This article critically examines how international media outlets, such as the BBC, CNN, Al Jazeera, and CGTN, have covered conflict stories in Ethiopia from 2020 to 2025, a period widespread of conflicts across many parts of the country. The article used a descriptive quantitative approach. All stories during the sample period were first collected from these four media outlets. Then the article used systematic random sampling and purposive sampling to select stories, yielding a representative sample from each outlet. The data was coded using a content analysis tool and presented quantitatively. The data were also discussed by using framing theory. The results indicate that international media tend to demonstrate significant selective exposure, disproportionately focusing on the Tigray conflict while marginalizing concurrent conflicts in the Amhara and Oromia regions. The framing predominantly attributes responsibility to the Ethiopian government and utilizes episodic narratives that decontextualize the conflicts. This coverage suggests patterns reflective of geographical interests and a limited understanding of the complex historical and political drivers of instability and humanitarian crises in Ethiopia. This suggests that international media pay insufficient attention to conflicts across the country and lack a deep understanding of the underlying causes of the country’s politics and conflicts.
Introduction Motivated health workers are pivotal in providing adequate health services. This study aims to understand what motivates and demotivates maternal health workers. We do so in Somalia, an understudied country in Africa with pervasive security challenges and one of the highest avoidable maternal mortality rates.Methods This qualitative study explores health workers’ motivation in three tertiary hospitals in the capital, Mogadishu. Twenty skilled healthcare professionals were interviewed, including nurses, midwives, physicians, specialists and supervisors. The interviews were transcribed verbatim and analysed using thematic analysis.Results Key factors influencing healthcare workers’ motivation include job satisfaction, monetary and work-related support, effective managerial practices, career development and intrinsic motivation. Most health workers expressed a powerful combination of altruism, volunteerism and religious conviction, driving their professional commitment to the community. Challenges that led to demotivation included high patient volume, staff shortages, limited supplies, infrastructural constraints, unregulated managerial practices and health system limitations. While most health workers primarily wanted to meet patients’ needs and did not consider salary a decisive motivating factor, others were demotivated by low pay and heavy workload.Conclusion Maternal health workers in Somalia face challenges that impact their motivation. Mitigating burnout through workload management and continued education can contribute to a more motivated and resilient healthcare workforce. Policy recommendations include offering long-term contracts, providing access to training and implementing fair and transparent employment policies. Further research is needed to evaluate the effectiveness of both financial and non-financial incentives in motivating health workers in Somalia.
Medicine (General), Infectious and parasitic diseases
Magne Olufsen, Mai Lill Suhr, Magdalena Kersting
et al.
Practical work has been demonstrated to offer various benefits for science learning. Despite benefits, several studies have indicated that practical work does not necessarily improve the learning of content knowledge. This study employed a video observation manual to systematically analyse the practical work in 73 videotaped science lessons from ten primary and ten lower secondary classrooms in Norway. Our findings suggest that students were more active and often participated in science-related discussions when involved in practical work. We also found that pre- and post-activities were particularly crucial for facilitating the learning of content knowledge, particularly in primary schools. Besides, the duration of practical work influenced the observed teaching: we noted a greater emphasis on learning content knowledge during shorter practical sequences. These findings contribute to a better understanding of the opportunities for practical work in science education.
Lauren G. Hitt, Malte Willmes, George Whitman
et al.
Abstract As fish populations face compounding pressures under climate change, highly modified rivers are receiving increasing research and conservation attention as important sites for restoration. Across the North Pacific Ocean, Chinook salmon (Oncorhynchus tshawytscha) have experienced unprecedented declines and extirpations because of habitat loss and fragmentation and climate variability. Here, we studied a rare example of a novel salmon population developing in Putah Creek, California, a dam‐controlled stream flowing through an area of intensive agriculture where salmon were unlikely to occur prior to the rehabilitation of a more natural flow regime. We used otoliths from adult Chinook salmon carcasses recovered from Putah Creek to determine river or hatchery of origin for five spawning year classes. Our results provide evidence of successful salmon reproduction, outmigration survival, and natal homing of individuals back to Putah Creek in recent years. Although hatchery‐origin fish that strayed to Putah Creek to spawn dominated returns each year, this study documents life‐cycle completion required for the potential development of a self‐sustaining salmon population. This study demonstrates that targeted restoration and flow rehabilitation efforts can generate viable new salmon spawning habitat in dam‐controlled river systems, which could help mitigate habitat lost to dams and developments. Further, successful anadromous life‐cycle completion can occur in new spawning habitat within the first several generations, which will help inform efforts to restore or reintroduce salmon in other altered river systems.
Laura C. Zwiers, Diederick E. Grobbee, Rob Schneijdenberg
et al.
<b>Background</b>: Myocarditis and pericarditis are recognised risks following COVID-19 vaccination, including the mRNA-1273 vaccine. Most cases occur shortly following the second dose of this vaccine, and incidence is highest among young males. However, little is known about risk factors beyond age and sex and about the longer-term clinical course. This study aims to identify possible risk factors for myocarditis and pericarditis following mRNA-1273 vaccination, to characterise the clinical course of myocarditis and pericarditis, both associated with mRNA-1273 vaccination and not associated with vaccination, and to identify risk factors for severe outcomes (i.e., cardiac or thromboembolic complications, severe hospital outcomes, all-cause hospital readmission, and death). <b>Methods</b>: This study is being conducted within the Vaccine Monitoring Collaboration for Europe (VAC4EU) association using routinely collected healthcare data from five data sources from four European countries (Denmark, Norway, Spain, and the United Kingdom). The study is being performed using a common data model, and all analyses are performed separately in each data source in a federated manner following a common protocol. A case–cohort analysis set is identified within each data source for identifying potential risk factors for myocarditis and pericarditis following mRNA-1273 vaccination using logistic regression analysis. The clinical course of myocarditis and pericarditis is being assessed using a cohort study design and describes all cases (i.e., cases associated with mRNA-1273 and unexposed cases). Cox regression analysis is applied to assess the associations between risk factors and several follow-up outcomes. <b>Conclusions</b>: This protocol describes the study methodology of an international collaborative initiative with the aim of assessing the risk factors and clinical course of myocarditis and pericarditis following mRNA-1273 vaccination using a federated network of five European data sources.
Serhiy Pankiv, Anette Kathinka Dahl, Aleksander Aas
et al.
We identify BEACH domain–containing proteins (BDCPs) as novel membrane coat proteins involved in the sorting of transmembrane proteins (TMPs) on the trans-Golgi network and tubular sorting endosomes. The seven typical mammalian BDCPs share a predicted alpha-solenoid-beta propeller structure, suggesting they have a protocoatomer origin and function. We map the subcellular localization of seven BDCPs based on their dynamic colocalization with RAB and ARF small GTPases and identify five typical BDCPs on subdomains of dynamic tubular-vesicular compartments on the intersection of endocytic recycling and post-Golgi secretory pathways. We demonstrate that BDCPs interact directly with the cytosolic tails of selected TMPs and identify a subset of TMPs, whose trafficking to the plasma membrane is affected in cells lacking BDCP. We propose that the competitive binding of BDCPs and clathrin coat adaptors to the cytosolic tails of TMPs, followed by their clustering to distinct subdomains of secretory/recycling tubules function as a mechanism for sorting of TMPs in pleomorphic tubular-vesicular compartments that lack a clathrin coat.
Ice accretion on rotary-wing unmanned aerial vehicles (RWUAVs) needs to be studied separately from the fixed-wing UAVs because of the additional flow complexities induced by the propeller rotation. The aerodynamics of rotatory wings are extremely challenging compared to the fixed-wing configuration. Atmospheric icing can be considered a hazard that can plague the operation of UAVs, especially in the Arctic region, as it can impose severe aerodynamic penalties on the performance of propellers. Rotary-wing structures are more prone to ice accretion and ice shedding because of the centrifugal force due to rotational motion, whereby the shedding of the ice can lead to mass imbalance and vibration. The nature of ice accretion on rotatory wings and associated performance degradation need to be understood in detail to aid in the optimum design of rotary-wing UAVs, as well as to develop adequate ice mitigation techniques. Limited research studies are available about icing on rotary wings, and no mature ice mitigation technique exists. Currently, there is an increasing interest in research on these topics. This paper provides a comprehensive review of studies related to icing on RWUAVs, and potential knowledge gaps are also identified.
The eight-toothed spruce bark-beetle Ips typographus is the most damaging insect pest of Norway spruce in Europe, and it poses a serious risk to spruce in other countries where it is not currently present but might be introduced. The beetle is not native to the UK and before 2018 it had not been found established anywhere within the country. In November 2018, however, several adult Ips typographus were found in a billet trap set up as part of annual surveys that the UK carries out to monitor for this and other quarantine bark beetle pests. The finding of adult beetles in the billet trap, a few miles south of Ashford in Kent, led to the discovery of a breeding population in an adjacent woodland. Delimiting surveys to 1 km and further surveys to 50 km showed that the infestation was confined to a single stand of Norway spruce. The stand was felled in January and February 2019, and the material destroyed, and beetles emerging on the site were trapped out using pheromone traps, billet piles and trap trees. These prompt actions eradicated the breeding population, but small numbers of adult Ips typographus continued to be caught on the outbreak site in 2020 and 2021. These captures, and numerous adult Ips typographus caught in pheromone traps set up across the region in response to the outbreak, indicate that incursions of adult Ips typographus are occurring on a regular basis, most likely from source populations in northern France and Belgium. The arrival of adult Ips typographus over a wide area and the potential for further outbreaks represents a continuing threat to spruce woodlands in south-east England, and has important implications for surveillance and monitoring and the management of spruce in this part of the UK.
Jan-Erik Gjertsen, Daniel Nilsen, Ove Furnes
et al.
Background and purpose: Uncemented stems increase the risk of revision in elderly patients. In 2018, we initiated a national quality improvement project aiming to increase the proportion of cemented stems in elderly female total hip arthroplasty (THA) and hip fracture hemiarthroplasty (HA) patients. We aimed to evaluate the association of this project on the frequency of cemented stems and the risk of secondary procedures in the targeted population.
Methods: 10,815 THAs in female patients ≥ 75 years in the Norwegian Arthroplasty Register and 19,017 HAs in hip fracture patients ≥ 70 years in the Norwegian Hip Fracture Register performed in 2015–2017 and 2019–2021 at all Norwegian hospitals were included in this retrospective cohort study. The quality improvement project was implemented at 19 hospitals (8,443 patients). 1-year revision risk (THAs) and reoperation risk (HAs) were calculated for uncemented and cemented stems by Kaplan–Meier and Cox adjusted hazard rate ratios (aHRRs) with all-cause revision/reoperation as main endpoint.
Results: The use of cemented stem fixation in the targeted population increased from 26% to 80% for THAs and from 27% to 91% for HAs. For THAs, the 1-year revision rate decreased from 3.7% in 2015–2017 to 2.1% in 2019–2021 (aHRR 0.7, 95% confidence interval [CI] 0.5–0.9) at the intervention hospitals. For HAs, the reoperation rate decreased from 5.9% in 2015–2017 to 3.3% in 2019–2021 (aHRR 0.6, CI 0.4–0.8) at the intervention hospitals.
Conclusion: The quality improvement project resulted in a significant increase in the proportion of cemented stems and reduced risk of secondary procedures for both THAs and HAs.
Giulia M. Giordano, Pasquale Pezzella, Armida Mucci
et al.
IntroductionIn this study we assessed the contribution of psychopathology, including the two domains of negative symptoms (motivational deficit and expressive deficit), processing speed as an index of neurocognition, and emotion recognition, as an index of social cognition, to poor functional outcomes in people with schizophrenia.MethodsThe Positive and Negative Syndrome Scale was used to evaluate positive symptoms and disorganization and the Brief Negative Symptom Scale to assess negative symptoms. The Symbol Coding and the Trail Making Test A and B were used to rate processing speed and the Facial Emotion Identification Test to assess emotion recognition. Functional outcome was assessed with the Personal and Social Performance Scale (PSP). Regression analyses were performed to identify predictors of functional outcome. Mediation analyses was used to investigate whether social cognition and negative symptom domains fully or partially mediated the impact of processing speed on functional outcome.ResultsOne hundred and fifty subjects from 8 different European centers were recruited. Our data showed that the expressive deficit predicted global functioning and together with motivational deficit fully mediated the effects of neurocognition on it. Motivational deficit was a predictor of personal and social functioning and fully mediated neurocognitive impairment effects on the same outcome. Both motivational deficit and neurocognitive impairment predicted socially useful activities, and the emotion recognition domain of social cognition partially mediated the impact of neurocognitive deficits on this outcome.ConclusionsOur results indicate that pathways to functional outcomes are specific for different domains of real-life functioning and that negative symptoms and social cognition mediate the impact of neurocognitive deficits on different domains of functioning. Our results suggest that both negative symptoms and social cognition should be targeted by psychosocial interventions to enhance the functional impact of neurocognitive remediation.
Alpaslan Demirci, Said Mirza Tercan, Eihab E. E. Ahmed
et al.
Prosumer communities are integrating renewable energy sources to reduce energy costs and carbon emissions for sustainable and clean energy awareness. However, increasing solar photovoltaic penetration in low-voltage distribution networks leads to serious power quality challenges, such as overvoltage for grid operators and prosumers. Integrating electric vehicles (EVs) as deferable loads can reduce prosumer costs and maximize environmental benefits as EV charging is managed. Therefore, this paper proposes a novel EV charging management that maximizes prosumer communities’ power quality and benefits PV-rich prosumers by applying a dynamic active power curtailment framework. The methodology calculates each prosumer’s maximum power injection into the grid based on their voltage sensitivities. The performance of the developed charging management is examined on the European 906 bus low-voltage distribution networks under unmanaged, managed, and vehicle-to-grid (V2G)-empowered scenarios. The prosumers’ individual and aggregated economic cost-benefit results are analyzed considering increasing EV penetration. The results show that the proposed method considering fair active power curtailment could increase self-consumption and renewable fraction for prosumers. It is observed that increasing EV penetration could reduce the curtailed energy by 14.6%. The V2G-empowered method also increased up to 20% more renewable energy for charging EVs, improved self-consumption and renewable fraction up to 11% and 19.4%. Moreover, the V2G option reduced total costs by up to 37.93%. This work can potentially promote renewable energy sources by modifying consumers’ charging behaviors to be more sustainable and environmentally friendly.
Lars-Erik Persson, Natasha Samko, George Tephnadze
Abstract The current status concerning Hardy-type inequalities with sharp constants is presented and described in a unified convexity way. In particular, it is then natural to replace the Lebesgue measure dx with the Haar measure $dx/x$ d x / x . There are also derived some new two-sided Hardy-type inequalities for monotone functions, where not only the two constants are sharp but also the involved function spaces are (more) optimal. As applications, a number of both well-known and new Hardy-type inequalities are pointed out. And, in turn, these results are used to derive some new sharp information concerning sharpness in the relation between different quasi-norms in Lorentz spaces.
Dennis van der Meer, Weiqiu Cheng, Jaroslav Rokicki
et al.
Abstract Background Schizophrenia is a highly heritable brain disorder with a typical symptom onset in early adulthood. The 2-hit hypothesis posits that schizophrenia results from differential early neurodevelopment, predisposing an individual, followed by a disruption of later brain maturational processes that trigger the onset of symptoms. Study design We applied hierarchical clustering to transcription levels of 345 genes previously linked to schizophrenia, derived from cortical tissue samples from 56 donors across the lifespan. We subsequently calculated clustered-specific polygenic risk scores for 743 individuals with schizophrenia and 743 sex- and age-matched healthy controls. Study results Clustering revealed a set of 183 genes that was significantly upregulated prenatally and downregulated postnatally and 162 genes that showed the opposite pattern. The prenatally upregulated set of genes was functionally annotated to fundamental cell cycle processes, while the postnatally upregulated set was associated with the immune system and neuronal communication. We found an interaction between the 2 scores; higher prenatal polygenic risk showed a stronger association with schizophrenia diagnosis at higher levels of postnatal polygenic risk. Importantly, this finding was replicated in an independent clinical cohort of 3233 individuals. Conclusions We provide genetics-based evidence that schizophrenia is shaped by disruptions of separable biological processes acting at distinct phases of neurodevelopment. The modeling of genetic risk factors that moderate each other’s effect, informed by the timing of their expression, will aid in a better understanding of the development of schizophrenia.
Sleipner is the world's first commercial Carbon Capture and Storage (CCS) project, located off the coast of Norway, with the goal of reducing carbon emissions by capturing CO2 and storing it in a utsira saline aquifer sandstone reservoir capable of storing up to 600 billion tonnes of CO2. The CO2 injection in these projects increases year after year, so the CO2 development must be monitored to see the distribution pattern and its implications for the reservoir zone. The purpose of this research is to calculate and model the CO2 distribution resulting from acoustic impedance inversion using 4-dimensional inversion, to calculate the repeatability from seismic data between baseline and monitor using the Normalized Root Mean Square attribute. In the processing, baseline and monitor data must be matched in the overburden zone using a cross-equalization process so that the inversion process. The results revealed a correlation between the two seismic data sets (baseline and monitor) with the classification of Reasonable Repeatability, and CO2 distribution in a securely stored reservoir that spreads laterally and does not leak.
Gunnar Andreas Walaas, Shreya Gopalakrishnan, Ingunn Bakke
et al.
BackgroundThe epithelium in the colonic mucosa is implicated in the pathophysiology of various diseases, including inflammatory bowel diseases and colorectal cancer. Intestinal epithelial organoids from the colon (colonoids) can be used for disease modeling and personalized drug screening. Colonoids are usually cultured at 18-21% oxygen without accounting for the physiological hypoxia in the colonic epithelium (3% to <1% oxygen). We hypothesize that recapitulating the in vivo physiological oxygen environment (i.e., physioxia) will enhance the translational value of colonoids as pre-clinical models. Here we evaluate whether human colonoids can be established and cultured in physioxia and compare growth, differentiation, and immunological responses at 2% and 20% oxygen.MethodsGrowth from single cells to differentiated colonoids was monitored by brightfield images and evaluated with a linear mixed model. Cell composition was identified by immunofluorescence staining of cell markers and single-cell RNA-sequencing (scRNA-seq). Enrichment analysis was used to identify transcriptomic differences within cell populations. Pro-inflammatory stimuli induced chemokines and Neutrophil gelatinase-associated lipocalin (NGAL) release were analyzed by Multiplex profiling and ELISA. Direct response to a lower oxygen level was analyzed by enrichment analysis of bulk RNA sequencing data.ResultsColonoids established in a 2% oxygen environment acquired a significantly larger cell mass compared to a 20% oxygen environment. No differences in expression of cell markers for cells with proliferation potential (KI67 positive), goblet cells (MUC2 positive), absorptive cells (MUC2 negative, CK20 positive) and enteroendocrine cells (CGA positive) were found between colonoids cultured in 2% and 20% oxygen. However, the scRNA-seq analysis identified differences in the transcriptome within stem-, progenitor- and differentiated cell clusters. Both colonoids grown at 2% and 20% oxygen secreted CXCL2, CXCL5, CXCL10, CXCL12, CX3CL1 and CCL25, and NGAL upon TNF + poly(I:C) treatment, but there appeared to be a tendency towards lower pro-inflammatory response in 2% oxygen. Reducing the oxygen environment from 20% to 2% in differentiated colonoids altered the expression of genes related to differentiation, metabolism, mucus lining, and immune networks.ConclusionsOur results suggest that colonoids studies can and should be performed in physioxia when the resemblance to in vivo conditions is important.