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S2 Open Access 2009
Cancer Statistics, 2009

A. Jemal, R. Siegel, Elizabeth E. Ward et al.

Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute, Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. Incidence and death rates are standardized by age to the 2000 United States standard million population. A total of 1,479,350 new cancer cases and 562,340 deaths from cancer are projected to occur in the United States in 2009. Overall cancer incidence rates decreased in the most recent time period in both men (1.8% per year from 2001 to 2005) and women (0.6% per year from 1998 to 2005), largely because of decreases in the three major cancer sites in men (lung, prostate, and colon and rectum [colorectum]) and in two major cancer sites in women (breast and colorectum). Overall cancer death rates decreased in men by 19.2% between 1990 and 2005, with decreases in lung (37%), prostate (24%), and colorectal (17%) cancer rates accounting for nearly 80% of the total decrease. Among women, overall cancer death rates between 1991 and 2005 decreased by 11.4%, with decreases in breast (37%) and colorectal (24%) cancer rates accounting for 60% of the total decrease. The reduction in the overall cancer death rates has resulted in the avoidance of about 650,000 deaths from cancer over the 15‐year period. This report also examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, education, geographic area, and calendar year. Although progress has been made in reducing incidence and mortality rates and improving survival, cancer still accounts for more deaths than heart disease in persons younger than 85 years of age. Further progress can be accelerated by applying existing cancer control knowledge across all segments of the population and by supporting new discoveries in cancer prevention, early detection, and treatment. CA Cancer J Clin 2009;59:225‐249. ? 2009 American Cancer Society, Inc.

7610 sitasi en Medicine
S2 Open Access 2005
Cancer Statistics, 2005

A. Jemal, Taylor Murray, Elizabeth E. Ward et al.

Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute and mortality data from the National Center for Health Statistics. Incidence and death rates are age‐standardized to the 2000 US standard million population. A total of 1,372,910 new cancer cases and 570,280 deaths are expected in the United States in 2005. When deaths are aggregated by age, cancer has surpassed heart disease as the leading cause of death for persons younger than 85 since 1999. When adjusted to delayed reporting, cancer incidence rates stabilized in men from 1995 through 2001 but continued to increase by 0.3% per year from 1987 through 2001 in women. The death rate from all cancers combined has decreased by 1.5% per year since 1993 among men and by 0.8% per year since 1992 among women. The mortality rate has also continued to decrease from the three most common cancer sites in men (lung and bronchus, colon and rectum, and prostate) and from breast and colorectal cancers in women. Lung cancer mortality among women has leveled off after increasing for many decades. In analyses by race and ethnicity, African American men and women have 40% and 20% higher death rates from all cancers combined than White men and women, respectively. Cancer incidence and death rates are lower in other racial and ethnic groups than in Whites and African Americans for all sites combined and for the four major cancer sites. However, these groups generally have higher rates for stomach, liver, and cervical cancers than Whites. Furthermore, minority populations are more likely to be diagnosed with advanced stage disease than are Whites. Progress in reducing the burden of suffering and death from cancer can be accelerated by applying existing cancer control knowledge across all segments of the population.

5583 sitasi en Medicine
S2 Open Access 2001
Impact of overweight on the risk of developing common chronic diseases during a 10-year period.

A. Field, E. Coakley, A. Must et al.

BACKGROUND Overweight adults are at an increased risk of developing numerous chronic diseases. METHODS Ten-year follow-up (1986-1996) of middle-aged women in the Nurses' Health Study and men in the Health Professionals Follow-up Study to assess the health risks associated with overweight. RESULTS The risk of developing diabetes, gallstones, hypertension, heart disease, and stroke increased with severity of overweight among both women and men. Compared with their same-sex peers with a body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) between 18.5 and 24.9, those with BMI of 35.0 or more were approximately 20 times more likely to develop diabetes (relative risk [RR], 17.0; 95% confidence interval [CI], 14.2-20.5 for women; RR, 23.4; 95% CI, 19.4-33.2 for men). Women who were overweight but not obese (ie, BMI between 25.0 and 29.9) were also significantly more likely than their leaner peers to develop gallstones (RR, 1.9), hypertension (RR, 1.7), high cholesterol level (RR, 1.1), and heart disease (RR, 1.4). The results were similar in men. CONCLUSIONS During 10 years of follow-up, the incidence of diabetes, gallstones, hypertension, heart disease, colon cancer, and stroke (men only) increased with degree of overweight in both men and women. Adults who were overweight but not obese (ie, 25.0 < or = BMI < or = 29.9) were at significantly increased risk of developing numerous health conditions. Moreover, the dose-response relationship between BMI and the risk of developing chronic diseases was evident even among adults in the upper half of the healthy weight range (ie, BMI of 22.0-24.9), suggesting that adults should try to maintain a BMI between 18.5 and 21.9 to minimize their risk of disease.

1809 sitasi en Medicine
arXiv Open Access 2026
"Unmatched" From Skewed Births to a Structural Surplus of Grooms

Praveen N, Suddhasil Siddhanta

Data on marriage flows are not available in most developing countries, making marriage market imbalance difficult to measure. Existing measures use crude fertility rates and do not account for early-life mortality, overstating the number of births surviving to marriageable ages. This paper develops the Surplus Groom Index to quantify marriage market imbalance under monogamy using census age structure, vital registration of births and deaths, and marriage timing data. The index incorporates effective fertility-total births adjusted for under-five mortality - to reflect actual cohort progression from birth to marriageable ages. This adjustment matters in settings where child mortality shapes the supply of marriage partners. Using India's 2011 Census data, we find that eleven percent of men aged 15-54 cannot marry due to bride shortage, approximately 39 million men. Marriage imbalance is widespread rather than regionally concentrated. Punjab records the highest deficit at 33 percent, but states considered demographically progressive show substantial imbalance: Kerala 18 percent, West Bengal 14 percent, Karnataka and Tamil Nadu 11 percent each. Declining fertility has produced smaller female cohorts unable to absorb male-heavy cohorts from earlier birth years. Balanced sex ratios at birth do not ensure marriage market equilibrium once fertility declines and marriage is delayed.

en econ.GN
arXiv Open Access 2025
Five Blind Men and the Internet: Towards an Understanding of Internet Traffic

Ege Cem Kirci, Ayush Mishra, Laurent Vanbever

The Internet, the world's largest and most pervasive network, lacks a transparent, granular view of its traffic patterns, volumes, and growth trends, hindering the networking community's understanding of its dynamics. This paper leverages publicly available Internet Exchange Point traffic statistics to address this gap, presenting a comprehensive two-year study (2023-2024) from 472 IXPs worldwide, capturing approximately 300 Tbps of peak daily aggregate traffic by late 2024. Our analysis reveals a 49.2% global traffic increase (24.5% annualized), uncovers regionally distinct diurnal patterns and event-driven anomalies, and demonstrates stable utilization rates, reflecting predictable infrastructure scaling. By analyzing biases and confirming high self-similarity, we establish IXP traffic as a robust proxy for overall Internet growth and usage behavior. With transparent, replicable data--covering 87% of the worldwide IXP port capacity--and plans to release our dataset, this study offers a verifiable foundation for long-term Internet traffic monitoring. In particular, our findings shed light on the interplay between network design and function, providing an accessible framework for researchers and operators to explore the Internet's evolving ecosystem.

arXiv Open Access 2025
Abortion Bans and Young Women's Labor Supply: Evidence from the Dobbs Decision

Rintaro Ando

This paper studies the impact of the 2022 Dobbs decision and subsequent state level abortion bans on the labor supply of young women (ages 18-24). Using monthly CPS micro data from January 2021 to December 2023, I exploit cross state variation in post Dobbs abortion policy and estimate Difference-in-Differences (DiD) and Triple-Difference (DDD) models. In a simple DiD comparing young women in ban versus protected states, labor force participation in ban states rises by 3.6 percentage points, while participation among young men in the same states falls by 2.9 percentage points, suggesting that the female response is unlikely to be driven by stronger local labor demand. The preferred DDD specification with state-by-month and gender interacted fixed effects implies a 6.6 percentage point increase in labor force participation for young women in ban states relative to young men. School enrollment does not change significantly, whereas employment increases by about 3 percentage points. These results suggest that abortion bans are associated with an immediate increase in young women's labor market attachment, potentially shifting their short run focus toward current earnings rather than human capital accumulation.

en econ.GN
arXiv Open Access 2025
Non-Invasive Detection of PROState Cancer with Novel Time-Dependent Diffusion MRI and AI-Enhanced Quantitative Radiological Interpretation: PROS-TD-AI

Baltasar Ramos, Cristian Garrido, Paulette Narv'aez et al.

Prostate cancer (PCa) is the most frequently diagnosed malignancy in men and the eighth leading cause of cancer death worldwide. Multiparametric MRI (mpMRI) has become central to the diagnostic pathway for men at intermediate risk, improving de-tection of clinically significant PCa (csPCa) while reducing unnecessary biopsies and over-diagnosis. However, mpMRI remains limited by false positives, false negatives, and moderate to substantial interobserver agreement. Time-dependent diffusion (TDD) MRI, a novel sequence that enables tissue microstructure characterization, has shown encouraging preclinical performance in distinguishing clinically significant from insignificant PCa. Combining TDD-derived metrics with machine learning may provide robust, zone-specific risk prediction with less dependence on reader training and improved accuracy compared to current standard-of-care. This study protocol out-lines the rationale and describes the prospective evaluation of a home-developed AI-enhanced TDD-MRI software (PROSTDAI) in routine diagnostic care, assessing its added value against PI-RADS v2.1 and validating results against MRI-guided prostate biopsy.

en eess.IV, cs.CV

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