Hasil untuk "math.GN"

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CrossRef Open Access 2022
Pan-Cancer Pyroptosis Analyses Identified Novel Immunology and Chemotherapy-Related Prognostic Signatures in Cancer Subtypes

Canrong Li, Cha Lin, Xiaoduo Xie

Despite mounting evidence linking pyroptotic cell death to tumor growth, the clinical significance and disease mechanism of pyroptosis in cancer remain uncertain. In this study, we established a unique gene signature (π signature) that can be used as a predictive and prognostic tool in pyroptosis-related cancer subtypes. We found that the 13 core pyroptosis genes exerted opposite prognostic effects in different cancer types, which were subgrouped as pyroptosis positively related cancer and pyroptosis negatively related cancer. Subsequently, π signature was identified separately from the hub genes in pyroptosis positively related cancer and pyroptosis negatively related cancer subtypes. It was shown that π signature was well correlated with patient survival, pathological stages, tumor lymphocyte infiltration, and immunotherapy response. π signature was also applied as a predictive tool for chemotherapy drug responses and used as an independent factor for patient overall survival prediction. In short, this elaborated genetic signature could help us understand the oncogenic mechanism and pave the way for further therapeutic strategies based on pyroptosis.

1 sitasi en
arXiv Open Access 2016
SPM Bulletin 40

Boaz Tsaban

This issue surveys some of the activities in the field since the previous issue, and announces a conference fully dedicated to the topic of selection principles.

en math.GN, math.LO
arXiv Open Access 2010
SPM Bulletin 30

Boaz Tsaban

This is the 30th issue of this bulletin, dedicated to mathematical selection principles and related areas. Now in a concise format.

en math.GN, math.LO

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