA), dependent OWA (DOWA) and cluster‐based DOWA (Clus‐DOWA) operators.

G. Gustafsson, M. André, T. Carozzi et al.

Highlights are presented from studies of the electric field data from various regions along the CLUS- TER orbit. They all point towards a very high coherence for phenomena recorded on four spacecraft that are sepa- rated by a few hundred kilometers for structures over the whole range of apparent frequencies from 1 mHz to 9 kHz. This presents completely new opportunities to study spatial- temporal plasma phenomena from the magnetosphere out to the solar wind. A new probe environment was con- structed for the CLUSTER electric field experiment that now produces data of unprecedented quality. Determination of plasma flow in the solar wind is an example of the capability of the instrument.

Alexei M. Frolov, David M. Wardlaw

Results of accurate computations of bound states in three- and four-electron atomic systems are discussed. Bound state properties of the four-electron lithium ion Li$^{-}$ in its ground $2^{2}S-$state are determined from the results of accurate, variational computations. We also consider a closely related problem of accurate numerical evaluation of the half-life of the beryllium-7 isotope. This problem is of paramount importance for modern radiochemistry.

Jing Wu, Xiaolei Xie, S. Nie et al.

P. Senet, P. Combemale, C. Debure et al.

J. Connell, R. Voola

Piyush Rai, S. Duvall

M. Šilić, G. Delač, S. Srbljic

M. Braoudaki, G. Lambrou, Konstantinos Vougas et al.

The current study evaluated the differential expression detected in the proteomic profiles of low risk- and high risk- ALL pediatric patients to characterize candidate biomarkers related to diagnosis, prognosis and patient targeted therapy. Bone marrow and peripheral blood plasma and cell lysates samples were obtained from pediatric patients with low- (LR) and high-risk (HR) ALL at diagnosis. As controls, non-leukemic pediatric patients were studied. Cytogenetic analysis was carried out by G- banding and interphase fluorescent in situ hybridization. Differential proteomic analysis was performed using two-dimensional gel electrophoresis and protein identification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The differential expression of certain proteins was confirmed by Western blot analysis. The obtained data revealed that CLUS, CERU, APOE, APOA4, APOA1, GELS, S10A9, AMBP, ACTB, CATA and AFAM proteins play a significant role in leukemia prognosis, potentially serving as distinctive biomarkers for leukemia aggressiveness, or as suppressor proteins in HR-ALL cases. In addition, vitronectin and plasminogen probably contributed to leukemogenesis, whilst bicaudal D-related protein 1 could afford a significant biomarker for pediatric ALL therapeutics.

M. Clus

Aurelie Perveaux, David Lauvergnat, Fabien Gatti et al.

Numerical simulations are presented to validate the possible use of cutting-edge attosecond time- resolved photoelectron spectroscopy to observe in real time the creation of an electronic wavepacket and subsequent electronic motion in a neutral molecule photoexcited by a UV pump pulse within a few femtoseconds.

Kong Hui, Tong lianhai, Zhou yahui

The charge ordering (CO) transition in polycrystalline La1/3Sr2/3MnO3 has been studied by measuring the resistivity, magnetization and transverse ultrasonic velocity. At about 235K, a conspicuous increase in resistivity was observed, while the magnetization shows a cusp structure, corresponding to an antiferromagnetic charge ordering transition. Around this transition temperature, dramatic anomaly in transverse sound velocity was observed. The simultaneous occurrence of electron, magnon and phonon anomalous features implies strong spin-phonon coupling and electron-phonon in La1/3Sr2/3MnO3. The analysis suggests that the spin-phonon interaction is due to single-ion magnetostriction, and electron-phonon coupling originates from the Jahn-Teller effect of Mn3+.