Banafsheh Karimian, Alexis Guichemerre, Soufiane Belharbi
et al.
Breast cancer remains a leading cause of cancer-related mortality worldwide. Longitudinal mammography risk prediction models improve multi-year breast cancer risk prediction based on prior screening exams. However, in real-world clinical practice, longitudinal histories are often incomplete, irregular, or unavailable due to missed screenings, first-time examinations, heterogeneous acquisition schedules, or archival constraints. The absence of prior exams degrades the performance of longitudinal risk models and limits their practical applicability. While substantial longitudinal history is available during training, prior exams are commonly absent at test time. In this paper, we address missing history at inference time and propose a longitudinal risk prediction method that uses mammography history as privileged information during training and distills its prognostic value into a student model that only requires the current exam at inference time. The key idea is a privileged multi-teacher distillation scheme with horizon-specific teachers: each teacher is trained on the full longitudinal history to specialize in one prediction horizon, while the student receives only a reconstructed history derived from the current exam. This allows the student to inherit horizon-dependent longitudinal risk cues without requiring prior screening exams at deployment. Our new Privileged History Distillation (PHD) method is validated on a large longitudinal mammography dataset with multi-year cancer outcomes, CSAW-CC, comparing full-history and no-history baselines to their distilled counterparts. Using time-dependent AUC across horizons, our privileged history distillation method markedly improves the performance of long-horizon prediction over no-history models and is comparable to that of full-history models, while using only the current exam at inference time.
Automated program repair (APR) has recently shifted toward large language models and agent-based systems, yet most systems rely on local snapshot context, overlooking repository history. Prior work shows that repository history helps repair single-line bugs, since the last commit touching the buggy line is often the bug-introducing one. In this paper, we investigate whether repository history can also improve agentic APR systems at scale, especially for complex multi-hunk bugs. We present HAFixAgent, a History-Aware Bug-Fixing Agent that injects blame-derived repository heuristics into its repair loop. A preliminary study on 854 Defects4J (Java) and 501 BugsInPy (Python) bugs motivates our design, showing that bug-relevant history is widely available across both benchmarks. Using the same LLM (DeepSeek-V3.2-Exp) for all experiments, including replicated baselines, we show: (1) Effectiveness: HAFixAgent outperforms RepairAgent (+56.6\%) and BIRCH-feedback (+47.1\%) on Defects4J. Historical context further improves repair by +4.4\% on Defects4J and +38.6\% on BugsInPy, especially on single-file multi-hunk (SFMH) bugs. (2) Robustness: under noisy fault localization (+1/+3/+5 line shifts), history provides increasing resilience, maintaining 40 to 56\% success on SFMH bugs where the non-history baseline collapses to 0\%. (3) Efficiency: history does not significantly increase agent steps or token costs on either benchmark.
John Drummond, Wayne Orchiston, Carolyn Brown
et al.
C/1910 A1 was one of the Great Comets of the twentieth century. Although it was widely observed from the Northern Hemisphere, it was first discovered by observers south of the Equator. The comet arrived just months before the widely anticipated apparition of Comet 1P/Halley and was significantly more spectacular. As a result, the two comets were confused, and many who, in later years, talked about how prominent Comet 1P/Halley was in 1910 were often remembering C/1910 A1. In this paper, we present the results of a detailed search through historical records and media publications in Aotearoa / New Zealand, to investigate how extensively C/1910 A1 was observed from New Zealand. We compare our results with observations reported for Comet 1P/Halley later in 1910, finding that surprisingly few observations of C/1910 A1 were made by New Zealand observers. We discuss cases where the comet was misidentified as being an early sighting of 1P/Halley and compare the observations made in New Zealand with international observations/records/accounts. We find that, although the Great January Comet of 1910 was observed from New Zealand, it was witnessed by few compared to other parts of the world, meaning that the apparition of C/1910 A1 was something of a missed opportunity for New Zealand astronomers.
Problems with uniform probabilities on an infinite support show up in contemporary cosmology. This paper focuses on the context of inflation theory, where it complicates the assignment of a probability measure over pocket universes. The measure problem in cosmology, whereby it seems impossible to pick out a uniquely well-motivated measure, is associated with a paradox that occurs in standard probability theory and crucially involves uniformity on an infinite sample space. This problem has been discussed by physicists, albeit without reference to earlier work on this topic. The aim of this article is both to introduce philosophers of probability to these recent discussions in cosmology and to familiarize physicists and philosophers working on cosmology with relevant foundational work by Kolmogorov, de Finetti, Jaynes, and other probabilists. As such, the main goal is not to solve the measure problem, but to clarify the exact origin of some of the current obstacles. The analysis of the assumptions going into the paradox indicates that there exist multiple ways of dealing consistently with uniform probabilities on infinite sample spaces. Taking a pluralist stance towards the mathematical methods used in cosmology shows there is some room for progress with assigning probabilities in cosmological theories.
The history of the Jews in Portugal is often divided into three distinct periods: what I call the “time of the Jews”, the “time of the Inquisition” and the “time of return”. In this article, I will argue that the particular role played by the personal and collective multiple memories in each of these historical periods (by analyzing an array of primary and secondary sources, including medieval chronicles, inquisitorial sources and historiographical works), paradoxically blurs their chronological contours (namely, before 1497, between 1536 and 1821 and afterwards), and transforms the Jewish presence in Portugal into a challenging issue, from both a Jewish and a non-Jewish perspective, with far reaching biopolitical implications.
Entre novembro de 1918 e março de 1921, 69 bombas explodiram no Rio de Janeiro, provocando sete mortes e 50 feridos. Na maioria dos casos (30), os alvos foram padarias, mas vários outros estabelecimentos comerciais e prédios públicos também foram atingidos. A autoria dos atentados, na maior parte dos casos, não foi descoberta. Mas a polícia apontou o vínculo entre as explosões e a militância anarquista, fortemente vinculada às associações sindicais. As investigações também apontaram o protagonismo de imigrantes, principalmente portugueses que, sob a acusação de anarquismo, foram deportados. Eles seriam 37 dos 59 estrangeiros deportados por delito político entre 1919 e 1921. Pesquisas sobre tais eventos, efetuadas na documentação do Ministério da Justiça, mapearam o fenômeno, mas a leitura de jornais de época apontam novas (e eventualmente discrepantes) informações sobre o papel dos anarquistas, bem como o protagonismo dos proletários portugueses, na maior onda de atentados já testemunhada na então capital do Brasil.
The Jeffreys-Lindley paradox exposes a rift between Bayesian and frequentist hypothesis testing that strikes at the heart of statistical inference. Contrary to what most current literature suggests, the paradox was central to the Bayesian testing methodology developed by Sir Harold Jeffreys in the late 1930s. Jeffreys showed that the evidence against a point-null hypothesis $\mathcal{H}_0$ scales with $\sqrt{n}$ and repeatedly argued that it would therefore be mistaken to set a threshold for rejecting $\mathcal{H}_0$ at a constant multiple of the standard error. Here we summarize Jeffreys's early work on the paradox and clarify his reasons for including the $\sqrt{n}$ term. The prior distribution is seen to play a crucial role; by implicitly correcting for selection, small parameter values are identified as relatively surprising under $\mathcal{H}_1$. We highlight the general nature of the paradox by presenting both a fully frequentist and a fully Bayesian version. We also demonstrate that the paradox does not depend on assigning prior mass to a point hypothesis, as is commonly believed.
Automata models between determinism and nondeterminism/alternations can retain some of the algorithmic properties of deterministic automata while enjoying some of the expressiveness and succinctness of nondeterminism. We study three closely related such models -- history determinism, good for gameness and determinisability by pruning -- on quantitative automata. While in the Boolean setting, history determinism and good for gameness coincide, we show that this is no longer the case in the quantitative setting: good for gameness is broader than history determinism, and coincides with a relaxed version of it, defined with respect to thresholds. We further identify criteria in which history determinism, which is generally broader than determinisability by pruning, coincides with it, which we then apply to typical quantitative automata types. As a key application of good for games and history deterministic automata is synthesis, we clarify the relationship between the two notions and various quantitative synthesis problems. We show that good-for-games automata are central for "global" (classical) synthesis, while "local" (good-enough) synthesis reduces to deciding whether a nondeterministic automaton is history deterministic.
Gairo Garreto, João Santos Baptista, Antônia Mota
et al.
The Brazilian economy was, until the end of the 19th Century, based on slave labour. However, in this first quarter of the 21st Century, the problem persists. These situations tend to be mistaken with “simple” violations of labour laws. This work aims to establish Occupational Health and Safety parameters, focusing on energy needs, to distinguish between the breach of labour legislation and modern rural slavery in the 21st Century in Brazil. In response to this challenge, bibliographical research was carried out on the feeding and energy replenishment conditions of Brazilian slaves in the 19th Century. Obtained data were compared with a sample where 392 cases of neo-slavery in Brazil are described. The energy spent and the energy supplied was calculated to identify the enslaved workers’ general feeding conditions in the two historical periods. The general conditions of food and water supply were analysed. It was possible to identify three comparable parameters: food quality, food quantity, and water supply. It was concluded that there is a parallelism of energy replenishment conditions between Brazilian slaves and neo-slaves of the 19th and 21st centuries, respectively, different from that of free workers. This difference can help authorities identify and punish instances of modern slavery.
Four years after seizing power, the Republicans who founded the United States of Brazil mounted a representation at the World’s Columbian Exposition in Chicago in 1893. Under the threat of a monarchist insurrection and in order to affirm their authority, the Republicans employed this exhibition to re-write the Brazilian imperial past and ascertain their political future. Relying on an analysis of design history, this article discusses exhibition displays –carriage from D. Pedro I framed as a bygone past, the installation of a golden pyramid to flaunt regional power, and a selection of Fine Arts that revealed the Republicans’ desire for a particular social order– as points of access to unpack this first republican representation at World’s Fairs, and the competing political and economic interests behind this show of order and progress.
ABSTRACT By analysing three museums exhibition, this article investigates how the history of European colonialism is approached in an attempt to identify potential for decolonising European minds. The case studies consist of a temporary exhibition (2016–2017) concerning German colonialism at the Deutsches Historisches Museum in Berlin; the permanent exhibition of the House of European History in Brussels and the permanent exhibition of the Sagres Promontory (Portugal), a heritage site related to the conquest of the Americas. The analysis will focus on three aspects: 1) acknowledgement of connections between colonial histories and their contemporary influences in and for Europe; 2) the role of historical consciousness when dealing with the history of colonialism and 3) re-narrations of colonial history through enabling new voices. Ultimately this approach involves ‘past presencing’, in bringing the many connections of Europe’s colonial past and postcolonial present together. It is argued, that although museums are increasingly engaging with decolonisation, there exists a need to better include decolonisation of European minds in these processes. Heritage as a future-oriented project and a tool to manage memory can be used to support historical consciousness and imagine a just future.
We consider a fast, data-sparse directional method to realize matrix-vector products related to point evaluations of the Helmholtz kernel. The method is based on a hierarchical partitioning of the point sets and the matrix. The considered directional multi-level approximation of the Helmholtz kernel can be applied even on high-frequency levels efficiently. We provide a detailed analysis of the almost linear asymptotic complexity of the presented method. Our numerical experiments are in good agreement with the provided theory.
This is brief review of acceleration of electrons in plasma wakefields driven by either intense laser pulses or particle beams following lectures at the 2019 CERN Accelerator School on plasma accelerators, held at Sesimbra, Portugal. The commonalities between drivers and their strength parameters and operating parameter regimes for current experiments in laser wakefield acceleration (LWFA) and beam driven plasma wakefield acceleration (PWFA) are summarized. Energy limitations are introduced, including the dephasing and depletion lengths for lasers, and the transformer ratio for beam driven plasmas. The concept of the wake Hamiltonian is introduced and the resulting particle orbits are identified in phase space, which illustrates how the peak energy and energy spread of accelerated electrons are determined.
Albert Einstein's practice in physics and his philosophical positions gradually reoriented themselves from more empiricist towards rationalist viewpoints. This change accompanied his turn towards unified field theory and different presentations of himself, eventually leading to his highly programmatic Autobiographical Notes in 1949. Einstein enlisted his own history and professional stature to mold an ideal of a theoretical physicist who represented particular epistemic virtues and moral qualities. These in turn reflected the theoretical ideas of his strongly mathematical unification program and professed Spinozist beliefs.
Azimuthal anisotropies of muons from charm and bottom hadron decays are measured in Pb+Pb collisions at sNN=5.02TeV. The data were collected with the ATLAS detector at the Large Hadron Collider in 2015 and 2018 with integrated luminosities of 0.5nb−1 and 1.4nb−1, respectively. The kinematic selection for heavy-flavor muons requires transverse momentum 4<pT<30GeV and pseudorapidity |η|<2.0. The dominant sources of muons in this pT range are semi-leptonic decays of charm and bottom hadrons. These heavy-flavor muons are separated from light-hadron decay muons and punch-through hadrons using the momentum imbalance between the measurements in the tracking detector and in the muon spectrometers. Azimuthal anisotropies, quantified by flow coefficients, are measured via the event-plane method for inclusive heavy-flavor muons as a function of the muon pT and in intervals of Pb+Pb collision centrality. Heavy-flavor muons are separated into contributions from charm and bottom hadron decays using the muon transverse impact parameter with respect to the event primary vertex. Non-zero elliptic (v2) and triangular (v3) flow coefficients are extracted for charm and bottom muons, with the charm muon coefficients larger than those for bottom muons for all Pb+Pb collision centralities. The results indicate substantial modification to the charm and bottom quark angular distributions through interactions in the quark-gluon plasma produced in these Pb+Pb collisions, with smaller modifications for the bottom quarks as expected theoretically due to their larger mass.
Use of new psychoactive substances (NPS) across Europe remains a public health challenge. The study describes potentials and limitations of methods in a transnational survey of recent marginalised, nightlife and online community NPS users in Germany, Hungary, Ireland, the Netherlands, Poland and Portugal (n = 3023). In terms of demographic profile, drug use history and type of NPS, different methods reached different segments of the NPS-using population. Last year use of different NPS varied across countries and groups. Respondents used NPS in a variety of settings, with public spaces most common in the marginalised group. The study suggests that prevalence rates can reveal a picture of the NPS market that significantly deviates from what law enforcement seizures indicate. Outreach in nightlife settings and peer education are recommended to inform users about health risks and to improve access to drug services and care.
Klebsiella pneumoniae invasive syndrome (KPIS) is a rare clinical condition characterized by primary liver abscess associated with metastatic infection. Most case reports are from Southeast Asia, with only one case described in Portugal. The Authors present the case of a 44-year-old man with a history of fever, dry cough and cervicalgia. A thoracic computed tomography (CT) scan showed multiple pulmonary and hepatic nodules, suggestive of metastatic malignancy. Both blood cultures and bronchoalveolar lavage were positive for Klebsiella pneumoniae. Imaging studies were repeated during his hospital stay, showing a reduction in both number and volume of identified lesions, thus revealing their infectious nature. This case illustrates how much this entity can mimic other illnesses. LEARNING POINTS Klebsiella pneumoniae invasive syndrome is emerging as a global disease. The imaging-led diagnosis of neoplasia was proved incorrect and could have been deleterious for the patient. The lack of diagnostic suspicion can lead to shorter antibiotic treatment regimens, therefore compromising the patient’s full recovery.
Biological, sociocultural, demographic and environmental factors are major contributors to the contemporary burden of oncological diseases. Although cancer's current epidemiological landscape is fairly well known, its past occurrence and history seem more obscure. In order to test the hypothesis that paleopathological diagnosis is an adequate measure of the prevalence of malignant neoplasms in human remains, 131 skeletons (78 females, 53 males, age-at-death range: 15-93 years) from Coimbra and Lisbon Identified Skeletal Collections, 19th/20th century (Portugal), were examined. The cause of death for all of the selected skeletons was a malignant neoplasm, as recorded in the collection's documental files. Through the application of standard paleopathological protocols, it was determined that 17.6% (n = 23) of the skeletons had unequivocal osseous signs of metastatic and/or neoplastic lesions. Forty-five percent (n = 59) had manifest osseous lesions, however the lesional patterns were not clearly pathognomonic. Although all of the analyzed individuals were documented as having succumbed to malignant neoplastic disease, a total of 37.4% (n = 49) of the individuals did not exhibit osseous abnormalities. Individuals with breast cancer often exhibited lesions. This study presents a quantitative estimate of the accuracy of paleopathological diagnosis; as well as a theoretical reflection on the burden of cancer in the past. We emphasize the need for a paradigm shift while thinking about the future of paleo-oncology.
We discuss some fundamental properties of discrete system-time history states. Such states arise for a quantum reference clock of finite dimension and lead to a unitary evolution of system states when satisfying a static discrete Wheeler-DeWitt-type equation. We consider the general case where system-clock pairs can interact, analyzing first their different representations and showing there is always a special clock basis for which the evolution for a given initial state can be described by a constant Hamiltonian $H$. It is also shown, however, that when the evolution operators form a complete orthogonal set, the history state is maximally entangled for any initial state, as opposed to the case of a constant $H$, and can be generated with a simple two-clock setting. We then examine the quadratic system-time entanglement entropy, providing an analytic evaluation and showing it satisfies strict upper and lower bounds determined by the energy spread and the geodesic evolution connecting the initial and final states. We finally show that the unitary operator that generates the history state can itself be considered as an operator history state, whose quadratic entanglement entropy determines its entangling power. Simple measurements on the clock enable to efficiently determine overlaps between system states and also evolution operators at any two times.