Hasil untuk "Life"

Nita Handastya

Childhood socioeconomic disadvantage is a well established determinant of health in later life. Less is known about how early-life deprivation unfolds when individuals experience major institutional transformation and migration in adulthood. Cohorts socialized under Soviet institutions provide a useful setting to examine life-course divergence under systemic change. This study uses harmonized data from the Survey of Health, Ageing and Retirement in Europe (SHARE) on older adults residing in Estonia, Latvia, and Israel to examine the association between retrospectively reported childhood deprivation and multiple health outcomes in later life, including poor self-rated health, chronic disease burden, functional limitation, depression, and a composite multifrailty indicator. Logistic regression models and predicted probabilities assess whether childhood deprivation predicts late-life health across different adult institutional contexts and whether associations vary by linguistic affiliation. Higher levels of childhood deprivation are consistently associated with poorer health outcomes across all three countries. Individuals in the highest deprivation quintile show substantially higher odds of adverse health outcomes, including multifrailty. Stratified analyses for Estonia and Latvia indicate broadly similar deprivation-health gradients among national-language and Russian-speaking populations. These findings highlight the persistence of childhood disadvantage and the importance of early-life conditions in shaping health inequalities in ageing populations exposed to systemic transformation.

Domenec Espriu

Alexander Andreevich Andrianov was a remarkable personality in Russian physics during the last decades. A member of th prestigious school of theoretical physics in Saint Petersburg, he made relevant contributions to a number of topics along his life. His activity ran in parallel with profound changes in his home country and the international arena. He was very much involved in this series of conferences, being the host of the 2014 edition in Saint Petersburg. In this presentation made at the XVI Conference on Quark Confinement and Hadron Spectrum I will provide a vision -- necessarily personal -- of his life and his activities and how these influenced many of us.

Michiel Rollier, Lucas Caldeira de Oliveira, Odemir M. Bruno et al.

We present a strong theoretical foundation that frames a well-defined family of outer-totalistic network automaton models as a topological generalisation of binary outer-totalistic cellular automata, of which the Game of Life is one notable particular case. These "Life-like network automata" are quantitatively described by expressing their genotype (the mean field curve and Derrida curve) and phenotype (the evolution of the state and defect averages). After demonstrating that the genotype and phenotype are correlated, we illustrate the utility of these essential metrics by tackling the firing squad synchronisation problem in a bottom-up fashion, with results that exceed a 90% success rate.

Vladimir Subbotin, Gennady Fiksel

Life demonstrates remarkable homochirality of its major building blocks: nucleic acids, amino acids, sugars, and phospholipids. We propose a mechanism that places the root of life homochirality in the formation of phospholipid bilayer vesicles (liposomes). These liposomes are formed at the water-air interface from Langmuir layers and contain ribose, presumably delivered to Early Earth by carbonaceous meteorites. Although the extraterrestrial ribose was initially racemic, life is homochiral, based on D-ribose and its derivatives. The phospholipid membrane high permeability to D-ribose, combined with the ribose interaction with the bilayer charged phosphate groups, leads to ribose phosphorylation, forming D-ribose-5-phosphate. Once inside, the D-ribose-5-phosphate molecules cannot cross the membrane. The catalytic action of Fe (3+ions) greatly enhances the phosphorylation rate. Overall, this process is enantioselective, substantially favoring the buildup of D-ribose over L-ribose. Through liposome fusion, fission, and self-replication, this eventually leads to the Darwinian evolution of these structures and to the conversion of D-ribose-5-phosphate into complex functional molecules, such as ribozymes and RNA, and eventually into DNA, all of which inherit D-ribose chirality.

Jiaqi Yao, Jiaqi Yao, Xinjian Lu et al.

BackgroundCompared to single-shell diffusion tensor imaging (DTI), free water (FW) and neurite orientation dispersion and density imaging (NODDI) offer a more comprehensive evaluation of microstructural alterations in cerebral white matter (WM), particularly in detecting crossing fibers. However, research utilizing multi-shell diffusion imaging to investigate thyroid-associated ophthalmopathy (TAO) remains limited. This study employs FW and NODDI to investigate microstructural changes in the white matter of the visual pathways in patients with TAO.MethodsMulti-shell diffusion magnetic resonance imaging (dMRI) scans were performed on 45 patients with TAO and 31 age- and sex-matched healthy controls (HC). Tract-based spatial statistics (TBSS) analysis was conducted using eight FW and NODDI-derived metrics to identify group differences in white matter microstructure. Furthermore, correlations between these microstructural changes and clinical measures were examined.ResultsTBSS analysis revealed that, compared to HC, patients with TAO exhibited lower free-water corrected fractional anisotropy (fwFA) and free-water corrected axial diffusivity (fwAD), while free-water corrected mean diffusivity (fwMD), free-water corrected radial diffusivity (fwRD), and orientation dispersion index (ODI) were significantly increased (p < 0.05, FWE). Notably, ODI demonstrated the highest area under the curve (AUC) among these metrics. Furthermore, fwFA, fwAD, fwMD, fwRD, and ODI showed significant correlations with the Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), and the Graves’ Orbitopathy Quality of Life Questionnaire (GO-QOL2) scores.ConclusionThis study suggests that abnormalities in the white matter microstructure of TAO patients can be detected through the complementary use of FW and NODDI metrics, and it is revealed that these changes may have an impact on mental health.

William Bains, Janusz J. Petkowski, Sara Seager

Life is a complex, dynamic chemical system that requires a dense fluid solvent in which to take place. A common assumption is that the most likely solvent for life is liquid water, and some researchers argue that water is the only plausible solvent. However, a persistent theme in astrobiological research postulates that other liquids might be cosmically common, and could be solvents for the chemistry of life. In this paper we present a new framework for the analysis of candidate solvents for life, and deploy this framework to review substances that have been suggested as solvent candidates. We categorize each solvent candidate through four criteria: occurrence, solvation, solute stability and solvent chemical functionality. Our semi-quantitative approach addresses all the requirements for a solvent not only from the point of view of its chemical properties but also from the standpoint of their biochemical function. Only the protonating solvents fulfil all the chemical requirements to be a solvent for life, and of those only water and concentrated sulfuric acid are also likely to be abundant in a rocky planetary context. Among the non-protonating solvents liquid CO2 stands out as a planetary solvent, and its potential as a solvent for life should be explored. We conclude with a discussion of whether it is possible for a biochemistry to change solvents, as an adaptation to radical changes in a planet's environment. Our analysis provides the basis for prioritizing future experimental work exploring potential complex chemistry on other planets.

Pru Holder, Bethan Page, Julia Hackett et al.

ABSTRACT Background Guidance and principles for involving the public in research or service planning exist but are not specific to the needs of parents of children with life‐limiting conditions or bereaved parents. Aim Review the evidence on involving parents of children with life‐limiting conditions and bereaved parents in research, service planning and advocacy, and use this to develop best practice guidance. Methods Rapid review following the Cochrane Rapid Reviews Methods Group Guidance. MEDLINE and EMBASE were searched for primary studies of any design and literature/systematic reviews, and grey literature searching was conducted. Sources reporting on involving parents of children with life‐limiting conditions or bereaved parents in healthcare, research, or charity work in any setting, were included. Data were charted using the UK standards for public involvement in research (PPI). Two PPI consultation workshops were conducted with parents (n = 13) and healthcare professionals/charity representatives (n = 7). Results Six sources were included. Four reported benefits of parental involvement and two reported burdens. In relation to best practice, two reported on the importance of inclusive opportunities, three on working together, four on support and learning, three on communications, one on impact, and one on governance. PPI consultation workshops highlighted new factors which were not present in the literature around communication and understanding the impact of involvement. Conclusion Organisations working with this group should consider offering inclusive approaches to improve diversity, levelling power imbalances, ensuring flexibility of approach, and appropriate communication and impact. Patient or Public Contribution The study was conducted in collaboration with 13 parents of children with life‐limiting conditions and bereaved parents, and seven palliative care professionals. The group were involved at key stages of the review and contributed to the development of the findings and conduct of the review.

Tae Hyeon Heo, Hyeon Park, Nam-Wook Kim et al.

Waxy maize is mainly cultivated in South Korea for the production of food and snacks, and colored maize with increased anthocyanin content is used in the production of functional foods and medicinal products. Association mapping analysis (AMA) is supported as the preferred method for identifying genetic markers associated with complex traits. Our study aimed to identify molecular markers associated with two anthocyanin content and six seed coat color traits in near-isogenic lines (NILs) of colored waxy maize assessed through AMA. We performed AMA for 285 SSR loci and two anthocyanin content and six seed coat color traits in 10 NILs of colored waxy maize. In the analysis of population structure and cluster formation, the two parental lines (HW3, HW9) of “Mibaek 2ho” variety waxy maize and the 10 NILs were clearly divided into two groups, with each group containing one of the two parental inbred lines. In the AMA, 62 SSR markers were associated with two seed anthocyanin content and six seed coat color traits in the 10 NILs. All the anthocyanin content and seed coat color traits were associated with SSR markers, ranging from 2 to 12 SSR markers per characteristic. The 12 SSR markers were together associated with both of the two anthocyanin content (kuromanin and peonidin) traits. Our current results demonstrate the effectiveness of SSR analysis for the examination of genetic diversity, relationships, and population structure and AMA in 10 NILs of colored waxy maize and the two parental lines of the “Mibaek 2ho” variety waxy maize.

Andrew D. Leavitt, Johnny Mahlangu, Priyanka Raheja et al.

Background: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection. Objectives: Determine valoctocogene roxaparvovec durability, efficacy, and safety 4 years after treatment. Methods: In the phase 3 GENEr8-1 trial, 134 adult male persons with severe hemophilia A without inhibitors and previously using FVIII prophylaxis received a 6 × 1013 vg/kg infusion of valoctocogene roxaparvovec. Efficacy endpoints included annualized bleed rate, annualized FVIII infusion rate, FVIII activity, and the Haemophilia-Specific Quality of Life Questionnaire for Adults. Adverse events and immunosuppressant use were assessed. Change from baseline was assessed after participants discontinued prophylaxis (scheduled for week 4). Results: Median follow-up was 214.3 weeks; 2 participants discontinued since the previous data cutoff. Declines from baseline in mean treated annualized bleed rate (−82.6%; P < .0001) and annualized FVIII infusion rate (−95.5%; P < .0001) were maintained from previous years in the primary analysis population of 112 participants who enrolled from a noninterventional study. During year 4, 81 of 110 rollover participants experienced 0 treated bleeds. Week 208 mean and median chromogenic FVIII activity were 16.1 IU/dL and 6.7 IU/dL, respectively, in 130 modified intention-to-treat participants. Seven participants resumed prophylaxis since the previous data cutoff. Mean change from baseline to week 208 in Haemophilia-Specific Quality of Life Questionnaire for Adults Total Score (P < .0001) remained clinically meaningful for modified intention-to-treat participants. Alanine aminotransferase elevation was the most common adverse event during year 4 (56/131 participants); none required immunosuppressants. Conclusion: Valoctocogene roxaparvovec provides persistent FVIII expression, hemostatic control, and health-related quality of life improvements with no new safety signals.

Caterina Conigliani, Martina Iorio, Salvatore Monni

According to the UN's Sustainable Development Agenda, to effectively achieve sustainable development, strategies for building economic growth should also address social needs, including access to essential services. Sustainable integrated management of water resources for both primary use and energy production is crucial, especially in territories such as the Amazonian State of Pará, where a primary good like fresh water is also the main source of electricity. However, the territorial transformations occurring in Pará over installing new hydroelectric plants have jeopardised local development. This was mainly caused by the top-down approach underlying national strategic projects that have paid little attention to local needs, thus paving the way for detrimental conditions for implementing the UN's 2030 Agenda. This paper aims to analyse the relationship between a municipality's level of development and quality of life and the most relevant key determinants of sustainable development in Pará. To this end, we consider a spatial regression analysis, with particular attention devoted to the role of access to both energy and water. The presence of significant spillover effects implies that providing public services on a geographically broad basis could induce self-reinforcing benefits.

Grace Aprilia Helena, Shoen Kume

Diabetes is an epidemic caused by a multitude of factors. Despite the studies attempting to unravel its mechanism, there is still more to discover about glucose–insulin dynamics. In a recent issue of the Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β‐cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β‐cells.Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β‐cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β‐cells. Their multiomics approach might provide a deeper understanding of high glucose and translational regulation of genes involved in β‐cell insulin impairment caused by prolonged high‐glucose exposure.

Hiroki Sato, Tanner Lund, Takahide Yoshida et al.

We study life over the course of video game history as represented by their mechanics. While there have been some variations depending on genre or "character type", we find that most games converge to a similar representation. We also examine the development of Conway's Game of Life (one of the first zero player games) and related automata that have developed over the years. With this history in mind, we investigate the viability of one popular form of automata, namely Neural Cellular Automata, as a way to more fully express life within video game settings and innovate new game mechanics or gameplay loops.

Andrew Skumanich

This memoire covers my life history starting with my family's background and their immigration to the US. It continues with my childhood, my early education, and my introduction to science. It then covers my professional research included a variety of institutions and areas of Physics ending ultimately in Solar Physics.

Michalina Gruszczyńska, Adam Jarzemski, Agnieszka Kolossa et al.

Introduction and objective: Treatment with antiepileptic drugs (AEDs) is frequently used all around the world. Just like in the course of all the drugs administration, side effects may appear, including characteristic side effects presenting on the skin. The aim of the study was to analyse adverse skin reactions to antiepileptic drugs, focusing on their epidemiology, symptoms and treatment. Methods: Databases including PubMed and Google Scholar were browsed using keywords. Description of the state of knowledge: The majority of adverse skin reactions (ASRs) constitute mild rashes and urticaria, however in about 10% cases severe reactions may occur, which can be life-threatening. They include Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Stevens-Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN), Serum Sickness and Serum Sickness - like Reactions and Drug Induced Vasculitis. In the course of TEN mortality rates are highest, however all reactions can be dangerous and treatment should be applied immediately. In mild and moderate cases drug withdrawal is usually sufficient, however more severe cases need to be treated with immunosuppressive agents. Summary: The awareness about possible adverse effects and their treatment is crucial as some can be life-threatening and immediate therapy increases the chance of recovery.

Mario Fargnoli, Luca Murgianu

Nowadays, services related to IT technologies have assumed paramount importance in most sectors, creating complex systems involving different stakeholders. Such systems are subject to unpredictable risks that differ from what is usually expected and cannot be properly managed using traditional risk assessment approaches. Consequently, ensuring their reliability represents a critical task for companies, which need to adopt resilience engineering tools to reduce the occurrence of failures and malfunctions. With this goal in mind, the current study proposes a risk assessment procedure for cloud migration processes that integrates the application of the Functional Resonance Analysis Method (FRAM) with tools aimed at defining specific performance requirements for the suppliers of this service. In particular, the Critical-To-Quality (CTQ) method was used to define the quality drivers of the IT platform customers, while technical standards were applied to define requirements for a security management system, including aspects relevant to the supply chain. Such an approach was verified by means of its application to a real-life case study, which concerns the analysis of the risks inherent to the supply chain related to cloud migration. The results achieved can contribute to augmenting knowledge in the field of IT systems’ risk assessment, providing a base for further research.

Yun-Fei Li, Xu Ren, Liang Zhang et al.

Traumatic brain injury (TBI) is a serious disease that threatens life and health of people. It poses a great economic burden on the healthcare system. Thus, seeking effective therapy to cure a patient with TBI is a matter of great urgency. Microglia are macrophages in the central nervous system (CNS) and play an important role in neuroinflammation. When TBI occurs, the human body environment changes dramatically and microglia polarize to one of two different phenotypes: M1 and M2. M1 microglia play a role in promoting the development of inflammation, while M2 microglia play a role in inhibiting inflammation. How to regulate the polarization direction of microglia is of great significance for the treatment of patients with TBI. The polarization of microglia involves many cellular signal transduction pathways, such as the TLR-4/NF-κB, JAK/STAT, HMGB1, MAPK, and PPAR-γ pathways. These provide a theoretical basis for us to seek therapeutic drugs for the patient with TBI. There are several drugs that target these pathways, including fingolimod, minocycline, Tak-242 and erythropoietin (EPO), and CSF-1. In this study, we will review signaling pathways involved in microglial polarization and medications that influence this process.

Radhika Varma, Keerankulangara Devi, Neelakandhan Asokan

Qian YF, Geng GL, Ren YQ et al.

Yu-Fei Qian,1 Gui-Ling Geng,1 Yu-Qin Ren,2 Xin-Tong Zhang,2 Wen-Jun Sun,2 Qing Li2 1Department of School of Nursing, Nantong University Medical School, Nantong, 226001, People’s Republic of China; 2Department of Emergency, Nantong First People’s Hospital, Nantong, 226006, People’s Republic of ChinaCorrespondence: Gui-Ling GengDepartment of School of Nursing, Nantong university Medical school, No. 19, Qixiu Road, Nantong City, Jiangsu Province, 226001, People’s Republic of ChinaTel +86 15152889466Fax +86-513-85051876Email geng_gl@126.comObjective: This study aimed to investigate community residents’ awareness of basic life support (BLS) and their willingness to attempt rescue.Methods: From October to December 2020, in the communities of Nantong City, a stratified three-stage random sampling method was adopted to select residents from 12 neighborhood committees over the age of 18 with whom to conduct a cross-sectional questionnaire survey. A self-designed questionnaire was adopted, the contents of which included the general situation of the respondent, knowledge, attitude, and behavior in relation to BLS; the Cronbach’s α coefficient of the questionnaire was 0.719.Results: A total of 3000 questionnaires were distributed, of which 2812 were valid, with a valid response rate of 93.73%. Of the 2812 respondents, 41.18% had seen an automatic external defibrillator (AED), 48.83% had experience of’ cardiopulmonary resuscitation (CPR), and 25.07% of the respondents had experience of’ AEDs. When an accident occurred, 50.50% of residents were willing to attempt rescue, 70.80% were willing to attempt rescue under professional guidance, and 71.23% were willing to attempt rescue after learning BLS techniques. Of the residents who were unwilling to attempt rescue, 32.75% were worried about their lack of ability, 27.91% were concerned about legal issues, 14.01% feared infectious diseases, and 10.35% were unwilling to perform mouth-to-mouth artificial respiration. Age, occupation, education level, and whether they had participated in first aid training were the influencing factors.Conclusion: Residents in Nantong have less knowledge of BLS, and their knowledge of CPR is better than that of AEDs. Residents have a strong willingness to learn BLS. Measures need to be taken to improve their understanding of BLS and their application skills. Residents have high levels of willingness to attempt rescue, but a certain percentage of residents have concerns. Interventions can be made to target the different reasons.Keywords: out-of-hospital cardiac arrest, basic life support, automatic external defibrillator, rescue willing

Christopher E. Doughty, Andrew Abraham, James Windsor et al.

Can multicellular life be distinguished from single cellular life on an exoplanet? We hypothesize that abundant upright photosynthetic multicellular life (trees) will cast shadows at high sun angles that will distinguish them from single cellular life and test this using Earth as an exoplanet. We first test the concept using Unmanned Arial Vehicles (UAVs) at a replica moon landing site near Flagstaff, Arizona and show trees have both a distinctive reflectance signature (red edge) and geometric signature (shadows at high sun angles) that can distinguish them from replica moon craters. Next, we calculate reflectance signatures for Earth at several phase angles with POLDER (Polarization and Directionality of Earth's reflectance) satellite directional reflectance measurements and then reduce Earth to a single pixel. We compare Earth to other planetary bodies (Mars, the Moon, Venus, and Uranus) and hypothesize that Earths directional reflectance will be between strongly backscattering rocky bodies with no weathering (like Mars and the Moon) and cloudy bodies with more isotropic scattering (like Venus and Uranus). Our modelling results put Earth in line with strongly backscattering Mars, while our empirical results put Earth in line with more isotropic scattering Venus. We identify potential weaknesses in both the modeled and empirical results and suggest additional steps to determine whether this technique could distinguish upright multicellular life on exoplanets.

Jin Quan Zhou, Wen Jin He

The industrial life cycle theory has proved to be helpful for describing the evolution of industries from birth to maturity. This paper is to highlight the historical evolution stage of Atlantic City's gambling industry in a structural framework covered by industrial market, industrial organization, industrial policies and innovation. Data mining was employed to obtain from local official documents, to verify the module of industrial life cycle in differential phases as introduction, development, maturity and decline. The trajectory of Atlantic City's gambling sector evolution reveals the process from the stages of introduction to decline via a set of variables describing structural properties of this industry such as product, market and organization of industry under a special industry environment in which industry recession as a result of theory of industry life cycle is a particular evidence be proved again. Innovation of the gambling industry presents the ongoing recovering process of the Atlantic City gambling industry enriches the theory of industrial life cycle in service sectors.