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S2 Open Access 1920
The Economic Consequences of the Peace

J. Keynes

John Maynard Keynes's classic 1919 work is a scathing critique of the Treaty of Versailles that ended World War I. Keynes, who attended the Peace Conference as a representative of the British Treasury but resigned in protest at the terms of the treaty, argues in this book that the economic stability of Europe depends on the prosperity of Germany. The work predicts that the heavy war reparations demanded by the Allies from Germany were unpayable and that this punitive attitude would collapse the German economy and drag the whole of Europe into misery. Keynes emphasizes that while the treaty focused on political borders and vengeance, it neglected the economic rehabilitation of post-war Europe, the supply of food and raw materials, and financial order. The author warns that this economic destruction will sow the seeds of hunger, social unrest, and ultimately a new war. The book is not only an economic analysis but also an early diagnosis of the political mistakes that shaped 20th-century history.

817 sitasi en Economics, Political Science
DOAJ Open Access 2026
Burden of disease in adult patients with hereditary angioedema: results from a multinational survey

Maureen Watt, Inmaculada Martinez-Saguer, Angela Simon et al.

Abstract Background Hereditary angioedema (HAE) is a rare genetic disease manifesting as recurrent painful, burdensome, and potentially life-threatening swelling attacks. This noninterventional, cross-sectional, web-based survey of adult (aged ≥ 18 years) participants with HAE from Argentina, Brazil, Colombia, Croatia, Denmark, Germany, Hungary, Ireland, Norway, Poland, Portugal, Romania, and Sweden sought to deepen the understanding of HAE burden. Individuals were eligible if they had a self-reported physician diagnosis of HAE, ≥ 1 HAE attack or prodromal symptom within the last year, and received HAE medications within the last 2 years. Data were collected on participant demographics, clinical characteristics, and patient-reported outcomes using validated questionnaires; these included disease control (Angioedema Control Test [AECT]), health-related quality of life (HRQoL; Angioedema Quality of Life [AE-QoL]), general health status (12-Item Short Form Survey [SF-12 v2]), anxiety and depression (Hospital Anxiety and Depression Scale [HADS]), and work productivity impairment (Work Productivity and Activity Impairment: General Health [WPAI:GH]). Results Overall, 260 participants were included; age (mean ± SD) was 43.3 ± 13.5 years; 72.7% of participants were female, 89.6% had HAE due to C1 inhibitor deficiency, and 78.5% reported family history of HAE. Participants reported 11.5 ± 14.2 (mean ± SD) HAE attacks in the 6 months before the survey, with 68.5% reporting their most recent attack occurring within the last 4 weeks. Of 260 participants, 153 (58.8%) reported currently using any medication for long-term prophylaxis, but only 56/153 (36.6%) reported using a first-line LTP option per international guidelines. Patient-reported disease burden included, on average, moderate to large HRQoL impairment (AE-QoL total score [mean ± SD] 42.9 ± 23.2), poor disease control (AECT score [mean ± SD] 7.4 ± 3.1), and work productivity impairment (WPAI:GH overall work productivity loss score [mean ± SD] 26.9% ± 32.2). Participants with a lower versus higher number of HAE attacks in the past 6 months reported better disease control, less HRQoL impairment, and less work productivity loss. Conclusion Results of this large multinational survey highlight that patients included in this study, most of whom were not using first-line LTP, reported being burdened by their disease, including frequent HAE attacks, HRQoL impairment, poor disease control, and work productivity impairment.

DOAJ Open Access 2024
Nematode community structure suggests perennial grain cropping cultivation as a nature‐based solution for resilient agriculture

Alena Förster, Karin Hohberg, Frank Rasche et al.

Abstract Introduction Conventional agricultural land‐use may negatively impact biodiversity and the environment due to the increased disturbances to the soil ecosystem by tillage, for example. Cultivation of the perennial grain intermediate wheatgrass (Thinopyrum intermedium, IWG, Kernza®) is a nature‐based solution for sustainable agriculture, improving nutrient retention mainly through its extensive root system. Nematodes serve as sensitive bioindicators, detecting early changes in the soil food web, reflecting in changes in their community structure. Materials and Methods IWG and annual wheat sites in South France, Belgium and South Sweden were investigated in April 2022 for two depths (5–15 cm; 25–35 cm) to evaluate the difference in nematode community structure among the cropping systems. Results Sites with IWG cultivation held an accumulation of structure indicators (c‐p 3–5 nematodes) compared to sites with annual wheat cultivation. A generalised linear mixed model revealed significantly more root feeders, especially for the subsoil, under IWG as a result of the perennial cultivation. The maturity index, plant‐parasitic index, channel index and structure index were greater for IWG sites. The enrichment index was greater for annual wheat sites due to the dominance of bacterivores and enrichment indicators (c‐p 1 nematodes). The nematode community structure (weighted faunal profile analysis) indicates IWG sites as being a generally undisturbed system with efficient nutrient cycling and balanced distribution of feeding types, as well as higher metabolic footprint values for root feeders (including plant‐parasitic nematodes) and fungivores. Annual wheat sites, on the other hand, held indicators of a disturbed system with increased occurrence of opportunistic species and a more bacterial driven pathway. The topsoil had an increased occurrence of structure indicators in both cropping systems. Conclusion IWG creates favourable conditions for a diverse food web, including improved nutrient cycling and a heterogeneous resource environment, regardless of climatic conditions, establishing it as a stable and resilient agricultural management system.

Agriculture (General), Environmental sciences
DOAJ Open Access 2024
SoxY gene family expansion underpins adaptation to diverse hosts and environments in symbiotic sulfide oxidizers

Marta Sudo, Jay Osvatic, John D. Taylor et al.

ABSTRACT Sulfur-oxidizing bacteria (SOB) have developed distinct ecological strategies to obtain reduced sulfur compounds for growth. These range from specialists that can only use a limited range of reduced sulfur compounds to generalists that can use many different forms as electron donors. Forming intimate symbioses with animal hosts is another highly successful ecological strategy for SOB, as animals, through their behavior and physiology, can enable access to sulfur compounds. Symbioses have evolved multiple times in a range of animal hosts and from several lineages of SOB. They have successfully colonized a wide range of habitats, from seagrass beds to hydrothermal vents, with varying availability of symbiont energy sources. Our extensive analyses of sulfur transformation pathways in 234 genomes of symbiotic and free-living SOB revealed widespread conservation in metabolic pathways for sulfur oxidation in symbionts from different host species and environments, raising the question of how they have adapted to such a wide range of distinct habitats. We discovered a gene family expansion of soxY in these genomes, with up to five distinct copies per genome. Symbionts harboring only the “canonical” soxY were typically ecological “specialists” that are associated with specific host subfamilies or environments (e.g., hydrothermal vents, mangroves). Conversely, symbionts with multiple divergent soxY genes formed versatile associations across diverse hosts in various marine environments. We hypothesize that expansion and diversification of the soxY gene family could be one genomic mechanism supporting the metabolic flexibility of symbiotic SOB enabling them and their hosts to thrive in a range of different and dynamic environments.IMPORTANCESulfur metabolism is thought to be one of the most ancient mechanisms for energy generation in microorganisms. A diverse range of microorganisms today rely on sulfur oxidation for their metabolism. They can be free-living, or they can live in symbiosis with animal hosts, where they power entire ecosystems in the absence of light, such as in the deep sea. In the millions of years since they evolved, sulfur-oxidizing bacteria have adopted several highly successful strategies; some are ecological “specialists,” and some are “generalists,” but which genetic features underpin these ecological strategies are not well understood. We discovered a gene family that has become expanded in those species that also seem to be “generalists,” revealing that duplication, repurposing, and reshuffling existing genes can be a powerful mechanism driving ecological lifestyle shifts.

DOAJ Open Access 2023
End-of-life decisions: A focus group study with German health professionals from human and veterinary medicine

Felicitas Selter, Kirsten Persson, Peter Kunzmann et al.

IntroductionAt first glance, human and (companion animal) veterinary medicine share challenging processes in end-of-life (EOL) decision-making. At the same time, treatment options in both professions are substantially different. The potential of an interdisciplinary exchange between both fields has been neglected by empirical research so far.MethodsIn this qualitative study, professionals from both fields were brought together in interdisciplinary focus groups to investigate the ethical aspects of convergences and divergences in EOL situations in human and veterinary medicine. The authors present and discuss an innovative mix of materials and methods as stimuli for discussion and for generating hypotheses.ResultsThe results point toward a general convergence of issues, challenges, and judgements in EOL situations in both fields, such as professional ethos, communication with the family and the role thereof as well as the ideals of death, clearly exceeding the expectations of study participants. At the same time, the study highlights a few prominent differences such as the access to patients' preferences or legal and practical constraints.DiscussionThe findings suggest that using social science methods in empirical interdisciplinary biomedical-veterinary ethics could help to shed more light on this new area. Animal as well as human patients can potentially benefit from this mutual, scientifically accompanied exchange and the resulting identification and corrections of misconceptions.

Veterinary medicine
DOAJ Open Access 2023
A Systematic Review On Traditional Use, Phytochemical And Pharmacological Properties Of Some Medicinal Plants Growing In Kurdistan Region – Iraq

Anwer N. Mamdoh, Lazgin A. Jamil, Faiq H.S. Hussain

Many products labeled as "traditional herbal remedies" have a lengthy history of usage by definition of the term "traditional." Large segments of the population in many developing countries rely on traditional healers and their arsenal of medicinal plants to meet their healthcare requirements. Because of historical and cultural factors, herbal treatments are still widely used in modern medicine despite their antiquity. In industrialized nations, such things have become more accessible commercially. Current medical systems frequently recommend using chemicals in ways they weren't designed to be used. In certain parts of the world, the manufacture of herbal medicines are subjected to tight regulations, but this is not the case in other parts. In Germany Pharmacological goods are bound to the same criteria of efficacy, safety, and quality as herbal remedies, they are sold as "phytomedicines. On the other hand, most herbal products are marketed and monitored as food supplements in the United States, no pre-approval is required for this product category in the United Kingdom. As numerous academics in Iraq and the Kurdistan area have indicated, herbs have been utilized as a traditional cure for a wide range of illnesses in the past. Tribulus terrestris, Artemisia splendens Willd, Crataegus azarolus, Teucrium chamaedrys, Adiantum capillus-veneris and Matricaria chamomilla are the herbs discussed in this study, and their medicinal and traditional usage across the world, as well as some of the chemical components in these herbs' biological activity, are discussed.

DOAJ Open Access 2023
Pseudoscorpions of Israel: Annotated Checklist and Key, with New Records of Two Families (Arachnida: Pseudoscorpiones)

Sharon Warburg, Shlomi Aharon, Igor Armiach Steinpress et al.

The location of Israel at the junction of three continents leads to a unique fauna of both Palearctic and Afrotropical zoogeographic origins. Following systematic revisions over the past sixty years and the discovery of new species, the only available key to the pseudoscorpions of Israel has become outdated. We provide here an up-to-date checklist of the pseudoscorpion species of Israel including distribution maps, and the first illustrated identification key of the Israeli fauna based on morphological characters. Prior to our study, this fauna comprised twelve families, 26 genera and 52 morphospecies, including several “subspecies”. We increase this number and list 61 pseudoscorpion morphospecies that belong to 28 genera and fourteen families. Most species are Palearctic and Mediterranean, and only a few are Afrotropical. Two families new to Israel are reported here for the first time: Syarinidae and Cheiridiidae. Both families are cosmopolitan and have representatives in the Mediterranean region. The putative new species are presented here at a genus level and will be described separately elsewhere.

Biology (General)
DOAJ Open Access 2023
The influence of habitat properties on sex determination in cavity-nesting Hymenoptera

Katharina Wittmann, Alexandra-Maria Klein, Michael Staab

Unravelling the relationships between insect population dynamics and habitat properties is often complex. Established theoretical concepts, which predict an influence of available resources on sex determination, have often not been tested with quantitative field data. Cavity-nesting Hymenoptera are suitable to assess the influence of habitat properties on reproductive parameters, as haplodiploidy enables direct responses to local conditions. We hypothesize that with increasing resource availability, the population sex ratio (share of females per site), sex allocation preference per individual offspring (the probability of producing either a male or a female offspring per brood cell) and resource allocation per individual offspring will be favouring towards females. We sampled offspring of Osmia cornuta, Osmia caerulescens and Trypoxylon figulus and their resource provisions using trap nests on 30 study sites in an agricultural landscape in southwest Germany, from March to August 2020. The potential influence of resource availability, landscape variables, temperature, seasonal progression, and nesting opportunities on sex and resource provisions was tested. Population sex ratio was not related to habitat properties. Sex allocation preference in the three species, however, depended on several variables including cavity size and seasonal progression, with pronounced differences amongst species. Individual resource provisioning mainly differed between sexes, as male larvae received less provisions than female larvae. As there was no influence of resource availability, we conclude that the sex ratio of established populations was balanced at the selected study sites by available resources in the landscape. At the individual scale, sex and resource allocation were influenced in species-specific ways. As such, sex determination and resource allocation are essential life history properties of sexually reproducing organisms.

DOAJ Open Access 2023
The Global Turn in Nationalism: The USA as a Battleground for Hinduism and Hindu Nationalism

Sophie-Jung H. Kim

Hindu nationalism operates on a global scale today. Evinced by the transnational networks of the Sangh Parivar and the replication of strategies such as amending textbooks and patriotic rewriting of history, politics and discourse of Hindu nationalism are not solely contained to the territorial boundary of the nation. In this globalized battle for and against Hindu nationalism, the United States of America serves as an important site. In light of this, this article puts together existing scholarship on diasporic Hindu nationalism with late nineteenth-and early twentieth-century deterritorial history of Indian nationalism to present a broader framework for historicizing Indian activism in the US. It argues that while long-distance Hindu nationalism in the US cannot be traced before the 1970s, examining the early experiences of Indian activists in the US offers useful insights with which to evaluate the ongoing battles of Hindu nationalism in the US and opens another field of enquiry: Hindutva’s counterpublic.

Religions. Mythology. Rationalism
DOAJ Open Access 2022
Chemical Modification of Biomarkers through Accelerated Degradation: Implications for Ancient Plant Identification in Archaeo-Organic Residues

Barbara Huber, Daniel Giddings Vassão, Patrick Roberts et al.

Biochemical and biomolecular archaeology is increasingly used to elucidate the consumption, use, origin, and trade of plants in the past. However, it can be challenging to use biomarkers to identify the taxonomic origin of archaeological plants due to limited knowledge of molecular survival and degradation for many key plant compounds in archaeological contexts. To gain a fundamental understanding of the chemical alterations associated with chemical degradation processes in ancient samples, we conducted accelerated degradation experiments with essential oil derived from cedar (<i>Cedrus atlantica</i>) exposed to materials commonly found in the archaeological record. Using GC-MS and multivariate analysis, we detected a total of 102 compounds across 19 treatments that were classified into three groups. The first group comprised compounds that were abundant in fresh cedar oil but would be unlikely to remain in ancient residues due to rapid degradation. The second group consisted of compounds that remained relatively stable or increased over time, which could be potential biomarkers for identifying cedar in archaeological residues. Compounds in the third group were absent in fresh cedar oil but were formed during specific experiments that could be indicative for certain storage conditions. These results show that caution is warranted for applying biomolecular profiles of fresh plants to ancient samples and that carefully designed accelerated degradation experiments can, at least in part, overcome this limitation.

Organic chemistry
S2 Open Access 2021
The orbit and stellar masses of the archetype colliding-wind binary WR 140

Joshua D Thomas, N. Richardson, J. Eldridge et al.

We present updated orbital elements for the Wolf–Rayet (WR) binary WR 140 (HD 193793; WC7pd  + O5.5fc). The new orbital elements were derived using previously published measurements along with 160 new radial velocity measurements across the 2016 periastron passage of WR 140. Additionally, four new measurements of the orbital astrometry were collected with the CHARA Array. With these measurements, we derive stellar masses of $M_{\rm WR} = 10.31\pm 0.45 \, \mathrm{M}_\odot$ and $M_{\rm O} = 29.27\pm 1.14 \, \mathrm{M}_{\odot }$. We also include a discussion of the evolutionary history of this system from the Binary Population and Spectral Synthesis model grid to show that this WR star likely formed primarily through mass-loss in the stellar winds, with only a moderate amount of mass lost or transferred through binary interactions.

22 sitasi en Physics
DOAJ Open Access 2021
Structure of the Region-Technology Network as a Driver for Technological Innovation

Dion R. J. O’Neale, Dion R. J. O’Neale, Shaun C. Hendy et al.

Agglomeration and spillovers are key phenomena of technological innovation, driving regional economic growth. Here, we investigate these phenomena through technological outputs of over 4,000 regions spanning 42 countries, by analyzing more than 30 years of patent data (approximately 2.7 million patents) from the European Patent Office. We construct a bipartite network—based on revealed comparative advantage—linking geographic regions with areas of technology and compare its properties to those of artificial networks using a series of randomization strategies, to uncover the patterns of regional diversity and technological ubiquity. Our results show that the technological outputs of regions create nested patterns similar to those of ecological networks. These patterns suggest that regions need to dominate various technologies first (those allegedly less sophisticated), creating a diverse knowledge base, before subsequently developing less ubiquitous (and perhaps more sophisticated) technologies as a consequence of complementary knowledge that facilitates innovation. Finally, we create a map—the Patent Space Network—showing the interactions between technologies according to their regional presence. This network reveals how technology across industries co-appear to form several explicit clusters, which may aid future works on predicting technological innovation due to agglomeration and spillovers.

Information technology
DOAJ Open Access 2021
Prestige and content biases together shape the cultural transmission of narratives

Richard E.W. Berl, Alarna N. Samarasinghe, Seán G. Roberts et al.

Cultural transmission biases such as prestige are thought to have been a primary driver in shaping the dynamics of human cultural evolution. However, few empirical studies have measured the importance of prestige relative to other effects, such as content biases present within the information being transmitted. Here, we report the findings of an experimental transmission study designed to compare the simultaneous effects of a model using a high- or low-prestige regional accent with the presence of narrative content containing social, survival, emotional, moral, rational, or counterintuitive information in the form of a creation story. Results from multimodel inference reveal that prestige is a significant factor in determining the salience and recall of information, but that several content biases, specifically social, survival, negative emotional, and biological counterintuitive information, are significantly more influential. Further, we find evidence that reliance on prestige cues may serve as a conditional learning strategy when no content cues are available. Our results demonstrate that content biases serve a vital and underappreciated role in cultural transmission and cultural evolution.

Human evolution, Evolution
DOAJ Open Access 2021
Innovator of Reformation Studies: Subject Matter and Style in the Works of Yu. Golubkin

Serhiy Karikov, Inna Pidhorodetska

The article outlines the range of problems in the history of the Reformation explored in the oeuvre of the outstanding medievalist Yuri Golubkin. Golubkin authored more than 90 academic and popular works on medieval and early modern history. He was particularly interested in the writings of Martin Luther and in Luther’s participation in the events of the Reformation. The study employs the historical-typological, historicalgenetic, and historical-comparative methods and is based on the principles of historicism and objectivity. Its originality lies in identifying the main avenues of the study of the Reformation in the work of Yu. Golubkin and in defining the principal phases of his evolution as a scholar. The authors argue that the first phase (1970s–1980s) was marked by a focus on the socio-political views of Martin Luther and his participation in the early bourgeois revolution in Germany, while in the second phase (1990s–2000s) Golubkin was primarily interested in the formation of Luther’s religious beliefs and his participation in the creation of the Evangelical Church. The scholar’s articles and translations are notable for their distinctive style, characterized by expressiveness and wide use of metaphor, epithet, and idiom. The authors further suggest that translation of Luther’s main works was central to Golubkin’s research trajectory. The need to engage with Golubkin’s innovative approach to Martin Luther’s life and work determines the prospects for further exploration of the historian’s oeuvre as a significant contribution to Reformation studies.

History (General), Archaeology
DOAJ Open Access 2021
Digital Capitalism and Critical Media Education

Horst Niesyto

Digital capitalism has produced a new concentration of capital, knowledge, and power unprecedented in history. Quantification is fundamental to digital and capitalistic structural principles. In view of a comprehensive quantification and measurement of life and society, questions of meaning and significance must be asked beyond quantifying process structures. The first part of the article identifies capitalistic and digital structural principles, showing affinities between both principles. The second part points out central challenges and problem areas of digital capitalism. The third part discusses the manoeuvres of the IT industry in Germany to gain more influence on the education sector. Against the background of these developments, the last part outlines the need for alternative pathways and presents dimensions of a critical media education.[1]   [1] The article is based on two German language publications (Niesyto, 2017a, 2021).

Education (General)
DOAJ Open Access 2020
Cahul District in the First Weeks of the Soviet Occupation (June-August 1940)

Sergiu Cornea

As a result of direct diplomatic and military pressure exerted by the Soviet Union and blackmail by Germany and Italy in support of the aggressor, in June 1940 the Romanian administration and army left the territory of Bessarabia. The aim of the research is to reconstruct the events that occurred in a very complex and equally controversial period in the history of Cahul county –the establishment of the soviet occupation regime in summer 1940. In order to elucidate the subject, was used the method of content analysis of the official documents drawn up by the competent authorities of the “Lower Danube” Land, contained in the archive funds. A reliable source of information on the early days of soviet occupation is the refugees’ testimonies from Bessarabia. Although they provided stoning information, marked by personal feelings, they are still an important source of information because they were provided by eyewitnesses of the events. From the very first days of soviet occupation, soviet-type power structures were created in Bessarabia, and a number of political, economic, social and propaganda measures were taken to establish the soviet regime as soon as possible. The repressive measures taken by the new authorities caused discontent among the population, causing disappointment even to those who enjoyed the “moment of liberation”.

International relations

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