Hasil untuk "Pharmacy and materia medica"

Ali Mirzazadeh, Simon Cadavid, Kaiwen Zha et al.

Antidepressant nonadherence is pervasive, driving relapse, hospitalization, suicide risk, and billions in avoidable costs. Clinicians need tools that detect adherence lapses promptly, yet current methods are either invasive (serum assays, neuroimaging) or proxy-based and inaccurate (pill counts, pharmacy refills). We present the first noninvasive biomarker that detects antidepressant intake from a single night of sleep. A transformer-based model analyzes sleep data from a consumer wearable or contactless wireless sensor to infer antidepressant intake, enabling remote, effortless, daily adherence assessment at home. Across six datasets comprising 62,000 nights from >20,000 participants (1,800 antidepressant users), the biomarker achieved AUROC = 0.84, generalized across drug classes, scaled with dose, and remained robust to concomitant psychotropics. Longitudinal monitoring captured real-world initiation, tapering, and lapses. This approach offers objective, scalable adherence surveillance with potential to improve depression care and outcomes.

Mahmudul Hasan, Phi-Hung Tran, Jingsong Gao et al.

The concept of using photoelectron interferometry in short laser fields to probe electron dynamics and target structures was introduced more than two decades ago. However, the quality of experimental data has remained insufficient for quantitative analysis, largely due to the instability of few-cycle Ti:Sa laser pulses, the current workhorse of short pulses. Here, we report the first systematic strong-field ionization experiments performed with industrial-grade, carrier-envelope-phase (CEP) stabilized, near-single-cycle Yb lasers. By measuring photoelectron momentum distributions in the direct-ionization regime, we show that single-cycle cosine-shaped pulses can separate and enhance both spider-leg and fishbone holographic structures. The spider-leg structure enables extraction of the electron scattering phase from the Ar atomic potential-information typically accessible only through attosecond metrology, while the fishbone structure reveals the orbital-parity contrast between Ar atoms and nitrogen molecules. Our measurements are quantitatively reproduced by both semiclassical Herman-Kluk-propagator and \textit{ab initio} simulations, paving the way for precision studies of electron-molecule scattering with widely accessible industrial-grade lasers.

Maxime Richard, Irénée Frérot, Sylvain Ravets et al.

Exciton-polaritons in semiconductor microcavities exhibit large two-body interactions that, thanks to ever refined nanotechnology techniques, are getting closer and closer to the quantum regime where single-photon nonlinearities start being relevant. To foster additional progress in this direction, in this work we experimentally investigate the microscopic mechanism driving polariton-polariton interactions. We measure the dispersion relation of the collective excitations that are thermally generated on top of a coherent fluid of interacting lower-polaritons. By comparing the measurements with the Bogoliubov theory over both the lower and upper polariton branches simultaneously, we find that polariton-polariton interactions stem dominantly from a mechanism of saturation of the exciton oscillator strength.

Mohammad Amini, Linghao Yan, Orlando J. Silveira et al.

Van der Waals heterostructures are a core tool in quantum material design. The recent addition of monolayer ferroelectrics expands the possibilities of designer materials. Ferroelectric domains can be manipulated using electric fields, thus opening a route for external control over material properties. In this paper we explore the possibility of engineering magneto-electric coupling in ferroelectric heterostructures by studying the interface of bilayer SnTe with iron phthalocyanine molecules as a model system. The molecules act as sensor spins, allowing us to sample the magneto-electric coupling with nanometer precision through scanning tunneling microscopy. Our measurements uncover a structural, and therefore material-independent and intrinsic, mechanism to couple electric and magnetic degrees of freedom at the nanoscale.

Lin Liu, Jie Lv, Xiuxiu Wang et al.

Joko Priyanto Wibowo, Restu Dara Wewengkang, Medina Nurrahmah et al.

Methicillin-resistant Staphylococcus aureus (MRSA) is a major concern in healthcare due to its resistance to antibiotics and ability to form biofilms. This study investigated the antibacterial and antibiofilm activity of the extract and fractions of kelakai (Stenochlaena palustris) leaves against MRSA. Phytochemical screening revealed the presence of alkaloids, flavonoids, steroids, tannins, and triterpenoids in S. palustris leaves. The ethanolic extract of S. palustris leaves exhibited dose-dependent antibacterial activity against MRSA at concentrations up to 500 ppm. Among the fractions, the n-hexane fraction exhibited antibacterial activity at 500 and 1000 ppm, while the methanolic fraction showed inhibition only at 1000 ppm. The ethyl acetate fraction did not show any inhibition. All fractions and extract demonstrated antibiofilm activity, with the n-hexane fraction exhibiting the strongest activity (91.33 ± 1.52%) at 125 ppm. The crude extract of S. palustris leaves showed the weakest antibiofilm activity (32.66 ± 8.14%). These findings suggest that S. palustris leaves contain compounds with antibacterial and antibiofilm properties against MRSA, with the n-hexane fraction being the most promising. Further studies are needed to isolate and characterize the active compounds responsible for these activities.

Aditya S. Dupare, Mukta Motwani, Aarati Panchbhai et al.

Temporomandibular joint disorders (TMD) involve pain and dysfunction of the temporomandibular joint and associated muscles. Emerging evidence suggests associations with bruxism, poor sleep quality, anxiety disorders, and tension-type headache (TTH). To systematically review the associations between bruxism, sleep quality, anxiety disorders, and TTH in patients with TMD. Systematic searches were conducted in PubMed, Scopus, Web of Science, and Cochrane Library up to May 2025. Studies included adults with TMD and reported associations with bruxism, sleep quality, anxiety, or TTH. Risk of bias was assessed using the Newcastle-Ottawa Scale. Data were narratively synthesized. Twenty-six studies were included. Bruxism prevalence ranged from 45% to 87% in TMD patients, with significant associations with myofascial pain (P < 0.05). Poor sleep quality was reported in 40–75% of TMD patients and correlated with pain severity. Anxiety disorders were present in 30–60% of TMD patients, often exacerbating pain perception. TTH coexisted in 25–65% of TMD patients, sharing central sensitization as a mechanism. Study heterogeneity prevented meta-analysis. Bruxism, poor sleep quality, anxiety disorders, and TTH frequently coexist with TMD. Multidisciplinary assessment is crucial. Future longitudinal studies are warranted.

Dejian Liu, Ye Xu, YingJie Li et al.

We identify a molecular bubble, and study the star formation and its feedback in the S Mon region, using multiple molecular lines, young stellar objects (YSOs), and infrared data. We revisit the distance to S Mon, ~722+/-9 pc, using Gaia Data Release 3 parallaxes of the associated Class II YSOs. The bubble may be mainly driven by a massive binary system (namely 15 Mon), the primary of which is an O7V-type star. An outflow is detected in the shell of the bubble, suggesting ongoing star formation activities in the vicinity of the bubble. The total wind energy of the massive binary star is three orders of magnitude higher than the sum of the observed turbulent energy in the molecular gas and the kinetic energy of the bubble, indicating that stellar winds help to maintain the turbulence in the S Mon region and drive the bubble. We conclude that the stellar winds of massive stars have an impact on their surrounding environment.

Ruiqi Liu, Shuang Zheng, Qingqing Wu et al.

Reconfigurable Intelligent Surfaces (RISs) are a novel form of ultra-low power devices that are capable to increase the communication data rates as well as the cell coverage in a cost- and energy-efficient way. This is attributed to their programmable operation that enables them to dynamically manipulate the wireless propagation environment, a feature that has lately inspired numerous research investigations and applications. To pave the way to the formal standardization of RISs, the European Telecommunications Standards Institute (ETSI) launched the Industry Specification Group (ISG) on the RIS technology in September 2021. This article provides a comprehensive overview of the status of the work conducted by the ETSI ISG RIS, covering typical deployment scenarios of reconfigurable metasurfaces, use cases and operating applications, requirements, emerging hardware architectures and operating modes, as well as the latest insights regarding future directions of RISs and the resulting smart wireless environments.

Hota Sankirtha, Sugumar Vimal, Alex Arockia et al.

Aeromonas hydrophila is a Gram-negative bacterium that has been linked to serious illnesses in both humans and animals. The presence of hemolysin, a virulence factor, is critical in the development of A. hydrophila-related illnesses. As a result, precise and timely detection of the hemolysin gene is critical for efficient diagnosis and prevention of many illnesses. The PCR is used in this study to detect the hemolysin gene of A. hydrophila in a novel, fast, and highly sensitive one-step technique. Specific primers were constructed to amplify a conserved area within the hemolysin gene to achieve both specificity as well as sensitivity. The PCR assay was rigorously optimized, taking temperature, primer concentration, and reaction time into account, in order to maximize the efficiency and reliability of this method. In conclusion, this method’s simplicity, sensitivity, and specificity make it highly promising for regular diagnostic applications. Its application would allow for the early detection of A. hydrophila infections, allowing for more effective treatment and control methods.

Shenoi Pratima R, Bhongade Bhoomendra A, Shingane Shrikant A et al.

Herbal extracts have evoked interest owing to the small number of terpenoids and phenolic compounds, which impart antimicrobial, antioxidant, and anti-inflammatory properties. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) of four herbal extracts (lemon grass oil, basil oil, peppermint oil, and Obicure tea extract) against endodontic pathogens along with the MIC: MBC/MFC ratio were evaluated. The antimicrobial activity by detecting the MIC of three essential oils and tea extract was evaluated against eight common endodontic pathogens by the broth dilution method, while MBC was detected by subculturing onto blood agar from the first –three to five tubes from the MIC dilution tubes (showing no turbidity), which were plated on blood agar. All herbal extracts proved to be effective antimicrobials against tested endodontic pathogens. Basil oil had a bacteriostatic effect on all the organisms (P < 0.05). Mint oil showed bacteriostatic activity on Enterococcus (E.) faecalis and Peptostreptococcus (P > 0.05). Tea extract had a bacteriostatic effect (P > 0.05) against all tested microbes except Actinomyces, Lactobacilli, Staphylococcus (S.) aureus, and Fusobacterium (F.) nucleatum. Lemon grass oil had a bactericidal effect against all the organisms and a bacteriostatic effect against Peptostreptococcus (P > 0.05). It can be concluded that basil oil showed a strong bactericidal effect on the test organisms. The MIC for the organisms ranged from 0.2 to 50 μg/ml.

Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh et al.

Exposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca²⁺ concentration ([Ca²⁺]_i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary vasoconstriction and proliferation. This study investigated the mechanism by which KMUP-1, a xanthine derivative with phosphodiesterase inhibitory activity, inhibits hypoxia-induced canonical transient receptor potential channel 1 (TRPC1) protein overexpression and regulates [Ca²⁺]_i through store-operated calcium channels (SOCs). Ex vivo PASMCs were cultured from Sprague-Dawley rats in a modular incubator chamber under 1% O₂/5% CO₂ for 24 h to elucidate TRPC1 overexpression and observe the Ca²⁺ release and entry. KMUP-1 (1 μM) inhibited hypoxia-induced TRPC family protein encoded for SOC overexpression, particularly TRPC1. KMUP-1 inhibition of TRPC1 protein was restored by the protein kinase G (PKG) inhibitor KT5823 (1 μM) and the protein kinase A (PKA) inhibitor KT5720 (1 μM). KMUP-1 attenuated protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA, 1 μM)-upregulated TRPC1. We suggest that the effects of KMUP-1 on TRPC1 might involve activating the cyclic guanosine monophosphate (cGMP)/PKG and cyclic adenosine monophosphate (cAMP)/PKA pathways and inhibiting the PKC pathway. We also used Fura 2-acetoxymethyl ester (Fura 2-AM, 5 μM) to measure the stored calcium release from the sarcoplasmic reticulum (SR) and calcium entry through SOCs in hypoxic PASMCs under treatment with thapsigargin (1 μM) and nifedipine (5 μM). In hypoxic conditions, store-operated calcium entry (SOCE) activity was enhanced in PASMCs, and KMUP-1 diminished this activity. In conclusion, KMUP-1 inhibited the expression of TRPC1 protein and the activity of SOC-mediated Ca²⁺ entry upon SR Ca²⁺ depletion in hypoxic PASMCs.

Pratiksha Munjewar, Ranjana Sharma, Gauri Chandrashekhar Mahakalkar et al.

Background: Chronic kidney disease (CKD) is a global health issue, affecting 13.4% of the population. Many CKD patients progress to end-stage renal disease, necessitating lifelong renal replacement therapy like dialysis. Hemodialysis significantly alters patients’ lifestyles, causing social isolation, work–life changes, financial strain, and family role shifts. These challenges lead to fatigue, pain, depression, and sleep disturbances, severely impacting patients’ quality of life and daily activities. Among these symptoms, fatigue is one of the most common and disruptive. Aim: To assess the effectiveness of video-assisted teaching on knowledge regarding the management of post-hemodialysis fatigue among patients attending hemodialysis. Material and Method: This study was based on a quantitative research approach and one group pretest and post-test research design. This study includes 200 patients attending hemodialysis from Acharya Vinoba Bhave Rural Hospital Wardha with the nonprobability convenience sampling technique. A questionnaire was used to assess the knowledge of the patient. Result: After the educational program, the knowledge score improved significantly. The poor category decreased to 50 participants (25.0%), while the average category dropped to participants (5.0%). The good category increased substantially to 110 participants (55.5%), and 30 participants (15.0%) achieved an excellent level of knowledge. Conclusion: Results suggest that after applying intervention, the knowledge regarding post-hemodialysis fatigue is increased in patients attending hemodialysis.

Yen Chi Loo, Yi-Hong Tsai, Hsieh Chen et al.

Fish mint, Houttuynia cordata Thunb. (HCT) is an edible vegetable that has also been used in traditional folk medicines. As both a medicinal herb and a dietary source, HCT has been clinically proven to be a pivotal ingredient in formulas administered to alleviate COVID-19 symptoms. With the increasing market demand for imported materials, ensuring the quality consistency of HCT becomes a significant concern. In this study, the growing time for hydroponically-cultivated HCT with seaweed extract and amino acids added (HCTW) reduced by half compared to conventional soil-cultivated HCT (HCTS). Key quantified components in HCTW, flavonoid glycosides and caffeoylquinic acid derivatives, exhibited a 143% increase over HCTS. These crucial constituents were responsible for possessing antioxidant activity (IC50 < 25 μg/mL) and anti-nitrite oxide production (IC50 < 20 μg/mL). An economically-designed hydroponic system with appropriate additives is proposed to replace HCTS with improvements of growth time, overall production yields, and bioactive qualities.

Rabimba Karanjai, Sangwon Shin, and Wujie Xiong et al.

Cryptographic schemes like Fully Homomorphic Encryption (FHE) and Zero-Knowledge Proofs (ZKPs), while offering powerful privacy-preserving capabilities, are often hindered by their computational complexity. Polynomial multiplication, a core operation in these schemes, is a major performance bottleneck. While algorithmic advancements and specialized hardware like GPUs and FPGAs have shown promise in accelerating these computations, the recent surge in AI accelerators (TPUs/NPUs) presents a new opportunity. This paper explores the potential of leveraging TPUs/NPUs to accelerate polynomial multiplication, thereby enhancing the performance of FHE and ZKP schemes. We present techniques to adapt polynomial multiplication to these AI-centric architectures and provide a preliminary evaluation of their effectiveness. We also discuss current limitations and outline future directions for further performance improvements, paving the way for wider adoption of advanced cryptographic tools.

Zhengliang Liu, Zihao Wu, Mengxuan Hu et al.

In this study, we introduce PharmacyGPT, a novel framework to assess the capabilities of large language models (LLMs) such as ChatGPT and GPT-4 in emulating the role of clinical pharmacists. Our methodology encompasses the utilization of LLMs to generate comprehensible patient clusters, formulate medication plans, and forecast patient outcomes. We conduct our investigation using real data acquired from the intensive care unit (ICU) at the University of North Carolina Chapel Hill (UNC) Hospital. Our analysis offers valuable insights into the potential applications and limitations of LLMs in the field of clinical pharmacy, with implications for both patient care and the development of future AI-driven healthcare solutions. By evaluating the performance of PharmacyGPT, we aim to contribute to the ongoing discourse surrounding the integration of artificial intelligence in healthcare settings, ultimately promoting the responsible and efficacious use of such technologies.

Florio M. Ciaglia aand Fabio Di Cosmo

In this paper some reflections on the concept of transition are presented: groupoids are introduced as models for the construction of a ``generalized logic'' whose basic statements involve pairs of propositions which can be conditioned. In this sense, we could distinguish between classical probability theory where propositions can be conditioned if they have a non-zero intersection, from cases where ``non-local'' conditioning are allowed. The algebraic and geometrical properties of groupoids can be exploited to construct models of such non-local description.

Yongguang Gao, Xinhua Liu, Na Chen et al.

Gene therapy, as an emerging therapeutic approach, has shown remarkable advantages in the treatment of some major diseases. With the deepening of genomics research, people have gradually realized that the emergence and development of many diseases are related to genetic abnormalities. Therefore, nucleic acid drugs are gradually becoming a new boon in the treatment of diseases (especially tumors and genetic diseases). It is conservatively estimated that the global market of nucleic acid drugs will exceed $20 billion by 2025. They are simple in design, mature in synthesis, and have good biocompatibility. However, the shortcomings of nucleic acid, such as poor stability, low bioavailability, and poor targeting, greatly limit the clinical application of nucleic acid. Liposome nanoparticles can wrap nucleic acid drugs in internal cavities, increase the stability of nucleic acid and prolong blood circulation time, thus improving the transfection efficiency. This review focuses on the recent advances and potential applications of liposome nanoparticles modified with nucleic acid drugs (DNA, RNA, and ASO) and different chemical molecules (peptides, polymers, dendrimers, fluorescent molecules, magnetic nanoparticles, and receptor targeting molecules). The ability of liposome nanoparticles to deliver nucleic acid drugs is also discussed in detail. We hope that this review will help researchers design safer and more efficient liposome nanoparticles, and accelerate the application of nucleic acid drugs in gene therapy.

Amir Rahmani, David Colas, Nina Voronova et al.

Quantum vortices are the quantized version of classical vortices. Their center is a phase singularity or vortex core around which the flow of particles as a whole circulates and is typical in superfluids, condensates and optical fields. However, the exploration of the motion of the phase singularities in coherently-coupled systems is still underway. We theoretically analyze the propagation of an interference dislocation in the regime of strong coupling between light and matter, with strong mass imbalance, corresponding to the case of microcavity exciton-polaritons. To this end, we utilize combinations of vortex and tightly focused Gaussian beams, which are introduced through resonant pulsed pumping. We show that a dislocation originates from self-interference fringes, due to the non-parabolic dispersion of polaritons combined with moving Rabi-oscillating vortices. The morphology of singularities is analyzed in the Poincaré space for the pseudospin associated to the polariton states. The resulting beam carries orbital angular momentum with decaying oscillations due to the loss of overlap between the normal modes of the polariton system.

Wenjing Ma, Zackary Rousseau, Sladjana Slavkovic et al.

Doxorubicin (Dox) is a widely utilized chemotherapeutic; however, it carries side effects, including drug-induced immune thrombocytopenia (DITP) and increased risk of venous thromboembolism (VTE). Currently, the mechanisms for Dox-associated DITP and VTE are poorly understood, and an effective inhibitor to relieve these complications remains to be developed. In this study, we found that Dox significantly induced platelet activation and enhanced platelet phagocytosis by macrophages and accelerated platelet clearance. Importantly, we determined that salvianolic acid C (SAC), a water-soluble compound derived from Danshen root traditionally used to treat cardiovascular diseases, inhibited Dox-induced platelet activation more effectively than current standard-of-care anti-platelet drugs aspirin and ticagrelor. Mechanism studies with tyrosine kinase inhibitors indicate contributions of phospholipase C, spleen tyrosine kinase, and protein kinase C signaling pathways in Dox-induced platelet activation. We further demonstrated that Dox enhanced platelet-cancer cell interaction, which was ameliorated by SAC. Taken together, these findings suggest SAC may be a promising therapy to reduce the risk of Dox-induced DITP, VTE, and the repercussions of amplified platelet-cancer interaction in the tumor microenvironment.