In the face of complex challenges in the global business environment, organizational performance is a major concern. Evaluation of organizational performance plays an important role in modern management. This research integrates the management perspective with a Structural Equation Modeling (SEM) approach using SmartPLS. Through keywords such as leadership, organizational culture, employee motivation, and other variables, this study identifies key factors that affect organizational performance. The results provide an in-depth view of how organizational management can influence and improve their performance. This research has significant practical implications for different types of organizations. This article details the methodology, variables, data analysis, and expected findings, all in the context of combining management and SEM for organizational performance evaluation.
Abstract In this modern world, almost everyone uses ATM machines which allow people to transfer and withdraw cash. This study is based on executing a fingerprint method in the ATM System. We chose this field to improve safety and security for people to make the transaction easier. The fingerprints are unique for each person. There is no insecurity of losing an ATM card and no requirement to carry an ATM card with you every time. On comparison of different technologies for ATM security, the fingerprint technology operates better and safer than others. These reasons make this mechanism an effortless and secure way of transaction and also maintains a coherent ambience with users and ATM machines. This is the most latest technology in electronic cash transactions.
Currently, many construction companies offer construction services for Pile Foundation work and Bored Pile or Struss Pile for Buildings, Bridges, BTS Towers, Residential Houses, Shophouses, Hotels and the like using the Bored Pile or Strauss Pile method. The problem that exists is because of the influence of employee performance on construction where there are still some employees who are not satisfied with the leadership. This study aims to determine the effect of influence on employee performance and to see the influence of Organizational Culture on employee performance. This study tested three hypotheses with data sources originating from respondents from PT. Queen of the Great Foundation. Information, primary and secondary data in this study were only obtained from PT. Queen of the Great Foundation. The population and sample of this study were all employees of PT. The Great Foundation Queen of various divisions that opened 90 people. This study uses a quantitative approach method. The data collection technique used primary data in the form of a questionnaire. The data analysis technique of this research used the Structural Equation Modeling-Partial Least Square (SEM-PLS) method. This study shows that 1) Leadership has a positive and significant effect on Employee Performance, 2) Leadership has a positive and significant influence on Organizational Culture, 3) Organizational culture has a positive and significant influence on employee performance.
This article (and all articles in the proceedings volume relating to the same conference) has been retracted by IOP Publishing following an extensive investigation in line with the COPE guidelines. This investigation has uncovered evidence of systematic manipulation of the publication process and considerable citation manipulation. IOP Publishing respectfully requests that readers consider all work within this volume potentially unreliable, as the volume has not been through a credible peer review process. IOP Publishing regrets that our usual quality checks did not identify these issues before publication, and have since put additional measures in place to try to prevent these issues from reoccurring. IOP Publishing wishes to credit anonymous whistleblowers and the Problematic Paper Screener [1] for bringing some of the above issues to our attention, prompting us to investigate further. [1] Cabanac G, Labbé C and Magazinov A 2021 arXiv: 2107.06751v1 Retraction published: 23 February 2022
Apolipoprotein E (APOE) ε4 genotype is associated with increased cerebral amyloid beta (Aβ) deposition in nondemented elderly and suggested to influence ApoE as well as ApoJ (clusterin [Clu]) and ApoA1 expression. We aimed to assess whether APOE affects early Alzheimer's disease pathophysiology via these apolipoproteins. Cerebrospinal fluid (CSF) ApoE, Clu, ApoA1, and CSF amyloid beta1-42 (Aβ42) and tau levels were assessed in 403 individuals with subjective cognitive decline and mild cognitive impairment using enzyme-linked immunosorbent assay. Whether CSF apolipoprotein levels mediated APOEε4 allele frequency effects on CSF Aβ42 and tau in nondemented elderly was investigated using mediation analysis, with age- and gender-adjusted linear regression analyses. CSF ApoE mediated 48% of the association between APOEε4 and CSF tau, whereas Clu and ApoA1 did not. In addition, CSF Clu partially mediated the relation between CSF ApoE and tau (12%). CSF apolipoproteins did not mediate the inverse relation between APOEε4 and CSF Aβ42, despite a strong association between the latter 2 biomarkers. In summary, our findings suggest that ApoE and Clu are involved in Aβ-independent pathways as part of the cascade leading to Alzheimer pathology.
A. Salvador, Andrew T. Askow, Colleen F. McKenna
et al.
ABSTRACT During a traditional set configuration of resistance exercise (TRD), characterized by a continuous completion of repetitions, a decrease in power output tends to occur throughout a set of repetitions. Inclusion of intraset rest, otherwise known as a cluster set configuration (CLU), counteracts this power decline. However, the effect of a CLU configuration on postexercise myofibrillar protein synthesis rates (MPS) and anabolic signaling has not been investigated. Purpose We aimed to determine if any mechanistic differences exist between TRD and CLU signaling events associated with muscle anabolism. Methods In randomized crossover trials, eight resistance-trained participants (23 ± 1 yr, 81 ± 4.7 kg, body fat: 18% ± 1.9%; 1 repetition maximum [1RM], 150 ± 9.1 kg) performed an acute bout of CLU (4 sets × (2 × 5) repetitions, 30-s intraset rest, 90-s interset rest) and TRD (4 sets × 10 repetitions, 120-s interset rest) barbell back squats at approximately 70% 1RM with total volume load equated during primed continuous l-[ring-13C6]phenylalanine infusions. Blood and muscle biopsy samples were collected at rest and after exercise at 0, 2, and 5 h. Results There was no difference in postexercise MPS between the CLU and TRD condition (P > 0.05) and no changes in phosphorylation of mTORC1 downstream targets (p70S6K and 4EBP1). Total and phosphorylated yes-associated protein on Ser127 transiently increased (P < 0.01) immediately after exercise (t = 0) in CLU (~2.1-fold) and TRD condition (~2.2-fold). Conclusions Our results show that CLU is a viable anabolic option by preserving power output with similar MPS stimulation when compared with the TRD condition in trained young adults.
Recurrent pregnancy loss (RPL) is a perplexing problem experienced with two or more consecutive miscarriages wherein the cause remains unexplained in >50% of cases. However, despite several evidences of involvement of paternal factors on early embryogenesis and placental development, its contribution towards RPL has been largely unexplored. There is augmented lipid peroxidation, protein carbonylation, thionylation and enhanced histone retention in spermatozoa of RPL patients. Differentially expressed proteins in the spermatozoa of RPL patients may contribute towards aberrant embryo development and pregnancy loss. The present study comprised of male partners of RPL patients (n = 16) with the absence of any female factor abnormality and age‐matched fertile healthy donors (n = 20). Pooled sperm samples from each group were subjected to high‐throughput liquid chromatography–tandem mass spectrophotometry (LC‐MS/MS) and subsequent bioinformatic analysis that identifies key proteins to be differentially expressed (DEPs). A total of 23 DEPs were identified with ≥2.0 fold change were considered to be significant. A key finding of the study was clusterin (CLUS), a predominant oxidative stress protein that takes part in an array of pre‐ and post‐fertilisation molecular processes, found to be underexpressed as it was confirmed by Western blot analysis. This pilot study supports contributions of paternal oxidative predominance in RPL and encourages further investigation.
Abstract In this paper we report new calculations of the shape of the Raman rotational lines of hydrogen in solution with water. The method was based on a perturbative treatment and the calculations were performed for a system at room temperature and pressure ≈14 MPa, a thermodynamic state at which both measurements and accurate non-adiabatic calculations were available. The scope of the paper is to compare our numerical findings both with the computational results obtained with the non-adiabatic method and with the measured widths of the rotational lines. We found that our results are very similar to those obtained with the non-adiabatic method. Calculations of the widths were made with different models for the hydrogen–water intermolecular potential. The comparison of the numerical evaluations with the experimental findings allows us to judge how dependable the potential models are. The same calculations were performed also at larger pressures, up to 160 MPa. It was found that the widths of the rotational lines increased by increasing the pressure whereas, at the same pressure, they decreased when the rotational quantum number of the initial state was increased.
BackgroundThe aims of this study were to analyse the serum concentrations of clusterin (CLU) in patients with hand osteoarthritis (OA) and in healthy controls, to compare CLU levels between patients with erosive and non-erosive disease, and to examine the association of CLU levels with clinical and laboratory parameters.MethodsA total of 135 patients with hand OA (81 with erosive and 54 with non-erosive disease) and 53 healthy individuals were included in this study. All patients underwent clinical and hand joint ultrasound examination. The Australian/Canadian (AUSCAN) hand osteoarthritis index, algofunctional index and a visual analogue scale (VAS) for the measurement of pain were assessed. Serum levels of CLU were measured by an enzyme-linked immunosorbent assay (ELISA).ResultsSerum levels of CLU were significantly lower in patients with hand OA than in control subjects (p < 0.0001). In addition, patients with erosive hand OA had significantly lower CLU levels than those with non-erosive disease (p = 0.044). Negative correlations between CLU levels and pain as assessed by the AUSCAN score and the VAS were found in patients with erosive hand OA (r = − 0.275; p = 0.013 and r = − 0.220; p = 0.049, respectively).ConclusionThe present study demonstrates that lower concentrations of CLU are found in hand OA patients than in healthy individuals, especially in those with erosive disease, and that CLU concentrations have a negative association with hand pain.
Clusterin (CLU) is a stress‐activated molecular chaperone that confers treatment resistance to taxanes when highly expressed. While CLU inhibition potentiates activity of taxanes and other anti‐cancer therapies in preclinical models, progression to treatment‐resistant disease still occurs implicating additional compensatory survival mechanisms. Taxanes are believed to selectively target cells in mitosis, a complex mechanism controlled in part by balancing antagonistic roles of Cdc25C and Wee1 in mitosis progression. Our data indicate that CLU silencing induces a constitutive activation of Cdc25C, which delays mitotic exit and hence sensitizes cancer cells to mitotic‐targeting agents such as taxanes. Unchecked Cdc25C activation leads to mitotic catastrophe and cell death unless cells up‐regulate protective mechanisms mediated through the cell cycle regulators Wee1 and Cdk1. In this study, we show that CLU silencing induces a constitutive activation of Cdc25C via the phosphatase PP2A leading to relief of negative feedback inhibition and activation of Wee1‐Cdk1 to promote survival and limit therapeutic efficacy. Simultaneous inhibition of CLU‐regulated cell cycle effector Wee1 may improve synergistic responses of biologically rational combinatorial regimens using taxanes and CLU inhibitors.
ABSTRACT Loss of mitochondrial function often leads to neurodegeneration and is thought to be one of the underlying causes of neurodegenerative diseases such as Parkinson's disease (PD). However, the precise events linking mitochondrial dysfunction to neuronal death remain elusive. PTEN-induced putative kinase 1 (PINK1) and Parkin (Park), either of which, when mutated, are responsible for early-onset PD, mark individual mitochondria for destruction at the mitochondrial outer membrane. The specific molecular pathways that regulate signaling between the nucleus and mitochondria to sense mitochondrial dysfunction under normal physiological conditions are not well understood. Here, we show that Drosophila Clueless (Clu), a highly conserved protein required for normal mitochondrial function, can associate with Translocase of the outer membrane (TOM) 20, Porin and PINK1, and is thus located at the mitochondrial outer membrane. Previously, we found that clu genetically interacts with park in Drosophila female germ cells. Here, we show that clu also genetically interacts with PINK1, and our epistasis analysis places clu downstream of PINK1 and upstream of park. In addition, Clu forms a complex with PINK1 and Park, further supporting that Clu links mitochondrial function with the PINK1-Park pathway. Lack of Clu causes PINK1 and Park to interact with each other, and clu mutants have decreased mitochondrial protein levels, suggesting that Clu can act as a negative regulator of the PINK1-Park pathway. Taken together, these results suggest that Clu directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control. Summary: The protein Clueless is crucial for mitochondrial function and can interact genetically and physically with the PINK1-Parkin mitophagy complex.