Hasil untuk "Homeopathy"

E. Silva, D. Madsen

This article investigates the popularity of Integrative and Complementary Health Practices by analyzing internet search behavior during distinct periods. The objective was to examine the public’s interest in searching for these practices before and during the covid-19 pandemic in Brazil, using data from Google Trends. Quantitative digital analysis methods were applied to assess the relative volume of searches in 2019 and 2020. Subsequently, a paired t-test was conducted to identify significant differences in search activity. The practices that showed an increase in average search volume were ayurveda, phytotherapy, medicinal plants, chiropractic, and yoga. In contrast, acupuncture, homeopathy, meditation, osteopathy, ozone therapy, and reiki showed a decrease. The study reveals that internet users expressed interest in these approaches, with variations depending on the specific modality. Among them, yoga stood out with a significant increase, suggesting heightened relevance during the pandemic period.

M. Frass, R. Strassl, H. Friehs et al.

M. Angell, J. Kassirer

C. Lamba, V. Gupta, R. van Haselen et al.

Abstract Objectives The objective of this study was to establish the reliability and content validity of the “Modified Naranjo Criteria for Homeopathy—Causal Attribution Inventory” as a tool for attributing a causal relationship between the homeopathic intervention and outcome in clinical case reports. Methods Purposive sampling was adopted for the selection of information-rich case reports using pre-defined criteria. Eligible case reports had to fulfil a minimum of nine items of the CARE Clinical Case Reporting Guideline checklist and a minimum of three of the homeopathic HOM-CASE CARE extension items. The Modified Naranjo Criteria for Homeopathy Inventory consists of 10 domains. Inter-rater agreement in the scoring of these domains was determined by calculating the percentage agreement and kappa (κ) values. A κ greater than 0.4, indicating fair agreement between raters, in conjunction with the absence of concerns regarding the face validity, was taken to indicate the validity of a given domain. Each domain was assessed by four raters for the selected case reports. Results Sixty case reports met the inclusion criteria. Inter-rater agreement/concordance per domain was “perfect” for domains 1 (100%, κ = 1.00) and 2 (100%, κ = 1.00); “almost perfect” for domain 8 (97.5%, κ = 0.86); “substantial” for domains 3 (96.7%, κ = 0.80) and 5 (91.1%, κ = 0.70); “moderate” for domains 4 (83.3%, κ = 0.60), 7 (67.8%, κ = 0.46) and 9 (99.2%, κ = 0.50); and “fair” for domain 10 (56.1%, κ = 0.38). For domains 6A (46.7%, κ = 0.03) and 6B (50.3%, κ = 0.18), there was “slight agreement” only. Thus, the validity of the Modified Naranjo Criteria for Homeopathy tool was established for each of its domains, except for the two that pertain to direction of cure (domains 6A and 6B). Conclusion The Modified Naranjo Criteria for Homeopathy—Causal Attribution Inventory was identified as a valid tool for assessing the likelihood of a causal relationship between a homeopathic intervention and clinical outcome. Improved wordings for several criteria have been proposed for the assessment tool, under the new acronym “MONARCH”. Further assessment of two MONARCH domains is required.

Anubhav Dubey, Mamta Kumari, Mayankesh Pandey

Background: Diabetes is a condition that happens when your blood sugar (glucose) is too high. It develops when your pancreas doesn’t make enough insulin or any at all, or when your body isn’t responding to the effects of insulin properly. Diabetes affects people of all ages. Most forms of diabetes are chronic (lifelong), and all forms are manageable with medications and/or lifestyle changes. So many health problems can develop in diabetic people, like heart diseases, kidney diseases, eye problems, etc. Diabetes mellitus is a chronic disease. A qualified homeopathic doctor needs to be consulted for the selection of the right medicine and its potency. Objective: There are many allopathic medicines available for the treatment of diabetes, but they have lots of side effects. The main objective of this study is to find out the appropriate homeopathic medicines for the treatment of diabetes. Methods: A literature search was conducted on the databases, namely Science Direct and PubMed, with the help of different keywords such as "homeopathic medicine treatment of diabetes." The search was customized by applying the appropriate filters so as to get the most relevant articles to meet the objective of this review article. Result: There are different research and review papers based on the homeopathic medicine treatment of diabetes and the activity of new drug molecules. Conclusion: On the basis of our study, we found that some treatments approach homeopathic medicines for the treatment of diabetes and suggested that if we used homeopathic medicine to reduce the side effects of allopathic medicines.

V. Văcăraș, D. Muresanu, A. Buzoianu et al.

Gut microbiota, the total microorganisms in our gastrointestinal tract, might have an implication in multiple sclerosis (MS), a demyelinating neurological disease. Our study included 50 MS patients and 21 healthy controls (HC). Twenty patients received a disease modifying therapy (DMT), interferon beta1a or teriflunomide, 19 DMT combined with homeopathy and 11 patients accepted only homeopathy. We collected in total 142 gut samples, two for each individual: at the study enrolment and eight weeks after treatment. We compared MS patients' microbiome with HC, we analysed its evolution in time and the effect of interferon beta1a, teriflunomide and homeopathy. There was no difference in alpha diversity, only two beta diversity results related to homeopathy. Compared to HC, untreated MS patients had a decrease of Actinobacteria, Bifidobacterium, Faecalibacterium prauznitzii and increased Prevotella stercorea, while treated patients presented lowered Ruminococcus and Clostridium. Compared to the initial sample, treated MS patients had a decrease of Lachnospiraceae and Ruminococcus and an increased Enterococcus faecalis. Eubacterium oxidoreducens was reduced after homeopathic treatment. The study revealed that MS patients may present dysbiosis. Treatment with interferon beta1a, teriflunomide or homeopathy implied several taxonomic changes. DMTs and homeopathy might influence the gut microbiota.

K. Gaertner, K. von Ammon, P. Fibert et al.

BACKGROUND Randomised controlled trials (RCTs) are an established research method to investigate the effects of an intervention. Several recent systematic reviews and meta-analyses of RCTs with homeopathic interventions have identified shortcomings in design, conduct, analysis, and reporting of trials. Guidelines for RCTs in homeopathic medicine are lacking. OBJECTIVES This paper aims to fill this gap in order to enhance the quality of RCTs in the field of homeopathy. METHODS Identification of the homeopathy-specific requirements for RCTs by reviewing literature and experts' communications. Systematization of the findings using a suitable checklist for planning, conducting, and reporting RCTs, namely the SPIRIT statement, and high-quality homeopathy RCTs as examples. Cross-checking of the created checklist with the RedHot-criteria, the PRECIS criteria, and a qualitative evaluation checklist. Consideration of the REFLECT statement and the ARRIVE Guidelines 2.0 for veterinary homeopathy. RESULTS Recommendations for future implementation of RCTs in homeopathy are summarized in a checklist. Alongside, identified useful solutions to the issues encountered when designing and conducting homeopathy RCTs are presented. CONCLUSIONS The formulated recommendations present guidelines additional to those in the SPIRIT checklist, on how to better plan, design, conduct, and report RCTs in homeopathy.

H. R. Parsani, K. P. Shyma, J. A. Patel et al.

The present study was aimed to treat bovine mastitis with homeopathic remedies Masta-forte+Actino Cure along with antibiotic therapy. A total 160 animals suffering from clinical bovine mastitis were used for study. All the animals were categories according to their physical condition of udder as redness, oedematous, fibrosis, bloody milk, white clot in milk, and watery milk. All the animals were group in to two groups A (n=80) and (n=80). All the animals were basically treated with higher antibiotics. In group A animal were treated with homeopathic medicine (2 ml. Masta-Forte+2 ml Actino Cure) orally with syringe bid for 20 days along with antibiotic therapy were as group B only treated with antibiotic therapy. Out of 160 animals 124 animals recovers with reduce normal milk. Among group A animals were recovery rate 90.00% (N=80) where as group B recovery rate 65.00% (n=80) animal. In group A animals having no fibrosis, where in group B animals having affected quarters were hard and fibrotic in nature. Homoeopathy drugs may be used as alternate therapy in organic farming system might be one of the preferred treatment methods.

Yaqoob Hassan, Abu Shahma, Afzal Anees et al.

Femoral hernia is an uncommon entity in males and is limited to case reports in the medical literature. Because of the narrow neck of the femoral canal, a femoral hernia can easily incarcerate and/or strangulate. Surgical intervention is the only option for definitive treatment. We report the case of a 59-year-old male patient who presented with a 10 days history of generalised abdominal pain, distension, and a few episodes of vomiting. The patient was resuscitated, and contrast-enhanced CT tomography revealed a left femoral hernia as well as features of small bowel obstruction. A gangrenous ileal loop with perforation within the left femoral canal was discovered after surgery. The patient underwent ileal resection and ileostomy, followed by primary femoral ring repair. However, on postoperative day 3rd, the patient developed a sudden cardiac arrest and died. Proper referral, early diagnosis, and treatment are vital in cases of femoral hernia to avoid such a fatal outcome and could have changed the prognosis of the patient. It is important for peripheral health-care providers to pay attention to persistent abdominal symptoms and to be aware of the proper and timely referral.

R. Barbieri, David Ferreira Lopes Santos

Abstract Eco-innovative business models are prominent elements of the development of sustainable production and consumption systems in organizations of all sizes, especially for small and medium enterprises, where a key challenge is to direct eco-innovation strategies toward the goals of their business model. Therefore, using product life cycle assessment, this research analyzed the alignment between the sustainable business model and the eco-innovative strategies of a Brazilian company in the veterinary homeopathy pharmaceutical industry. Disregarding the controversial discussion about homeopathy, this activity has shown significant growth, having a representative economic importance in the animal protein production chain. The research adopted a case study method for one of Brazil’s leading companies in this activity. Data were collected through interviews, process analysis and company records. The results were built through quantitative and qualitative techniques that demonstrated that the eco-innovations developed by the company are directed toward the creation of new production methods and, above all, new products. The management model was framed in the “adopt a management role” archetype, in accordance with the literature. It was found that eco-innovation strategies are important for the development of the company’s business model and that this alignment is possible only when there is a management system and investments in the company’s ability to eco-innovate in product, process and organizational structure.

R. van Haselen

Ayushi Lodha, Shylaja Someshwar

Background: Topical corticosteroids are widely used for treating various dermatoses. People have been self-medicating them for fungal infections, pigmentary disorders, and for many other dermatoses. This overzealous and irrational use of corticosteroid makes individuals susceptible for its adverse effects. Aim: The aim of this study was to evaluate steroid sensitivity in various dermatoses. Materials and Methods: Patch testing with Indian standard series and corticosteroid series was performed in sixty subjects where thirty patients were cases and thirty were controls. Histopathological examination and As it is (ASIS) were done only for the case group. Patches were applied on the back for 48 h and reading was done on day 2, day 4, and day 7 according to the International Contact Dermatitis Research group grading. Results: The maximum cases were in the age group of 20–30 years (33.3%) while 31–40 years was the most common age range (50%) among controls. Among the case group, 60% were male and 40% were female. Maximum patients affected in the case group were homemakers (36.7%) followed by laborers (13.3%). The case group showed 16.7% positive patch test reactions while none were positive in the control group. Thiomersal was positive in 13.3% of cases and neomycin in 3.3% of cases. ASIS was negative in all cases. Thiomersal is commonly used as a preservative in topical medicaments, cosmetics, and vaccines. Conclusions: Steroid sensitivity is hard to diagnose clinically, thereby causing difficulty in managing such cases. Patch test is a noninvasive gold standard procedure without major adverse effects and helps in treating the dermatoses with appropriate class of corticosteroid by avoiding the suspected allergen.

Gashaw Adane MSc, Mulualem Lemma MSc, Demeke Geremew MSc et al.

Background. Mycobacterium tuberculosis has become the leading cause of morbidity and death in humans worldwide. Thus, genetic variability of the host plays a major role in human susceptibility to the pathogen, among others. Therefore, the objective of this finding was to assess the association of genetic polymorphisms of cytokines with tuberculosis infection. Method. A cross-sectional study was conducted between January and May 2018. Five ml of whole blood was collected and extracted the genomic DNA through simple salting out method. The patterns of genetic polymorphism were determined by amplification refractory method PCR using specific primers. Finally, the PCR run on electrophoresis of agarose gel and the band was visualized under UV light. A logistical regression model has been adapted to assess the association of genetic polymorphisms with tubercular infection. In order to determine the association between the explanatory and outcome variable, the odds ratio with 95% CI was calculated. P < 0.05 is a statistically significant value. Result. In present study, the frequency of TNF-α -308 G allele and GG genotype OR (95% CI)= 0.20 (0.11-0.37), and OR (95% CI)= 0.29 (0.18-0.46)), respectively) and IFN-γ +874 A allele and AA genotype OR (95% CI)= 3.80 (2.11-6.86) and (OR (95% CI)= 1.61(1.13-2.28), respectively) were significantly associated with tuberculosis incidence. In contrast, there is no significant correlation between IL-10 -1082 A and AA of allele and genotype, respectively in tuberculosis patients (p > 0.05) was evident. Conclusion. From our finding, the genetic variability of TNF-α -308 A and IFN-γ +874 alleles are the potent host genetic risk factors associated with tuberculosis infection.

H. Kiene, G. Kienle, T. von Schön-Angerer

P. Posadzki, Leala K. Watson, A. Alotaibi et al.

This systematic review aimed to estimate the prevalence of use of complementary and alternative medicine (CAM) in the UK. Five databases were searched for English language, peer-reviewed surveys published between 1 January 2000 and 7 October 2011. In addition, relevant book chapters and files from our own departmental records were searched by hand. Eighty-nine surveys were included, with a total of 97,222 participants. Most studies were of poor methodological quality. Across surveys on CAM in general, the average one-year prevalence of use of CAM was 41.1% and the average lifetime prevalence was 51.8%. In methodologically sound surveys, the equivalent rates were 26.3% and 44%, respectively. In surveys with response rates >70%, average one-year prevalence was nearly threefold lower than in surveys with response rates between 21% and 50%. Herbal medicine was the most popular CAM, followed by homeopathy, aromatherapy, massage and reflexology. Many patients and consumers in the UK use CAM; healthcare professionals should therefore responsibly advise their patients about the use of CAM.

R. Mathie, N. Ramparsad, L. Legg et al.

BackgroundA rigorous systematic review and meta-analysis focused on randomised controlled trials (RCTs) of non-individualised homeopathic treatment has not previously been reported. We tested the null hypothesis that the main outcome of treatment using a non-individualised (standardised) homeopathic medicine is indistinguishable from that of placebo. An additional aim was to quantify any condition-specific effects of non-individualised homeopathic treatment.MethodsLiterature search strategy, data extraction and statistical analysis all followed the methods described in a pre-published protocol. A trial comprised ‘reliable evidence’ if its risk of bias was low or it was unclear in one specified domain of assessment. ‘Effect size’ was reported as standardised mean difference (SMD), with arithmetic transformation for dichotomous data carried out as required; a negative SMD indicated an effect favouring homeopathy.ResultsForty-eight different clinical conditions were represented in 75 eligible RCTs. Forty-nine trials were classed as ‘high risk of bias’ and 23 as ‘uncertain risk of bias’; the remaining three, clinically heterogeneous, trials displayed sufficiently low risk of bias to be designated reliable evidence. Fifty-four trials had extractable data: pooled SMD was –0.33 (95% confidence interval (CI) –0.44, –0.21), which was attenuated to –0.16 (95% CI –0.31, –0.02) after adjustment for publication bias. The three trials with reliable evidence yielded a non-significant pooled SMD: –0.18 (95% CI –0.46, 0.09). There was no single clinical condition for which meta-analysis included reliable evidence.ConclusionsThe quality of the body of evidence is low. A meta-analysis of all extractable data leads to rejection of our null hypothesis, but analysis of a small sub-group of reliable evidence does not support that rejection. Reliable evidence is lacking in condition-specific meta-analyses, precluding relevant conclusions. Better designed and more rigorous RCTs are needed in order to develop an evidence base that can decisively provide reliable effect estimates of non-individualised homeopathic treatment.

B. Rubik

Syed Mubashar Sabir, Syed Rizwan Abbas, Shabnam Shahida et al.

Abstract Objective To evaluate the antioxidant activities and to identify the bioactive compounds in hot water extracts of Terminalia chebula fruit. Methods The antioxidant activities were determined by DPPH assay, lipid peroxidation assay, iron chelation and total antioxidant assay. The phenolic composition was determined by HPLC-DAD. Human Rab8b Protein was used for the validation of compounds as anti-inflammation. String analysis for protein synergism was used. Results The analysis of Terminalia chebula Retzius (Combretaceae) phenolics showed anti-inflammatory effect. The specific phenolic compositions were determined by high performance liquid chromatography (HPLC) and resulted in the identification of rutin, catechin, caffeic acid, gallicacid, ellagic acid, epicatechin, and quercetin as antioxidant compounds. Human Rab8b protein is selected for protein docking and all compounds except rutin showed good results. ADMET properties were checked by using AdmetSar and all seven compounds showed validation for AMET properties. The synergisms of compounds were analyzed by STRING analysis and our ligands shows strong binding with human Rab8b proteins. The aqueous extract was capable of inhibiting the lipid peroxidation in egg yolk phospholipid homogenate. The extract scavenged the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) (IC50,71.5 ± 2.1 μg/ml). The extract displayed the high metal chelation activities and reducing abilities on the phosphomolybdenum assay. Conclusions It is concluded that extracts of T. chebula have good antioxidant and anti-inflammation activities and are rich in phenolics.

R. Mathie, S. Lloyd, L. Legg et al.

BackgroundA rigorous and focused systematic review and meta-analysis of randomised controlled trials (RCTs) of individualised homeopathic treatment has not previously been undertaken. We tested the hypothesis that the outcome of an individualised homeopathic treatment approach using homeopathic medicines is distinguishable from that of placebos.MethodsThe review’s methods, including literature search strategy, data extraction, assessment of risk of bias and statistical analysis, were strictly protocol-based. Judgment in seven assessment domains enabled a trial’s risk of bias to be designated as low, unclear or high. A trial was judged to comprise ‘reliable evidence’ if its risk of bias was low or was unclear in one specified domain. ‘Effect size’ was reported as odds ratio (OR), with arithmetic transformation for continuous data carried out as required; OR > 1 signified an effect favouring homeopathy.ResultsThirty-two eligible RCTs studied 24 different medical conditions in total. Twelve trials were classed ‘uncertain risk of bias’, three of which displayed relatively minor uncertainty and were designated reliable evidence; 20 trials were classed ‘high risk of bias’. Twenty-two trials had extractable data and were subjected to meta-analysis; OR = 1.53 (95% confidence interval (CI) 1.22 to 1.91). For the three trials with reliable evidence, sensitivity analysis revealed OR = 1.98 (95% CI 1.16 to 3.38).ConclusionsMedicines prescribed in individualised homeopathy may have small, specific treatment effects. Findings are consistent with sub-group data available in a previous ‘global’ systematic review. The low or unclear overall quality of the evidence prompts caution in interpreting the findings. New high-quality RCT research is necessary to enable more decisive interpretation.

Gui-lin Jin, Yan-ping Su, Ming Liu et al.