Hasil untuk "Medicine"

D. Armstrong

A. Diplock

S. Jain

B. Ritchie, G. Harrison, L. Harrison et al.

D. Cutler, M. McClellan

N. Sanvicens, M.-Pilar Marco

M. Abdollahi, K. Abe, T. Abo et al.

We thank the scientists and scholars listed here who have given anonymously of their time in order to make CAM more rigorous. Without your astute comments, an evidence base for CAM would remain a dream. We have starred the names of those who have demonstrated great support in reviewing five or more papers.

A. Roses

L. Rodrigues, I. Banat, José Teixeira et al.

B. Patwardhan, Dnyaneshwar Warude, P. Pushpangadan et al.

Ayurveda, the traditional Indian medicine (TIM) and traditional Chinese medicine (TCM) remain the most ancient yet living traditions. There has been increased global interest in traditional medicine. Efforts to monitor and regulate herbal drugs and traditional medicine are underway. China has been successful in promoting its therapies with more research and science-based approach, while Ayurveda still needs more extensive scientific research and evidence base. This review gives an overview of basic principles and commonalities of TIM and TCM and discusses key determinants of success, which these great traditions need to address to compete in global markets.

G. Hanks, N. Cherny, N. Christakis et al.

E. Lillie, B. Patay, J. Diamant et al.

Lynda Chin, Lynda Chin, Jannik N Andersen et al.

Michael Januszyk, G. Gurtner

L. Hood, Mauricio Flores

Wenying Liu, S. Thomopoulos, Younan Xia

Keer Lu, Zheng Liang, Da Pan et al.

Large Language Models (LLMs) have exhibited remarkable capabilities in clinical scenarios. Despite their potential, existing works face challenges when applying LLMs to medical settings. Strategies relying on training with medical datasets are highly cost-intensive and may suffer from outdated training data. Leveraging external knowledge bases is a suitable alternative, yet it faces obstacles such as limited retrieval precision and poor effectiveness in answer extraction. These issues collectively prevent LLMs from demonstrating the expected level of proficiency in mastering medical expertise. To address these challenges, we introduce Med-R^2, a novel LLM physician framework that adheres to the Evidence-Based Medicine (EBM) process, efficiently integrating retrieval mechanisms as well as the selection and reasoning processes of evidence, thereby enhancing the problem-solving capabilities of LLMs in healthcare scenarios and fostering a trustworthy LLM physician. Our comprehensive experiments indicate that Med-R^2 achieves a 13.27\% improvement over vanilla RAG methods and even a 4.55\% enhancement compared to fine-tuning strategies, without incurring additional training costs. Furthermore, we find that our LLaMA3.1-70B + Med-R$^2$ surpasses frontier models, including GPT-4o, Claude3.5-Sonnet and DeepSeek-V3 by 1.05\%, 6.14\% and 1.91\%. Med-R$^2$ effectively enhances the capabilities of LLMs in the medical domain.

Xinhan Zheng, Huyu Wu, Ruotai Li et al.

Traditional Chinese medicine (TCM) exhibits remarkable therapeutic efficacy in disease treatment and healthcare through patienti-specific formulas. However, current AI-based TCM formula recommendation models and methods mainly focus on data-based textual associations between symptoms and herbs, and have not fully utilized their features and relations at different scales, especially at the molecular scale. To address these limitations, we propose the Fusion of Multiscale Associations of Symptoms and Herbs (FMASH), an novel framework that effectively combines molecular-scale features and macroscopic properties of herbs with clinical symptoms, and provides the refined representation of their multiscale associations, enhancing the effectiveness of TCM formula recommendation. This framework can integrate molecular-scale chemical features and macroscopic properties of herbs, and capture complex local and global relations in the heterogeneous graph of symptoms and herbs, providing the effective embedding representation of their multiscale features and associations in a unified semantic space. Based on the refined feature representation, the framework is not only compatible with both traditional unordered formula recommendation task and the ordered herb sequence generation task, but also improves model's performance in both tasks. Comprehensive evaluations demonstrate FMASH's superior performance on the TCM formula recommendation over the state-of-the-art (SOTA) baseline, achieving relative improvements of 9.45\% in Precision@5, 12.11% in Recall@5, and 11.01% in F1@5 compared to the SOTA model on benchmark datasets. This work facilitates the practical application of AI-based TCM formula recommendation system.

Xiaoyang Wang, Christopher C. Yang

The rapid growth of healthcare data and advances in computational power have accelerated the adoption of artificial intelligence (AI) in medicine. However, AI systems deployed without explicit fairness considerations risk exacerbating existing healthcare disparities, potentially leading to inequitable resource allocation and diagnostic disparities across demographic subgroups. To address this challenge, we propose FairGrad, a novel gradient reconciliation framework that automatically balances predictive performance and multi-attribute fairness optimization in healthcare AI models. Our method resolves conflicting optimization objectives by projecting each gradient vector onto the orthogonal plane of the others, thereby regularizing the optimization trajectory to ensure equitable consideration of all objectives. Evaluated on diverse real-world healthcare datasets and predictive tasks - including Substance Use Disorder (SUD) treatment and sepsis mortality - FairGrad achieved statistically significant improvements in multi-attribute fairness metrics (e.g., equalized odds) while maintaining competitive predictive accuracy. These results demonstrate the viability of harmonizing fairness and utility in mission-critical medical AI applications.

Rui Yang, Matthew Yu Heng Wong, Huitao Li et al.

The rapid growth of medical knowledge and increasing complexity of clinical practice pose challenges. In this context, large language models (LLMs) have demonstrated value; however, inherent limitations remain. Retrieval-augmented generation (RAG) technologies show potential to enhance their clinical applicability. This study reviewed RAG applications in medicine. We found that research primarily relied on publicly available data, with limited application in private data. For retrieval, approaches commonly relied on English-centric embedding models, while LLMs were mostly generic, with limited use of medical-specific LLMs. For evaluation, automated metrics evaluated generation quality and task performance, whereas human evaluation focused on accuracy, completeness, relevance, and fluency, with insufficient attention to bias and safety. RAG applications were concentrated on question answering, report generation, text summarization, and information extraction. Overall, medical RAG remains at an early stage, requiring advances in clinical validation, cross-linguistic adaptation, and support for low-resource settings to enable trustworthy and responsible global use.