Hasil untuk "Homeopathy"

Ebtesam N. Nagy PhD, Marwa Shafiek PhD, Hend Elsheimy PhD et al.

Objective To find out the effect of high-intensity interval training (HIIT) and mindfulness breathing on the levels of sex hormones, insulin resistance, lipid profiles, and tumor biomarkers in postmenopausal obese women. Design Seventy obese postmenopausal women (aged 55-65 years, with a body mass index (BMI) ranging from 35–44.9 kg/m 2 ) were allocated into two groups for this prospective, randomized, controlled study: the experimental group, which received HIIT and mindfulness breathing in addition to their medications, and the control group, which only received medication. Serum sex hormone levels (estradiol, total testosterone [TT], free testosterone [FT], and sex hormone-binding globulin [SHBG]), insulin resistance assessment using the homeostasis model [HOMA-IR], lipids (total cholesterol [TC], triglycerides [TGs], high-density lipoprotein [HDL], and TC/HDL), and tumor markers (Carcino Embryonic Antigen [CEA] and Cancer Antigen [CA125]) were among the pre and post assessments conducted after 12 weeks. Results After 12 weeks of the study, the HIIT and mindfulness breathing group showed significant decreases in weight, BMI, FT, TT, estradiol, HOMA-IR, CEA, CA125, TC, TGs, and TC/HDL and increases in SHBG and HDL (all p  < 0.001). In contrast, the control group had increases in weight, BMI, FT, TT, estradiol, HOMA-IR, CEA, CA125, TC, TGs, and TC/HDL and decreases in SHBG and HDL (all p  < 0.001). Conclusion HIIT and mindfulness breathing were efficient approaches for lowering metabolic, hormonal, and tumor-related risk factors in obese postmenopausal women.

Igbayilola Yusuff Dimeji, Hamidu Lawan Jabba, Saka Waidi Adeoye et al.

Abstract Metabolic syndrome (MetS) consists of a combination of metabolic irregularities, such as insulin resistance, abdominal obesity, hypertension, and dyslipidemia, which together increase the risk of developing type II diabetes mellitus and atherosclerotic cardiovascular diseases (CVDs). To diagnose MetS, a person must present at least three of these metabolic issues, underscoring the importance of early identification and targeted treatments. The occurrence of MetS is increasing worldwide, impacting more than 20% of the population in the United States and Europe, primarily because of the obesity crisis. The critical mechanisms that connect MetS to CVD include endothelial dysfunction and arterial stiffness, both of which significantly increase cardiovascular risk. The endothelium is essential for sustaining vascular balance, and more studies indicate that endothelial dysfunction serves as both a precursor and a contributing factor to atherosclerotic disease. Moreover, increased arterial stiffness, especially in central arteries such as the aorta, is closely linked to systolic hypertension, coronary artery disease, stroke, heart failure, and atrial fibrillation, indicating that it is a key element in the cardiovascular decline associated with aging. Curcumin, a bioactive polyphenol sourced from Curcuma longa, has gained attention as a potentially beneficial agent for enhancing cardiometabolic health. Its positive effects on endothelial dysfunction and arterial stiffness arise from its capacity to influence inflammation, oxidative stress, and the availability of nitric oxide. This review examines the molecular and cellular mechanisms through which curcumin affects vascular function, emphasizing its promise as an adjunctive therapeutic approach for addressing MetS and lowering cardiovascular risk.

M Pavithra, Arvind Muthukrishnan

Introduction: Ayurveda, Yoga, Unani, Siddha and Homeopathy (AYUSH) is an alternative medical system and has found acceptance globally for its use of rich medical plants, minerals, and other natural commodities in treating different illness. In November 2020, AYUSH changed its curriculum guidelines for its postgraduate students, which allowed them to perform a variety of general surgery, including orthopedic, ophthalmology, Ear Nose Throat (ENT), and dental treatments. Aim: To assess the awareness and perception among the dentists of these new AYUSH guidelines and to record their opinion. Materials and Methods: The cross-sectional study was conducted in Department of Oral Medicine and Radiology at Saveetha Dental College, Chennai, Tamil Nadu, India,from January 2021 to February 2021. A self-constructed questionnaire of 15 questions was circulated via google forms. The response was collected from 123 dentists. Statistical analysis was done on the IBM software 24 version. Chi-square test was used to assess the relationship between dentists’ awareness of dental procedures included under the new AYUSH curriculum and their perception of ayurvedic practitioners performing the dental treatment efficiently. Results: Only 58.5% (n=79) of dentists were aware of the term AYUSH and 53 (43%) dentists were aware of the new guidelines added to the postgraduate curriculum in AYUSH. About, 57.7% of dentists reported that the Ayurvedic practitioners cannot handle the complications occurring during dental procedures. Conclusion: Dentists were not in favor of AYUSH practitioners performing dental treatments. The present study also concluded that dental procedures cannot be effectively and efficiently performed by AYUSH practitioners.

Kaushal Sharma, Kaushal Sharma, Indranill Basu-Ray et al.

AimCommon Yoga Protocol (CYP) is a standardized yoga protocol authored by experts from all over the world under the aegis of the Ministry of AYUSH, Ayurveda, Yoga and Naturopathy, Unani, Siddha, Sowa Rigpa and Homeopathy (AYUSH). The potential of CYP can be determined as a cost-effective lifestyle modification to prevent the risk of developing cardiovascular diseases (CVD).MethodsIn this prospective trial, we compared the effect of CYP at baseline and after 1 month. A total of 374 yoga-naïve participants performed CYP under the supervision of experienced trainers. Physiological [body mass index (BMI), blood pressure, percent oxygen saturation], biochemical (fasting blood glucose and lipid profile), and neurocognitive parameters were measured before and after the intervention.ResultsAt day 30 of yoga practice, serum levels of low-density lipoprotein (LDL), total cholesterol (TC), and high-density lipoprotein (HDL) were found significantly improved as compared to the baseline levels observed at the time of enrollment. Similarly, the lipid profile was also obtained from experienced trainers and found to be significantly different from those of yoga-naïve volunteers. When the intervention was compared between the healthy yoga-naïve participants with yoga-naïve participants suffering from medical issues, it was found that cholesterol profile improved significantly in the healthy-naive group as compared to the diseased group (hypertension, diabetes, underwent surgery, and CVD).ConclusionThese results highlight the need for further research to better understand the effects of yoga on the primary prevention of CVD.

Silvia Waisse

Abstract Thromboinflammation is a still not well-understood phenomenon, which has recently come to the foreground as a function of its relevance in the pathophysiology of coronavirus disease 2019 (COVID-19). The patient described in the present case report exhibited acute fever, giant urticaria, elevated acute phase reactants, and very high d-dimer levels, thus characterizing thromboinflammation. She was diagnosed as a COVID-19 suspect case, which was not confirmed; urticarial vasculitis was ruled out. Homeopathic treatment was started with the earliest clinical manifestations, resulting in rapid and drastic reduction of inflammation and hypercoagulability within the first 12 hours, and full recovery on 10-day follow-up assessment. This case demonstrates the effectiveness of homeopathy in a severe acute disorder, and points to the need to include laboratory testing in homeopathic clinical assessment to achieve an accurate picture of disease, and to avoid the risk of passing over life-threatening disorders.

Prasad Neerati, Harika Prathapagiri

Abstract Background Chronic neuropathic pain syndrome is associated with impaired quality of life and is poorly manageable. Alpha lipoic acid (ALA) is a powerful antioxidant and showed its effectiveness on diabetic neuropathy and other acute peripheral nerve injuries but it was not evaluated in the chronic neuropathic pain, chronic constriction injury (CCI) in rat model by using duloxetine (DLX) as standard. Methodology The main objective of the study was to expedite ALA effect on chronic peripheral neuropathy induced by CCI of sciatic nerve in rats. In this study, male Wister rats were randomly divided into six groups (n = 8) including, normal saline, sham operated, surgery control, DLX 30mg/kg treated, ALA treated 25mg/kg, and ALA+DLX. The CCI of sciatic nerve was conducted on all animals except normal saline group and studied for 21 days (i.e. 14 days treatment period & 7 days treatment free period) by using different behavioral, biochemical and, histopathology studies. Results ALA showed minor but significant decrease of thermal hyperalgesia, cold allodynia, malondialdehyde (MDA), total protein, lipid peroxidation, and nitric oxide levels and significant increase of motor coordination, glutathione level and decreased axonal degeneration significantly. These effects sustained even during treatment free period. ALA enhanced the effect of DLX when given in combination by showing sustained effect. In conclusion, ALA acted as potent antioxidant may be this activity is responsible for the potent neuroprotective effect. Conclusion Hence, ALA attenuated the nueroinflammation mediated by chronic peripheral neuropathy. Further studies are warranted with ALA to develop as a clinically relevant therapeutic agent for the treatment of neuropathic pain.

Ruhaila Thekkath, Chellappan Nonam, Rani Mathew et al.

Background: Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein which is expressed in various tissues. Aberrant EGFR signaling plays an important role in carcinogenesis. Gefitinib, an EGFR inhibitor, is a promising drug in treatment of various malignancies. Awareness about the various mucocutaneous side effects of gefitinib will help in optimum management. Hence, we decided to conduct this study. Materials and Methods: We did a descriptive study and observed the various cutaneous side effects in 40 patients who were treated with gefitinib in a tertiary care center in South Kerala. Results: Dermatological adverse reactions were observed in 87.5% of our patients, the most common being dryness and pruritus in 67.5% and 65% of patients, respectively. Rashes were of Grade 1/2 severity in most of our cases. Conclusions: Cutaneous reactions, though common, were mild in majority of our patients. Studies with more sample size and follow-up are needed to improve our knowledge.

Melody Hermel MD, Megan Sweeney MPH, Yu-Ming Ni MD et al.

Worldwide, the turmoil of the SARS-CoV-2 (COVID-19) pandemic has generated a burst of research efforts in search of effective prevention and treatment modalities. Current recommendations on natural supplements arise from mostly anecdotal evidence in other viral infections and expert opinion, and many clinical trials are ongoing. Here the authors review the evidence and rationale for the use of natural supplements for prevention and treatment of COVID-19, including those with potential benefit and those with potential harms. Specifically, the authors review probiotics, dietary patterns, micronutrients, antioxidants, polyphenols, melatonin, and cannabinoids. Authors critically evaluated and summarized the biomedical literature published in peer-reviewed journals, preprint servers, and current guidelines recommended by expert scientific governing bodies. Ongoing and future trials registered on clinicaltrials.gov were also recorded, appraised, and considered in conjunction with the literature findings. In light of the controversial issues surrounding the manufacturing and marketing of natural supplements and limited scientific evidence available, the authors assessed the available data and present this review to equip clinicians with the necessary information regarding the evidence for and potential harms of usage to promote open discussions with patients who are considering dietary supplements to prevent and treat COVID-19.

M. Habs, M. Koller

Homeopathy is widely used and broadly accepted by health care professionals and the general public but less in academic circles. To assess possible material health risks of homeopathic medicinal products, it is necessary to identify, select, and synthesize the findings of recent reviews of controlled homeopathic clinical trials. Matching these findings with experimental data from toxicological studies helps to clarify what is known and not known about the material risks of homeopathic medicines. Rules for toxicological risk assessment and management need to be applied independently of individual attitudes towards specific therapeutic options. European regulatory bodies have developed special protocols and decision trees to assure the safety of nonindividualized homeopathic remedies. This narrative review leads to suggestions that could ease and improve toxicological decision making. No homeopathy-specific type or pattern of side effects could be extracted from the meta-analysis data. No differences in the frequency of adverse reactions between homeopathic treatment and placebo treatment could be seen, no matter whether adverse events were reported in a quantitative or a qualitative manner. Some patterns of side effects show that adverse reactions do not necessarily correlate with treatment but with the condition of the patient. Overall, the controlled clinical data available for the material risk assessment of homeopathic remedies support the statement that, if a risk exists, it must be so small that it has not yet been established. To make our risk findings useful for personal decisions regarding homeopathy, we provide a thought experiment based on four different health situations and ask the question: is homeopathy as a monotherapy or as an add-on treatment an option or should it be rejected?

Lethso Thibaut Ocko Gokaba, Olivia Firmine Atipo Galiba, Géril Sekangue Obili et al.

The association between Chronic Myeloid Leukaemia (CML)-Filariasis is rare. Moreover, finding microfilariae in the bone marrow is uncommon. We reported the case of 47-year-old patient living in a rural area who was admitted in the haematology ward in order to further examine a splenomegaly he had which was associated with a leucocytosis. Physical examination revealed oedematous lower limbs and peripheral blood film comment showed the presence of myelocytosis and eosinophilia. The myelogram showed hyperplasia of immature granulocytes and presence of Loa loa, Wuchereria bancrofti and Mansonella perstans microfilariae. The diagnosis of CML was then confirmed by the presence of the gene translocation t (9; 22) and the MBCR-ABL transcription type b3a2 on cytogenetic examination. This case represents a semiotic interest because oedema of both upper and lower limbs associated with a leucocytosis in filarial endemic zone must first of all indicate a haematological malignancy associated with filariasis.

B. I. C. Brai, J. A. Falode, R. A. Adisa et al.

Abstract Background Avocado (Persea americana) is one of the plants widely used in ethnomedicine in Nigeria. The present study was aimed at investigating effects of aqueous Avocado (Persea americana) leaf extract on total cholesterol, triacylglycerols, protein and haematological parameters in carbon tetrachloride (CCl4)-intoxicated rats. Methods We evaluated the possible effects of pre-treatment with aqueous extract of Persea americana (AEPA) on protein, total cholesterol (T-CHOL), triacylglycerols (TAGs) and haematological parameters in Wistar male albino rats intoxicated with CCl4. Group 1 was the healthy control; group 2 rats were pre-treated with Reducdyn® (100 mg/kg/day) as a standard drug, groups 4 and 5 rats were pre-treated with AEPA at a dose of 100 mg/kg and 200 mg/kg per day respectively, the treatments were administered orally for 7 days. On the seventh day, rats in the treatment groups were injected with a fresh mixture of CCl4 and olive oil (3 ml/kg, 1:1; sc). Results Pre-treatment of rats with AEPA resulted in marked increase (p < 0.05) in total protein and reduction in T-CHOL (19–34%) compared to CCl4 alone. Also, there was significant decrease (p < 0.05) in serum TAG concentration when rats were pre-treated with 100 mg and 200 mg kg− 1 b. wt. AEPA. Similarly, AEPA provoked (p < 0.05) a lowering of T-CHOL and TAG levels and an increase in liver protein concentration in the rats. Administration of AEPA at both concentrations restored (p < 0.05) WBC count and ameliorated neutropenia and lymphocytosis caused by CCl4 intoxication. Conclusion These results suggest that AEPA could be protective against the development of fatty liver and might also be exhibiting the potential to prevent alterations in haematological parameters caused by CCl4 intoxication in rats.

Basiru Olaitan Ajiboye PhD, Oluwafemi Adeleke Ojo PhD, Babatunji Emmanuel Oyinloye PhD et al.

Artocarpus heterophyllus Lam (Moraceae) stem bark has been used locally in managing diabetes mellitus with sparse scientific information. This study investigates the in vitro antioxidant potential of polyphenolic-rich extract of A heterophyllus stem bark as well as its antidiabetic activity in streptozotocin-induced diabetic rats. Fifty male Wistar rats were used with the induction of diabetes by a single intraperitoneal injection of streptozotocin (45 mg/kg body weight) and were orally administered 400 mg/kg free and bound phenols of A heterophyllus stem bark. The animals were sacrificed on the 28th day of the experiment using the cervical dislocation method; antihyperglycemia and anti-inflammatory parameters were subsequently assessed. The polyphenolic extracts demonstrated antioxidant potentials (such as hydrogen peroxide and diphenyl-1-picrylhydrazyl), as well as strong inhibitory activity against amylase and glucosidase. There was a significant ( P < .05) increase in glycogen, insulin concentration, pancreatic β-cell scores (HOMA-β), antioxidant enzymes and hexokinase activities, as well as glucose transporter concentration in diabetic animals administered the extracts and metformin. Also, a significant ( P < .05) reduction in fasting blood glucose, lipid peroxidation, glucose-6-phosphatase, and all anti-inflammatory parameters were observed in diabetic rats administered the extracts and metformin. The extracts demonstrated antidiabetic potential, which may be useful in the management of diabetes mellitus

Marcus Zulian Teixeira

Abstract Introduction In addition to the four pillars of homeopathy, vitalism and the miasmatic theory are often used to explain the health–disease process. According to Hahnemann's concepts, homeopathic miasms are the main obstacle to the cure of chronic diseases, with psora being the fundamental cause of all forms of diseases. According to modern genetics, the disease-promoting epigenetic alterations are the fundamental cause of the manifestation of chronic diseases. Objective This article develops a philosophical–scientific correlation between chronic miasms and disease-promoting epigenetic modifications, aiming to justify the isopathic use of auto-sarcode of an individual's DNA as homeopathic medicine. Results Based on the study of homeopathic doctrine and epigenetics, a conceptual and functional correlation is observed between homeopathic chronic miasms and disease-promoting epigenetic modifications. Additionally, several experimental studies suggest that homeopathy's mechanism of action may be by modulating gene expression. Conclusions By the philosophical–scientific correlations described, it is inferred that disease-promoting epigenetic alterations are the biological representation of the chronic miasms, suggesting the isopathic use of auto-sarcode of DNA as homeopathic therapeutic modulator of gene expression for the management of chronic diseases.

Bilińska Elżbieta, Buchwald Waldemar

Introduction: Fresh herbs of poison hemlock (Conii maculati herba) are used in homeopathy. The plant is also used in pharmacological and toxicological studies. There are few articles on seed germination capability in available literature.

Efe Obade, Omotayo B. Ilesanmi, Olamide Crown et al.

Abstract Background In the past few years, there has been a tremendous increase in the number of plant-based health supplements with respect to their safety and efficacy in diseases treatment and prevention. Solanum dasyphyllum, also known as Africa eggplant is ethnomedicinally used as an antivenom, pain reliever and anticonvulsant in various part of Nigeria, however, there is no scientific data to support some of these claims. Methods This study evaluated the protective effect of solvent fractions of Solanum dasyphyllum, hexane fraction of S. dasyphyllum (HFSD), dichloromethane fraction of S. dasyphyllum (DFSD), ethylacetate fraction of S. dasyphyllum (EAFSD), methanolic fraction of S. dasyphyllum (MFSD) and crude fraction of S. dasyphyllum (CFSD) on cyanide-induced oxidative stress and neurotoxicity in vitro in the cerebral cortex. Neuroprotective activities were evaluated by assaying for markers of oxidative stress, neurotoxicity and electron transport system enzymes via evaluating lipid peroxidation (LPO), protein carbonyl (PC), reduced glutathione (GSH), acetylcholinesterase (AChE), NADH-succinate dehydrogenase (NSD), NADH-cytochrome c reductase (NCR), and succinate-cytochrome c reductase (SCR) in the homogenate of cerebral cortex. Results The results showed that all solvent fractions of S. dasyphyllum significantly ameliorated cyanide-induced oxidative stress (P < 0.05). It inhibited the activity of acetylcholinesterase-HFSD (68.42 ± 5.37%), DFSD (36.32 ± 5.45%), EFA (20 ± 0.69%), MFSD (33.16 ± 4.8%) and CFSD (35.79 ± 2.8%), increased the activity of NSD [HFSD (94.74 ± 7.3%), EAFSD (78.95 ± 5.4%) and CFSD (60.53 ± 4.6%)], while DFSD (− 5.26 ± 1.4%) and MFSD (− 7.9 ± 0.4%) had a negative effect, increased the activity of NCR [HFSD (91.89 ± 7.1%), DFSD (90.54 ± 8.2%), EAFSD (62.16 ± 4.7%); MFSD (306.76 ± 7.2%) and CFSD (154.0 ± 8.1%)]. All the solvent fractions also significantly increased the activity of SCR [HFSD (70.59 ± 3.8%), EAFSD (58.82 ± 6.4%), MFSD (88.24 ± 9.0%) CFSD (76.47 ± 8.2%)] apart from DFSD (− 5.88 ± 1.2%) in rat cerebral cortex. Conclusion This result shows that S. dasyphyllum has neuroprotective activities, however HFSD shows the most potent bioactivities in maintaining mitochondria integrity by preserving the electron transport system. Further work can be done on isolating and characterizing the bioactive compound in HFSD for novel natural product in the treatment of neurological disorders.

R. Mathie, M. Van Wassenhoven, A. Rutten et al.

N. Samuels, Yakov Freed, R. Weitzen et al.

Background: Homeopathy has the potential to reduce symptoms related to cancer treatment. The present study examined the feasibility of a homeopathic consultation and treatment program, provided as part of an integrative oncology service. Methods: The electronic medical files of patients undergoing a homeopathic consultation in an integrative oncology service clinic were examined retrospectively. Adherence to the homeopathic treatment regimen and perceived response to the treatment were evaluated. Results: The files of 124 patient (34 males, 90 females) were examined, of which two-thirds reported acquiring and self-administering the homeopathic remedy as prescribed, and nearly three-quarters reporting a beneficial effect. Adherence to the homeopathic treatment regimen was greatest among patients attending a second visit, as opposed to having only telephone/e-mail follow-up (P < .005). An association was found between a perceived beneficial effect of treatment with attending a follow-up visit (P = .04), female gender (P = .02), younger age (P = .048), diagnosis of breast cancer (P = .014), and current radiation treatment (vs chemotherapy; P = .003). Patients reporting chemotherapy-induced peripheral neuropathy were also more likely to report a beneficial effect (P = .004), as were female patients reporting hot flashes (P = .005) and those referred by an oncologist (P = .046). No adverse effects were attributed to the homeopathic treatment. Conclusions: Homeopathy can be successfully incorporated within a supportive care integrative oncology service. In addition to demographic and cancer-related characteristics, as well as symptoms, patients attending a second visit (vs only telephone/e-mail follow-up) were more likely to adhere to and perceive a beneficial effect from the homeopathic regimen.

S. Cartwright

A systematic approach to the design of simple, chemical systems for investigating the nature of homeopathic medicines has led to the development of an experimental protocol in which solvatochromic dyes are used as molecular probes of serially diluted and agitated solutions. Electronic spectroscopy has been used to follow changes in the absorbance of this class of dyes across the visible spectrum in the presence of homeopathic potencies. Evidence is presented using six different solvatochromic dyes in three different solvent systems. In all cases homeopathic potencies produce consistent and reproducible changes in the spectra of the dyes. Results suggest that potencies influence the supramolecular chemistry of solvatochromic dyes, enhancing either dye aggregation or disaggregation, depending upon dye structure. Comparable dyes lacking the intramolecular charge transfer feature of solvatochromic dyes are unaffected by homeopathic potencies, suggesting potencies require the oscillating dipole of solvatochromic dyes for effective interaction. The implications of the results presented, both for an eventual understanding of the nature of homeopathic medicines and their mode of action, together with future directions for research in this area, are discussed.

Ali Karimi PhD, Mahmoud Rafieian-Kopaei PhD, Mohammad-Taghi Moradi PhD student et al.

This research was aimed to evaluate anti–herpes simplex virus type-1 (anti-HSV-1) activity of crude ethanol extract and 4 corresponding fractions of Quercus brantii acorn in vitro. Crude ethanol extract was prepared and subjected to fractionation with different polarity. Anti-HSV-1 activity was evaluated on baby hamster kidney cell line using MTT assay. The inhibitory effect of the plant materials on adsorption and/or post-adsorption stages of HSV-1 replication cycle were determined. Regression analysis was used to determine 50% inhibitory concentration and 50% cytotoxicity concentration, from which selective index was calculated. Based on our results, the chloroform fraction and the crude extract had the highest effect against HSV-1 with selectivity indices of 53.8 and 48.4, respectively. The n -hexane, n -butanol, and chloroform fractions inhibited HSV-1 replication in postadsorption stage ( P < .001). The results obtained indicated that the chloroform fraction of Q brantii acorn with high inhibitory effect against HSV-1 replication could be a new promising anti-HSV-1 agent.