Hasil untuk "Encyclopedias"

Juciele Pereira Dias, Luciana Nogueira

Este trabalho filia-se à Análise do Discurso Materialista, no entremeio com a História das Ideias Linguísticas, com o objetivo compreender o funcionamento discursivo das enciclopédias digitais – como instrumentos digitais - que estão na base de práticas de produção de saberes linguísticos em circulação na sociedade e na história. Perguntamos como esses instrumentos, ao inscreverem-se na materialidade do digital, (re)significam o saber sobre a linguagem e a produção e circulação dos saberes. Tomamos para análise enciclopédias on-line, vinculadas a projetos no campo da Análise de Discurso no Brasil – ENCIDI, ELB, ENCIDIS e EnciDiSer. Compreendemos que as enciclopédias digitais configuram práticas de saber e de formação determinadas por processos histórico-ideológicos que afetam a relação entre linguagem, tecnologia e conhecimento.

Anna Iatsyshyn, Nataliia Boiko, Iryna Hryhorenko et al.

Hans-Jürgen Lüsebrink

Dave Muddiman

M. Bakker, D. Eckroth

I. Wilson, E. Adlard, M. Cooke et al.

J. Wishart

H. Rapaport

N. Wickramasinghe

W. White, D. Culver

D. Henderson

Dimas Yusuf, S. Butland, Magdalena I. Swanson et al.

Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium of over 100 researchers has collectively contributed over 130 mini review articles on pertinent human, mouse and rat TFs. Notable features of the TFe website include a high-quality PDF generator and web API for programmatic data retrieval. TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe.

G. Crow

I. Kufareva, A. Ilatovskiy, R. Abagyan

The importance of binding site plasticity in protein–ligand interactions is well-recognized, and so are the difficulties in predicting the nature and the degree of this plasticity by computational means. To assist in understanding the flexible protein–ligand interactions, we constructed the Pocketome, an encyclopedia of about one thousand experimentally solved conformational ensembles of druggable binding sites in proteins, grouped by location and consistent chain/cofactor composition. The multiplicity of pockets within the ensembles adds an extra, fourth dimension to the Pocketome entry data. Within each ensemble, the pockets were carefully classified by the degree of their pairwise similarity and compatibility with different ligands. The core of the Pocketome is derived regularly and automatically from the current releases of the Protein Data Bank and the Uniprot Knowledgebase; this core is complemented by entries built from manually provided seed ligand locations. The Pocketome website (www.pocketome.org) allows searching for the sites of interest, analysis of conformational clusters, important residues, binding compatibility matrices and interactive visualization of the ensembles using the ActiveICM web browser plugin. The Pocketome collection can be used to build multi-conformational docking and 3D activity models as well as to design cross-docking and virtual ligand screening benchmarks.

P. Robinson

S. Goldstein, J. Naglieri

J. Janick, R. Paull

H. Henderson

Computers play a crucial role in our day-to-day lives. With more than 150 black-and-white photographs and illustrations, "Encyclopedia of Computer Science and Technology, Revised Edition" provides a detailed examination of this fascinating field for students and general readers alike. This necessary update boasts more than 50 - per cent new material - a total of more than 550 updated entries, nearly 200 new to this edition, that reflect current information. Helpful appendixes include a chronology of significant events in computing, a listing of achievements in the field, and brief descriptions and contact information for some important organizations in the computer field. Major corporations and organizations in the computer field are now covered, as well as many new biographies. Further reading sections have been revised and expanded with the latest resources.

Kevin E. Lawson