Hasil untuk "Logic"

B. Edvardsson, B. Tronvoll, Thorsten Gruber

Patricia H. Thornton, W. Ocasio

Nicholas Asher, A. Lascarides

G. Micheli

Patricia H. Thornton, W. Ocasio

Ian Kuon, Jonathan Rose

Wilfrid S. Sellars

P. Suppes

R. Jeffrey

P. Krauss, H. Kyburg

E. Lemmon, D. Scott, K. Segerberg

V. Pratt

R. Kowalski

D. Dalen

Seongho Hong, Yelin Lim, Hansol Kang et al.

Abstract Background Programmed ribosomal frameshifting (PRF) is a translational mechanism that enables the ribosome to shift reading frames and access alternative coding sequences. PRF occurs naturally in a wide range of organisms, including viruses, bacteria, and eukaryotes, where it supports compact encoding and stoichiometric control of protein expression. Despite the great potential of PRF in synthetic circuit designs, a broader adoption of PRF in circuit designs has been hampered by rather strict sequence constraints and structural requirements. Results This work introduces a synthetic translational regulatory platform, protein-inducible ribosomal frameshifting (PIRF), by integrating aptamer–protein interactions with a − 1 PRF motif to enable regulated translation in Escherichia coli. PIRF modules respond to intracellular RNA-binding proteins such as PP7 and MS2, triggering frameshifting in a condition-dependent manner. PIRF could be used to program logic gate operations through frame-dependent translation and enable multilayered regulation in synthetic circuits. Further, the flexible PIRF designs enable reading frame-dependent control of fusion protein expression, protein aggregation, and periplasmic localization via strategic positioning of peptide tags and protein coding sequences. While PIRF enabled regulated frameshifting and could be flexibly reconfigured for a variety of circuits and applications, a measurable level of basal frameshifting was often observed, which may require additional strategies for further optimization in the future. Together, PIRF supports applications in programmable and logical control of downstream protein expression, including condition-dependent aggregation and regulated subcellular localization. Conclusions PIRF provides a compact and genetically encoded strategy for programmable protein-level regulation, expanding the synthetic biology toolkit for translational control, biosensing and biotherapeutics. Graphical Abstract

Francesco Raniolo

This short note is inspired by Piero Ignazi’s article in this issue of QOE–IJES. The basic idea is that the legitimacy of political parties is the outcome of an ongoing, contingent, tension-laden and ambivalent process (legitimization). This ambivalence is not merely circumstantial but embedded in the very logic of partisan action. Which we can characterize as a set of conceptual oppositions between ideals and practices, normative expectations and organizational realities, what parties are and what they do. The article discusses four partisan ambivalences (or dichotomies): part vs. whole, conflict vs. integration, society vs. state, and representation vs. government.  In times of democratic regression these ambivalences become disruptive, undermining the credibility of parties as legitimate actors. The crisis of party legitimacy, then is a symptom of a broader transformation in the role of political parties in the 21st century. Transformations that redefine the very function and identity of political parties.

Richard Shiff

Within the fields of aesthetics and psychology, there is a long tradition of arguing that affect precedes cognition. A verbalized thought following upon a feeling and associated with it does not translate the feeling precisely or adequately. In fact, as C. S. Peirce would argue, the thought itself projects its own affect, which is independent of its logic. The essence of affect or feeling will always elude linguistic capture. This essay argues that experiences of belief and doubt are affective sensations, and both can be graphed on a scale of sensuous intuition or cognitive guessing (which, again, projects affect). The failure of language to grasp what we refer to as instances of emotion, feeling, sensation, affect, belief, doubt, and the like is more of an intractable problem for philosophical aesthetics than it is for the aesthetics of the art experience. Examples of the art of Cy Twombly, Barnett Newman, Donald Judd, Bridget Riley, and Katharina Grosse are invoked to argue through the gap between thought and feeling.

Yongjie Zhong, Ling Ji, Chengjun Tang et al.

The regional source–grid–load friendly interaction and precision regulation of adjustable resources with high sensitivity provide important support for the development of a new power system, improving its regulation ability and efficiency and promoting the safe, efficient, and reliable operation. Therefore, a precision regulation strategy for a regional source–grid–load friendly interaction based on a double-layer sensitivity model is proposed in this paper. Firstly, from the two perspectives of power grid-application requirements and power node-adjustable resources, the overall implementation process of the double-layer sensitivity analysis method is described, and the layered logic architecture of the precision regulation platform for regional source–grid–load friendly interaction is constructed in order to realize and apply the proposed double-layer sensitivity model and precision-regulation strategy. Secondly, the first-layer power transmission line-sensitivity analysis model is proposed for the power grid side to obtain the power transmission line-sensitivity matrix. A fine-grained second-layer adjustable resources sensitivity-analysis model is further established for the diversified adjustable resource aggregated under the power node to complete the quantitative ranking of adjustable resource-regulation sensitivity. Then, the application process of double-layer sensitivity analysis results is designed in detail, and the regulation sequence and regulation quantity of source and load are defined. Finally, taking a power system with seven lines, five power nodes, two power sources, and seven types of adjustable resources as an example, the effectiveness and rationality of the proposed model and strategy are verified. The results indicate that the proposed precise regulation strategy can accurately select high-sensitivity power nodes and effectively sort high-sensitivity adjustable resources when solving the multiple scenarios’ application needs of power grids.

Safara Bibi, Guillermo Huerta-Cuellar, José Luís Echenausía-Monroy et al.

We present an innovative method harnessing multistability within a diode-pumped erbium-doped fiber laser to construct logic gates. Our approach involves manipulating the intensity of external noise to regulate the probability of transitioning among four concurrent attractors. In this manner, we facilitate the realization of OR, AND, NOR, and NAND logic operations, aligning with the coexisting period-1, period-3, period-4, and period-5 orbits. Employing detrended fluctuation analysis, we establish equilibrium in the probability distributions of these states. The obtained results denote a substantial advancement in the field of optical logic gate development, representing a pivotal stride toward the seamless integration of an all-optical logic gate within laser oscillator-based systems.

Lin Ji, Abdrasulov Sovetbek Misirkulovich, Yuhao Zhao et al.

With the rapid development of artificial intelligence, the demand of urban development for talents with relevant technical and theoretical knowledge is constantly increasing, which is of great significance for the promotion of scientific and technological progress and social development. This study through the construction of China city talent vitality evaluation index system, analysis of Luoyang, Ningbo, Wuhu city talent vitality level, summarizes the Chinese city talent development and deficiencies, from the talent growth, talent competitiveness, talent entrepreneurship, talent mobility and talent innovation in the practice of Chinese city talent strategy logic thinking.