Hasil untuk "cond-mat.other"

Oleg Tchernyshyov

These lecture notes from the 2023 Summer "School Principles and Applications of Symmetry in Magnetism" introduce the reader to the classical field theory of ferromagnets and antiferromagnets.

Kuang-Yung Lee, C. Seah, Ching Li et al.

Abstract Myotonic dystrophy (DM) is caused by expansions of C(C)TG repeats in the non-coding regions of the DMPK and CNBP genes, and DM patients often suffer from sudden cardiac death due to lethal conduction block or arrhythmia. Specific molecular changes that underlie DM cardiac pathology have been linked to repeat-associated depletion of Muscleblind-like (MBNL) 1 and 2 proteins and upregulation of CUGBP, Elav-like family member 1 (CELF1). Hypothesis solely targeting MBNL1 or CELF1 pathways that could address all the consequences of repeat expansion in heart remained inconclusive, particularly when the direct cause of mortality and results of transcriptome analyses remained undetermined in Mbnl compound knockout (KO) mice with cardiac phenotypes. Here, we develop Myh6-Cre double KO (DKO) (Mbnl1−/−; Mbnl2cond/cond; Myh6-Cre+/−) mice to eliminate Mbnl1/2 in cardiomyocytes and observe spontaneous lethal cardiac events under no anesthesia. RNA sequencing recapitulates DM heart spliceopathy and shows gene expression changes that were previously undescribed in DM heart studies. Notably, immunoblotting reveals a nearly 6-fold increase of Calsequestrin 1 and 50% reduction of epidermal growth factor proteins. Our findings demonstrate that complete ablation of MBNL1/2 in cardiomyocytes is essential for generating sudden death due to lethal cardiac rhythms and reveal potential mechanisms for DM heart pathogenesis.

B. Chalarca, A. Filiatrault, D. Perrone

AbstractThis paper investigates the seismic demand on acceleration-sensitive nonstructural components in buildings equipped with fluid viscous dampers. Nonlinear dynamic response analyses were cond...

J. Bagley, K. Burghardt, Ryan T. McManus et al.

Bagley, JR, Burghardt, KJ, McManus, R, Howlett, B, Costa, PB, Coburn, JW, Arevalo, JA, Malek, MH, and Galpin, AJ. Epigenetic responses to acute resistance exercise in trained vs. sedentary men. J Strength Cond Res 34(6): 1574-1580, 2020-Acute resistance exercise (RE) alters DNA methylation, an epigenetic process that influences gene expression and regulates skeletal muscle adaptation. This aspect of cellular remodeling is poorly understood, especially in resistance-trained (RT) individuals. The study purpose was to examine DNA methylation in response to acute RE in RT and sedentary (SED) young men, specifically targeting genes responsible for metabolic, inflammatory, and hypertrophic muscle adaptations. Vastus lateralis biopsies were performed before (baseline), 30 minutes after, and 4 hours after an acute RE bout (3 × 10 repetitions at 70% 1 repetition maximum [1RM] leg press and leg extension) in 11 RT (mean ± SEM: age = 26.1 ± 1.0 years; body mass = 84.3 ± 0.2 kg; leg press 1RM = 412.6 ± 25.9 kg) and 8 SED (age = 22.9 ± 1.1 years; body mass = 75.6 ± 0.3 kg; leg press 1RM = 164.8 ± 22.5 kg) men. DNA methylation was analyzed through methylation sensitive high-resolution melting using real-time polymerase chain reaction. Separate 2 (group) × 3 (time) repeated-measures analyses of variance and analyses of covariance were performed to examine changes in DNA methylation for each target gene. Results showed that acute RE (a) hypomethylated LINE-1 (measure of global methylation) in RT but not SED, (b) hypermethylated metabolic genes (GPAM and SREBF2) in RT, while lowering SREBF2 methylation in SED, and (c) did not affect methylation of genes associated with inflammation (IL-6 and TNF-α) or hypertrophy (mTOR and AKT1). However, basal IL-6 and TNF-α were lower in SED compared with RT. These findings indicate the same RE stimulus can illicit different epigenetic responses in RT vs. SED men and provides a molecular mechanism underpinning the need for differential training stimuli based on subject training backgrounds.

Ricardo Schultz Martins, P. Girouard, E. Elliott et al.

Martins, RS, Girouard, P, Elliott, E, and Mekary, S. Physiological responses of a jaw repositioning custom-made mouthguard on airway and their effects on athletic performance. J Strength Cond Res XX(X): 000-000, 2018-Advanced dental techniques such as jaw-repositioning have shown to increase lower body muscular power such as vertical jump, but its effects on acceleration and speed have not been studied. Similarly, jaw repositioning is commonly used to increase airways volume and ventilation in a special population (i.e., obstructive sleep apnea); however, its ergogenic effects on aerobic performance have yet not been studied. The purpose of the cross-over study was to investigate the effects of a jaw-repositioning custom-made mouthguard (JCM) on volumetric changes in airway and jaw position and determine the effects this may have on aerobic and anaerobic performance. Results indicated that jaw-repositioning custom-made mouthguard may have an ergogenic effect on performance. The JCM condition showed an increase of 13% in upper airway volume (p = 0.04), 10% in upper airway width (p = 0.004), 7% in ventilation (p = 0.006), 5% in maximal aerobic power (p = 0.003), 4% in time to exhaustion (p = 0.03), 3% in vertical jump (p = 0.03), 2% in broad jump (p = 0.009), and a decrease of 4% in 20-m (p = 0.04) and 2% in 40-m (p = 0.001) sprint times. This is the first study to demonstrate a significant link between jaw repositioning, airway volumetric change, and performance enhancement in both aerobic and anaerobic performances. The results of this study may lead to a change in culture for the use of mouthguards in different sports applications, from high orofacial injury risk sports to other sports, specifically for ergogenic enhancement.

Kevin Thomas, D. French, P. Hayes

E. S. de Villarreal, E. Kellis, W. Kraemer et al.

Allan G. Munro, L. Herrington

M. Chelly, M. Fathloun, N. Chérif et al.

C. Meylan, D. Malatesta

P. Cormie, J. Mcbride, Grant O. McCaulley

P. P. Gorman, R. Butler, Phillip J. Plisky et al.

V. Manzi, S. D'Ottavio, F. Impellizzeri et al.

D. Dwyer, T. Gabbett

H. Menzel, M. H. Chagas, L. Szmuchrowski et al.

C. Dobbs, N. Gill, D. Smart et al.

A. Chaouachi, M. Chtara, R. Hammami et al.

D. Hackett, N. Johnson, C. Chow

N. Souissi, H. Chtourou, Asma Aloui et al.

M. Reggiani, S. Quanz, M. Meyer et al.

We present L′- and J-band high-contrast observations of HD 169142, obtained with the Very Large Telescope/NACO AGPM vector vortex coronagraph and the Gemini Planet Imager, respectively. A source located at 0.″156 ± 0.″032 north of the host star (P.A. = 7.°4 ± 11.°3) appears in the final reduced L′ image. At the distance of the star (∼145 pc), this angular separation corresponds to a physical separation of 22.7 ± 4.7 AU, locating the source within the recently resolved inner cavity of the transition disk. The source has a brightness of L′ = 12.2 ± 0.5 mag, whereas it is not detected in the J band (J >13.8 mag). If its L′ brightness arose solely from the photosphere of a companion and given the J − L′ color constraints, it would correspond to a 28–32 MJupiter object at the age of the star, according to the COND models. Ongoing accretion activity of the star suggests, however, that gas is left in the inner disk cavity from which the companion could also be accreting. In this case, the object could be lower in mass and its luminosity enhanced by the accretion process and by a circumplanetary disk. A lower-mass object is more consistent with the observed cavity width. Finally, the observations enable us to place an upper limit on the L′-band flux of a second companion candidate orbiting in the disk annular gap at ∼50 AU, as suggested by millimeter observations. If the second companion is also confirmed, HD 169142 might be forming a planetary system, with at least two companions opening gaps and possibly interacting with each other.