Seesaw mechanism constrains from below mixing between active and sterile neutrinos for fixed sterile neutrino masses. Signal events associated with sterile neutrino decays inside a detector at fixed target experiment are suppressed by the mixing angle to the power of four. Therefore sensitivity of experiments such as SHiP and DUNE should take into account minimal possible values of the mixing angles. We extend the previous study of this subject arXiv:1312.2887 [hep-ph] to a more general case of non-zero CP-violating phases in the neutrino sector. Namely, we provide numerical estimate of minimal value of mixing angles between active neutrinos and two sterile neutrinos with the third sterile neutrino playing no noticeable role in the mixing. Thus we obtain a sensitivity needed to fully explore the seesaw type I mechanism for sterile neutrinos with masses below 2 GeV, that is relevant for the fixed-target experiments. Remarkably, we observe a strong dependence of this result on the lightest active neutrino mass and the neutrino mass hierarchy, not only on the values of CP-violating phases themselves. All these effects sum up to push the limit of experimental confirmation of sterile-active neutrino mixing by several orders of magnitude below the results of arXiv:1312.2887 [hep-ph] from $10^{-10}$ - $10^{-11}$ down to $10^{-12}$ and even to $10^{-20}$ in parts of parameter space; nonzero CP-violating phases are responsible for that.
Scott Mcdonald, Chun Shen, F. Fillion-Gourdeau
et al.
Abstract In this work we use the IP-Glasma+MUSIC+UrQMD framework to systematically study a wide range of hadronic flow observables at 2.76 TeV. In addition to the single particle spectra and anisotropic flow coefficients vn previously studied in [S. McDonald, C. Shen, F. Fillion-Gourdeau, S. Jeon and C. Gale, arXiv:1609.02958 [hep-ph] ], we consider event-plane correlations, non-linear response coefficients χnpq, and event shape engineering. Taken together, these observables provide a wealth of insight into the collective behavior of the QGP and initial state fluctuations. They shed light on flow fluctuations, flow at fixed system size but different initial geometries, as well as the non-linear hydrodynamic response to the initial state spatial eccentricities. By synthesizing this information we can gain further insight into the transport properties of the QGP as well as the fluctuation spectrum of the initial state.
Yersinia pestis genome sequencing projects have revealed six intact uncharacterized chaperone/usher systems with the potential to play roles in plague pathogenesis. We cloned each locus and expressed them in the Δfim Escherichia coli strain AAEC185 to test the assembled Y. pestis surface structures for various activities. Expression of each chaperone/usher locus gave rise to specific novel fibrillar structures on the surface of E. coli. One locus, y0561-0563, was able to mediate attachment to human epithelial cells (HEp-2) and human macrophages (THP-1) but not mouse macrophages (RAW264.7), while several loci were able to facilitate E. coli biofilm formation. When each chaperone/usher locus was deleted in Y. pestis, only deletion of the previously described pH 6 antigen (Psa) chaperone/usher system resulted in decreased adhesion and biofilm formation. Quantitative RT-PCR (qRT-PCR) revealed low expression levels for each novel chaperone/usher system in vitro as well as in mouse tissues following intravenous infection. However, a Y. pestis mutant in the chaperone/usher locus y1858-1862 was attenuated for virulence in mice via the intravenous route of infection, suggesting that expression of this locus is, at some stage, sufficient to affect the outcome of a plague infection. qRT-PCR experiments also indicated that expression of the chaperone/usher-dependent capsule locus, caf1, was influenced by oxygen availability and that the well-described chaperone/usher-dependent pilus, Psa, was strongly induced in minimal medium even at 28 °C rather than 37 °C, a temperature previously believed to be required for Psa expression. These data indicate several potential roles for the novel chaperone/usher systems of Y. pestis in pathogenesis and infection-related functions such as cell adhesion and biofilm formation.