Nuria Peña, Irene Lafuente, Ester Sevillano
et al.
Background/Objectives: Antimicrobial peptides (AMPs) have emerged as promising alternatives to conventional antibiotics in livestock, offering a sustainable strategy for controlling bacterial pathogens in food production systems. In addition to their direct antimicrobial effects, AMPs play a key role in modulating host-associated microbiomes, influencing both microbial composition and function. Advances in metagenomic sequencing and bioinformatic tools now enable comprehensive exploration of AMP diversity and activity within complex microbial ecosystems. Methods: In this study, we employed Illumina-based next-generation sequencing (NGS) to analyze intestinal contents from six gut sections of broiler chickens obtained from a Spanish slaughterhouse. Results: Through de novo assembly and bioinformatic annotation, we identified biosynthetic gene clusters (BGCs) encoding ribosomally synthesized and post-translationally modified peptides (RiPPs), other specialized bioactive secondary metabolites, antimicrobial resistance genes (ARGs), virulence factor genes (VFGs), and a diverse microbial community. Among all gut sections, the cecum exhibited the highest genetic richness, characterized by a high diversity of RiPP-like clusters and antimicrobial resistance determinants. Conclusions: These findings highlight the poultry gut, particularly the cecum, as a significant reservoir of antimicrobial peptides (AMPs) with potential implications in antibiotic-free poultry production and enhanced food safety.
The cytochrome bcl complex is an oligomeric membrane protein complex which is a component of the mitochondrial respiratory chain and of the electron transfer chains of numerous bacteria which use oxygen, nitrogen, and sulfur compounds as terminal electron acceptors. The cytochrome bcl complex also participates in the cyclic transfer of electrons to and from the photosynthetic reaction centers in anoxygenic photosynthetic bacteria. In all of these species the cytochrome bcl complex transfers electrons from ubiquinol to cytochrome c and links this electron transfer to translocation of protons across the membrane in which the bcl complex resides. The mechanism by which the cytochrome bcl complex links electron transfer to proton translocation is the protonmotive Q cycle (1). This protonmotive electron transfer is one of the most important mechanisms of cellular energy transduction, found in a phylogenetically diverse range of organisms (2). The purpose of this review is to explain the protonmotive Q cycle.
During the last four decades, digital technologies have disrupted many industries. Car control systems have gone from mechanical to digital. Telephones have changed from sound boxes to portable computers. But have the firms that digitized their products and services become more valuable than firms that didn’t? Here we introduce the construct of digital proximity, which considers the interdependent activities of firms linked in an economic network. We then explore how the digitization of products and services affects a company’s Tobin’s q—the ratio of market value over assets—a measure of the intangible value of a firm. Our panel regression methods and robustness tests suggest the positive influence of a firm’s digital proximity on its Tobin’s q. This implies that firms able to come closer to the digital sector have increased their intangible value compared to those that have failed to do so. These findings contribute a new way of measuring digitization and its impact on firm performance that is complementary to traditional measures of information technology (IT) intensity.
D. Vernooy, Vladimir S. Ilchenko, H. Mabuchi
et al.
Measurements of the quality factor Q approximately 8x10(9) are reported for the whispering-gallery modes (WGM's) of quartz microspheres for the wavelengths 670, 780, and 850 nm; these results correspond to finesse f approximately 2.2x10(6) . The observed independence of Q from wavelength indicates that losses for the WGM's are dominated by a mechanism other than bulk absorption in fused silica in the near infrared. Data obtained by atomic force microscopy combined with a simple model for surface scattering suggest that Q can be limited by residual surface inhomogeneities. Absorption by absorbed water can also explain why the material limit is not reached at longer wavelengths in the near infrared.
We investigate the suitability of toroidal microcavities for strong-coupling cavity quantum electrodynamics (QED). Numerical modeling of the optical modes demonstrate a significant reduction of the modal volume with respect to the whispering gallery modes of dielectric spheres, while retaining the high-quality factors representative of spherical cavities. The extra degree of freedom of toroid microcavities can be used to achieve improved cavity QED characteristics. Numerical results for atom-cavity coupling strength g, critical atom number No, and critical photon number no for cesium are calculated and shown to exceed values currently possible using Fabry-Perot cavities. Modeling predicts coupling rates g/2π exceeding 700 MHz and critical atom numbers approaching 10^(-7) in optimized structures. Furthermore, preliminary experimental measurements of toroidal cavities at a wavelength of 852 nm indicate that quality factors in excess of 108 can be obtained in a 50-µm principal diameter cavity, which would result in strong-coupling values of (g/(2π),n(0),N-0) = (86 MHz, 4.6 x 10^(-4), 1.0 x 10^(-3)).
We have demonstrated all-optical bistable switching operation of resonant-tunnelling devices with ultra-small high-Q Si photonic-crystal nanocavities. Due to their high Q/V ratio, the switching energy is extremely small in comparison with that of conventional devices using the same optical nonlinear mechanism. We also show that they exhibit all-opticaltransistor action by using two resonant modes. These ultrasmall unique nonlinear bistable devices have potentials to function as various signal processing functions in photonic-crystal-based optical-circuits.
Using a photoalignment technique with a sulphonic azo-dye as the surfactant aligning material, we fabricated electrically tunable liquid crystal q-plates with topological charge 0.5, 1.5 and 3 for generating optical vortex beams with definite orbital angular momentum (OAM) 1,3 and 6 per photon (in units of ¯h), respectively. We carried out several tests on our q-plates, including OAM tomography, finding excellent performances. These devices can have useful applications in general and quantum optics.
For H. Exton's q-analogue of the Bessel function (going back to W. Hahn in a special case, but different from F. H. Jackson's q-Bessel functions) we derive Hansen-Lommel type orthogonality relations, which, by a symmetry, turn out to be equivalent to orthogonality relations which are q-analogues of the Hankel integral transform pair. These results are implicit, in the context of quantum groups, in a paper by Vaksman and Korogodskii. As a specialization we get q-cosines and q-sines which admit q-analogues of the Fourier-cosine and Fourier-sine transforms
In this paper we study the theory Q. We prove a basic result that says that, in a sense explained in the paper, Q can be split into two parts. We prove some consequences of this result. (i) Q is not a poly-pair theory. This means that, in a strong sense, pairing cannot be defined in Q. (ii) Q does not have the Pudlák Property. This means that there two interpretations of $$\mathsf{S}^1_2$$S21 in Q which do not have a definably isomorphic cut. (iii) Q is not sententially equivalent with $$\mathsf{PA}^-$$PA-. This tells us that we cannot do much better than mutual faithful interpretability as a measure of sameness of Q and $$\mathsf{PA}^-$$PA-. We briefly consider the idea of characterizing Q as the minimal-in-some-sense theory of some kind modulo some equivalence relation. We show that at least one possible road towards this aim is closed.