Hasil untuk "Men"

M. Hallek

V. Kasivisvanathan, A. Rannikko, M. Borghi et al.

H. Ahmed, A. El-Shater Bosaily, L. Brown et al.

BACKGROUND Men with high serum prostate specific antigen usually undergo transrectal ultrasound-guided prostate biopsy (TRUS-biopsy). TRUS-biopsy can cause side-effects including bleeding, pain, and infection. Multi-parametric magnetic resonance imaging (MP-MRI) used as a triage test might allow men to avoid unnecessary TRUS-biopsy and improve diagnostic accuracy. METHODS We did this multicentre, paired-cohort, confirmatory study to test diagnostic accuracy of MP-MRI and TRUS-biopsy against a reference test (template prostate mapping biopsy [TPM-biopsy]). Men with prostate-specific antigen concentrations up to 15 ng/mL, with no previous biopsy, underwent 1·5 Tesla MP-MRI followed by both TRUS-biopsy and TPM-biopsy. The conduct and reporting of each test was done blind to other test results. Clinically significant cancer was defined as Gleason score ≥4 + 3 or a maximum cancer core length 6 mm or longer. This study is registered on ClinicalTrials.gov, NCT01292291. FINDINGS Between May 17, 2012, and November 9, 2015, we enrolled 740 men, 576 of whom underwent 1·5 Tesla MP-MRI followed by both TRUS-biopsy and TPM-biopsy. On TPM-biopsy, 408 (71%) of 576 men had cancer with 230 (40%) of 576 patients clinically significant. For clinically significant cancer, MP-MRI was more sensitive (93%, 95% CI 88-96%) than TRUS-biopsy (48%, 42-55%; p<0·0001) and less specific (41%, 36-46% for MP-MRI vs 96%, 94-98% for TRUS-biopsy; p<0·0001). 44 (5·9%) of 740 patients reported serious adverse events, including 8 cases of sepsis. INTERPRETATION Using MP-MRI to triage men might allow 27% of patients avoid a primary biopsy and diagnosis of 5% fewer clinically insignificant cancers. If subsequent TRUS-biopsies were directed by MP-MRI findings, up to 18% more cases of clinically significant cancer might be detected compared with the standard pathway of TRUS-biopsy for all. MP-MRI, used as a triage test before first prostate biopsy, could reduce unnecessary biopsies by a quarter. MP-MRI can also reduce over-diagnosis of clinically insignificant prostate cancer and improve detection of clinically significant cancer. FUNDING PROMIS is funded by the UK Government Department of Health, National Institute of Health Research-Health Technology Assessment Programme, (Project number 09/22/67). This project is also supported and partly funded by UCLH/UCL Biomedical Research Centre and The Royal Marsden and Institute for Cancer Research Biomedical Research Centre and is coordinated by the Medical Research Council Clinical Trials Unit (MRC CTU) at UCL. It is sponsored by University College London (UCL).

M. Oelke, A. Bachmann, A. Descazeaud et al.

E. Duflo

Women's empowerment and economic development are closely related: in one direction, development alone can play a major role in driving down inequality between men and women; in the other direction, empowering women may benefit development. Does this imply that pushing just one of these two levers would set a virtuous circle in motion? This paper reviews the literature on both sides of the empowerment-development nexus, and argues that the inter-relationships are probably too weak to be self-sustaining, and that continuous policy commitment to equality for its own sake may be needed to bring about equality between men and women.

Cynthia L Ogden, M. Carroll, Brian K. Kit et al.

Trevor G. Cooper, E. Noonan, S. V. Eckardstein et al.

T. Gordon, W. Castelli, M. Hjortland et al.

E. Calle, M. Thun, Jennifer M. Petrelli et al.

M. Hertog, E. Feskens, P. Hollman et al.

R. Doll, R. Peto, J. Boreham et al.

D. Irwin, I. Milsom, S. Hunskaar et al.

Peter Glick, S. Fiske

J. Archer

Pam Flaskrud, Kari Dietzler, Ingrid Niehans et al.

E. Benjamin, Daniel Levy, S. Vaziri et al.

Nils Lid Hjort

All men are created equal, proclaimed Jefferson in 1776 -- but some are more equal than others, added Orwell in Animal Farm in 1945. So what's the probability that two skaters are exactly equal, to the third decimal places, after four distances?

Francesca Barigozzi, Pietro Biroli, Chiara Monfardini et al.

This paper introduces a novel, scalable methodology to measure individual perceptions of gaps in mental load -- the cognitive and emotional burden associated with organizing household and childcare tasks -- within heterosexual couples. Using original data from the TIMES Observatory in Italy, the study combines time-use diaries with new survey indicators to quantify cognitive labor, emotional fatigue, and the spillover of mental load into the workplace. Results reveal systematic gender asymmetries: women are significantly more likely than men to bear organizational responsibility for domestic tasks, report lower satisfaction with this division, and experience higher emotional fatigue. These burdens are underestimated by their partners. The effects are particularly pronounced among college-educated and employed women, who also report greater spillovers of family responsibilities than men during paid work hours. The perceived responsibility for managing family activities is more strongly associated with within-couple gaps in time use than with the absolute time spent on their execution, underscoring the relational and conflictual nature of mental load.

Xinyi Zhao, Anna I. Thoma, Ralph Hertwig et al.

Although more women than men enter social science disciplines, they are underrepresented at senior levels. To investigate this leaky pipeline, this study analyzed the career trajectories of 78,216 psychology researchers using large-scale bibliometric data. Despite overall constituting over 60\% of these researchers, women experienced consistently higher attrition rates than men, particularly in the early years following their first publication. Academic performance, particularly first-authored publications, was strongly associated with early-career retention -- more so than collaboration networks or institutional environment. After controlling for gender differences in publication-, collaboration-, and institution-level factors, women remained more likely to leave academia, especially in early-career stages, pointing to persistent barriers that hinder women's academic careers. These findings suggest that in psychology and potentially other social science disciplines, the core challenge lies in retention rather than recruitment, underscoring the need for targeted, early-career interventions to promote long-term gender equity.

Johannes Brustle, Simone Fioravanti, Tomasz Ponitka et al.

Sortition is the practice of delegating public decision-making to randomly selected panels. Recently, it has gained momentum worldwide through its use in citizens' assemblies, sparking growing interest within the computer science community. One key appeal of sortition is that random panels tend to be more representative of the population than elected committees or parliaments. Our main conceptual contribution is a novel definition of representative panels, based on the Wasserstein distance from statistical learning theory. Using this definition, we develop a framework for analyzing the panel complexity problem -- determining the required panel size to ensure desirable properties. We focus on three key desiderata: (1) that efficiency at the panel level extends to the whole population, measured by social welfare; (2) that fairness guarantees for the panel translate to fairness for the population, captured by the core; and (3) that the probability of an outlier panel, for which the decision significantly deviates from the optimal one, remains low. We establish near-tight panel complexity guarantees for these desiderata across two fundamental social choice settings: participatory budgeting and facility location.