Hasil untuk "econ.GN"

Akhilesh Kumar Sharma, Sushil Kumar Rai

Canrong Li, Cha Lin, Xiaoduo Xie

Despite mounting evidence linking pyroptotic cell death to tumor growth, the clinical significance and disease mechanism of pyroptosis in cancer remain uncertain. In this study, we established a unique gene signature (π signature) that can be used as a predictive and prognostic tool in pyroptosis-related cancer subtypes. We found that the 13 core pyroptosis genes exerted opposite prognostic effects in different cancer types, which were subgrouped as pyroptosis positively related cancer and pyroptosis negatively related cancer. Subsequently, π signature was identified separately from the hub genes in pyroptosis positively related cancer and pyroptosis negatively related cancer subtypes. It was shown that π signature was well correlated with patient survival, pathological stages, tumor lymphocyte infiltration, and immunotherapy response. π signature was also applied as a predictive tool for chemotherapy drug responses and used as an independent factor for patient overall survival prediction. In short, this elaborated genetic signature could help us understand the oncogenic mechanism and pave the way for further therapeutic strategies based on pyroptosis.

Nix Barnett, James P. Crutchfield

Ling Qin, Xixiao Ma, Lülin Kuang et al.

Walter Vogels

Alfred Marx

Abstract The present note argues that, as formerly mostly accepted, the P account of the creation ends in Gn 2,4a.

GN Prabhakara

GN Prabhakara

Joseph de Joannis

Véronique Isenmann

GN Prabhakara

GN Prabhakara

GN Prabhakara

GN Prabhakara

GN Prabhakara

GN Prabhakara

GN Prabhakara