Anna Luiza Vidal França, Carolina Longo, Edward Araujo Júnior
et al.
Congenital cystic adenomatoid malformation (CCAM) is a rare fetal lung anomaly characterized by benign multicystic masses that can lead to severe complications, such as pulmonary hypoplasia, fetal hydrops, and neonatal death. This literature review examines current knowledge on antenatal therapies for CCAM, focusing on pharmacological, procedural, and surgical interventions. Betamethasone, the first-line pharmacological treatment, has shown efficacy in reducing lesion size and resolving hydrops, particularly in microcystic CCAM. Procedural options, such as thoracoamniotic shunting, are effective for macrocystic lesions but carry risks including preterm labor and thoracic deformities. Open fetal surgery remains a last-resort intervention for severe cases, while emerging techniques, like percutaneous laser ablation and sclerotherapy, offer promising minimally invasive alternatives. A proposed treatment algorithm emphasizes individualized care based on lesion type, gestational age, and the presence of complications. The authors searched the US National Library of Medicine Database, Google Scholar, and PubMed Central to gather information on antenatal therapies for CCAM. This review emphasizes that, despite significant advancements, considerable challenges persist, underscoring the need for prospective studies to refine therapeutic protocols and assess long-term outcomes.
Alyssa R. Hersh, Alexandra C. Gallagher, Lucy Ward
et al.
Abstract Objective Current guidance recommends universal screening with a postpartum oral glucose tolerance testing (OGTT) 4–12 weeks following delivery among pregnancies complicated by gestational diabetes mellitus (GDM) to identify or assess risk for prediabetes and type 2 diabetes (T2D). Continuous glucose monitoring (CGM) is not currently a tool for screening for T2D among pregnant or postpartum people. Our objective was to assess CGM data during the postpartum OGTT. Methods This was a secondary analysis of a trial that randomized people with GDM to CGM versus capillary blood glucose (CBG). Participants were included if CGM data were available during their OGTT. Our primary outcome was mean glucose during the postpartum OGTT (75 g 2‐h challenge), comparing those with dysglycemia on OGTT (fasting ≥100 mg/dL and/or 2‐h ≥140 mg/dL) to normal OGTT results. Results A total of 51 patients met the inclusion criteria for this secondary analysis. Mean CGM glucoses were higher at all time points for those with dysglycemia compared with a normal OGTT result. Among those with dysglycemia, the mean fasting plasma glucose was 104.3 ± 10.5 and the mean 2‐h plasma glucose was 129.9 ± 37.5. For those with normal OGTT results, the mean fasting plasma glucose was 89.8 ± 5.2 and the mean 2‐h plasma glucose was 103.5 ± 17.9. When stratified by GDM type, mean CGM glucose was similar between groups. Conclusion In this study, we found that glucose measured by CGM follows the expected curve in response to the postpartum OGTT among individuals with pregnancies complicated by GDM. Those with dysglycemia had higher mean CGM glucose at all time points assessed. Future studies will need to assess the role of CGM in risk stratifying those with dysglycemia postpartum without an OGTT.
The objective of this study was to determine the relationship between the prevalence of high-risk human papillomavirus (HRHPV) and age in women with cervical neoplasia or cervical cancer. This retrospective study involved 470 women referred for abnormal cervical cytology between January 2021 and December 2023. The Cobas 4800 test was used to identify HRHPV genotypes; it specifically identified genotypes 16 and 18 and grouped the other high-risk genotypes into another category. The Cobas 4800 test was performed together with colposcopy and biopsies of cervical lesions. From the analysis, we selected 470 women who underwent cervical biopsies and HPV testing. Of them, 208 (44.3%) were HPV-negative. Among the 262 women positive for HPV, 13.0% were positive for genotype 16 only, 1.3% for genotype 18 only, and 35.1% for other HPV genotypes. HPV-16 was found in 58.3% of cases of cervical intraepithelial neoplasia grade 3 (CIN 3) in women under 35 years of age and in 20.9% of cases in women over 35 years of age. Furthermore, 51.9% of patients with cervical cancer tested positive for other high-risk HPV types, whereas 30.8% had HPV-16. Although other HPV genotypes were more frequent than HPV-16 and HPV-18 in individuals with cervical cancer, HPV-16 was the most common individual high-risk genotype in women ≥ 35 years of age with CIN-3.
Andrea Johana Carmenes-Carrasco, Bertha Aurora Landa-Maturrano
Objetivo: Establecer los factores asociados al embarazo reincidente en adolescentes atendidas en un hospital público del Perú, 2021-2022. Materiales y Métodos: Estudio de enfoque cuantitativo, observacional, analítico transversal. Se obtuvo información de las historias clínicas de todas las gestantes adolescentes (N=252) atendidas en un hospital público de atención médica general. Se evaluaron factores sociodemográficos, familiares y gineco-obstétricos de las adolescentes. El estudio fue aprobado por el comité de ética hospitalario y la asociación se determinó mediante la prueba de Regresión de Poisson. Resultados: El 16.67% de las gestantes presentó embarazo recurrente durante el 2021 y 2022, siendo 20.67% y 10.78%, respectivamente. Se identificó que estar casada (p<0.001; RPa:0.06), residir solo con una hermana (p<0.001; RPa:0.032) y tener una edad más avanzada en primer embarazo (p<0.001; RPa:0.41) fueron factores que reducen la probabilidad del embarazo recurrente, por otro lado, presentar al menos un antecedente de un aborto (p<0.001; RPa:4.49) incrementa la probabilidad de un embarazo recurrente. Conclusión: Se identificaron factores sociodemográficos, familiares y gineco- obstétricos que se asocian con la reincidencia del embarazo en las adolescentes atendidas en un hospital público del Perú.
Background Uterine contractions may interfere with embryo implantation in assisted reproductive technology. To reduce these contractions and improve success rates, the oxytocin antagonist atosiban has been suggested for administration during embryo transfer. The aim of this study is to evaluate the effectiveness of atosiban in increasing live birth rates among women who have previously experienced a single implantation failure and are scheduled for single blastocyst transfer.Methods and analysis We conduct a single-centre randomised controlled study comparing atosiban and placebo in women undergoing a single blastocyst transfer with a previous failed blastocyst transfer. Women with endocrine or systemic illnesses, recurrent miscarriages, uterine malformations or fibroids, untreated hydrosalpinx, endometriosis (stage III or IV) or uterine fibroids, as well as women undergoing preimplantation genetic testing, are ineligible. The primary outcome is live birth resulting from the frozen-thawed embryo transfer. Secondary outcomes include biochemical/clinical pregnancy, miscarriage, ectopic pregnancy, multiple pregnancies as well as maternal and perinatal outcomes. We plan to recruit 1100 women (550 women per group). This will allow us to demonstrate or refute an increase in live birth rate from 40% to 50%. Data analysis will follow the intention-to-treat principle. We will measure patterns of uterine peristalsis which will allow subgroup analysis for women with or without uterine peristalsis.Ethics and dissemination This study has been approved by the Institutional Review Board of Northwest Women’s and Children’s Hospital (No. SZ2019001). Written informed consent will be obtained from each participant before randomisation. The results of the trial will be presented at scientific meetings and reported in publications.Trial registration number ChiCTR1900022333.
Cervical intraepithelial neoplasia (CIN) is a precancerous condition inducing local lesions on the surface of the squamocolumnar junction of the cervix. Despite the role of vaginal microbiota having been under-discussed, the role of the cervical microbiome and the microbial migration across the reproductive tract involved in CIN was limitedly studied. We aimed to synchronously characterize the dysbiosis associated with CIN in both the cervix and vagina in a Chinese population. Profiling of cervical and vaginal microbiota from 60 CIN women and 60 healthy women was conducted. 16S rRNA sequencing was adopted. By comparing the microbial profiles between different parts of the reproductive tract, our results demonstrated an increased shift of microbial diversity in the cervix compared with that in the vagina for the CIN patients, specifically in CIN 1. Less dysbiosis was found between the CIN patients and controls, in either the vagina or cervix. The microbial community may be modulated by the onset of sexual activity, a known clinical risk factor for cervical neoplasia. Distinct patterns of perturbated bacteria were found in the vaginal and cervical microbiota, in which reduced Actinobacteria-related operational taxonomic units (OTUs) and increased Proteobacteria-related OTUs were found in the vagina and cervix, respectively. A good agreement between the direction of the top-significant perturbated OTUs was observed between the vaginal and cervical microbiome, suggesting a potential microbial migration in the reproductive tract. Enriched genera such as Sphingomonas and Stenotrophomonas were found in cervical microbiota-associated CIN. Multivariate analysis revealed Comamonas, Rhizobium, and Pseudomonas as independent genera contributing to CIN in the cervix. In summary, this study revealed the perturbation of microbiota in the presence of CIN and demonstrated a distinct pattern of characteristic bacteria community between the vagina and cervix involved in the development of CIN.
Antioxidant proteins can not only balance the oxidative stress in the body, but are also an important component of antioxidant drugs. Accurate identification of antioxidant proteins is essential to help humans fight diseases and develop new drugs. In this paper, we developed a friendly method AOPM to identify antioxidant proteins. 188D and the Composition of k-spaced Amino Acid Pairs were adopted as the feature extraction method. In addition, the Max-Relevance-Max-Distance algorithm (MRMD) and random forest were the feature selection and classifier, respectively. We used 5-folds cross-validation and independent test dataset to evaluate our model. On the test dataset, AOPM presented a higher performance compared with the state-of-the-art methods. The sensitivity, specificity, accuracy, Matthew’s Correlation Coefficient and an Area Under the Curve reached 87.3, 94.2, 92.0%, 0.815 and 0.972, respectively. In addition, AOPM still has excellent performance in predicting the catalytic enzymes of antioxidant drugs. This work proved the feasibility of virtual drug screening based on sequence information and provided new ideas and solutions for drug development.
Restuaji B.K. Umam, Nur I. Purnamasari, I Putu Sudayasa
et al.
Objectives: To analyze the correlation between sociodemographic factors and cesarean section delivery at Referral Hospital in Kendari.
Method: This was a cross-sectional study conducted at dr. Ismoyo Hospital in Kendari. Data were obtained from medical records of cesarean section delivery from January to December 2019. Sampling used simple random sampling techniques. Data were analyzed using the Chi-square test.
Result: There were 50.5% emergency cesarean and 49.5% elective cesarean. The maternal age was 18-44 years. Most cases are aged 20-35 years (78.5%), have a higher education level (65.1%), employees (53.2%), and multipara (56.5%). There was a correlation between age and cesarean section (p = 0.027). There was no correlation between education level (p = 0.618), occupation (p = 0.563), and parity (p = 0.365) with cesarean section.
Conclusion: There is a correlation between maternal age and cesarean section. Education, counseling, and antenatal care should be done for early detection.
Keywords: age, cesarean section, education level, occupation, parity
Maria Jose Soriano, Inmaculada Molina Botella, Sara Sadeghi
et al.
Context: Some vaginal lubricants and ultrasound gels are known to be detrimental to sperm function and therefore could negatively affect fertility. Aims: The aim of the current study was to develop a sperm motility index (SMI) to test the sperm toxicity of ultrasound gels and vaginal lubricants used in reproductive medicine. Settings and Design: Two ultrasound gels (Aquasonic® and Kefus®) and five vaginal lubricants (Vaginesil™, Velastisa®, K-Y Jelly®, Control®, and Durex®) were studied. Three different concentrations (1%, 5%, and 10%) of each lubricant were tested. Subjects and Methods: SMI was calculated dividing the percentage of progressively motile sperm in each tested gel by that in the control at 0.5, 1, 2, and 24 h of incubation at 5% of CO2 and 37°C. SMI values <0.75 indicate sperm toxicity. Statistical Analysis Used: The main outcome measured was SMI for each concentration and time of incubation. Results: Only Durex® did not show any deleterious effect on sperm quality. The rest of lubricants presented different degrees of toxicity. Vaginesil™ resulted in toxic for all concentrations and incubation periods (SMI < 0.12). Control® and Velastisa® presented toxicity at 10% after 2 h, while K-Y Jelly® showed toxicity at 10% from 1 h of incubation. Regarding ultrasound gels, Aquasonic® showed toxic effects after only 0.5 h (SMI = 0.70 ± 0.15), while Kefus® showed slightly toxic effects after 2 h (SMI 0.69 ± 0.07). Conclusions: SMI is an accurate tool to evaluate sperm toxicity. One of the main strengths of the article is the inclusion of representative semen samples and known products used worldwide. This study has a relevant clinical translation since it highlights the importance of evaluating the possible sperm toxicity of simple products used in reproductive medicine.
Abstract Background Sudden cardiac arrest during spinal anesthesia is a rare event. However, its management by an unprepared team is difficult and carries poor outcomes. Hypoglycemia as the cause of sudden cardiac arrest is rarely reported. This case illustrates lifesaving procedures for sudden cardiac arrest secondary to hypoglycemia during cesarean delivery under spinal anesthesia. Case summary We report a case, from rural Ethiopia of sudden cardiac arrest secondary to hypoglycemia during cesarean delivery under spinal anesthesia. The case was successfully managed by a team of anesthetists and other operating teams. The mother and newborn were discharged from the hospital on the 7th postoperative day. Conclusion Hypoglycemia during cesarean delivery under spinal anesthesia can cause sudden cardiac arrest. Therefore, identifying patients at risk of developing hypoglycemia, monitoring the patient’s condition, and initiating prompt intervention at the first sign of cardiovascular instability is advisable. Determining serum blood glucose levels at admission to the labor ward and monitoring blood glucose levels during spinal anesthesia should be routine practices.
Abstract Background In developing countries, 20,000 under 18 children give birth every day. In Ethiopia, teenage pregnancy is high with Afar and Somalia regions having the largest share. Even though teenage pregnancy has bad maternal and child health consequences, to date there is limited evidence on its spatial distribution and driving factors. Therefore, this study is aimed to assess the spatial distribution and spatial determinates of teenage pregnancy in Ethiopia. Methods A secondary data analysis was conducted using 2016 EDHS data. A total weighted sample of 3381 teenagers was included. The spatial clustering of teenage pregnancy was priorly explored by using hotspot analysis and spatial scanning statistics to indicate geographical risk areas of teenage pregnancy. Besides spatial modeling was conducted by applying Ordinary least squares regression and geographically weighted regression to determine factors explaining the geographic variation of teenage pregnancy. Result Based on the findings of exploratory analysis the high-risk areas of teenage pregnancy were observed in the Somali, Afar, Oromia, and Hareri regions. Women with primary education, being in the household with a poorer wealth quintile using none of the contraceptive methods and using traditional contraceptive methods were significant spatial determinates of the spatial variation of teenage pregnancy in Ethiopia. Conclusion geographic areas where a high proportion of women didn’t use any type of contraceptive methods, use traditional contraceptive methods, and from households with poor wealth quintile had increased risk of teenage pregnancy. Whereas, those areas with a higher proportion of women with secondary education had a decreased risk of teenage pregnancy. The detailed maps of hotspots of teenage pregnancy and its predictors had supreme importance to policymakers for the design and implementation of adolescent targeted programs.
Gynecology and obstetrics, Public aspects of medicine
Aaminah Hanif, Tariq Sarfraz, Humaira Tariq
et al.
Objective: To determine the utility of Syndecan–1 (CD138) in the diagnosis of Chronic endometritis in patients with Abnormal Uterine Bleeding.
Study Design: Cross-sectional study.
Place and Duration: The study was carried out in department of Pathology, Army Medical College, Rawalpindi in collaboration with the department of Obstetrics & Gynecology, Pak Emirates Military Hospital (PEMH), Rawalpindi. The study duration was from Jan 2018 to Oct 2018.
Methodology: A total of one hundred endometrial biopsies of patients with clinical or histological suspicion of chronic endometritis were taken. Hematoxylin and Eosin (H & E) stain was performed on all the biopsies and a diagnosis was made. Later on, Syndecan-1 was applied on all the biopsies and an immunohistochemical diagnosis was made. Both the diagnoses were then compared and analyzed.
Results: Mean age of the study participants was 43.67 ± 8.95 years, with a range of 23-70 years. Out of 100 biopsies, forty-five cases (45%) were diagnosed as Chronic endometritis on H & E, while fifty-five cases (55%) were not showing Chronic endometritis and were diagnosed as disordered proliferative endometrium (DPE). On application of Syndecan-1 (CD 138), it was seen that these 19 out of 45 cases, diagnosed as Chronic endometritis on H & E were actually over-diagnosed and didn’t show plasma cells. Out of 55 cases which were negative for Chronic endometritis, 15 cases were underdiagnosed as they showed plasma cells with immunohistochemistry application (Syndecan-1).
Conclusion: In cases suspected as Chronic endometritis, no plasma cells were clearly visible on H & E staining, Sydnecan-1 helps identifying plasma cells easily.
Maryam Musavinasab, Maryam Ravanipour, Shahnaz Pouladi
et al.
Background: Chronic diseases and functional decline can affect empowerment among the elderly in the lifestyle management to benefit from social support. Aim: The aim of the present study was to determine the psychometric properties of Social Support Questionnaire to measure empowerment in elderly patients with cardiovascular disease in Iran. Method: This study was conducted on 250 elderly patients with cardiovascular disease referring to the medical centers of Bushehr city, Iran, using the convenience sampling method. Results: Content validity index and content validity ratio were calculated as 0.94 and 0.96 respectively. Based on the exploratory factor analysis, the number of the questionnaire items was reduced to 23 items. Empowerment was classified under seven factors. The internal and external reliabilities of the questionnaire were estimated as 0.85 and 0.83, respectively. Implications for Practice: The final questionnaire had appropriate psychometric properties and strength of factor structure. Therefore, this tool can be used by the healthcare providers in the health care systems of Iran.
Berdasarkan sekian banyak alat kontrasepsi yang beredar di masyarakat alat kontrasespsi yang paling populer di Indonesia adalah kontrasepsi suntik. Kontrasepsi suntik adalah alat kontrasepsi yang berupa cairan yang berisikan hormon progesterone atau hormon estrogen yang di suntikkan ke bokong atau otot panggul secara IM (Intra Muscular) setiap 3 bulan atau 1 bulan sekali. Tujuan penelitian ini untuk mengetahui tingkat pendidikan ibu dengan pemilihan alat kontrasepsi KB suntik di Puskesmas Gunung Samarinda Balikpapan tahun 2017. Jenis penelitian ini menggunakan metode deskriptif analitik dengan rancangan penelitian cross sectional. Teknik pengambilan sampel menggunakan Accidental Sampling dengan jumlah sampel 92 responden yang menggunkan alat kontrasepsi KB. Teknik pengambilan data menggunakan wawancara. Teknik analisa data menggunakan analisa univariat dengan distribusi frekuensi dan analisa bivariat dengan uji statistic Chi Square (c2) pada taraf signifikan a 0,05. Hasil penelitian ini sebanyak 46 orang (50%) tingkat pendidikan rendah, sebanyak 75 orang (81,5%) memilih akseptor KB suntik, dan ada hubungan yang signifikan antara tingkat pendidikan ibu dengan pemilihan alat kontrasepsi KB suntik Pvalue = 0,001 <a = 0,05 danc2hitung > c2tabel (13,291 > 5,991). Berdasarkan hasil penelitian diatas dapat disimpulkan bahwa ada Hubungan Tingkat Pendidikan Ibu dengan Pemilihan Alat Kontrasepsi KB Suntik di Puskesmas Gunung Samarinda Balikpapan Tahun 2017. Saran bagi Puskesmas Gunung Samarinda diharapkan dapat membuat program bimbingan, dan konseling dimana PUS diberikan penyuluhan terlebih dahulu dalam menetapkan pilihan alat kontrasepsi yang tepat dan sesuai dengan keadaan dirinya. Dan bagi responden agar mampu meningkatkan informasi dan wawasan tentang alat kontrasepsi dengan cara bertanya pada tenaga kesehatan, membaca buku dan sebagainya sehingga ibu mengetahui apa saja alat kontrasepsi.
Jennifer Huberty, Jeni Matthews, Jenn Leiferman
et al.
Abstract Background In the USA, stillbirth (in utero fetal death ≥20 weeks gestation) is a major public health issue. Women who experience stillbirth, compared to women with live birth, have a nearly sevenfold increased risk of a positive screen for post-traumatic stress disorder (PTSD) and a fourfold increased risk of depressive symptoms. Because the majority of women who have experienced the death of their baby become pregnant within 12–18 months and the lack of intervention studies conducted within this population, novel approaches targeting physical and mental health, specific to the needs of this population, are critical. Evidence suggests that yoga is efficacious, safe, acceptable, and cost-effective for improving mental health in a variety of populations, including pregnant and postpartum women. To date, there are no known studies examining online-streaming yoga as a strategy to help mothers cope with PTSD symptoms after stillbirth. Methods The present study is a two-phase randomized controlled trial. Phase 1 will involve (1) an iterative design process to develop the online yoga prescription for phase 2 and (2) qualitative interviews to identify cultural barriers to recruitment in non-Caucasian women (i.e., predominately Hispanic and/or African American) who have experienced stillbirth (N = 5). Phase 2 is a three-group randomized feasibility trial with assessments at baseline, and at 12 and 20 weeks post-intervention. Ninety women who have experienced a stillbirth within 6 weeks to 24 months will be randomized into one of the following three arms for 12 weeks: (1) intervention low dose (LD) = 60 min/week online-streaming yoga (n = 30), (2) intervention moderate dose (MD) = 150 min/week online-streaming yoga (n = 30), or (3) stretch and tone control (STC) group = 60 min/week of stretching/toning exercises (n = 30). Discussion This study will explore the feasibility and acceptability of a 12-week, home-based, online-streamed yoga intervention, with varying doses among mothers after a stillbirth. If feasible, the findings from this study will inform a full-scale trial to determine the effectiveness of home-based online-streamed yoga to improve PTSD. Long-term, health care providers could use online yoga as a non-pharmaceutical, inexpensive resource for stillbirth aftercare. Trial registration NCT02925481
Purpose: To evaluate the accuracy of axillary ultrasound (AUS) in detecting nodal metastasis in patients with early-stage breast cancer and to identify AUS features with high predictive power.
Materials and Methods: Prospective single-center preliminary study in 105 patients with a primary diagnosis of breast cancer and clinically negative axilla. AUS was performed using a 12 MHz linear-array transducer before ultrasound-guided needle biopsy. Nodal characteristics (shape, longitudinal-transverse [LT] axis ratio, margins, cortical thickness, hyperechoic hilum) were correlated with histopathological nodal status after SLNB or axillary lymph node dissection (ALND).
Results: Nodal metastases were present in 42/105 patients (40.0%). Univariate analyses showed that absence of hyperechoic hilum, round shape, LT axis ratio<2, sharp margins and cortical thickness>3 mm were associated with lymph node metastasis. Multivariate logistic regression analysis revealed cortical thickness > 3 mm as an independent predictive parameter for nodal involvement. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 66.7, 74.6, 63.6, 77.0% and 71.4% respectively when cortical thickness > 3 mm was applied as the criterion for AUS positivity. Axillary tumor volume was low in patients with pT1/2 tumors and negative AUS, since only 3.2% of patients had > 2 metastatic lymph nodes.
Conclusion: Cortical thickness>3 mm is a reliable predictor of nodal metastatic involvement. Negative AUS does not exclude lymph node metastases, but extensive axillary tumor volume is rare.
Medicine, Medical physics. Medical radiology. Nuclear medicine
Ana C. Gómez-Ríos, Mauricio E. Carrillo-Rozo, Jorge A. Rodríguez-Ortiz
Objetivo: describir la morbilidad y mortalidad materna y perinatal asociadas a la infección por VIH en el Hospital Simón Bolívar entre el año 2003 y el 2011. Materiales y métodos: estudio descriptivo de cohorte histórica. Se incluyeron pacientes gestantes con diagnóstico confirmado de infección por VIH que asistieron al control prenatal y a quienes se les atendió el parto y el puerperio entre enero de 2003 y diciembre de 2011, en el Hospital Simón Bolívar, institución de tercer nivel de complejidad, centro de referencia para pacientes con VIH, ubicado en el noroccidente de Bogotá. Se realizó muestreo consecutivo y se evaluaron las características sociodemográficas y clínicas basales, y la morbilidad materna durante la gestación, al momento del parto o el puerperio, como también la morbilidad perinatal. Se realizó análisis descriptivo de la morbilidad por medio de proporciones y análisis exploratorio de la asociación entre el recuento de linfocitos CD4 y la carga viral con los resultados maternos y perinatales. Resultados: un total de 136 pacientes tenían diagnóstico de VIH confirmado en la institución, de estas se obtuvo información completa en 106 (78 %). No hubo ningún caso de muerte materna y se presentaron 2 casos de muerte fetal in utero. Las principales comorbilidades maternas encontradas fueron anemia (18 %), ETS (22,6 %), neumonía (5,7 %) y fiebre puerperal (4,7 %). Las comorbilidades perinatales más frecuentes fueron bajo peso al nacer (21,7 %) y convulsiones (2,8 %). No se encontró asociación entre la carga viral y el recuento CD4 con la morbilidad materna o perinatal. Conclusión: la paciente gestante con infección por VIH presenta en general un ligero aumento de las complicaciones maternas y perinatales. Es importante realizar nuevos estudios en los diferentes grupos poblacionales para poder valorar adecuadamente todas estas asociaciones.
Ernesto Perucca P, Moisés León V, Sylvia Márquez C
et al.
Se estima que en Chile, hasta marzo de 2008 se han efectuado 637 trasplantes hepáticos ortotópicos (THO), siendo la principal causa la cirrosis hepática. Según estadísticas norteamericanas, en el año 2006 existían 3000 mujeres con THO en edad reproductiva. Presentamos el caso de una paciente de 25 años, trasplantada hepática hace 6 años, en terapia inmunosupresora, con buen resultado materno-perinatal.<br>Until March 2008, Chile had 637 orthotopic liver transplantation (OLT), the main cause was liver cirrhosis. According to US statistics, in 2006 there were 3000 women of reproductive age with OLT. We report a 25-year-old, liver transplant six years ago in immunosuppressive therapy, with good maternal and perinatal outcome.