Hasil untuk "Homeopathy"

Chatchaphan Udompatanakorn PhD, Panan Ratthawongjirakul PhD

The aim of this study was to evaluate the effect of curcumin combined with Lactobacillus rhamnosus GG cell-free supernatant (LGG CFS) on the proliferation and induction of apoptosis in SCC-9 oral squamous cell carcinoma (OSCC) cells. Curcumin (40 µg/ml) and 25% v/v LGG CFS (10 8 CFU/ml), both alone and in a combination regimen, significantly decreased the viability of SCC-9 cells and normal human gingival fibroblast (HGF) cells. Interestingly, the combination of low doses of curcumin (5 µg/ml) and 25% v/v LGG CFS (10 6 CFU/ml) had no effect on the HGF cells but significantly inhibited the viability of SCC-9 cells (p < 0.05). Flow cytometric analysis revealed that SCC-9 cells treated with the combination of low-dose curcumin and low-dose LGG CFS had a higher apoptotic rate than the cells in the control group and the single treatment groups ( p  < 0.05). The combined treatment also significantly increased the Bax/Bcl2 mRNA and protein expression in SCC-9 cells ( p  < 0.05) but not in HGF cells, indicating the underlying mechanism of the combination regimen. There was no significant difference in caspase-3 protein expression or the Bcl-xL/Bak and Mcl-1/Bak ratios between the treatment and control groups in both cell lines. These findings suggested that the coadministration of curcumin and LGG could exhibit anticancer effects in SCC-9 cells without causing toxicity to normal fibroblast cells.

Sunil Kumar Verma, Minakshi Pandey, Avinash Sharma et al.

Abstract Background The integration of Ayurveda, Yoga, Unani, Siddha, and Homeopathy (AYUSH) with modern medicine aims to provide a more personalized and effective approach to healthcare. Ayurveda is a traditional medicine system in India that emphasizes the balance between mind, body, and spirit. It is based on the belief that every individual is unique and requires personalized treatment. The fundamental principles of Ayurveda revolve around maintaining equilibrium among three doshas: Vata (air and space), Pitta (fire and water), and Kapha (earth and water). Imbalances in these doshas are believed to cause diseases. Main body of the abstract The integration of Ayurveda with modern medicine seeks to utilize the best of both systems, focusing on using natural remedies and treatments that have been used for centuries in Ayurveda. The integration involves combining the strengths of both systems, including the use of Ayurvedic principles in modern medicine and the incorporation of modern medicine into Ayurvedic practices. Several studies have explored the efficacy of Ayurvedic treatments for various diseases, and the integration of Ayurvedic principles into modern medicine can provide a more comprehensive approach to patient care. Short conclusion Ayurveda is a traditional medical system deeply rooted in Indian culture that offers a holistic approach to healthcare. Its principles emphasize personalized treatment based on an individual's constitution. Integrating Ayurveda with modern medicine can enhance patient care by providing a more comprehensive approach towards health management. However, challenges exist regarding the standardization of Ayurvedic practices due to variations in formulations and the need for more scientific evidence for some treatments. Further studies are needed for validation purposes.

J. Shanmugapriya, Seema Mehta, Swati Garg et al.

Despite ongoing research, there is a lack of emphasis on implementing strategies to improve medication safety and enhance patient care, highlighting the urgent need for robust interventions. This review aims to synthesize existing literature, advocate for greater attention to medication safety practices, and catalyze efforts toward fostering a culture of safety and excellence in medication management in Indian healthcare systems. Following PRISMA-ScR guidelines, a systematic review was conducted, utilizing various databases to search for relevant Indian papers. A total of 29 papers were categorized and subjected to thorough analysis to fulfill the review’s objectives. The analysis revealed that a majority of articles identified prescription errors as the most prevalent, often attributed to non-adherence. Antibiotics emerged as a significant contributor to medication errors, as highlighted by several studies, with errors categorized predominantly as A and B according to NCCMERP criteria. The literature review underscores a predominance of prospective observational and quantitative studies, notably lacking qualitative research which could enrich insights into patient communication strategies on medication errors. Studies predominantly conducted in individual hospital settings lack region-wide prevalence calculations, and while some intervention studies were identified, specific recommendations for further action remain lacking, suggesting a need for future research to bridge this gap.

Somsri Wiwanitkit, Viroj Wiwanitkit

Ali Malekzadeh Shafaroudi DDS, Nadia Elyassi Gorji DDS, Pegah Nasiri DDS et al.

Background and purpose Candida infections have increased significantly in the antimicrobial resistance era, and synthetic antifungal drugs have limitations. The present work aimed to review the antifungal properties of Zataria multiflora ( Z. multiflora ) as an herbal remedy. Method PubMed, Scopus, ScienceDirect, Web of Science, SID, Civilica, and Magiran databases were searched for the antifungal activity on in vitro , in vivo , dental biofilm, and clinical studies of Z. multiflora on Candida species. Results Overall, 33 articles evaluated the effect of Z. multiflora on Candida species and classified them into four groups, as follows in vitro (23), dental biofilm (6), in vivo (2), and clinical studies (3). All studies considered Z. multiflora effective in reducing or even inhibiting the growth of Candida species. NoMFC significant differences were seen in the effect of Z. multiflora on susceptible Candida compared to the resistant groups of Candida in the studies. It was also influential in inhibiting C. parapsilosis, C. glabrata, C. krusei, C. kefyer, and C. zeylanoides . Conclusion Considering the side effects and resistance of current antifungal drugs as well as the benefits of using herbal medicines, such as lower cost, less likely to develop drug resistance, the absence of side effects, and toxicity compared with chemical ones , it is possible as a powerful alternative to replace or combine with the current antifungal for Candida infection therapy along with other therapies.

Tomas Koltai MD, PhD, Larry Fliegel PhD

The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6 flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and silychristin. Silybin is functionally the most active of these compounds. This group of flavonoids has been extensively studied and they have been used as hepato-protective substances for the mushroom Amanita phalloides intoxication and mainly chronic liver diseases such as alcoholic cirrhosis and nonalcoholic fatty liver. Hepatitis C progression is not, or slightly, modified by silymarin. Recently, it has also been proposed for SARS COVID-19 infection therapy. The biochemical and molecular mechanisms of action of these substances in cancer are subjects of ongoing research. Paradoxically, many of its identified actions such as antioxidant, promoter of ribosomal synthesis, and mitochondrial membrane stabilization, may seem protumoral at first sight, however, silymarin compounds have clear anticancer effects. Some of them are: decreasing migration through multiple targeting, decreasing hypoxia inducible factor-1α expression, inducing apoptosis in some malignant cells, and inhibiting promitotic signaling among others. Interestingly, the antitumoral activity of silymarin compounds is limited to malignant cells while the nonmalignant cells seem not to be affected. Furthermore, there is a long history of silymarin use in human diseases without toxicity after prolonged administration. The ample distribution and easy accessibility to milk thistle—the source of silymarin compounds, its over the counter availability, the fact that it is a weed, some controversial issues regarding bioavailability, and being a nutraceutical rather than a drug, has somehow led medical professionals to view its anticancer effects with skepticism. This is a fundamental reason why it never achieved bedside status in cancer treatment. However, in spite of all the antitumoral effects, silymarin actually has dual effects and in some cases such as pancreatic cancer it can promote stemness. This review deals with recent investigations to elucidate the molecular actions of this flavonoid in cancer, and to consider the possibility of repurposing it. Particular attention is dedicated to silymarin's dual role in cancer and to some controversies of its real effectiveness.

Suman Ray, Mahesh Kumar Saini

Abstract Herbs contribute to more than 60-70% in development of modern medicines in the world market either directly or indirectly. The herbal treatments for congestive heart failure, systolic hypertension, angina, atherosclerosis, cerebral insufficiency and venous insufficiency etc. has been known since ancient times. Unlike allopathic medicines, Ayurveda medicines are considered safe, however, the adverse reactions of herbal drugs is also reported. In this paper, we have compiled 128 herbs and their parts that have medicinal value to prevent, alleviate or cure heart disease related disorders. Jaccard Neighbour-joining cluster analysis using Free Tree software was used to assess the relative importance of plants in context with its healing potential for heart related disease. Based on the medicinal value in context with the heart, five major clusters of the selected 128 herbs were made. Correlation of the distance between herbs revealed that most of these herbs were found to have more than one medicinal property. The distance in dendogram depicted closeness of properties curing heart disease; as less the distance between two medicinal plants or two groups they will more close to cure particular heart disease. During drug development, a medicinal plant can be replaced by another plant of same group or by another plant of its neighbour group but from same pedigree. Thus, in case of non-availability of herbs or if it belongs to the category of rare, threatened, and endangered species, such method may add to new ways of drug development.

Shrabanti Dev, Rabindra Nath Acharyya, Sheuly Akter et al.

Abstract Background Sonneratia caseolaris (L.) Engl. (S. caseolaris) belonging to the Sonneratiaceae family is commonly known as Ora. It is traditionally used as an astringent, antiseptic, to treat sprains, swellings, cough and in arresting hemorrhage. The ethanolic extract of S. caseolaris (L.) Engl. fruits was investigated in the present study for its toxicity as well as anti-allergic and anti-hyperglycemic potentials. Methods Major phenolic compounds were identified and quantified by HPLC. Behavioral change, body weight, mortality and different blood parameters were measured to assess the toxicological effect of the extract. Anti-allergic activity was evaluated using TDI-induced allergic model mice. Oral glucose tolerance test (OGTT) and STZ-induced diabetic mice were used to evaluate the anti-hyperglycemic activity. Results Crude extract contained ellagic acid, vanillic acid and myrecitin (27.41, 3.06 and 7.93 mg per 100 g dry extract respectively). No major toxicity was observed in both acute and sub-acute toxicity study. Oral administration of the extract significantly ameliorated TDI-induced allergic symptoms like sneezing, scratching, swelling, redness and watery rhinorrhoea in the experimental mice. The extracts also reduced the total and differential count of leukocytes in the blood. The extract treated mice showed significant reduction in blood glucose, SGOT, SGPT, cholesterol, triglycerides, urea, creatinine and bilirubin level. Conclusions S. caseolaris contains bioactive phytoconstituents which may be the possible precursors to isolate and characterize the novel compounds targeting the diseases like allergy and diabetes.

Raphael John Ogbe, Carrol Domkat Luka, Godwin Ichekanu Adoga

Abstract Background There is high incidence of liver and kidney diseases worldwide but medicinal plants may provide remedy. This study evaluated and compared the protective effects of Cassia spectabilis extract (CSE) and Newbouldia laevis extract (NLE) against diclofenac (DF) induced hepatorenal oxidative damage in rats. Methods Twenty four rats were divided into 4 groups with 6 rats in each. Normal saline was given to the rats in group I while those in groups III and IV were treated with 250 mg/kg b. wt. CSE and NLE respectively for 28 days by oral gavages. Those in groups II to IV were exposed to 10 mg/kg DF in the last 7 days of treatment. Serum was separated from the blood and used for estimations of hepatorenal injury markers while the homogenized tissue supernatants were used for assays of oxidative stress markers. Results There was a significant (p < 0.01) increase in the levels of ALT, AST, GGT, MDA, creatinine and BUN but a significant (p < 0.01) decrease in the levels of SOD, CAT, GPx, GST, GSH and G6Pase of DF-exposed rats when compared with normal control. However, treatment of DF-exposed rats with CSE and NLE significantly (p < 0.01) increased the levels of SOD, CAT, GPx, GST, GSH, and G6Pase but significantly (p < 0.01) reduced the levels of ALT, AST, GGT, MDA, creatinine and BUN when compared with DF control. Conclusion The current findings showed that treatments with CSE and NLE may have protective effects against DF-induced hepatorenal oxidative damage in rats, attributed to certain phytochemicals, but CSE has greater bioactivity than NLE.

Donna Bach ND, Gary Groesbeck BCIA, Peta Stapleton PhD et al.

Emotional Freedom Technique (EFT) is an evidence-based self-help therapeutic method and over 100 studies demonstrate its efficacy. However, information about the physiological effects of EFT is limited. The current study sought to elucidate EFTs mechanisms of action across the central nervous system (CNS) by measuring heart rate variability (HRV) and heart coherence (HC); the circulatory system using resting heart rate (RHR) and blood pressure (BP); the endocrine system using cortisol, and the immune system using salivary immunoglobulin A (SigA). The second aim was to measure psychological symptoms. Participants (N = 203) were enrolled in a 4-day training workshop held in different locations. At one workshop (n = 31), participants also received comprehensive physiological testing. Posttest, significant declines were found in anxiety (−40%), depression (−35%), posttraumatic stress disorder (−32%), pain (−57%), and cravings (−74%), all P < .000. Happiness increased (+31%, P = .000) as did SigA (+113%, P = .017). Significant improvements were found in RHR (−8%, P = .001), cortisol (−37%, P < .000), systolic BP (−6%, P = .001), and diastolic BP (−8%, P < .000). Positive trends were observed for HRV and HC and gains were maintained on follow-up, indicating EFT results in positive health effects as well as increased mental well-being.

E. Said, Mrs J RawDr C M Smith. K Kapur

Marcus Zulian Teixeira

In July 2017, to demystify the fallacy – or post-truth – asserting “there are no scientific evidence for homeopathy”, the Technical Chamber for Homeopathy, Regional Medical Council of the State of São Paulo (Cremesp, Brazil) published the Dossiê Especial: “Evidências Científicas em Homeopatia”,1 available online and in printed editions of the scientific journal of the São Paulo Homeopathic Medical Association (APH), Revista de Homeopatia.2,3 After this publication, in view of the request of homeopathic physicians and institutions from other countries, the Technical Chamber for Homeopathy (TC-Homeopathy, Cremesp) produced an English edition of the dossier (Special Dossier: “Scientific Evidence for Homeopathy”), which is also available online at the Revista de Homeopatia webpage.4 Encompassing nine reviews on several lines of homeopathic research (and two randomized clinical trials developed by members of the TC-Homeopathy), containing hundreds of scientific articles published in various journals, this dossier highlights, to the scientific and medical class, as well as to the general public, the state of the art of homeopathic research.

J. Demangeat

Today, despite non-recognition and even opposition by scientific and medical institutions, homeopathy is the most widely used form of alternative medicine in the world. According to the World Health Organization, approximately 500 million people worldwide are treated by homeopathy. It is also used widely by veterinarians. Its origin goes back to Hahnemann [1] over 200 years ago. It is based on the “law of similia”: a substance that elicits symptoms in a healthy organism is able to cure similar symptoms in a diseased organism. Despite positive meta-analyses of hundreds of studies-clinical [2-6], biological [7,8] and physicochemical [9]its efficacy remains a subject of controversy due to trials judged to be insufficiently reliable [10-14]. Yet a recent review established the good quality of the physicochemical research in this field [15]. But the main reason for mistrusting homeopathy is ignorance concerning its mode of action, especially incredulity towards the action of infinitesimally diluted substances. In accordance with the pharmacopoeia, homeopathic remedies are prepared following a specific iterative centesimal dilution/agitation procedure-also called dilution/dynamization, dilution/succussion or potency(with C1 corresponding to a 102-fold dilution, and Cn to a 102n-fold dilution), so that the initial solute is virtually no longer present beyond C12 (Avogadro=6x1023).

L. Nwabudike

E. Rossi, M. Stefano, M. Picchi et al.

R. Aversa, R. Petrescu, A. Apicella et al.

Homeopathy or homoeopathy (from the Greek όμοιος/homoios, "similar" and πάθος/pathos, "suffering" or "disease") is a science created by Samuel Hahnemann in 1796. The homeopathic practice rests on three principles: The similarity, the individualization of cases and the infinitesimal. The use of the infinitesimal was proposed by Hahnemann in the early nineteenth century with the publication of "Organon der Heilkunst" (Organon of the art of healing). The compounds used do not become homeopathic unless they respect the principle of similarity, according to which a patient should be treated with a substance producing experimentally in a healthy person symptoms similar to those presented by the affected person, use of the substance being adapted to the patient thanks to the principle of individualization according to which the homeopath analyzes all the symptoms of the person and not only those related to the disease. Substances chosen according to this method can be administered in non-toxic weighted doses, but most prescribers use them in dilutions, sometimes very large, which have previously been subjected to very high and very frequent vibrations. Although some clinical trials produce positive results, multiple systematic reviews indicate that this is due to chance, questionable research methods, or publication biases. Despite a certain popularity, the therapeutic efficacy of homeopathy has not been demonstrated as a general and permanent solution. The vast majority of the scientific and medical community considers that homeopathy is a pseudo-science coming into contradiction with current knowledge in chemistry and biology established after the fundamental principles of homeopathy themselves proposed more than two Centuries. In particular, they point out that certain homeopathic dilutions are such that the excipient no longer contains a single molecule of the diluted remedy and therefore can't act chemically. Moreover, the fact that effects are observed is disputed by published meta-analyzes which conclude that homeopathy has not demonstrated its clinical efficacy beyond the placebo effect and yet, the Homeopathy works, despite some malicious feedback.

A. Nekratova, L. Kosmodemyanskiy

Abstract Background A current priority of national health care in Russia is to expand the range of drug substances, based on naturally occurring compounds, to use for treating socially significant diseases, such as cancer and cardiovascular diseases. Objective The main objective of our study was to compile a contemporary list of Siberia's ‘homeopathic plants’, describing for each plant the corresponding therapeutic indications or main symptoms of disease. Methods The textbook, Global Resources of Homeopathic Medicinal Raw Materials, was used to scrutinize the 709 species that are allowed for use in Russia, designating each of the 709 as either indigenous or non-indigenous to the region of Siberia. A homeopathic repertory, containing description of more than 1,800 single-component homeopathic medicines, was used to identify Siberia's medicinal plants used in homeopathy, along with the medical indications of each. Results The medicinal plants of Siberia used in homeopathy comprise 137 species of flowering plants, gymnosperms and sporophytes, belonging to 52 families. The most represented are the Compositae, Rosaceae, and Lamiaceae families. Conclusion The inventory of Siberian plants has allowed us to identify the plants of this region used in homeopathy and will help to inform research on additional species with the potential for introduction into homeopathic practice.

Bosco F, Cidin S, Maceri F et al.

This study investigates the effect of a combination of homeopathic medicine and electro- acupuncture in two patients with breast cancer and severe liver disease who could not receive standard anaesthesia therapy due to liver problems. Specifically, measurable and quantifiable parameters were used to evaluate whether an integrated approach—consisting of electro- acupuncture and a homeopathic medicine diluted above Avogadro&#39;s limit (that is, above a potency of 12CH) during the pre-surgical, surgical and post-surgical phases-can improve general well-being of a patient undergoing breast cancer surgery. In breast cancer surgery, we employed an integrated approach consisting of induction with hypnotics and muscle relaxants, followed by maintenance with anaesthetic gas, combined with a homeopathic treatment (Arnica montana 15CH and Apis mellifica 15CH) before and after surgery and an electro- acupuncture treatment performed in the preand post-surgical phases without any analgesic/pain relieving medications. Both of the patients treated with the integrated approach improved their overall condition without need for other common pain relieving medicines. Additionally, thanks to their rapid awakening, the patients were not relocated to a protected area and the hospitalization was shorter. A multidisciplinary approach incorporating homeopathic medicine and electro-acupuncture can be a solution for patients who need or ask about a different and/or safer alternative to the standard treatment. This approach can offer a safe, much less expensive, non-invasive and viable alternative for such cases. Moreover it can be useful for an opioids free anesthesia.

Basiru O. Ajiboye PhD, Oluwafemi A. Ojo MSc, Olivia S. Akuboh BSc et al.

In this study, anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini leaves in alloxan-induced diabetic rats were determined. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg body weight) in female Wistar rats. The rats were orally administered with 400 mg/kg free phenol, 400 mg/kg bound phenol, and 5 mg/kg metformin, respectively. On the 14th day of oral administration, the animals were sacrificed, anti-hyperglycemic and anti-inflammatory were assessed. Fasting blood glucose and glycated hemoglobin levels; homeostasis model assessment–insulin resistance scores, lipid peroxidation concentration, glucose-6-phosphatase activity, and all concentrations of anti-inflammatory studied in alloxan-induced diabetic rats were significantly ( P < .05) reduced with the administration of polyphenolic-rich extract of Syzygium cumini leaves. Also there was significant ( P < .05) increase in glycogen and insulin concentrations, pancreatic β-cell scores, antioxidant enzymes and hexokinase activities, as well as glucose transporter levels in diabetic animals administered with polyphenolic-rich extract of S cumini leaves. The results indicate that S cumini leaves possess anti-hyperglycemic and anti-inflammatory activities.

K. Banerjee, R. Mathie, C. Costelloe et al.