Most of the celestial γ rays detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope originate from the interstellar medium when energetic cosmic rays interact with interstellar nucleons and photons. Conventional point-source and extended-source studies rely on the modeling of this diffuse emission for accurate characterization. Here, we describe the development of the Galactic Interstellar Emission Model (GIEM), which is the standard adopted by the LAT Collaboration and is publicly available. This model is based on a linear combination of maps for interstellar gas column density in Galactocentric annuli and for the inverse-Compton emission produced in the Galaxy. In the GIEM, we also include large-scale structures like Loop I and the Fermi bubbles. The measured gas emissivity spectra confirm that the cosmic-ray proton density decreases with Galactocentric distance beyond 5 kpc from the Galactic Center. The measurements also suggest a softening of the proton spectrum with Galactocentric distance. We observe that the Fermi bubbles have boundaries with a shape similar to a catenary at latitudes below 20° and we observe an enhanced emission toward their base extending in the north and south Galactic directions and located within ∼4° of the Galactic Center.
Abstract Background Conservation of resources theory (COR) establishes a link between resource loss and the stress response. The aim of this study was to assess the contribution of resource loss in the form of home damage and the choice of active or passive coping strategies to PTSD symptoms in survivors of the 2020 Petrinja (Croatia) earthquake. Methods A total of 374 adults (29.9% men) aged 18–64 years living in the counties surrounding the epicenter of the Petrinja (Croatia) earthquake participated in an online cross-sectional survey. The questionnaire included the PTSD Checklist for DSM-5 (PCL-5), the Coping Inventory, and the binary item assessing whether or not the participants' home was damaged. Results Hierarchical regression analysis showed that home damage was a significant predictor of PTSD symptoms. Participants whose homes were damaged by the earthquake were significantly more likely to use passive coping strategies, namely avoidance and emotional venting, and one active coping strategy, action, than those whose homes were spared. Finally, more frequent use of passive coping was associated with a higher risk of PTSD symptoms. Conclusions The study corroborates the COR theory link between resource loss and the stress response, as well as the general consensus that passive coping is a less adaptive strategy than active coping. In addition to passive coping, individuals who lacked resources may have been inclined to take some active steps because they either needed to repair or relocate their homes and because most buildings were only moderately to minimally damaged in the Petrinja earthquake.
The goal of the current study was to evaluate the effects of arachidonic acid, as a representative polyunsaturated fatty acid, on the viability of a Hep G2 cell line, which has been transduced to express human cytochrome P4502E1 (CYP2E1). Arachidonic acid produced a concentration- and time-dependent toxicity to Hep G2-MV2E1-9 cells, which express CYP2E1, but little or no toxicity was found with control Hep G2-MV-5 cells, which were infected with retrovirus lacking human CYP2E1 cDNA. In contrast to arachidonic acid, oleic acid was not toxic to the Hep G2-MV2E1-9 cells. The cytotoxicity of arachidonic acid appeared to involve a lipid peroxidation type of mechanism since toxicity was enhanced after depletion of cellular glutathione; formation of malondialdehyde and 4-hydroxy-2-nonenal was markedly elevated in the cells expressing CYP2E1, and toxicity was prevented by antioxidants such as α-tocopherol phosphate, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (trolox), propylgallate, ascorbate, and diphenylphenylenediamine, and the iron chelator desferrioxamine. Transfection of the Hep G2-MV2E1-9 cells with plasmid containing CYP2E1 in the sense orientation enhanced the arachidonic acid toxicity, whereas transfection with plasmid containing CYP2E1 in the antisense orientation decreased toxicity. The CYP2E1-dependent arachidonic acid toxicity appeared to involve apoptosis, as demonstrated by terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling and DNA laddering experiments. Trolox, which prevented toxicity of arachidonic acid, also prevented the apoptosis. Transfection with a plasmid containing bcl-2 resulted in complete protection against the CYP2E1-dependent arachidonic acid toxicity. It is proposed that elevated production of reactive oxygen intermediates by cells expressing CYP2E1 can cause lipid peroxidation, which subsequently promotes apoptosis and cell toxicity when the cells are enriched with polyunsaturated fatty acids such as arachidonic acid. The Hep G2-MV2E1-9 cells appear to be a valuable model to study interaction between CYP2E1, polyunsaturated fatty acids, reactive radicals, and the consequence of these interactions on cell viability and to reproduce several of the key features associated with ethanol hepatotoxicity in the intragastric infusion model of ethanol treatment.
V. V. Braguta, P. V. Buividovich, M. N. Chernodub
et al.
Using numerical simulations of quenched SU(2) gauge theory we demonstrate that an external magnetic field leads to spontaneous generation of quark condensates with quantum numbers of electrically charged rho mesons if the strength of the magnetic field exceeds the critical value eBc = 0.927(77) GeV^2 or Bc =(1.56 \pm 0.13) 10^{16} Tesla. The condensation of the charged rho mesons in strong magnetic field is a key feature of the magnetic-field-induced electromagnetic superconductivity of the vacuum.
P. V. Buividovich, T. Kalaydzhyan, M. I. Polikarpov
We study the effect of cooling on the spatial distribution of the topological charge density in quenched SU(2) lattice gauge theory with overlap fermions. We show that as the gauge field configurations are cooled, the Hausdorff dimension of regions where the topological charge is localized gradually changes from d = 2..3 towards the total space dimension. Therefore, the cooling procedure destroys some of the essential properties of the topological charge distribution.
P. V. Buividovich, M. N. Chernodub, D. E. Kharzeev
et al.
We study the correlator of two vector currents in quenched $SU\lr{2}$ lattice gauge theory with a chirally invariant lattice Dirac operator with a constant external magnetic field. It is found that in the confinement phase the correlator of the components of the current parallel to the magnetic field decays much slower than in the absence of a magnetic field, while for other components the correlation length slightly decreases. We apply the maximal entropy method to extract the corresponding spectral function. In the limit of zero frequency this spectral function yields the electric conductivity of the quenched theory. We find that in the confinement phase the external magnetic field induces nonzero electric conductivity along the direction of the field, transforming the system from an insulator into an anisotropic conductor. In the deconfinement phase the conductivity does not exhibit any sizable dependence on the magnetic field.
We propose a stochastic method for solving Schwinger-Dyson equations in large-N quantum field theories. Expectation values of single-trace operators are sampled by stationary probability distributions of the so-called nonlinear random processes. The set of all histories of such processes corresponds to the set of all planar diagrams in the perturbative expansions of the expectation values of singlet operators. We illustrate the method on the examples of the matrix-valued scalar field theory and the Weingarten model of random planar surfaces on the lattice. For theories with compact field variables, such as sigma-models or non-Abelian lattice gauge theories, the method does not converge in the physically most interesting weak-coupling limit. In this case one can absorb the divergences into a self-consistent redefinition of expansion parameters. Stochastic solution of the self-consistency conditions can be implemented as a "memory" of the random process, so that some parameters of the process are estimated from its previous history. We illustrate this idea on the example of two-dimensional O(N) sigma-model. Extension to non-Abelian lattice gauge theories is discussed.