Modelling Capillary Rise with a Slip Boundary Condition: Well-posedness and Long-time Dynamics of Solutions to Washburn's Equation
Isidora Rapaji'c, Srboljub Simi'c, Endre Suli Mathematical Institute of the Serbian Academy Sciences
et al.
The aim of this paper is to extend Washburn's capillary rise equation by incorporating a slip condition at the pipe wall. The governing equation is derived using fundamental principles from continuum mechanics. A new scaling is introduced, allowing for a systematic analysis of different flow regimes. We prove the global-in-time existence and uniqueness of a bounded positive solution to Washburn's equation that includes the slip parameter, as well as the continuous dependence of the solution in the maximum norm on the initial data. Thus, the initial-value problem for Washburn's equation is shown to be well-posed in the sense of Hadamard. Additionally, we show that the unique equilibrium solution may be reached either monotonically or in an oscillatory fashion, similarly to the no-slip case. Finally, we determine the basin of attraction for the system, ensuring that the equilibrium state will be reached from the initial data we impose. These results hold for any positive value of the nondimensional slip parameter in the model, and for all values of the ratio $h_0/h_e$ in the range $[0,3/2]$, where $h_0$ is the initial height of the fluid column and $h_e$ is its equilibrium height.
2 sitasi
en
Mathematics, Physics
The heart of NGC 5253 as seen with MUSE-NFM: nitrogen enrichment through stellar chemical feedback at parsec scales
Brigitte G.A. Pruijt, A. Monreal-Ibero, P. Weilbacher
et al.
NGC 5253 is a nearby (D=3.6 Mpc) Blue Compact Dwarf galaxy, notable for its three massive young super star clusters (SSCs) and nitrogen enrichment. Its similarity to extreme star-forming galaxies at high redshift makes it a good local analogue for studying chemical enrichment at high spatial resolution. We characterise the ionised gas and dust in the giant HII region in the proximity of the three SSCs in the centre of NGC 5253 using new Multi-Unit Spectroscopic Explorer Narrow Field Mode adaptive optics-assisted data at unprecedented spatial resolution of 0."15$\sim$2.3 pc. We derive the attenuation for the central SSCs and, for the first time, map the extinction parameter ($R_V$) in an extragalactic object. $R_V$ varies among SSCs, suggesting differences in dust physics. Electron temperature and density diagnostics yield flat temperature distributions $T_\mathrm{e,median}$([NII])$=12000 \pm 1700$ K and $T_\mathrm{e,median}$([SIII])$ = 11000 \pm 600$ K, and a structured $n_e$([SII]) of maximum $1930 \pm 40$ cm$^{-3}$. The direct method gives a flat helium abundance ($10^3y^+ = 81 \pm 4$) and uniform oxygen abundance ($12 + \log(\text{O/H}) = 8.22 \pm 0.05$). N/O shows a factor 2-3 enhancement around the SSCs, mapped here for the first time at such high spatial resolution. The total excess nitrogen mass is $\sim$0.3 $M_\odot$, which we estimate is producible by the observed WN-type Wolf-Rayet (WR) stars. Because there is no direct spatial overlap between the enrichment and WR star positions, the N-rich material appears to have been expelled from the original sites.
Peripheral Prints: Karamu House and the Rise of African American Art in the Midwest
Erin Benay
Covers and Front Matter
Columbia Journal of Law & the Arts
校園農場之食農教育:學習永續農業與土地親近感 Campus Farming and Agrifood Education: Learning Sustainable Agriculture and Kinship With the Land
林季怡 Chi-I Lin, 李育諭 Yuh-Yuh Li
本研究探討如何透過食農教育培養大學生生態觀點,特別是拉近人與環境的距離。食農教育,除了永續農業概念的學習,最重要的是營造人與土地的親近關係,人與土地親近關係的認識,是環境倫理人文思維的深層實踐,不易在傳統教室教學環境中傳遞。本研究參考後實證教學方式,規劃小農場實作,作為永續農業概念教學的主要場域。教學理念為透過提供
學生農業耕作知識內容及經驗脈絡,並適當維持學生正向愉悅的學習感覺,從而產生對土地之親近感。本研究探討除了永續農業概念的學習,校園農場作為食農教育教案是否可以,以及如何可以讓學生產生土地親近感,並以概念圖及開放式意見調查進行資料蒐集,針對111位學生在學期初與學期末進行永續農業概念圖評量及開放式意見調查。主要研究發現包括:一、透過概念圖分析,學生對永續農業的概念在學期末測驗分數是提高的,且在環境或是經濟面向分數會較社會面向分數高;二、學生土地親近感在學期末測量分數相較於學期初提高,土地親近感之改變顯示食農教育課程有助於永續農業概念之學習;三、概念圖作為永續農業概念測量方法,具有不錯的效度。本研究建議,未來食農教育可規劃校園農場作為提供知識文化刺激的場域,增加學生與真實農業問題互動的機會與動機。
In the Global Education 2030 Agenda, United Nations Educational, Scientific and Cultural Organization (UNESCO, 2017) emphasized that addressing the imbalance between humans and nature and promoting sustainable agriculture to end hunger and ensure food security are among the most essential educational goals. Community-based agriculture can be a key driver of change (UNESCO, 2017). On April 22, 2015, the Japanese government began promoting food and agriculture education and established the Basic Act on the Promotion of Urban Agriculture. One of the proposed strategies in this act is to “start from education and establish roots.” Similarly, on April
19, 2022, Taiwan established the Food and Agriculture Education Act, which was promulgated on May 4, 2022. According to Article 1 of the Food and Agriculture Education Act, the goals of food and agriculture education are to promote nationwide food and agriculture education; strengthen the
link between diet, environment, and agriculture; enhance national health; inherit and promote a culture of food and agricultural; promote sustainable development of rural areas, agriculture, and the environment; establish a sound national food and agriculture education system; and cultivate talent.
The fundamental goal of food and agriculture education is to strengthen the connection between diet, environment, and agriculture. One strategy to achieve this goal is to focus on strengthening the connection between humans and nature.
The relationship between humans and the environment has not received considerable attention from scholars in the fields of the social sciences and humanities. However, scholars have begun to shift their focus toward the interaction between humans and the environment. Aldo Leopold,
regarded as the father of environmental ethics, was the first scholar in the Western world to consider the relationship between humans and the environment. He introduced the concept of land ethics as a means of evaluating how humans should relate to their environment. According to Aldo Leopold’s land ethics, humans are members of a biotic community and must maintain the integrity of the land. Leopold emphasized the importance of the land, arguing that it is not merely a resource for human use but rather a mutually interdependent ecological community. Expanding on these reflections regarding humanity, Zalasiewicz et al. (2010) observed that human history has transitioned from the Holocene epoch to the Anthropocene epoch, a transition that began in approximately 1750.
Consequently, humans have become the primary agents shaping the Earth’s environment. The challenge of the Anthropocene epoch, however, lies in the growing alienation between humans and the land, which has led to humans altering the natural environment and has posed a threat to the sustainable existence of human society.
Seeking to understand the kinship between humans and the land represents a humanistic approach to environmental ethics. Such an approach can be challenging to employ in traditional classroom settings to achieve target learning outcomes. In the present study, we investigated how agrifood education can foster an ecological perspective in university students that strengthens the connection between humans and the environment. In addition to imparting the principles of sustainable agriculture, a key objective of agrifood education is cultivating a sense of kinship with
the land. Our primary research question was as follows: Beyond the acquisition of knowledge regarding sustainable agriculture, how and to what extent does the integration of information regarding small-scale farming practices into agrifood curricula enhance students’ sense of kinship
with the land?
In accordance with postpositivist approaches, we adopted a sustainability transdisciplinary education model as a teaching strategy and established a small campus farm. This small campus farm was established to facilitate on-site learning regarding sustainable agriculture and related practices. By directly involving students in the farming experience, we sought to create a positive and enjoyable learning environment and foster a deep connection with the land. The campus farm served as a platform for integrating interdisciplinary knowledge regarding agrifood. Situated within the university campus, it combined the elements of the land, natural vitality, and a communal space. It enabled the students to understand the importance of preserving the natural environment and enhanced their understanding of the inherent and interconnected relationships between individuals and society as well as between individuals and the environment.
We used concept mapping and open-ended questions to gather research data at the beginning and end of a semester, and we analyzed data obtained from 111 undergraduate students. Concept maps were used to evaluate the students’ understanding of sustainable agricultural development.
Subsequently, these concept maps were independently evaluated by two experts on the basis of predetermined criteria, and the interrater reliability was determined. To measure the students’ sense of connection to the land, an open-ended survey was conducted, and the textual content of the
students’ responses was analyzed. This survey was conducted at two time points: at the beginning of the study and at the end of the study. The first part involved a thematic apperception test similar to that used in psychology, in which the students were presented with an image of a piece of land and
asked to record their thoughts and associations with the image. In the second part, students were presented with open-ended questions through which they were asked to express their ideas regarding different agricultural cultivation methods.
The research participants primarily comprised university students enrolled in a two-semester general education course on food and agriculture. These students were affiliated with various colleges within the university, including the College of Science, College of Engineering, College of Marine Sciences, College of Management, College of Social Sciences, and College of the Humanities and Arts. Most of the students had only a basic understanding of agriculture, with a few having a family background in farming. Male students accounted for 57.7% of the participants, and female students accounted for 42.3%. The distribution among academic years was as follows: 25.2%
freshmen, 36.9% sophomores, 2.7% juniors, and 35.5% seniors.
Our results indicated the following. First, by the end of the course, the students’ understanding of and their attitude toward sustainable agriculture considerably improved. Second, the students’ sense of kinship with the land substantially improved. Third, the change in the students’ attitudes
toward sustainable agriculture and their sense of kinship with the land correlated with their on-site campus farming experience. Fourth, concept mapping is an effective tool for evaluating students’ understanding of sustainable agriculture.
Overall, our findings provide key empirical insights into the planning and execution of current agrifood educational practices. The humanistic perspective inherent to the concept of kinship with the land is fundamental for the successful implementation of sustainable agriculture education.
However, spatial accessibility must be considered when establishing a farm. Notably, students must have a robust foundation with respect to the concept of sustainability to be able to grasp higher-level sustainability concepts. In addition, sustainable literacy must be developed and enriched through ongoing sustainable education.
Education, Theory and practice of education
Assessing the predictive capability of Invalsi tests on high school final mark
Silvia Bacci Assessing, Bruno Bertaccini the predictive, Alessandra Petrucci capability of
et al.
Initial Experience of Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma in Real-World Clinical Practice
H. Iwamoto, S. Shimose, Y. Noda
et al.
Simple Summary Although the clinical trial of atezolizumab plus bevacizumab have revealed its efficacy for HCC, the outcomes in the real-world clinical practice are unclear. In the study, we retorspectively evaluated the efficacy and safety of atezoizumab plus bevacizumab for HCC. Atezorizumab plus bevacizumab was effective and safe even in the real-world clinical practice including patients with HCC in a previous MTA history or other than ALBI grade 1. Abstract Background: Atezolizumab plus bevacizumab was approved for patients with hepatocellular carcinoma (HCC). Although clinical trials have revealed its efficacy, the outcomes in the real-world clinical practice are unclear. We retrospectively evaluated the efficacy and safety of atezolizumab plus bevacizumab for HCC. Materials and Methods: This is a multicenter study conducted between November 2020 and March 2021. Among the 61 patients, 51 were assessed for progression-free survival (PFS), therapeutic response, and adverse events (AEs). Results: The median PFS was 5.4 months. The objective response rate (ORR) was 35.3%. The disease control rate (DCR) was 86.3%. The incidence rates of AEs at any grade and grade >3 were 98.0% and 29.4%, respectively. The most frequent AE at any grade and grade >3 was hepatic disorder. In patients with a previous history of molecular targeted agent (MTA) or the degree of albumin-bilirubin (ALBI) grade, there were no significant differences in the PFS, ORR, DCR, and incidence rates of AEs. Conclusion: The study demonstrated that atezolizumab plus bevacizumab was effective and safe for patients with HCC even in the real-world setting including patients with a previous MTA history or other than ALBI grade 1.
Pediatric COVID-19 Follow-Up with Lung Ultrasound: A Prospective Cohort Study
D. L. La Regina, D. Pepino, R. Nenna
et al.
During the COVID-19 pandemic, lung ultrasound (LUS) was widely used to assess SARS-CoV-2 infection. To date, there are patients with persistence of symptoms after acute infection. Therefore, it may be useful to have an objective tool to follow these patients. The aim of our study was to evaluate the presence of LUS artifacts after SARS-CoV-2 infection in children and to analyze the associations between time elapsed since infection and symptomatology during acute infection. We conducted an observational study, enrolling 607 children infected with SARS-CoV-2 in the previous twelve months. All patients performed a LUS and medical history of demographic and clinical data. We observed irregular pleural lines in 27.5%, B-lines in 16.9%, and subpleural consolidations in 8.6% of the cases. These artifacts were more frequently observed in the lower lobe projections. We have observed that the frequency of artifacts decreases with increasing time since infection. In symptomatic patients during COVID infection, B-lines (p = 0.02) were more frequently found. In our sample, some children, even after months of acute infection, have ultrasound artifacts and showed an improvement with the passage of time from the acute episode. Our study provides additional evidence about LUS in children with previous COVID-19 as a support to follow these patients in the months following the infection.
Look for the Domeykos! Images of "The Lord of Good Hope" from Santiago de Chile in the Vilnius Archdiocese
Sigita Maslauskaitė-Mažylienė
The article aims to find out whether the appearance of the images of The Lord of Good Hope with its rare iconography in Lithuania was influ enced by the family history of the famous geologist Ignacy Domeyko (Lith. Ignotas Domeika, 1802–1889), while emphasising the contribution of his son, Rev. Hernán Domeyko (1859–1931), towards the dissemination of this cult. The history and iconography of the image, as well as the development of the veneration tradition in Santiago de Chile and the Vilnius Archdiocese is explored. The authorship of the painting of Vilnius Cathedral is estab lished, the erroneous date of its creation established in historiography is corrected, and the votives belonging to the painting are identified.
Visual arts, History of the arts
Julius Carlebach (1909-1964)
Sandra Mühlenberend
The Jewish art dealer Julius Carlebach opened his art shop ‘Die Volkskunst’ in Berlin in 1932, specializing in antiques and cultural-historical objects. Carlebach quickly became a recognized businessman; he became known for supporting collectors and museums in their search for special artefacts, for supplying specific cultural-historical special collections and for having a wide network of suppliers and interested parties. When the National Socialists seized power in 1933, his private and professional situation changed in the course of the new National Socialist laws, hostilities and persecution in such a way that he lost his business and left his country towards the end of 1937 emigrating to the USA. The article focuses in particular on the period between the professional ban in 1936 and Carlebach’s emigration. In a research project funded by the German Lost Art Foundation at the German Optical Museum in Jena, it was possible to reconstruct Carlebach’s living situation at the time mentioned using high-quality historical documents and objects from the collection. Carlebach has sold around 1.000 objects on the subject of optics to the Optical Museum Jena. The surviving sales correspondence not only provides information about the objects, but also, in connection with Carlebach’s personal file of the Reich Chamber of Fine Arts, deep insights into Carlebach’s persecution scenario and into the special role of the Optical Museum Jena as a possible escape helper.
Keywords: Professional ban; Reich Chamber of Fine Arts; trade in optical instruments; Optical Museum Jena; emigration
Retrospective 8-Year Study on the Antibiotic Resistance of Uropathogens in Children Hospitalised for Urinary Tract Infection in the Emilia-Romagna Region, Italy
S. Esposito, G. Maglietta, M. Costanzo
et al.
The development and spread of antibiotic resistance is an increasingly important global public health problem, even in paediatric urinary tract infection (UTI). In light of the variability in the data, it is necessary to conduct surveillance studies to determine the prevalence of antibiotic resistance in specific geographical areas to optimize therapeutic management. In this observational, retrospective, multicentre study, the medical records of 1801 paediatric patients who were hospitalised for UTI between 1 January 2012, and 30 June 2020, in Emilia-Romagna, Italy, were analysed. Escherichia coli was the most frequently detected pathogen (75.6%), followed by Klebsiella pneumoniae (6.9%) and Pseudomonas aeruginosa (2.5%). Overall, 840 cases (46.7%) were due to antimicrobial-resistant uropathogens: 83 (4.7%) extended spectrum beta-lactamase (ESBL)-producing, 119 (6.7%) multidrug resistant (MDR) and 4 (0.2%) extensively drug resistant (XDR) bacteria. Empirical antibiotic therapy failed in 172 cases (9.6%). Having ESBL or MDR/XDR uropathogens, a history of recurrent UTI, antibiotic therapy in the preceding 30 days, and empirical treatment with amoxicillin or amoxicillin/clavulanate were significantly associated with treatment failure, whereas first-line therapy with third-generation cephalosporins was associated with protection against negative outcomes. In conclusion, the increase in the resistance of uropathogens to commonly used antibiotics requires continuous monitoring, and recommendations for antibiotic choice need updating. In our epidemiological context, amoxicillin/clavulanate no longer seems to be the appropriate first-line therapy for children hospitalised for UTI, whereas third-generation cephalosporins continue to be useful. To further limit the emergence of resistance, every effort to reduce and rationalise antibiotic consumption must be implemented.
Surviving Intensive Care: a report from the 2002 Brussels Roundtable
D. Angus, J. Carlet, on behalf of the pertussis Eqa participants
Livestreaming from the bedroom: Performing intimacy through domestic space on Twitch
Bonnie Ruberg, D. Lark
This article looks at the appearance of domestic spaces on the popular livestreaming platform Twitch.tv, with a focus on livestreams that appear to be shot in streamers’ bedrooms. Many Twitch streamers broadcast from their homes, making domestic space central to questions of placemaking for this rapidly growing digital media form. Within the home, bedrooms merit particular attention because they carry particular cultural connotations; they are associated with intimacy, embodiment, and erotics. Drawing from observations of gaming and nongaming streams, we map where bedrooms do and do not appear on Twitch. We locate the majority of bedrooms in categories that foreground connections between streamers and viewers, like Just Chatting, Music & Performing Arts, and autonomous sensory meridian response (ASMR). By contrast, across a wide range of video game genres, bedrooms remain largely absent from gaming streams. The presence of bedrooms on Twitch also breaks down along gender lines, with women streaming being far more likely to broadcast from their bedrooms than men. Here, we build from existing research on both livestreaming and digital placemaking to argue for an understanding of place on Twitch as fundamentally performative. This performance is inherently gendered and bound up with the affective labor of streaming. In addition, we demonstrate how the bedroom, even when it does not appear on screen, can be understood as a ‘structuring logic’ of placemaking on Twitch. Given the history of livestreaming, which grows out of women’s experiments with online ‘lifecasting’, the bedroom sets expectations for the type of spatial and emotional access a stream is imagined to offer viewers. In this sense, the absence of bedrooms in gaming streams can be understood as a disavowal of intimate domestic space: an attempt by predominantly male streamers to distance themselves from the implicit parallels between livestreaming and practices like webcam modeling.
ESBL-Producing, Carbapenem- and Ciprofloxacin-Resistant Escherichia coli in Belgian and Dutch Broiler and Pig Farms: A Cross-Sectional and Cross-Border Study
Sien De Koster, M. Ringenier, C. Lammens
et al.
Background. The use of antibiotics in food production selects for resistant bacteria and may cause a threat to human and animal health. Belgium and the Netherlands have one of the highest densities of broilers and pigs in Europe, making active monitoring of antibiotic use and resistance in this region vital. Objectives. This study aimed to quantify ESBL-producing (ESBL-E. coli), carbapenem- and ciprofloxacin-resistant (CiproR) Escherichia coli in animal feces on broiler and pig farms with a history of high antibiotic use in Belgium and the Netherlands. Methods. A total of 779 broiler and 817 pig fecal samples, collected from 29 conventional broiler and 31 multiplier pig farms in the cross-border region of Belgium and the Netherlands, were screened for the presence of antibiotic-resistant E. coli using selective culturing. Results. Carbapenem-resistant E. coli were not detected. ESBL-E. coli were remarkably more prevalent in samples from Belgian than Dutch farms. However, CiproR-E. coli were highly prevalent in broilers of both countries. The percentage of samples with ESBL- and CiproR-E. coli was lower in pig compared to poultry farms and varied between farms. No clear association with the on-farm antibiotic use in the year preceding sampling was observed. Multidrug resistance was frequently observed in samples from both countries, but ESBL-production in combination with ciprofloxacin resistance was higher in samples from Belgium. Conclusions. This study demonstrated marked differences in antibiotic resistance between countries, farms and within farms. The observed variation cannot be explained straightforward by prior quantity of antibiotic use suggesting that it results from more complex interactions that warrant further investigation.
End-to-End, Pixel-Wise Vessel-Specific Coronary and Aortic Calcium Detection and Scoring Using Deep Learning
Gurpreet Singh, S. Al’Aref, Benjamin C. Lee
et al.
Conventional scoring and identification methods for coronary artery calcium (CAC) and aortic calcium (AC) result in information loss from the original image and can be time-consuming. In this study, we sought to demonstrate an end-to-end deep learning model as an alternative to the conventional methods. Scans of 377 patients with no history of coronary artery disease (CAD) were obtained and annotated. A deep learning model was trained, tested and validated in a 60:20:20 split. Within the cohort, mean age was 64.2 ± 9.8 years, and 33% were female. Left anterior descending, right coronary artery, left circumflex, triple vessel, and aortic calcifications were present in 74.87%, 55.82%, 57.41%, 46.03%, and 85.41% of patients respectively. An overall Dice score of 0.952 (interquartile range 0.921, 0.981) was achieved. Stratified by subgroups, there was no difference between male (0.948, interquartile range 0.920, 0.981) and female (0.965, interquartile range 0.933, 0.980) patients (p = 0.350), or, between age <65 (0.950, interquartile range 0.913, 0.981) and age ≥65 (0.957, interquartile range 0.930, 0.9778) (p = 0.742). There was good correlation and agreement for CAC prediction (rho = 0.876, p < 0.001), with a mean difference of 11.2% (p = 0.100). AC correlated well (rho = 0.947, p < 0.001), with a mean difference of 9% (p = 0.070). Automated segmentation took approximately 4 s per patient. Taken together, the deep-end learning model was able to robustly identify vessel-specific CAC and AC with high accuracy, and predict Agatston scores that correlated well with manual annotation, facilitating application into areas of research and clinical importance.
Coronary Flow, Left Ventricular Contractile and Heart Rate Reserve in Non-Ischemic Heart Failure
C. Daros, Q. Ciampi, L. Cortigiani
et al.
Background: Left ventricular contractile reserve (LVCR), coronary flow velocity reserve (CFVR), and heart rate reserve (HRR) affect outcome in heart failure (HF). They can be simultaneously measured during dipyridamole stress echocardiography (DSE). Aim: To assess the value of comprehensive DSE in patients with non-ischemic HF. Methods: We evaluated 610 patients with HF, no history of coronary artery disease, and no inducible regional wall motion abnormalities: 270 patients with preserved ejection fraction (≥50%), 146 patients with mid-range ejection fraction (40–49%), and 194 patients with reduced ejection fraction (<40%). All underwent DSE (0.84 mg/kg in 6′) in 7 accredited laboratories. We measured LVCR (abnormal value ≤ 1.1), CFVR in left anterior descending artery (abnormal value: ≤2.0), and HRR (peak/rest heart rate; abnormal value: ≤1.22). All patients were followed up. Results: Abnormal CFVR, LVCR, and HRR occurred in 29%, 45%, and 47% of patients, respectively (p < 0.001). After a median follow-up time of 20 months (interquartile range: 12–32 months), 113 hard events occurred in 105 patients with 41 deaths, 8 myocardial infarctions, 61 admissions for acute HF, and 3 strokes. The annual mortality rates were 0.8% in 200 patients with none abnormal criteria, 1.8% in 184 patients with 1 abnormal criterion, 7.1% in 130 patients with 2 abnormal criteria, 7.5% in 96 patients with 3 abnormal criteria. Conclusions: Abnormal LVCR, CFVR, and HRR were frequent during DSE in non-ischemic HF patients. They target different pathophysiological vulnerabilities (myocardial function, coronary microcirculation, and cardiac autonomic balance) and are useful for outcome prediction.
The IGNITE network: a model for genomic medicine implementation and research
K. Weitzel, Madeline Alexander, B. Bernhardt
et al.
Patients, clinicians, researchers and payers are seeking to understand the value of using genomic information (as reflected by genotyping, sequencing, family history or other data) to inform clinical decision-making. However, challenges exist to widespread clinical implementation of genomic medicine, a prerequisite for developing evidence of its real-world utility. To address these challenges, the National Institutes of Health-funded IGNITE (Implementing GeNomics In pracTicE; www.ignite-genomics.org) Network, comprised of six projects and a coordinating center, was established in 2013 to support the development, investigation and dissemination of genomic medicine practice models that seamlessly integrate genomic data into the electronic health record and that deploy tools for point of care decision making. IGNITE site projects are aligned in their purpose of testing these models, but individual projects vary in scope and design, including exploring genetic markers for disease risk prediction and prevention, developing tools for using family history data, incorporating pharmacogenomic data into clinical care, refining disease diagnosis using sequence-based mutation discovery, and creating novel educational approaches. This paper describes the IGNITE Network and member projects, including network structure, collaborative initiatives, clinical decision support strategies, methods for return of genomic test results, and educational initiatives for patients and providers. Clinical and outcomes data from individual sites and network-wide projects are anticipated to begin being published over the next few years. The IGNITE Network is an innovative series of projects and pilot demonstrations aiming to enhance translation of validated actionable genomic information into clinical settings and develop and use measures of outcome in response to genome-based clinical interventions using a pragmatic framework to provide early data and proofs of concept on the utility of these interventions. Through these efforts and collaboration with other stakeholders, IGNITE is poised to have a significant impact on the acceleration of genomic information into medical practice.
Eyecatchers: Exceptional Works of Art from the Broere Charitable Foundation
Pieter Roelofs
تحليل البنية السردية لـ "حكاية أفشين وبودولف" من "تاريخ" البيهقي استنادًا إلى نظرية جيرار جينيت
احمد وحيدي, منصور نكبانه, رسول محمدي
يساعدنا تحليل العناصر المكونة للسرد وتمثيل القواعد التي تحكمه في فهم أفضل للآليات والعلاقات داخل العناصر السردية. نظرًا لأن علم السرد هو أحد الفروع الرئيسية للبنيوية ، فإن تحليل البنية السردية للنصوص السابقة وتطورها يمكن أن يؤدي إلى نتائج قيمة وفتح وجهات نظر جديدة ومختلفة للجمهور. يعد تاريخ البيهقي أحد النصوص الأساسية في النثر الفارسي. يحلل هذا البحث البنية السردية "حكاية أفشين وبودلوف" من "التاريخ" لبايهقي بناءً على أفكار البنيوي الفرنسي جيرار جينيت. تمت دراسة المستويات السردية لهذا العمل بالتفاعل مع مكونات المدة والمزاج والصوت) للكشف عن هيكله السردي المحدد وقوة كتابه البيهقي في الاستفادة من إمكانيات اللغة والأدب. على عكس المؤمنين بفكرة أن المحترفين السابقين للأدب الفارسي مجرد قصص وروايات ويفتقرون إلى بنية منظمة ومؤامرة قوية ، يُظهر هذا البحث الهيكل المنظم والحبكة القوية للحالة المدروسة وفقًا لأفكار جيرار جينيت.
History of scholarship and learning. The humanities, Arts in general
Vaclovo Miknevičiaus kūryba pramoninės ir architektūrinės keramikos srityse
Raimonda Simanaitienė
Straipsnyje analizuojamas dailininko Vaclovo Miknevičiaus daugiašakės keramikos palikimas. Šio menininko kūryba tyrimui pasirinkta, kaip dėsningai atspindinti esminius XX a. vidurio ir antros pusės Lietuvos autorinės, pramoninės ir architektūrinės keramikos pokyčius. Jai būdinga dauguma meninių tendencijų, išryškėjusių minėto laikotarpio stilistinėje raidoje. Tai art deco kryptis, liaudies meno įtaka, konstruktyvaus dizaino apraiškos, dažniausiai atsiskleidusios keramikos indų formose bei dekore, taip pat ekspresyvi arba, atvirkščiai, minimali plastika, vyravusi monumentaliuose keramiko darbuose. Reikšminga ir tai, kad tarpukario pabaigoje, steigdamas keramikos dirbtuves, o vėliau ilgą laiką kurdamas Kauno „Dailės“ kombinate, Miknevičius turėjo nemažos įtakos Lietuvos keramikos gamybos vystymuisi. Todėl straipsnyje išsamiai nagrinėjami ir su gamybiniais pasiekimais susieti jo kūrybinės veiklos aspektai, akcentuojamas dailininko indėlis pramoninės keramikos srityje. Taip pat išryškinami unikalūs technologiniai eksperimentai, vykdyti „Dailės“ kombinate, įgyvendinant buitinių ir dekoratyvinių dirbinių pavyzdžius ir monumentalios keramikos užsakymus.
Visual arts, History of the arts