Olfactory ensheathing cells (OECs) and mesenchymal stem cells (MSCs) differentiated towards Schwann-like have plasticity properties. These cells express the Glial fibrillary acidic protein (GFAP), a type of cytoskeletal protein that significantly regulates many cellular functions, including those that promote cellular plasticity needed for regeneration. However, the expression of GFAP isoforms (α, β, and δ) in these cells has not been characterized. We evaluated GFAP isoforms (α, β, and δ) expression by Polymerase Chain Reaction (PCR) assay in three conditions: (1) OECs, (2) cells exposed to OECs-conditioned medium and differentiated to Schwann-like cells (dBM-MSCs), and (3) MSC cell culture from rat bone marrow undifferentiated (uBM-MSCs). First, the characterization phenotyping was verified by morphology and immunocytochemistry, using p75, CD90, and GFAP antibodies. Then, we found the expression of GFAP isoforms (α, β, and δ) in the three conditions; the expression of the GFAPα (10.95%AUC) and GFAPβ (9.17%AUC) isoforms was predominantly in OECs, followed by dBM-MSCs (α: 3.99%AUC, β: 5.66%AUC) and uBM-MSCs (α: 2.47%AUC, β: 2.97%AUC). GFAPδ isoform has a similar expression in the three groups (OEC: 9.21%AUC, dBM-MSCs: 11.10%AUC, uBM-MSCs: 9.21%AUC). These findings suggest that expression of different GFAPδ and GFAPβ isoforms may regulate cellular plasticity properties, potentially contributing to tissue remodeling processes by OECs, dBM-MSCs, and uBM-MSCs.
Abstract The superfluid density $$n_{s}(T)$$ n s ( T ) of a superconductor is calculated based on the generalized Bose–Einstein condensation (GBEC) theory that addresses a fully-interacting ternary boson-fermion gas mixture of free electrons as fermions, plus two-electron Cooper pairs (2eCPs) and also, explicitly, two-hole Cooper pairs (2hCPs), both as bosons. Here we consider two special cases (i) 100%–0% (i.e., with no condensed 2hCPs) and (ii) 0%–100% (i.e., with no condensed 2eCPs). Subsumed in GBEC are the Bardeen–Cooper–Schrieffer (BCS) and Bose–Einstein condensation (BEC) theories along with the BCS-BEC crossover theory extended with 2hCPs. We find that in the weak-coupling regime $$n_{s}(0)$$ n s ( 0 ) agrees with data from the Uemura et al. (2004) graph for several elemental SCs by taking in 3D with a quadratic energy-dispersion relation while in 2D with a linear relation are much too far below the data. In the strong-coupling regime the linear behavior of critical temperature $$T_{c}$$ T c vs $$n_{s}(0)$$ n s ( 0 ) obtained here is just as Božović et al. (2016) found. However, in 2D with a linear relation accounting for 0%–100%, $$n_{s}(T)/n_{s}(0)$$ n s ( T ) / n s ( 0 ) compares well with some high-$$T_{c}$$ T c -cuprate SC data between the two coupling regimes.
D. Vernooy, Vladimir S. Ilchenko, H. Mabuchi
et al.
Measurements of the quality factor Q approximately 8x10(9) are reported for the whispering-gallery modes (WGM's) of quartz microspheres for the wavelengths 670, 780, and 850 nm; these results correspond to finesse f approximately 2.2x10(6) . The observed independence of Q from wavelength indicates that losses for the WGM's are dominated by a mechanism other than bulk absorption in fused silica in the near infrared. Data obtained by atomic force microscopy combined with a simple model for surface scattering suggest that Q can be limited by residual surface inhomogeneities. Absorption by absorbed water can also explain why the material limit is not reached at longer wavelengths in the near infrared.
In clinical practice, physicians make a series of treatment decisions over the course of a patient's disease based on his/her baseline and evolving characteristics. A dynamic treatment regime is a set of sequential decision rules that operationalizes this process. Each rule corresponds to a decision point and dictates the next treatment action based on the accrued information. Using existing data, a key goal is estimating the optimal regime, that, if followed by the patient population, would yield the most favorable outcome on average. Q- and A-learning are two main approaches for this purpose. We provide a detailed account of these methods, study their performance, and illustrate them using data from a depression study.
For H. Exton's q-analogue of the Bessel function (going back to W. Hahn in a special case, but different from F. H. Jackson's q-Bessel functions) we derive Hansen-Lommel type orthogonality relations, which, by a symmetry, turn out to be equivalent to orthogonality relations which are q-analogues of the Hankel integral transform pair. These results are implicit, in the context of quantum groups, in a paper by Vaksman and Korogodskii. As a specialization we get q-cosines and q-sines which admit q-analogues of the Fourier-cosine and Fourier-sine transforms
In this paper we study the theory Q. We prove a basic result that says that, in a sense explained in the paper, Q can be split into two parts. We prove some consequences of this result. (i) Q is not a poly-pair theory. This means that, in a strong sense, pairing cannot be defined in Q. (ii) Q does not have the Pudlák Property. This means that there two interpretations of $$\mathsf{S}^1_2$$S21 in Q which do not have a definably isomorphic cut. (iii) Q is not sententially equivalent with $$\mathsf{PA}^-$$PA-. This tells us that we cannot do much better than mutual faithful interpretability as a measure of sameness of Q and $$\mathsf{PA}^-$$PA-. We briefly consider the idea of characterizing Q as the minimal-in-some-sense theory of some kind modulo some equivalence relation. We show that at least one possible road towards this aim is closed.
Optical microresonators hold great potential for many fields of research and technology. However, due to their small dimensions typical microresonators exhibit a large frequency spacing between resonances and a limited tunability. This impedes their use in a large class of applications which either require a resonance of the microcavity to coincide with a predetermined frequency, e.g., an optical transition in atoms, or a tailored frequency spacing between resonances, e.g., for the generation of optical frequency combs. Here, we present a fully tunable ultra-high-Q whispering-gallery-mode “bottle microresonator”, fabricated from standard optical glass fibres. Due to its highly prolate shape, the bottle microresonator gives rise to a class of whispering-gallery-modes (WGMs) with advantageous properties, see Fig. 1. In addition to the radial confinement by continuous total internal reflection at the resonator surface, the light in these “bottle modes” oscillates back and forth along the resonator axis between two turning-points which are defined by an angular momentum barrier [1]. The resulting axial standing wave structure can be compared to the one observed in Fabry-Pérot microresonators.
Let $\mathbb{F}_{q}^{n}$ be a vector space of dimension $n$ over the finite field $\mathbb{F}_{q}$ . A $q$ -analog of a Steiner system (also known as a $q$ -Steiner system), denoted ${\mathcal{S}}_{q}(t,\!k,\!n)$ , is a set ${\mathcal{S}}$ of $k$ -dimensional subspaces of $\mathbb{F}_{q}^{n}$ such that each $t$ -dimensional subspace of $\mathbb{F}_{q}^{n}$ is contained in exactly one element of ${\mathcal{S}}$ . Presently, $q$ -Steiner systems are known only for $t\,=\,1\!$ , and in the trivial cases $t\,=\,k$ and $k\,=\,n$ . In this paper, the first nontrivial $q$ -Steiner systems with $t\,\geqslant \,2$ are constructed. Specifically, several nonisomorphic $q$ -Steiner systems ${\mathcal{S}}_{2}(2,3,13)$ are found by requiring that their automorphism groups contain the normalizer of a Singer subgroup of $\text{GL}(13,2)$ . This approach leads to an instance of the exact cover problem, which turns out to have many solutions.