Hasil untuk "Dermatology"

Bruna Morassi Sasso, Andrelou Fralete Ayres Vallarelli, Patricia Sammarco Rosa et al.

Objectives: Jorge Lobo’s disease (JLd), a cutaneous mycosis caused by the fungus Paracoccidioides lobogeorgii, follows a chronic course and is refractory to any treatment modality. On histopathological view, the dermis presents crowded macrophages that have M2 polarization, which is associated with an anti-inflammatory profile and maintenance of the infection. Lipid droplets (LDs) are organelles responsible for neutral lipid storage for energetic needs. Intracellular pathogens may utilize LDs both to evade the immune response and as a source of nutrients. LDs in JLd have not yet been evaluated. Methods: This is an immunohistochemical study of 54 JLd skin samples using anti-adipophilin antibody for LDs analysis and anti-CD163 and anti-CD204 M2 macrophage markers. LDs were characterized as focal or diffuse, and their density was semi-quantitatively evaluated as absent or very scarce, mild, or strong. M2 macrophage density was obtained through the ImageJ software aid. Results: LDs were present within macrophages in 72.22% of cases, with high density in 53.85%, regardless of M2 macrophage density. Conclusions: Host-derived LDs may play a role in the pathogenesis of JLd.

Nessr Abu Rached, Natalie Orlinski, Eggert Stockfleth et al.

Background: We present an interesting case involving a tumour comprising both basal cell tumour cells and sarcomatoid tumour cells. An 86-year-old woman presented with an erythematous lesion on her left cheek. Clinical and dermoscopic findings suggested BCC. Complete excision and histopathological examination revealed a BCC with a separate proliferation of atypical spindle and epithelioid cells. Immunohistochemical staining supported the diagnosis, with basaloid cells positive for CK5/6 and Ber-EP4 and sarcomatoid cells positive for CD10 and vimentin. Results: Histology and immunohistochemistry confirmed a basal cell carcinoma with sarcomatoid differentiation. The close proximity of sarcomatoid cells to the BCC component suggests a potential role of epithelial–mesenchymal interactions in tumour development. Further investigations into the exact origin of this tumour are required. Conclusion: Basal cell carcinoma with sarcomatoid differentiation is rare. This case highlights the importance of thorough histological and immunohistochemical evaluation. Further studies are necessary to better understand the pathogenesis of such collision tumours.

Yu Jin Lee, Jung Min Lee, June Hyunkyung Lee et al.

Abhinav Bansal, Pooja Arora, Sheetal Yadav et al.

Semra Akturk, Raikan Buyukavci, Sezgin Zontul et al.

Inigo Navarro-Fernandez

I have read the paper “A Terbinafine Sensitive <i>Trichophyton indotineae</i> Strain in Italy: The First Clinical Case of tinea corporis and onychomycosis” by Crotti et al [...]

Yun Zhu, Weimin Yan, Shuangyan Xu et al.

Backgroud: Renal fibrosis is the common characteristic of chronic kidney disease. Circular RNA plays an essential role in the occurrence and development of Renal fibrosis, but its regulative mechanism remains elusive.Methods: The animal and cell model of Renal fibrosis was established, and RNA-sequencing and real-time polymerase chain reaction (qRT-PCR) experiments were implemented. Subsequently, experiments for detecting apoptosis and proliferation of cell, were carried out, and the isobaric tags for relative and absolute quantification proteomics analyses were performed accordingly.Results: It was found that a newly discovered Circular RNA (circRNA_0002158), is highly expressed in kidneys or cells with fibrosis, implying that this Circular RNA might be associated with the occurrence and development of Renal fibrosis. Subsequently, the overexpression and knockdown of circRNA_0002158 were conducted in the human kidney epithelial cell line (HK-2) cells, and the results indicated that the circRNA_0002158 could inhibit apoptosis, and promote proliferation of cells. The kidney injury-related factors, including Fibronectin and plasminogen activator inhibitor-1 (PAI-1), were decreased in HK-2 cells with overexpression of circRNA_0002158, while the results were reversed in cells with knockdown of circRNA_0002158. Finally, to explore the regulative mechanism of circRNA_0002158, the iTRAQ proteomics analyses were implemented for the cell samples with OE of circRNA_0002158 and its control, it showed that multiple genes and functional pathways were associated with the occurrence and development of Renal fibrosis.Conclusion: CircRNA_0002158 is associated with regulating Renal fibrosis, and may contribute to ameliorating the progression of Renal fibrosis in the future.

Morinola Shobajo, MD, Safiyya Abdulkadir, MD, Christina N. Kraus, MD et al.

Christopher W. Chalaka, MD, Heather M. Mahurin, MD, Erica Tarabadkar, MD et al.

Background:. Patients with cutaneous T-cell lymphoma (CTCL) often experience debilitating symptoms that impair health-related quality of life (HRQoL). Existing evidence for HRQoL differences with respect to gender is conflicting. Objective:. To investigate potential gender differences in HRQoL for patients with CTCL. Methods:. We performed a cross-sectional study to assess HRQoL in patients with CTCL by partnering with the Cutaneous Lymphoma Foundation to distribute an electronic survey from February to April 2019. Results:. A total of 292 patient responses (66% women, mean age 57 years) were included in the analysis. Most of the cohort had early-stage (IA–IIA) (74%; 162/203) mycosis fungoides (MFs) (87%; 241/279), followed by Sézary syndrome (SS) (12%; 33/279). Women with CTCL experienced significantly worse HRQoL compared with men (Skindex-16: 51±26 vs. 36±26, P ≤ 0.001; FACT-G: 69±21 vs. 77±16, P = 0.005). This gender difference was present even when controlling for stage of disease. Women experienced worse HRQoL in all three of the Skindex-16 subscales (symptoms: β = 14.0, P ≤ 0.001; emotions: β = 15.1, P ≤ 0.001; functioning: β = 11.3, P = 0.006), but only two of the four FACT-G subscales (physical: β =-2.8, P ≤ 0.001; emotional: β = -2.0, P = 0.004). Limitations:. Due to the method of distribution of the survey, we were unable to estimate a participant response rate. Participants’ diagnosis and stage were self-reported. Conclusion:. In this cohort women with CTCL experienced significantly worse HRQoL when compared to men. Additional studies are necessary to determine what factors contribute to this gender disparity.

Adriana T. Lopez, T. Khanna, N. Antonov et al.

A. Nast, A. Altenburg, M. Augustin et al.

(1) Department of Dermatology, Venereology and Allergology, Division of Evidence-Based Medicine (dEBM), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany (2) Dermatology, Venereology and Allergology, Immunology Center, Dessau Municipal Hospital, Dessau, Germany (3) Department of Dermatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (4) Department of Dermatology and Venereology, University Hospital of Geneva, Geneva, Switzerland (5) Katholisches Klinikum Mainz, Mainz, Germany (6) Deutscher Psoriasis Bund e.V., Germany (7) Psoriasis Center, Department of Dermatology, Venereology, Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany (8) Department of Dermatology and Allergy, Klinikum Hanau, Hanau, Germany (9) Dermatology practice, Oranienburg, Germany (10) Dermatologikum Hamburg, Hamburg, Germany (11) Dermatology practice, Osnabrück, Germany (12) Dermatology practice, Oldenburg, Germany (13) Berolina Klinik, Löhne, Germany (14) Dermatology practice, Mahlow, Germany (15) Dermatology practice, Selters, Germany (16) Center of Dermatology and Venereology, Hospital of the Johann Wolfgang Goethe University Frankfurt/Main, Frankfurt/Main, Germany Based on:

A. Prohic, Tamara Jovović Sadiković, Mersiha Krupalija-Fazlić et al.

V. Sibaud, Nicole R. Lebœuf, H. Roché et al.

A. E. Torres, A. Lyons, I. Hamzavi et al.

Phototherapy is a safe and effective treatment for many dermatologic conditions. With the advent of novel biologics and small molecule inhibitors, it is important to critically evaluate the role of phototherapy in dermatology. Surveys have shown that many dermatology residency programs do not dedicate time to teaching residents how to prescribe or administer phototherapy. Limitations of phototherapy include access to a center, time required for treatments, and insurance approval. Home phototherapy, a viable option, is also underused. However, it should be emphasized that modern phototherapy has been in use for over 40 years, has an excellent safety profile, and does not require laboratory monitoring. It can be safely combined with many other treatment modalities, including biologics and small molecule inhibitors. In addition, phototherapy costs significantly less than these novel agents. Dermatologists are the only group of physicians who have the expertise and proper training to deliver this treatment modality to our patients. Therefore, to continue to deliver high-quality, cost-effective care, it is imperative that phototherapy be maintained as an integral part of the dermatology treatment armamentarium.

D. Jakhar, S. Kaul, I. Kaur

The current coronavirus disease (COVID-19) has forced the shutdown of many non-essential services in most of the high-risk countries. Most of the consultations (except emergencies) in dermatology are deferred as a precautionary measure to prevent the spread of COVID-19.

Catherine Smith, A. Anstey, J. Barker et al.

Ana Luiza Lima, T. Illing, S. Schliemann et al.

Reinhard Dummer, A. Hauschild, N. Lindenblatt et al.

F. Alfageme, X. Wortsman, O. Catalano et al.

Abstract Dermatologic ultrasound is a recent application of ultrasound for the evaluation of healthy skin and appendages and their diseases. Although the scientific literature regarding this application is still not sufficient for evidence-based guidelines, general recommendations issued by scientific societies are necessary. The EFSUMB (European Federation of Societies for Ultrasound in Medicine and Biology) steering committee for dermatologic ultrasound has developed a series of consensus position statements regarding the main fields of dermatologic ultrasound (technical requirement, normal skin and appendages, inflammatory skin diseases, tumoral skin diseases, aesthetic dermatology and practice-training requirements). This document is the foundation for future evidence-based recommendations and guidelines for dermatologic ultrasound practice.

Lianxi Song, Liang Zeng, Huan Yan et al.

Song, Zeng, Yan et al. validate the E1L3N monoclonal antibody for the detection of PD-L1 in NSCLC samples. The authors show that PD-L1 scores assessed with E1L3N are concordant with the 22C3 assay and are associated with response to first-line pembrolizumab monotherapy.