Andrada-Iasmina Roşu, Laura Andreea Ghenciu, Dan Cristian Roşu
et al.
<b>Background/Objectives</b>: Hydrocephalus is a complex neurological disorder marked by abnormal cerebrospinal fluid dynamics and ventricular enlargement. Despite breakthroughs in neuroimaging, diagnosis and longitudinal the application of imaging markers for the diagnosis and longitudinal monitoring of hydrocephalus remains challenging in routine clinical practice. The present study examines the behavior and cross-modality agreement of commonly used linear ventricular measurements under routine imaging conditions, at a single Romanian tertiary-care center characterized by heterogeneous acquisition protocols and limited availability of advanced volumetric techniques. <b>Methods</b>: We conducted a single-center retrospective observational study of 68 adults with hydrocephalus. Linear ventricular metrics, including Evans index and third-ventricle width, were measured on all available CT and MRI scans. CT–MRI agreement was assessed using paired examinations within a 90-day window. Longitudinal changes were analyzed using first–last and pre–post VP shunt comparisons. Associations between baseline imaging features and VP shunt placement were evaluated using rule-based and odds ratio analyses. <b>Results</b>: CT and MRI measurements demonstrated strong agreement for both Evans index (r = 0.93) and third-ventricle width (r = 0.90), with minimal systematic bias. Longitudinal analyses demonstrated small-magnitude changes in ventricular size following intervention, with substantial inter-individual variability. VP utilization increased across Evans index strata, reaching 100% in patients with values ≥0.50. Transependymal cerebrospinal fluid exudation showed the strongest association with subsequent VP shunting. Imaging-based rules exhibited expected trade-offs between sensitivity and specificity. <b>Conclusions:</b> Standard linear ventricular parameters exhibited adequate cross-modality agreement and clinically important longitudinal behavior in this cohort. While insufficient as standalone predictors, these readily available imaging markers remain important tools when combined with a comprehensive clinical assessment.
Rolv Petter Amdam, Teresa da Silva Lopes, Trudi Henrydotter Eikrem
et al.
Abstract This article examines the 1921–1923 trade war between Norway and Portugal as a historical case for exploring business responses to deglobalization and trade disruption. Focusing on the international supply chains (ISCs) of port wine and salted and dried cod, it investigates how business actors contributed to the recoupling of ISCs after a trade war. Drawing on a history‐to‐theory methodology and extensive archival research, the study offers new theoretical insights into how institutional environments shape business agency during periods of deglobalization. It develops a typology of trade wars structured around two dimensions: the degree of coordination within ISCs and the economic reach of the conflict. The findings demonstrate that, in processes of symmetric recoupling , where both nations restore disrupted supply chains on equal terms, business associations as well as multinational enterprises (MNEs) play a pivotal role in business diplomacy and supply‐chain reconstruction. The symmetric nature of the post‐trade war recoupling fosters mutual recovery and enhances long‐term competitiveness for the industries involved. The typology proposed also provides a framework for analysing other historical and contemporary trade wars across diverse geopolitical settings.
Arnold G. Schriemer, Ute Bültmann, Sterre H. Schriemer
et al.
Abstract Background Hearing loss is highly prevalent and the third largest cause of years lived with disability. The most frequent cause of adult-onset hearing loss is older age. As the retirement age increases in many countries, a growing number of workers will experience hearing loss, which may affect work participation. Limited research has been done on the consequences of hearing loss in workers in communicative professions. The present study examines the associations of hearing loss with work ability and sick leave among teachers. Methods Dutch teachers were recruited via schools, educational sector organizations, and trade unions. Teachers completed a survey questionnaire and performed a valid and reliable online speech-in-noise screening test for hearing loss. The survey measured work ability with the single-item Work Ability Score (range 0–10); scores were dichotomised into poor-moderate (score 0–7) and good-excellent (score 8–10) work ability. Teachers were asked if they had been on sick leave in the past three months (no / yes; if yes: how many days). Robust Poisson regression analyses were performed to examine the cross-sectional associations of hearing loss with both work ability (poor to moderate versus good to excellent) and sick leave (yes versus no), adjusted for age, sex, level of education, type of work tasks (only teaching versus a mixture with other (e.g. management) tasks, current work hours per week, and working as a physical education teacher. Results A total of 737 teachers participated in the study, of whom 86 (12%) had poor and 146 (20%) insufficient hearing. Teachers with poor and insufficient hearing had a higher prevalence of poor-moderate work ability than good hearing teachers (Prevalence Ratio (PR) = 1.67, 95% CI: 1.36–2.06 and PR = 1.40, 95% CI: 1.16–1.70, respectively). Teachers with poor hearing had a higher prevalence of sick leave than good hearing teachers (PR = 1.60, 95% CI: 1.21–2.01). Conclusions Among teachers, hearing loss was associated with poorer work ability and more sick leave. The results highlight the need for periodic hearing screening as recommended by the WHO. Earlier detection of hearing loss could enable timely work accommodations to prevent work disability of teachers.
The aim of this article is to address the questions of how the principle of freedom of association and the prohibition of discrimination on the basis of trade union membership are understood and to identify legal obstacles for an effective implementation of the right to join trade unions. International, EU regional and Lithuanian national legislation, as well as the case law of the European Court of Human Rights, the Court of Justice of the European Union and Lithuanian courts have been explored to carry out the current study. The results confirm that membership can be interpreted broadly; therefore, members of a trade union may be required to possess certain working and legal capacities, as well as meet other requirements related to the trade union’s objectives, which are sometimes unreasonable. Due to possible exceptions, various members may be subject to different collective rights, for example, certain officers may not be permitted to strike, and some may not even be allowed to join associations.
Law in general. Comparative and uniform law. Jurisprudence
Roman Bühler, Thomas V. Riecke, Kim Schalcher
et al.
Investigating among-individual differences in reproductive success and survival is essential for understanding eco-evolutionary processes. We used 5 years of demographic data from 556 breeding barn owls (Tyto alba) to estimate associations between intrinsic and extrinsic covariates on survival and reproduction throughout the annual cycle. As males and females have distinct roles in reproduction, environmental conditions and individual quality may be differentially linked to their fitness at different time points. Males breeding early and inhabiting prey-rich areas experienced higher reproductive success but faced greater reproductive costs. Indeed, the number of offspring a male cared for was negatively associated with his body condition and survival. However, our results indicate that these influences can be mitigated in males experiencing favourable post-breeding environmental conditions. For female owls, early breeding and high food availability during the breeding period were linked with increased reproductive success. Prey availability during incubation and higher reproductive output were associated with higher survival into the next breeding period in females. Unlike males, females did not exhibit obvious trade-offs between reproductive success and survival. Our research demonstrates trade-offs between fecundity and survival, and that females paired with males able to provide sufficient food experience higher survival and reproduction.
Background: Previous observational studies have indicated associations of physical activity (PA) and air pollution with mortality. A few studies have evaluated air pollution and PA interactions for health. Still, the trade-off between the harmful effects of air pollution exposure and the protective effects of PA remains controversial and unclear. Objective: This study aimed to investigate the joint association of air pollution and PA with mortality risks. Methods: This prospective cohort study included 322,092 participants from 2006 to 2010 and followed up to 2021 in the UK Biobank study. The concentrations of air pollutants (2006–2010), including particulate matter (PM) with diameters <=2.5 mm (PM2.5), <=10 mm (PM10), and between 2.5 and 10 mm (PM2.5–10), and nitrogen oxides (NO2 and NOx) were obtained. Information on PA measured by the International Physical Activity Questionnaire short form (2006–2010) and wrist-worn accelerometer (2013–2015) were collected. All-cause and cause-specific mortalities were recorded. Cox proportional hazard models were used to investigate the associations of air pollution exposure and PA with mortality risks. The additive and multiplicative interactions were also examined. Results: During a mean follow-up of 11.83 years, 16629 deaths were recorded. Compared with participants reporting low PA, higher PA was negatively associated with all-cause [hazard ratio (HR), 0.74; 95% CI, 0.71–0.78], cancer (HR, 0.85; 95% CI, 0.80–0.90), CVD (HR, 0.79; 95% CI, 0.71–0.87), and respiratory disease-specific mortality (HR, 0.51; 95% CI, 0.44–0.60). Exposure to PM2.5 (HR, 1.05; 95% CI, 1.00–1.09) and NOx (HR, 1.06; 95% CI, 1.02–1.10) was connected with increased all-cause mortality risk, and significant PM2.5-associated elevated risks for CVD mortality and NOx-associated elevated risks for respiratory disease mortality were observed. No obvious interaction between PA and PM2.5 or NOx exposure was detected. Conclusions: Our study provides additional evidence that higher PA and lower air pollutant levels are independently connected with reduced mortality risk. The benefits of PA are not significantly affected by long-term air pollution exposure, indicating PA can be recommended to prevent mortality regardless of air pollution levels. Our findings highlight the importance of public health policies and interventions facilitating PA and reducing air pollution in reducing mortality risks and maximizing health benefits. Future investigation is urgently needed to identify these findings in areas with severe air pollution conditions.
IntroductionBacterial spot, caused by diverse xanthomonads classified into four lineages within three species, poses a significant threat to global pepper and tomato production. In Taiwan, tomato bacterial spot xanthomonads phylogenetically related to an atypical Xanthomonas euvesicatoria pv. perforans (Xep) strain NI1 from Nigeria were found.MethodsTo investigate the genetic structure of Taiwanese Xep strains and determine the phylogenetic position of the atypical strains, we completed high-quality, gap-free, circularized genomes of seven Taiwanese Xep strains and performed comparative genomic analyses with genomes of X. euvesicatoria pathovars. Average nucleotide identity, core genome analysis, and phylogenomic analysis were conducted.ResultsThree sequenced strains were identified as typical Xep, while four clustered with the atypical strain NI1, forming a distinct genomovar within X. euvesicatoria, proposed as X. euvesicatoria genomovar taiwanensis (Xet). This new lineage likely originated in Taiwan and spread to Nigeria through global seed trade. At the genomovar level, chromosomes remained conserved among Taiwanese strains, while plasmids likely contributed to bacterial virulence, avirulence, and field fitness. Gap-free genomes revealed associations between the evolution of type III effectors, horizontal gene transfer events, plasmid diversity, and recombination.DiscussionThis study highlights the critical roles of horizontal gene transfer and plasmids in shaping the genetic makeup, evolution, and environmental adaptation of plant pathogenic xanthomonads. The identification of a new genomovar, X. euvesicatoria genomovar taiwanensis, provides insights into the diversity and global spread of bacterial spot pathogens through seed trade.
Around 80% of global trade by volume is transported by sea, and thus the maritime transportation system is fundamental to the world economy. To better exploit new international shipping routes, we need to understand the current ones and their complex systems association with international trade. We investigate the structure of the global liner shipping network (GLSN), finding it is an economic small-world network with a trade-off between high transportation efficiency and low wiring cost. To enhance understanding of this trade-off, we examine the modular segregation of the GLSN; we study provincial-, connector-hub ports and propose the definition of gateway-hub ports, using three respective structural measures. The gateway-hub structural-core organization seems a salient property of the GLSN, which proves importantly associated to network integration and function in realizing the cargo transportation of international trade. This finding offers new insights into the GLSN’s structural organization complexity and its relevance to international trade. It is crucial to understand the evolving structure of global liner shipping system. Here the authors unveiled the architecture of a recent global liner shipping network (GLSN) and show that the structure of global liner shipping system has evolved to be self-organized with a trade-off between high transportation efficiency and low wiring cost and ports’ gateway-ness is most highly associated with ports’ economic performance.
Abstract Globalisation has facilitated the spread of alien species, and some of them have significant impacts on biodiversity and human societies. It is commonly thought that biological invasions have accelerated continuously over the last centuries, following increasing global trade. However, the world experienced two distinct waves of globalisation (~1820–1914, 1960‐present), and it remains unclear whether these two waves have influenced invasion dynamics of many species. To test this, we built a statistical model that accounted for temporal variations in sampling effort. We found that insect and plant invasion rates did not continuously increase over the past centuries but greatly fluctuated following the two globalisation waves. Our findings challenge the idea of a continuous acceleration of alien species introductions and highlight the association between temporal variations in trade openness and biological invasion dynamics. More generally, this emphasises the urgency of better understanding the subtleties of socio‐economic drivers to improve predictions of future invasions.
Jie Feng, Ieee F. Richard Yu Fellow, Jianbo Du
et al.
The application of blockchain to mobile edge computing (MEC) systems has attracted great interests. However, the design and optimization of blockchain and MEC in most existing works are done separately, which will result in sub-optimal performance. In this paper, we propose a joint optimization framework for blockchain-enabled MEC systems to achieve the optimal trade-off between the performance of the MEC system and the performance of the blockchain system. Specifically, both MEC and blockchain are considered as services in the framework, where energy consumption and delay/time to finality (DTF) are the performance metrics for the MEC system and the blockchain system, respectively. We formulate an optimization problem to achieve the optimal trade-off through jointly optimizing user association, data rate allocation, block producer scheduling, and computational resource allocation. To solve the problem, we decouple the optimization variables for efficient algorithm design. In addition, we develop an iterative algorithm for user association and data rate allocation and a bisection algorithm for computing resource allocation. Simulation results show the convergence of the proposed algorithms, and the proposed scheme can achieve the optimal trade-off between energy consumption and DTF.
AbstractOnline gambling emerged in the 1990s in the midst of a process of market liberalisation. Here, scholars have argued that the gambling industry actively seeks state regulation to authorise and legitimate its activities. Why then, since the emergence of the online gambling industry, have trade associations continually sought to develop responsible gambling codes of conduct? In this paper, I address this puzzle by documenting and tracing the development and deployment of responsible gambling codes of conduct by trade associations from the emergence of the online gambling industry in the early 1990s and through processes of increased market liberalisation at the national level and market integration at the European Union level. I argue that online gambling trade associations deploy responsible gambling codes of conduct at particular moments of opportunity to shape their members’ external legal and regulatory environment and to reproduce and embed a particular understanding of how gambling-related risks should be regulated.
The article is devoted to the analysis of the integration policy of the ASEAN countries.
ASEAN includes countries with very different levels of economic development, population, and
area, but this integration association is successful and plays an important role in the economic
and political spheres in the Southeast Asian region. The article examines the ASEAN approach
to regional integration, which is characterized by a “soft character”, in contrast to the European
and North American approaches. The main stages of the development of the studied union
and the circumstances that prevented the economic integration of the participating countries
at the initial stage were analyzed. The main principles of ASEAN work, which are enshrined
in the Bangkok Declaration of 1967 and the ASEAN Charter of 2007, are defined. The main
directions and mechanisms of economic integration of countries are analyzed, namely: the
agreement on the formation of a preferential trade zone, the agreement on the creation of a free
trade area (AFTA), the framework agreement on the ASEAN investment zone (AIA), industrial
cooperation schemes (AICO), the ASEAN framework agreement with services (AFAS). Also,
the article provides an assessment of the main macroeconomic indicators of the participating
countries and the union as a whole: GDP volumes in dynamics, the structure and dynamics
of trade relations, the commodity and geographical structure of the union’s export-import
operations. Problematic issues of the ASEAN integration association have been identified.
The current state of cooperation between Ukraine and ASEAN was analyzed, including the
volume of export-import operations in terms of the product structure, and prospects for the
expansion of economic cooperation were also established. The paper draws conclusions about
the success of the ASEAN development strategy and suggests ways to develop cooperation
between ASEAN and Ukraine.