Parameters Impacting the 3D Direct Ink Writing (DIW) Silicone Printing Process and Investigating How the Size of 3D-Printed Aortic Heart Valve Models Influences Cardiac Efficiency
Atila Ertas, Erik Farley-Talamantes, Olkan Cuvalci
In the healthcare industry, the selection of biocompatible materials suitable for 3D printing is markedly less extensive than what is typically available through conventional manufacturing processes. Liquid silicone rubber (LSR) is distinguished by its exceptional stability, excellent biocompatibility, and considerable flexibility, offering significant prospects for manufacturers of medical devices involved in 3D printing. The primary aim of this research is to examine the essential factors and their interconnections that affect the 3D printing process with a Direct Ink Writing (DIW) 3D printer, which is specifically tailored for the production of aortic heart valves made from UV-cured silicone. Additionally, this study aims to investigate how the size of the heart valve impacts cardiac performance. This study implements House of Quality (HOQ) and Interpretive Structural Modeling (ISM) techniques to evaluate the interrelations among the different factors identified in the 3D printing process. Liquid silicone is especially advantageous for Direct Ink Writing (DIW) due to its low-temperature curing properties and low viscosity, which enable precise printing for intricate designs. Two different sizes of aortic heart valves, namely 23 mm and 36 mm, will be manufactured using UV-cured silicone, with both sizes having the same leaflet thickness of 0.8 mm and 1.6 mm. An examination will be conducted to assess how the size of the valve influences its performance and functionality. A Mock Circulatory Loop experimental setup will be used to test the silicone-printed heart valves, focusing on their capacity to maintain unidirectional flow and inhibit backflow through the flexible leaflets that function in alignment with the cardiac cycle.
Technology, Engineering design
Multi-Scale Model of Mid-Frequency Errors in Semi-Rigid Tool Polishing of Diamond-Turned Electroless Nickel Mirror
Pengfeng Sheng, Jingjing Xia, Jun Yu
et al.
Semi-rigid tool polishing is widely used in the high-precision manufacturing of electroless nickel surface due to its stable material removal and high efficiency in correcting mid- and high-frequency profile errors. However, predicting mid-frequency errors remains challenging due to the complexity of their underlying sources. In this study, a theoretical model for semi-rigid tool polishing was developed based on multi-scale contact theory, incorporating a bridging model, rough surface contact, and Hertzian contact mechanics. The model accounts for the effects of tool surface roughness, polishing force, and path spacing. A series of experiments on diamond-turned electroless nickel mirrors was conducted to quantitatively evaluate the model’s feasibility and accuracy. The results demonstrate that the model can effectively predict mid-frequency errors, reveal the material removal mechanisms in semi-rigid polishing, and guide the optimization of process parameters. Ultimately, a surface with mid-frequency errors of 0.59 nm Rms (measured over a 1.26 mm × 0.94 mm window) was achieved, closely matching the predicted value of 0.64 nm.
Production capacity. Manufacturing capacity
From complexity to resilience: clean innovation reshapes the load capacity curve dynamics
Elma Satrovic, Ummara Razi, Magdalena Radulescu
Abstract While the environmental implications of economic complexity and clean technology innovations have been individually addressed across various empirical contexts, their joint dynamics in fostering ecological resilience, specifically with the advanced economies, remain analytically unsettled. In this context, by farming the analysis within the Load Capacity Curve (LCC) hypothesis, the study assessed the direct impacts of economic prosperousness, economic complexity, clean technology innovation, financial advancement, and dirty, and clean energy on the ecological resilience. Notably, the objective of the study is to analyze the moderating effect of clean technology innovations in the economic complexity-ecological resilience relationship, considering the Group of Seven (G7) economies over the 1995–2020 period. The findings of the Method of Moments Quantile Regression and Fully Modified Ordinary Least Squares validated the LCC hypothesis. While economic complexity and reliance on dirty energy are associated with ecological degradation, clean energy, financial advancement, and clean innovation show resilience-enhancing effects. Importantly, the positive coefficient of the clean innovation-economic complexity interaction term elucidates that the innovation pattern facilitates a shift toward eco-sustainable economic sophistication. Hence, G7 economies are advised to encourage investments in sophisticated clean technologies like resource-efficient manufacturing processes to counteract the ecological aftermath of complex production.
Fast capacity computation for maze-like configurations
Harri Hakula, Oona Rainio, Matti Vuorinen
We study the conformal capacity ${\rm cap}(Ω,K)$ where $Ω$ is a bounded domain of $\mathbb{R}^2$ and $K$ is a compact connected set in $Ω$. Because the exact numerical value of the capacity is known only in a handful of special cases, it is important to find estimates for the capacity in terms of domain functionals, simpler than the capacity itself. Here, we study condensers of maze-like structure and compute their capacity by means of a high-order $hp$- finite element method. We compare these numerical results to the estimates given by the quasihyperbolic length and perimeter of the compact set. In particular, we consider the behaviour of these value pairs, numerical results and estimates, when the structure parameters vary and the walls of the maze approach the compact set. Over the configurations covered in the numerical experiments, the quasihyperbolic estimates are shown to have the desired asymptotic properties and superior computational efficiencies once the case-specific analysis is completed.
Comprehensive Distortion Analysis of a Laser Direct Metal Deposition (DMD)-Manufactured Large Prototype Made of Soft Martensitic Steel 1.4313
Indira Dey, Raphael Floeder, Rick Solcà
et al.
Additive manufacturing (AM) by using direct metal deposition (DMD) often causes erratic distortion patterns, especially on large parts. This study presents a systematic distortion analysis by employing numerical approaches using transient–thermal and structural simulations, experimental approaches using tomography, X-ray diffraction (XRD), and an analytical approach calculating the buckling distortion of a piston. The most essential geometrical features are thin walls situated between massive rings. An eigenvalue buckling analysis, a DMD process, and heat treatment simulation are presented. The eigenvalue buckling simulation shows that it is highly dependent on the mesh size. The computational effort of the DMD and heat treatment simulation was reduced through simplifications. Moreover, artificial imperfections were imposed in the heat treatment simulation, which moved the part into the buckling state inspired by the experiment. Although the numerical results of both simulations are successful, the eigenvalue and DMD simulation cannot be validated through tomography and XRD. This is because tomography is unable to measure small elastic strain fields, the simulated residual stresses were overestimated, and the part removal disturbed the residual stress equilibrium. Nevertheless, the heat treatment simulation can predict the distortion pattern caused by an inhomogeneous temperature field during ambient cooling in an oven. The massive piston skirt cools down and shrinks faster than the massive core. The reduced yield strength at elevated temperatures and critical buckling load leads to plastic deformation of the thin walls.
Production capacity. Manufacturing capacity
Soft Robot Design, Manufacturing, and Operation Challenges: A Review
Getachew Ambaye, Enkhsaikhan Boldsaikhan, Krishna Krishnan
Advancements in smart manufacturing have embraced the adoption of soft robots for improved productivity, flexibility, and automation as well as safety in smart factories. Hence, soft robotics is seeing a significant surge in popularity by garnering considerable attention from researchers and practitioners. Bionic soft robots, which are composed of compliant materials like silicones, offer compelling solutions to manipulating delicate objects, operating in unstructured environments, and facilitating safe human–robot interactions. However, despite their numerous advantages, there are some fundamental challenges to overcome, which particularly concern motion precision and stiffness compliance in performing physical tasks that involve external forces. In this regard, enhancing the operation performance of soft robots necessitates intricate, complex structural designs, compliant multifunctional materials, and proper manufacturing methods. The objective of this literature review is to chronicle a comprehensive overview of soft robot design, manufacturing, and operation challenges in conjunction with recent advancements and future research directions for addressing these technical challenges.
Production capacity. Manufacturing capacity
Assessing the Environmental Impact of Advanced Energy Storage Solutions: A Comparative Lifecycle Analysis
Mishra Mukul, Dutt Amit, Saini Neha
et al.
Biodiesel manufacturing from waste cooking oil has emerged as a potential alternative in the search of sustainable energy. This process helps mitigate environmental pollution and reduces reliance on fossil fuels. This research examines the catalytic efficiency of environmentally friendly catalysts in this process, with a specific emphasis on catalysts based on enzymes. It assesses their effectiveness in terms of the production of biodiesel, the rate of the chemical reactions, cost efficiency, and their influence on the environment. Experimental evidence demonstrates that enzyme-based catalysts have enhanced catalytic activity, leading to an average biodiesel production of 90%, outperforming traditional catalysts such as solid acids, bases, and heterogeneous metal catalysts. Moreover, enzyme catalysts exhibit enhanced reaction rates due to their unique enzymatic activity and gentle reaction conditions. The cost study shows that the manufacturing costs for enzyme catalysts are competitive, with an average total cost of $800, which is equivalent to traditional catalysts. Environmental impact evaluation emphasizes the sustainability of enzyme catalysts by demonstrating their lower energy consumption, waste production, and greenhouse gas emissions compared to traditional alternatives. The results highlight the capacity of green catalysts, namely enzyme- based catalysts, to enhance sustainable biodiesel production methods, hence promoting a more eco-friendly and robust energy framework.
Monitoring of the Weld Pool, Keyhole Morphology and Material Penetration State in Near-Infrared and Blue Composite Laser Welding of Magnesium Alloy
Wei Wei, Yang Liu, Haolin Deng
et al.
The laser welding of magnesium alloys presents challenges attributed to their low laser-absorbing efficiency, resulting in instabilities during the welding process and substandard welding quality. Furthermore, the complexity of signals during laser welding processes makes it difficult to accurately monitor the molten state of magnesium alloys. In this study, magnesium alloys were welded using near-infrared and blue lasers. By varying the power of the near-infrared laser, the energy absorption pattern of magnesium alloys toward the composite laser was investigated. The U-Net model was employed for the segmentation of welding images to accurately extract the features of the melt pool and keyhole. Subsequently, the penetrating states were predicted using the convolutional neural network (CNN), and the novel approach employing Local Binary Pattern (LBP) features + a backpropagation (BP) neural network was applied for comparison. The extracted images achieved MPA and MIoU values of 89.54% and 81.81%, and the prediction accuracy of the model can reach up to 100%. The applicability of the two monitoring approaches in different scenarios was discussed, providing guidance for the quality of magnesium welding.
Production capacity. Manufacturing capacity
Tackling Pharmaceutical Pollution Along the Product Lifecycle: Roles and Responsibilities for Producers, Regulators and Prescribers
Gillian Parker, Fiona A. Miller
Pharmaceuticals produce considerable environmental harm. The industry’s resource-intensive nature, coupled with high energy costs for manufacturing and transportation, contribute to the “upstream” harms from greenhouse gas emissions and ecosystem pollution, while factors such as overprescription, overuse, and pharmaceutical waste contribute to the “downstream” harms. Effectively addressing pharmaceutical pollution requires an understanding of the key roles and responsibilities along the product lifecycle. In this commentary, we argue that three actors—producers, regulators, and prescribers—have unique and interdependent responsibilities to address these issues. Producers and market access regulators are upstream actors who can manage and mitigate harms by both shifting manufacturing, business practices, and regulatory requirements and producing transparent, robust data on environmental harms. By contrast, prescribers are downstream actors whose capacity to reduce environmental harms arises principally as a “co-benefit” of reducing inappropriate prescribing and overuse. Potentially complicating the prescriber’s role are the calls for prescribers to recommend “environmentally preferable medicines”. These calls continue to increase, even with the sparsity of transparent and robust data on the impact of pharmaceuticals on the environment. Recognizing the interdependencies among actors, we argue that, rather than being ineffectual, these calls draw needed attention to the critical responsibility for upstream actors to prioritize data production, reporting standards and public transparency to facilitate future downstream efforts to tackle pharmaceutical pollution.
Pharmacy and materia medica
A Study of Drilling Parameter Optimization of Functionally Graded Material Steel–Aluminum Alloy Using 3D Finite Element Analysis
Ahmed M. Galal, Abdallah. A. Elsherbiny, Mona A. AbouEleaz
Composite materials, such as aluminum alloy FGMs, provide advantageous weight reduction properties compared to homogenous pure structures while still preserving sufficient stiffness for diverse applications. Despite various research on drilling simulation concepts and ideas for these materials, there still needs to be an agreement on the process modeling. Researchers have looked into a lot of different numerical methods, including Lagrangian, Eulerian, arbitrary Lagrangian–Eulerian (ALE), and coupled Eulerian–Lagrangian (CEL), to find solutions to problems like divergence issues and too much mesh distribution, which become more of a problem at higher speeds. This research provides a global analysis of bottom-up meshing for eleven 1 mm layers using ABAQUS<sup>®</sup> software. It combines the internal surface contact approach with the Lagrangian domain’s kinematic framework. The model uses the Johnson–Cook constitutive equation to precisely predict cutting forces, stress, and strain distributions, optimizing cutting parameters to improve drilling performance. According to Taguchi analysis, the most favorable parameters for reducing cutting force and improving performance are a rotational speed of 700 rpm, a feed rate of 1 mm/s, and a depth of cut of 3 mm. The findings suggest that increasing the feed rate and depth of cut substantially affects the cutting force, while the rotational speed has a comparatively little effect. These ideal settings serve as a foundation for improving FGM drilling efficiency.
Production capacity. Manufacturing capacity
Processing and Analysis of Hybrid Fiber-Reinforced Polyamide Composite Structures Made by Fused Granular Fabrication and Automated Tape Laying
Patrick Hirsch, Simon Scholz, Benjamin Borowitza
et al.
Fused granular fabrication (FGF) is a large format additive manufacturing (LFAM) technology and focuses on cost-effective granulate-based manufacturing by eliminating the need for semifinished filaments. This allows a faster production time and a broader range of usable materials for tailored composites. In this study, the mechanical and morphological properties of FGF test structures made of polyamid 6 reinforced with 40% of short carbon fibers were investigated. For this purpose, FGF test structures with three different parameter settings were produced. The FGF printed structures show generally significant anisotropic mechanical characteristics, caused by the layer-by-layer building process. To enhance the mechanical properties and reduce the anisotropic behavior of FGF structures, continuous unidirectional fiber-reinforced tapes (UD tapes), employing automated tape laying (ATL), were subsequently applied. Thus, a significant improvement in the flexural stiffness and strength of the manufactured FGF structures was observed by hybridization with 60% glass fiber-reinforced polyamide 6 UD tapes. Since the effectiveness of UD-tape reinforcement depends mainly on the quality of the bond between the UD tape and the FGF structure, the surface quality of the FGF structure, the interface morphology, and the tape-laying process parameters were investigated.
Production capacity. Manufacturing capacity
Commodity Booms, Local State Capacity, and Development
Dafne Murillo, Sebastian Sardon
State capacity may shape whether natural resources generate prosperity, as it determines if windfalls are effectively turned into useful projects or wasted. We test this hypothesis studying the 2004-2011 mining boom in Peru, where mines' profits are redistributed as windfall transfers to local governments. Our empirical strategy combines geological data with the central government's mining windfalls allocation formula to identify the windfalls' effects on household incomes and other measures of economic development. Proxying local state capacity with the ability to tax and relying on a triple difference strategy we uncover significant variation in treatment response, with positive effects of windfalls limited to high state capacity localities. We find suggestive evidence that only localities with high state capacity succeed at transforming windfalls into infrastructure stocks, which in turns contributes to structural transformation and market integration. Lastly, social unrest increases in low state capacity localities that receive windfalls but fail to perceive their benefits. Our findings underscore important complementarities between investments in extractive industries and in state capacity.
Thermomechanical Joining of Hypoeutectic Aluminium Cast Plates
Thomas Borgert, Moritz Neuser, Kay-Peter Hoyer
et al.
Consistent lightweight construction in the area of vehicle manufacturing requires the increased use of multi-material combinations. This, in turn, requires an adaptation of standard joining techniques. In multi-material combinations, the importance of integral cast components, in particular, is increasing and poses additional technical challenges for the industry. One approach to solve these challenges is adaptable joining elements manufactured by a thermomechanical forming process. By applying an incremental and thermomechanical joining process, it is possible to react immediately and adapt the joining process inline to reduce the number of different joining elements. In the investigation described in this publication, cast plates made of the cast aluminium alloy EN AC-AlSi9 serve as joining partners, which are processed by sand casting. The joining process of hypoeutectic AlSi alloys is challenging as their brittle character leads to cracks in the joint during conventional mechanical joining. To solve this, the frictional heat of the novel joining process applied can provide a finer microstructure in the hypoeutectic AlSi9 cast alloy. In detail, its Si is finer-grained, resulting in higher ductility of the joint. This study reveals the thermomechanical joining suitability of a hypoeutectic cast aluminium alloy in combination with adaptively manufactured auxiliary joining elements.
Production capacity. Manufacturing capacity
On some isoperimetric inequalities for the Newtonian capacity
Michiel van den Berg
Upper bounds are obtained for the Newtonian capacity of compact sets in $\R^d,\,d\ge 3$ in terms of the perimeter of the $r$-parallel neighbourhood of $K$. For compact, convex sets in $\R^d,\,d\ge 3$ with a $C^2$ boundary the Newtonian capacity is bounded from above by $(d-2)M(K)$, where $M(K)>0$ is the integral of the mean curvature over the boundary of $K$ with equality if $K$ is a ball. For compact, convex sets in $\R^d,\,d\ge 3$ with non-empty interior the Newtonian capacity is bounded from above by $\frac{(d-2)P(K)^2}{d|K|}$ with equality if $K$ is a ball. Here $P(K)$ is the perimeter of $K$ and $|K|$ is its measure. A quantitative refinement of the latter inequality in terms of the Fraenkel asymmetry is also obtained. An upper bound is obtained for expected Newtonian capacity of the Wiener sausage in $\R^d,\,d\ge 5$ with radius $\varepsilon$ and time length $t$.
Investigating the Friction Behavior of Turn-Milled High Friction Surface Microstructures under Different Tribological Influence Factors
Jonathan Schanner, Roman Funke, Andreas Schubert
et al.
The coefficient of friction (COF) is an important parameter for mechanical engineers to consider when designing frictional connections. Previous work has shown that a surface microstructuring of the harder friction partner leads to a significant increase in the COF. However, the impact of the changes in the tribological system on the COF are not known in detail. In this study, the tribological influence factors such as the nominal surface pressure, the material pairing, lubrication, and the surface properties of the counterbody are investigated. Microstructuring is applied by turn-milling of an annular contact surface of cylindrical specimens. A torsional test bench is used to measure the torque depending on the displacement of the two specimens, thus enabling the determination of the COF. All tests with the microstructured specimens result in higher COF than the reference test with unstructured samples. The manufacturing process of the counterbody surface, the nominal surface pressure, and the materials in contact have a significant influence on the COF. While lubrication reduces friction in the case of unstructured specimens, the COF does not change significantly for microstructured samples. This proves that the deformative friction component dominates over the adhesive. Microstructuring the harder friction partner increases the transmittable torque in frictional connections and reduces the sensitivity towards possible contamination with lubricants.
Production capacity. Manufacturing capacity
Mechanical Analysis of Parameter Variations in Large-Scale Extrusion Additive Manufacturing of Thermoplastic Composites
Nevine Tagscherer, André Marcel Bär, Swen Zaremba
et al.
Large structural parts manufactured by Extrusion Additive Manufacturing (EAM) are limited by strong anisotropy due to insufficient bond formation and reduced molecular entanglement along the layer interface. To understand the correlation between process and material parameters and to enable digital modeling of EAM, the effect of different substrate temperatures and layer heights on tensile strength was investigated. A simple testing methodology for pelletized carbon fiber-filled polyamide 6 was developed. Tensile tests were performed in a full factorial Design of Experiments (DoE) to determine the tensile properties. For bulk simulation, the nominal strength and modulus were also determined based on contact width obtained by optical microscopy. The results demonstrated high anisotropy, with the maximum transverse tensile strength reaching only 27% of the corresponding longitudinal results and the transverse tensile modulus reaching only 20% of its longitudinal value. The effects of varying layer height were less significant than varying substrate temperature. The results support the hypothesis that sufficient transverse tensile strength is achieved between the extrapolated crystallization onset and melt temperature. The methodology of this study can be used as a benchmark method to qualify new thermoplastic polymers for EAM processes and to determine optimal process parameters for improved fusion bonding.
Production capacity. Manufacturing capacity
Numerical Simulation of the Thermo-Mechanical Behavior of 6061 Aluminum Alloy during Friction-Stir Welding
Vasiliy Mishin, Ivan Shishov, Alexander Kalinenko
et al.
In this work, a finite-element model was elaborated to simulate the thermomechanical behavior of 6061 aluminum alloy during friction-stir welding (FSW). It was shown that FSW-induced deformation is a two-stage process. In addition to the stirring action exerted by the rotating tool probe, the material in the near-surface area of the stir zone also experienced a secondary deformation by the shoulder edge after passage of the welding tool. Both deformation steps were found to be comparable in terms of temperature and strain, but the secondary deformation was primarily concentrated in the near-surface layer. The effects of tool rotation and translation rates on FSW temperature and strain were also systematically examined. Depending on particular welding conditions, the peak welding temperature was predicted to vary from 360 to 500 °C, while the cumulative effective strain was from 12 to 45.
Production capacity. Manufacturing capacity
Continuous analytic capacity and holomorphic motions
Malik Younsi
We construct a compact set whose continuous analytic capacity does not vary continuously under a certain holomorphic motion, thereby answering a question of Paul Gauthier. Our example is inspired by holomorphic dynamics and relies on the works of Bishop--Carleson--Garnett--Jones and Browder--Wermer relating tangent points of Jordan curves, harmonic measure and Dirichlet algebras. Our approach also provides a new proof of a result of Ransford, Younsi and Ai on the variation of analytic capacity under holomorphic motions. In addition, we show that extremal functions for continuous analytic capacity may not exist.
MIMO Capacity Characterization for Movable Antenna Systems
Wenyan Ma, Lipeng Zhu, Rui Zhang
In this paper, we propose a new multiple-input multiple-output (MIMO) communication system with movable antennas (MAs) to exploit the antenna position optimization for enhancing the capacity. Different from conventional MIMO systems with fixed-position antennas (FPAs), the proposed system can flexibly change the positions of transmit/receive MAs, such that the MIMO channel between them is reconfigured to achieve higher capacity. We aim to characterize the capacity of MA-enabled point-to-point MIMO communication systems, by jointly optimizing the positions of transmit and receive MAs as well as the covariance of transmit signals. First, we develop an efficient alternating optimization algorithm to find a locally optimal solution by iteratively optimizing the transmit covariance matrix and the position of each transmit/receive MA with the other variables being fixed. Next, we propose alternative algorithms of lower complexity for capacity maximization in the low-SNR regime and for the multiple-input single-output (MISO) and single-input multiple-output (SIMO) cases. Numerical results show that our proposed MA systems significantly improve the MIMO channel capacity compared to traditional FPA systems as well as various benchmark schemes, and useful insights are drawn into the capacity gains of MA systems.
Emerging manufacturers engagements in the COVID −19 vaccine research, development and supply
S. Pagliusi, S. Jarrett, Benoit Hayman
et al.
Highlights • Broad research and development is key to achieving an effective safe COVID-19 vaccine.• Currently 19 Network members engaged in research & development of 22 COVID-19 vaccines.• Collectively 37 Network manufacturers supply around 3.5 billion vaccine doses annually.• Existing manufacturing capabilities can accelerate the availability of COVID vaccines.• Deploying available vaccine production capacity, will save time, resources and lives.