Hasil untuk "Human anatomy"

F. Melchels, M. Domingos, T. Klein et al.

Additive manufacturing techniques offer the potential to fabricate organized tissue constructs to repair or replace damaged or diseased human tissues and organs. Using these techniques, spatial variations of cells along multiple axes with high geometric complexity in combination with different biomaterials can be generated. The level of control offered by these computer-controlled technologies to design and fabricate tissues will accelerate our understanding of the governing factors of tissue formation and function. Moreover, it will provide a valuable tool to study the effect of anatomy on graft performance. In this review, we discuss the rationale for engineering tissues and organs by combining computer-aided design with additive manufacturing technologies that encompass the simultaneous deposition of cells and materials. Current strategies are presented, particularly with respect to limitations due to the lack of suitable polymers, and requirements to move the current concepts to practical application.

B. Engelhardt, P. Vajkoczy, R. Weller

M. Vianello

土居 健郎, J. Bester

S. Arnoczky, R. Warren

A. White, M. Panjabi

J. Price, W. Drevets

C. Honey, J. Thivierge, O. Sporns

M. Alini, S. Eisenstein, Keita Ito et al.

M. Glasser, J. Rilling

Claudia Bracco, Alberto Contri, Sandra Goericke-Pesch

This review provides a comprehensive exploration of the applications and advancements in ultrasonographic techniques for evaluating the uterus in domestic canines. Conventional grey-scale ultrasonography remains a cornerstone for detecting anatomical and pathological changes, while emerging modalities such as Doppler ultrasonography, contrast-enhanced ultrasonography (CEUS), and ultrasound elastography (UEl) have expanded diagnostic capabilities by providing insights into vascularity, tissue stiffness, and microvascular perfusion. Recent innovations in three-dimensional (3D) and four-dimensional (4D) ultrasonography have further revolutionized imaging by enabling detailed visualization of fetal anatomy and dynamic intrauterine processes. While these techniques have been extensively studied in human and veterinary medicine for various organs, their application to the canine uterus, both non-pregnant and pregnant, remains underexplored. This review bridges gaps in existing literature by incorporating findings from related fields and outlining future directions for research to improve the diagnosis and management of reproductive uterine disorders in dogs.

Sam Johnson, M. Everingham

Asha K. Nabirye, Ian G. Munabi, Aloysius G. Mubuuke et al.

Background: Clinical practice is an important part of nursing education as it helps nursing students transition into competent health professionals capable of providing quality services. However, research studies convey their significant role as a stressor for nursing students when they encounter end-of-life situations during clinical practice. Furthermore, the perceptions of nursing students regarding end-of-life care (EOLC) have not been exhaustively studied in the Ugandan context. Objective: This study was conducted to understand nursing students’ perceptions about EOLC during clinical practice at Mulago National Referral Hospital. Design: This qualitative study employed a phenomenological approach and was conducted among fifteen nursing students from Makerere University who were assigned to clinical practice at Mulago National Referral Hospital, Kampala, Uganda in 2023. Method: Participants were purposively selected for the study from third- and fourth-year undergraduate nursing students. Data were gathered through semi-structured in-depth interviews which were audio-recorded, transcribed, and thematically analyzed using Atlas.ti version 6 software. Results: Three main themes emerged from the data: (i) reactions to the physical process of EOLC; (ii) changes in ideas about dying patients; and (iii) student attitudes toward dying patients. Participants described their reactions as chaotic, devastated, and scared during their first encounter with care for dying patients. They also highlighted how their attitudes evolved from unfavorable impressions to positive perceptions as they gained experience. Conclusion: In this study, nursing students exhibited divisive attitudes toward EOLC starting with uncertainty and fear, then often growing into confidence and compassion. These powerful experiences show how much EOCL can shape students personally and professionally, highlighting the need for greater support in their educational journey. Further research could help understand how this process unfolds in different settings.

A. Tziortzi, G. Searle, Sofia Tzimopoulou et al.

Giulia Gregori, Lisa Johansson, Kristian F. Axelsson et al.

Abstract Background Physical function is an important risk factor for fracture. Previous studies found that different physical tests (e.g., one‐leg standing [OLS] and timed up and go [TUG]) predict fracture risk. This study aimed to determine which physical function test is the most optimal independent predictor of fracture risk, together with clinical risk factors (CRFs) used in fracture risk assessment (FRAX) and bone mineral density (BMD). Methods In total, 2321 women out of the included 3028 older women, aged 77.7 ± 1.6 (mean ± SD), in the Sahlgrenska University Hospital Prospective Evaluation of Risk of Bone Fractures study had complete data on all physical function tests and were included in the analysis. At baseline, hand grip strength, OLS, TUG, walking speed and chair stand tests were performed. All incident fractures were confirmed by X‐ray or review of medical records and subsequently categorized as major osteoporotic fractures (MOFs), hip fractures and any fracture. Multivariate Cox regression (hazard ratios [HRs] and 95% confidence intervals [CIs]) analyses were performed with adjustments for age, body mass index (BMI), FRAX CRFs, femoral neck BMD and all physical function tests as predictors both individually and simultaneously. Receiver operating characteristic (ROC) analyses and Fine and Gray analyses were also performed to investigate associations between physical function and incident fractures. Results OLS was the only physical function test to be significantly and independently associated with increased risk of any fracture (HR 1.13 [1.04–1.23]), MOF (HR 1.15 [1.04–1.26]) and hip fracture (HR 1.34 [1.11–1.62]). Adjusting for age, BMI, CRFs and femoral neck BMD did not materially alter these associations. ROC analysis for OLS, together with age, BMI, femoral neck BMD and CRFs, yielded area under the curve values of 0.642, 0.647 and 0.732 for any fracture, MOF and hip fracture, respectively. In analyses considering the competing risk of death, OLS was the only physical function test consistently associated with fracture outcomes (subhazard ratio [SHR] 1.10 [1.01–1.19] for any fracture, SHR 1.11 [1.00–1.22] for MOF and SHR 1.25 [1.03–1.50] for hip fracture). Walking speed was only independently associated with the risk of hip fracture in all Cox regression models and in the Fine and Gray analyses. Conclusions Among the five physical function tests, OLS was independently associated with all fracture outcomes, even after considering the competing risk of death, indicating that OLS is the most reliable physical function test for predicting fracture risk in older women.

S. Hbumuremyi, C. Niyibigira, V. Archibong et al.

Variations in the ureteral patterning, venous, and arterial of the kidneys are common; however, concomitant involvement with two systems is rare. The current case was discovered during a routine dissection course that took place in the Human Anatomy laboratory of the University of Rwanda. While dissecting the retroperitoneal space of one specimen, it was realized that the right kidney was mal-rotated with a ureter connected to the anterior side. That right kidney also had two aberrant arteries in addition to the main renal artery, those two aberrant arteries emerged from the inferior pole of the kidney. Renal arterial variants may be grouped as supernumerary, multiple, and aberrant, in the current case it is aberrant. It is expected that the kidney rotates from anterior to medial around the longitudinal axis during development, and the renal hilum turns toward the medial direction. However, in the current case, the hilum faced anteriorly.

Enrico Mingardo, Jeshurun C. Kalanithy, Gabriel Dworschak et al.

Abstract Isl1 has been described as an embryonic master control gene expressed in the pericloacal mesenchyme. Deletion of Isl1 from the genital mesenchyme in mice leads to an ectopic urethral opening and epispadias-like phenotype. Using genome wide association methods, we identified ISL1 as the key susceptibility gene for classic bladder exstrophy (CBE), comprising epispadias and exstrophy of the urinary bladder. The most significant marker (rs6874700) identified in our recent GWAS meta-analysis achieved a p value of 1.48 × 10− 24 within the ISL1 region. In silico analysis of rs6874700 and all other genome-wide significant markers in Linkage Disequilibrium (LD) with rs6874700 (D’ = 1.0; R2 > 0.90) revealed marker rs2303751 (p value 8.12 × 10− 20) as the marker with the highest regulatory effect predicted. Here, we describe a novel 1.2 kb intragenic promoter residing between 6.2 and 7.4 kb downstream of the ISL1 transcription starting site, which is located in the reverse DNA strand and harbors a binding site for EZH2 at the exact region of marker rs2303751. We show, that EZH2 silencing in HEK cells reduces ISL1 expression. We show that ezh2 −/− knockout (KO) zebrafish larvae display tissues specificity of ISL1 regulation with reduced expression of Isl1 in the pronephric region of zebrafish larvae. In addition, a shorter and malformed nephric duct is observed in ezh2 −/− ko zebrafish Tg(wt1ß:eGFP) reporter lines. Our study shows, that Ezh2 is a key regulator of Isl1 during urinary tract formation and suggests tissue specific ISL1 dysregulation as an underlying mechanism for CBE formation.

Marta Pośnik, Nicol Zielinska, Kacper Ruzik et al.

BACKGROUND: The muscles present in the pelvic girdle compartment demonstrate clinically significant anatomical variation regarding both their site of attachment and additions, such as accessory heads, muscles, or tendinous slips. Many of those variations might be considered potential traps during ultrasound examination, which may result in misdiagnosis. The aim of this study was to raise awareness of such a possibility. MATERIALS AND METHODS: A comprehensive search for morphological variations was performed in PubMed and NIH. Relevant papers were listed, and citation tracking was accomplished. RESULTS: Although several anatomical variations of pelvic girdle muscles have been presented, few studies have examined their relevance in ultrasound imaging. CONCLUSIONS: The morphological variability of the pelvic girdle muscles does not vary from such incidence in other regions of the human body; however, further ultrasound studies are needed of the numerous morphological variants that can be found in this region.

David Johnson, Sean Williams, Ben Bradley et al.

Background: The adolescent growth spurt is associated with an increased risk of injury in young athletes. Aim: This study aimed to use an interdisciplinary collaboration between technical coaches, sports scientists, and medical staff to mitigate this risk. Subjects and methods: 77 male academy footballers were followed across two seasons. At-risk players were identified using somatic maturity status and growth rate in stature and the lower limbs, using thresholds of 88% to 92.8% of predicted adult stature, ≥7.2 cm/year, and ≥3.6 cm/year, respectively. During the 2019–20 season, players with symptoms of a growth-related injury or two of three risk factors were included in an intervention strategy that included modified training load, football-specific skills, balance, coordination and landing drills, and an individualised strength program. Results: For players with the three risk factors, there was a significant reduction in the incidence (rate ratio [RR] = 0.14 (5.2 per 1000h → 0.8 per 1000h, p = 0.05) and burden (RR = 0.08 (216 per 1000h → 17 per 1000h, p = 0.02) between the seasons. For players with ≤2 risk factors, there were no significant differences in injury risk between the baseline and intervention seasons. Conclusion: Overall, it may be possible to mitigate injury incidence and burden during the adolescent growth spurt in high-risk athletes.

Gaute Floer Johnsen, Håvard Haugen, J, Liebert Parreiras Nogueira et al.

Introduction: The purpose of this study was to determine the degree of similarity between contralateral mandibular incisors utilising 3-dimensional (3D) models obtained from micro-computed tomographic (micro-CT) scans of extracted human teeth. The null hypothesis was that contralateral mandibular incisors do not exhibit matching symmetry. Methods: Sixty pairs (n = 120) of extracted mandibular incisors were obtained from 30 patients and scanned with micro-CT with a voxel size of 15.0 μm. 3D virtual models of the pulpal cavities were rendered. Geometric morphometric deviation analysis was performed after mirroring, automatic alignment, and co-registration of the models of contralateral teeth root mean square (RMS) errors were calculated. The quantitative analysis of the 3D models included 6 different geometric parameters. Data sets were examined with a 2-sample Kolmogorov–Smirnov test. Post hoc retrospective power analysis was performed to find statistical power (α = 0.05). Results: Contralateral pairs had a narrower distribution in deviation than random pairs. Also, contralateral pairs showed a statistically higher similarity coefficient (5 out of 6 geometric parameters) compared to random pairs (P < .001); no difference was found when comparing central to lateral pairs or between Vertucci type I configurations compared to non-type I. RMS errors had significantly lower Contralateral premolars (CPs) values than random pairs (P < .001). Conclusions: A high degree of similarity was demonstrated for pairing contralateral mandibular incisors using 3D models. The similarity between contralateral central and lateral incisors suggests that when screened and matched, these 4 teeth might be used in endodontic research where similar root canal anatomy is crucial.