Marie-Pierre Confort, Maëva Duboeuf, Adrien Thiesson
et al.
Rift Valley Fever virus (RVFV) and Toscana virus (TOSV) are two pathogenic arthropod-borne viruses responsible for zoonotic infections in both humans and animals; as such, they represent a growing threat to public and veterinary health. Interferon-induced transmembrane (IFITM) proteins are broad inhibitors of a large panel of viruses belonging to various families and genera. However, little is known on the interplay between RVFV, TOSV, and the IFITM proteins derived from their naturally infected host species. In this study, we investigated the ability of human, bovine, and camel IFITMs to restrict RVFV and TOSV infection. Our results indicated that TOSV was extremely sensitive to inhibition by all the animal IFITMs tested, while RVFV was inhibited by human IFITM-2 and IFITM-3, but not IFITM-1, and exhibited a more heterogeneous resistance phenotype towards the individual bovine and camel IFITMs tested. Overall, our findings shed some light on the complex and differential interplay between two zoonotic viruses and IFITMs from their naturally infected animal species.
AbstractMedication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of antiresorptive and antiangiogenic therapies. MRONJ is identified by chronic wounds in the oral mucosa associated with exposed necrotic bone. We hypothesized that zoledronic acid (ZOL) impairs keratinocyte and fibroblast function and reduces soft tissue vascularization; therefore, treating MRONJ with proangiogenic cells may benefit MRONJ patients. The effect of ZOL and dexamethasone (DEX) on gingival fibroblasts and keratinocytes was investigated.In-vitro, ZOL inhibited fibroblast and keratinocyte proliferation, delaying scratch healing.In-vivo, exposed bone was detected at tooth extraction sites, mainly in ZOL(+)/DEX(+) rats; and was associated with significantly decreased soft tissue vascularization, serum-VEGF, and tissue-VEGF. Local injection of early and late endothelial progenitor cells (EPCs) healed 13 of 14 MRONJ lesions compared with 2/7 lesions in the mesenchymal stem cells, and 2/6, in culture-medium group. The EPCs reduced necrotic bone area, increased serum and tissue VEGF levels. EPCs engraftment was minimal, suggesting their paracrine role in MRONJ healing. The EPC-conditioned medium improved scratch healing of keratinocytes and fibroblasts via VEGF pathway and elevated mRNA of VEGFA and collagen1A1. In conclusion, a novel MRONJ treatment with EPCs, increased vascularization and improved epithelial and fibroblast functions as well as cured the lesion.
Masatomo Matsushima, Hiroshi Ueno, Yoshiki Kamiya
et al.
This study tries to simulate a brain cell network using an electric circuit oscillator called electronic firefly. Multiple stability was observed in the electric circuit oscillator which is expressed by simple mathematical models.
The concept of forming harmonious coalitions is introduced to both classical and quantum symmetric cooperative game. In both cases, players are motivated to form coalitions. Also, the main feature of the cooperative game is conserved.
In this paper, we focus on the topic Synchronization and consensus of Complex Networks and their relationships. It is revealed that two topics are closely relating to each other and all results given in \cite{Li1,Li2} and many other papers can be obtained by the results in \cite{Chen1,Chen2}. It is pointed out that QUAD condition plays important role in discussing synchronization and consensus.
This note presents a minimal approach to the origin of life, following standard ideas. We pay special attention to the point of view of non-equilibrium statistical mechanics, and in particular to detailed balance. As a consequence we propose a characterization of pre-biological states.
We derive the Kuramoto-Sivashinsky-type phase equation from the Kuramoto-Sakaguchi-type phase model via the Ott-Antonsen-type complex amplitude equation and demonstrate heterogeneity-induced collective-phase turbulence in nonlocally coupled individual-phase oscillators.
General criterion for best efficiency of the interaction of a complex system with an ever-changing environment is derived. Its exclusive property, set by boundedness, is that the highly non-trivial interplay between parameters that participate in it renders the best survival strategy to go via non-extensive hierarchical super-structuring of the semantic-like response.
The process of social expansion in Europe can be better understood with various concepts related to complexity science. Findings of exploratory research show a typical process of social expansion in Europe within the period 1495-1945, in which wars have been instrumental. Furthermore, this research enables the identification of vulnerabilities, and conditions for success in a process of social expansion.
In this paper we investigate the influence of directed motifs on the synchronization properties of Kuramoto oscillators on directed networks. Building different types of sparse directed small world networks similar to the Watts and Strogatz procedure we establish that feed forward loops favour synchronization on directed networks. The paper highlights the importance of local network characteristics for synchronization.
We study non-locally coupled noisy integrate-and-fire neurons with the Fokker-Planck equation. A propagating pulse state and a wavy state appear as a phase transition from an asynchronous state. We also find a solution in which traveling pulses are emitted periodically from a pacemaker region.
A simple model for the formation of a complex organism is introduced. Individuals can communicate and specialize, leading to an increase in productivity. If there are limits to the capacity of individuals to communicate with other individuals, the individuals form groups that interact with each other, leading to a complex organism that has interacting units on all scales.
We study a simple replicator model with non-symmetric and nonlocal interactions. Hierarchical structures with prey-predator relations are self-organized from a homogeneous state, induced by the dynamical instability of nonlinear interactions.
This paper will consider the coevolution of species which are symbiotic in their interaction. In particular, we shall analyse the interaction of squirrels and oak trees, and develop a mathematical framework for determining the coevolutionary equilibrium for consumption and production patterns.
The engineering and design of self-organizing systems with emergent properties is a long-standing problem in the field of complex and distributed systems, for example in the engineering of self-organizing Multi-Agent Systems. The problem of combining engineering with emergence - to find a simple rule for a complex pattern - equals the problem of science in general. Therefore the answers are similar, and the scientific method is the general solution to the problem of engineering complex systems.
A novel mechanism for the generation of self-organized criticality (SOC) is discussed in terms of the coupled-vibration model where the total system is forced under the uniform expansion of the Hubble type. This system shows a robust SOC behavior while the maximum size of the fluctuation, number of correlated particles in it and the temporal size of the system evolve as a function of time.
A new type of dynamical behavior of a multistable system is reported. We found that a simple non-equilibrium system can reduce its effective temperature autonomously at a global minimum if the residual frustration at a global minimum is small enough, which highlights an unexpected feature of non-equilibrium multistable systems.
We develop the principle of dynamic invariance to obtain closed moment equations from the Fokker-Planck kinetic equation. The analysis is carried out to explicit formulae for computation of the lowest eigenvalue and of the corresponding eigenfunction for arbitrary potentials.