Aleksandra Sushchenko, Olena Yatsenko, Teemu Leinonen
The pervasive presence of digital technology in everyday life has intensified discussions about the shift to digital culture—an environment where our virtual and physical selves continually intertwine. This raises a question: which reality holds greater sway over our agency? Such inquiry requires close attention to design decisions, as they play a key role in shaping digital culture through the aesthetic experiences they enable and carry substantial ethical responsibility. In this paper, we explore how human agency is transformed within digital culture, offering a philosophical reflection on the concept of the metainterface as the discursive domain within which this transformation happens. Our central claim is that a critical interrogation of interface design is imperative to move beyond commercially driven models of digital metainterfaces that privilege control and efficiency toward autonomous agency. Instead, we advocate for design approaches rooted in enactivist theory, which emphasize participatory sense-making and embodied engagement. We argue that enactivist-informed, aesthetically oriented interfaces can provide conditions for autonomous agency, allowing users to engage with technology in reflective, value-driven, and ethically mindful ways. This shift is aimed at repositioning interface design as a meaningful cultural practice capable of supporting richer, more responsible forms of interaction.
The study aims to identify the trends of scientific research (master’s and PhD theses) at Al Wasl University by analysing and tracking the following elements and indicators: Degree awarded, Gender of the researcher, Nationality of the researcher, Gender of the research supervisor, Nationality of the research supervisor, Annual distribution of research, Research specialization, Type of research. Considering the above, there is a clear need to conduct a statistical analytical study to answer the following main question: What are the trends of scientific research (master’s and PhD theses) at Al Wasl University,Dubai, United Arab Emirates? A systematic bibliometric analysis was conducted using the Theses and Dissertations Approved in The University of Alwasl published between 1999 and August 2025. A total of 425 Theses and Dissertations were identified, involving 364 authors. The study recorded the theses approved at the master's and doctoral levels since the establishment of graduate studies at the university up to August 2025. showing a consistent growth in the number of master's and doctoral degrees and an increased approval rate in recent years, the languages thesis to master's and doctoral research. It is evident that the percentage of Arabic language is higher than that of other languages completed (99.07%), while other languages for (0.93%). The specializations of Master's and Doctoral theses at Al Wasl University, varied across five main areas. Leading these was the field of Emirati culture and society studies, with 203 theses, making up 46.99%, which is logically consistent with the university's context.
History of scholarship and learning. The humanities, Arts in general
Seprianus A. Nenotek, I. Made Suta Paramarta, Alya E. Sjioen
et al.
This study explores the role of linguistic elements in supporting or hindering sustainable and inclusive tourism, a vital factor for the economic growth of the regency, which depends heavily on tourism. The research aims to fill this gap by comprehensively analyzing the linguistic landscape in Timor Tengah Selatan Regency (TTS) of East Nusa Tenggara Province, Indonesia, and its impact on tourism development. Data for the study were gathered from all potential tourist destinations listed on the government website, including beaches, nature reserves, baths or waterfalls, tourist villages, and religious tourism sites. Data collection methods included observation, photographic documentation, and interviews. The collected data were analyzed using both qualitative approaches. The signage at these tourist locations typically included directional signs to the destinations, name boards, directional signs within the sites, and other informational signs, such as reminders to keep the area clean or to protect the trees. The signs were predominantly in Indonesian and English, presented in monolingual formats. The linguistic landscape in the tourist areas of TTS represents a critical intersection of language and tourism. This research adds to the broader discussion on sustainable tourism by emphasizing the significance of linguistic diversity and inclusive practices in achieving long-term sustainability objectives.
Yutaro Tsutsumi, Naoya Sakamoto, Kei Hirose
et al.
We determined the metal/silicate partition coefficients of hydrogen and carbon, DH and DC, simultaneously under typical conditions of Earth's core formation. Experiments demonstrate that both DH and DC diminish in the presence of carbon and hydrogen, respectively, indicating their strong interactions in liquid metal. With these partitioning data, we investigated the core and bulk Earth abundances of hydrogen and carbon based on core formation scenarios that are compatible with the bulk silicate Earth composition and the mass fraction and density deficit of the core. The results of the single-stage core formation modelling are markedly different from those using DH and DC individually determined in earlier experiments, indicating that the Earth building blocks do not match enstatite chondrites in water abundance and require contributions by carbonaceous chondrites. The multi-stage core formation models combined with an Earth accretion scenario accounting for isotopic composition show 0.18-0.49 wt% H and 0.19-1.37 wt% C in the core, leading to 0.53-1.40 wt% H2O (present as H in the core) and 0.07-0.44 wt% C in the bulk Earth. Our modelling also demonstrates that up to 53% and 72% of Earth's water (hydrogen) and carbon, respectively, could have been derived from non-carbonaceous chondritic materials.
Platelet distribution width (PDW), a marker of platelet size heterogeneity used as a readout of processes leading to platelet production and destruction, was recently reported to tag platelet activation variability. As platelets participate in the pathogenesis of many acute and chronic diseases, we evaluated PDW as a predictor of all-cause and cause-specific mortality. Longitudinal analysis was performed on 17,334 participants (52% women, mean age 55.6±12 years) in the Moli-sani study cohort, without a history of hematological diseases. Baseline PDW measurements were categorized in tertiles, the lowest acting as the reference. A multivariable Cox-proportional hazard model was used to estimate the association between PDW and mortality. Over a median follow-up of 11.6 years (interquartile range 10.7-12.5), 1,535 deaths [37.7% cardiovascular disease (CVD) and 36.5% cancer] were ascertained. As compared to those in the first PDW tertile (14.6-16.0 fL), individuals within the highest tertile (16.6-20.4 fL) had an increased risk of all-cause [hazard ratios (HR):1.20; 95% CI: 1.04-1.37] and CVD mortality (HR:1.29; 1.03-1.62). No association between PDW and cancer mortality was found in the whole sample. Subgroup analyses by two age classes (35-65y, ≥65y) showed that the association of PDW with both all-cause and cancer mortality was more apparent in the elderly (HR:1.34; 1.14-1.58, P for interaction =0.028 and HR:1.37; 1.01-1.85, P for interaction =0.020, respectively). We conclude that PDW-associated increase in CVD mortality risk could be related to accelerated/altered activation, production, or destruction of platelets, leading to several clinical conditions and death. In the elderly, PDW involvement in all-cause and cancer mortality should be further investigated. *Moli-sani investigatorsSteering committee: Licia Iacoviello, Giovanni de Gaetano, Maria Benedetta Donati. Scientific secretariat: Marialaura Bonaccio, Americo Bonanni, Chiara Cerletti, Simona Costanzo, Amalia De Curtis, Augusto Di Castelnuovo, Alessandro Gialluisi, Francesco Gianfagna, Mariarosaria Persichillo, Teresa Di Prospero. Safety and ethical committee: Jos Vermylen, Renzo Pegoraro, Antonio Spagnolo. External event adjudicating committee: Deodato Assanelli, Livia Rago. Baseline and follow-up data management: Simona Costanzo, Marco Olivieri, Teresa Panzera. Data analysis: Augusto Di Castelnuovo, Marialaura Bonaccio, Simona Costanzo, Simona Esposito, Alessandro Gialluisi, Francesco Gianfagna, Sabatino Orlandi, Emilia Ruggiero, Alfonsina Tirozzi. Biobank, molecular and genetic laboratory: Amalia De Curtis, Sara Magnacca, Fabrizia Noro, Alfonsina Tirozzi. Recruitment staff: Mariarosaria Persichillo, Francesca Bracone, Teresa Panzera. Communication and press office: Americo Bonanni. Regional institutions: Direzione Generale per la Salute - Regione Molise; Azienda Sanitaria Regionale del Molise; Agenzia Regionale per la Protezione Ambientale del Molise; Molise Dati Spa; Offices of vital statistics of the Molise region. Hospitals: Presidi Ospedalieri ASReM: Ospedale A. Cardarelli, Campobasso; Ospedale F. Veneziale, Isernia; Ospedale San Timoteo, Termoli (CB); Ospedale Ss. Rosario, Venafro (IS); Ospedale Vietri, Larino (CB); Ospedale San Francesco Caracciolo, Agnone (IS); Casa di Cura Villa Maria, Campobasso; Ospedale Gemelli Molise, Campobasso; IRCCS Neuromed, Pozzilli (IS), Italy.
Background. The profile of cellular immunological responses of children across the spectrum of COVID-19, ranging from acute SARS-CoV-2 infection to full recovery or Long COVID, has not yet been fully investigated. Methods. We examined and compared cytokines in sera and cell subsets in peripheral blood mononuclear cells (B and regulatory T lymphocytes) collected from four distinct groups of children, distributed as follows: younger than 18 years of age with either acute SARS-CoV-2 infection (n = 49); fully recovered from COVID-19 (n = 32); with persistent symptoms (Long COVID, n = 51); and healthy controls (n = 9). Results. In the later stages after SARS-CoV-2 infection, the cohorts of children, both with recovered and persistent symptoms, showed skewed T and B subsets, with remarkable differences when compared with children at the onset of the infection and with controls. The frequencies of IgD+CD27− naïve B cells, IgD+IgM+ and CD27−IgM+CD38dim B cells were higher in children with recent infection than in those with an older history of disease (p < 0.0001 for all); similarly, the total and natural Tregs compartments were more represented in children at onset when compared with Long COVID (p < 0.0001 and p = 0.0005, respectively). Despite the heterogeneity, partially due to age, sex and infection incidence, the susceptibility of certain children to develop persistent symptoms after infection appeared to be associated with the imbalance of the adaptive immune response. Following up and comparing recovered versus Long COVID patients, we analyzed the role of circulating naïve and switched B and regulatory T lymphocytes in counteracting the evolution of the symptomatology emerged, finding an interesting correlation between the amount and ability to reconstitute the natural Tregs component with the persistence of symptoms (linear regression, p = 0.0026). Conclusions. In this study, we suggest that children affected by Long COVID may have a compromised ability to switch from the innate to the adaptive immune response, as supported by our data showing a contraction of naïve and switched B cell compartment and an unstable balance of regulatory T lymphocytes occurring in these children. However, further prospective immunological studies are needed to better clarify which factors (epigenetic, diet, environment, etc.) are involved in the impairment of the immunological mechanisms in the Long COVID patients.
Phage-derived therapies comprise phage therapy and the use of phage-derived proteins as anti-bacterial therapy. Bacteriophages are natural viruses that target specific bacteria. They were proposed to be used to treat bacterial infections in the 1920s, before the discovery and widespread over-commercialized use of antibiotics. Phage therapy was totally abandoned in Western countries, whereas it is still used in Poland, Georgia and Russia. We review here the history of phage therapy by focusing on bone and joint infection, and on the development of phage therapy in France in this indication. We discuss the rationale of its use in bacterial infection and show the feasibility of phage therapy in the 2020s, based on several patients with complex bone and joint infection who recently received phages as compassionate therapy. Although the status of phage therapy remains to be clarified by health care authorities, obtaining pharmaceutical-grade therapeutic phages (i.e., following good manufacturing practice guidelines or being “GMP-like”) targeting bacterial species of concern is essential. Moreover, multidisciplinary clinical expertise has to determine what could be the relevant indications to perform clinical trials. Finally “phage therapy 2.0” has to integrate the following steps: (i) follow the status of phage therapy, that is not settled and defined; (ii) develop in each country a close relationship with the national health care authority; (iii) develop industrial–academic partnerships; (iv) create academic reference centers; (v) identify relevant clinical indications; (vi) use GMP/GMP-like phages with guaranteed quality bioproduction; (vii) start as salvage therapy; (vii) combine with antibiotics and adequate surgery; and (viii) perform clinical trials, to finally (ix) demonstrate in which clinical settings phage therapy provides benefit. Phage-derived proteins such as peptidoglycan hydrolases, polysaccharide depolymerases or lysins are enzymes that also have anti-biofilm activity. In contrast to phages, their development has to follow the classical process of medicinal products. Phage therapy and phage-derived products also have a huge potential to treat biofilm-associated bacterial diseases, and this is of crucial importance in the worldwide spread of antimicrobial resistance.
Residue was found in two cylindrical apothecary jars with similar inscriptions in the Rijksmuseum’s collection. There is a considerable difference in the age of these jars: the majolica albarello was made in Italy in the early sixteenth century, whereas the albarello made of tin-glazed earthenware was made in Delft more than two centuries later. Their inscriptions (JERA PIGRA and EL/ HIRAE PICRAE respectively) refer to the pharmaceutical preparation ‘hiera picra’ (Holy Bitter). The history of this medicine, which was said to give supernatural powers, goes back more than two thousand years. The main ingredient of this preparation was aloe Socotrina, which gave it its bitter taste. The research included the technique, shape, inscriptions, use and contents of these objects. Samples were taken from the residues found in both objects in order to determine the chemical composition. This was achieved using gas chromatographymass spectrometry (THM-GCMS) in combination with pyrolysis. A link to hiera picra could not be established, but the research provided a great deal of information about the background of both objects.
مقدمة
تخضع أصوات اللغة في استعمالها وعلاقة كل صوت فيها بالأصوات الأخرى لقواعد معينة يطلق عليها التشكيل الصوتي لذلك كانت دراسة الأصوات من ناحية المخارج والصفات مقدمة لدراسة التشكيل الصوتي .
إننا عندما نتكلم عن تأثير الأصوات في حال تجاورها في نحو الإبدال والإدغام والقلب وغير ذلك , مما يعتري الصوت اللغوي في حال التشكيل والمجاورة , لا نجدها غائبة عن البحث الصوتي عند القدامى , بل نجدها تسير وفقاً لقوانين صوتية تكاد تكون مضطردة , فقد كانت هذه القوانين محل اهتمام وتتبع عندهم , عندما تطرقوا إليها عند دراستهم لعلم الصرف الذي لا ينفك عن علم الأصوات .
يحاول البحث تلمس مواطن هذه القوانين الصوتية في شروح كتاب سيبويه ومدى فاعليتها في التشكيل الصوتي واضطرادها
History of scholarship and learning. The humanities, Arts in general
في هذا البحث حصلنا على معلومات ساعدتنا على إتمامه وإظهاره بالمظهر الذي يرضي الجميع إن شاء الله تعالى، فضلاً عن المخطوطات التي حصلنا عليها من المكتبات وفهارس المخطوطات التي ساعدتنا للوصول إلى معرفة أماكن كتابة هذه المخطوطات ومعرفة علمائها وتلاميذهم وبعد إتمامنا لهذا البحث، نرى في حاجة إلى الوقوف مليًّا عند بعض النَّتائج المهمة في البحث والتي استخلصناها كما يلي: إنَّ الحوزة العلمية في الحلَّة منذ انطلاقها العلمي في القرن السادس على يد الشيخ محمد بن إدريس (543ﻫ/1148م) (ت 598ﻫ/1201م) () وإلى حين أفولها في منتصف القرن العاشر الهجري كانت مركز للدراسات العلمية في العالم الإسلامي، والسبب الرئيس لهذا الانطلاق العلمي يرجع إلى دور العلماء والمدارس في النهضة العلمية لهذه المدينة، فقد كان اعتماد علماء الحلّة في بداية التَّدريس على بيوتاتهم، ولم يكن عقبة أمام علماء الحلَّة بل كان البديل لها هو بيوت العلماء فكانت هذه البيوتات تقوم بدور المدرسة، فأصبحت معاهد علم يؤمّها طلبة العلم من داخل المدينة ومن خارجها، وبعد ظهور الازدهار والتَّوسع العلمي الذي بلغ القمَّة في العطاء في القرن السابع والثامن الهجري وأصبحت الحِلَّة مركز علمي كبير ولجميع العلوم مثل: النَّسب والأدب فضلاً عن الفقه وأصوله وغيرها من العلوم، الكلمات المفتاحية: الرحلات، البيوتات، المدارس العلمية، العلماء، المجالس العلمية، إدريس
History of scholarship and learning. The humanities, Arts in general
يدور البحث الموسوم " مصاحف صنعاء القرآنية وآراء بعض المستشرقين الألمان فيها" وهو موضوع مهم جدا في حقل الدراسات الاثارية والتاريخية والشرعية الإسلامية ولاسيما انه موضوع مهم فيما يتعلق بمدى الرد على طعون المستشرقين حول مصداقية هذه الوثائق التي يرجع تاريخها الى القرن الأول الهجري وتحديدا الى عصر النبوة والخلفاء الراشدين(1-41هجرية/622م-642م) البحث يسلط الاضواء على التعريف بالمصاحف التي عثر عليها في الجامع الكبير في صنعاء وقراءة لسير المستشرقين الالمانيين بوين وبلاتيمر, ممن كرسوا جهودهم لدراسة تلك المصاحف وصيانتها ومن ثم التشكيك بمدى اصالتها ؟؟ ومن ثم الرد على تخرصاتهم ازاء مدى اصالتها .
History of scholarship and learning. The humanities, Arts in general
The diagnosis of primary headache disorders is clinical and based on the diagnostic criteria of the International Headache Society (ICHD-3-beta). However several brain conditions may mimic primary headache disorders and laboratory investigation may be needed. This necessity occurs when the treating physician doubts for the primary origin of headache. Features that represent a warning for a possible underlying disorder causing the headache are new onset headache, change in previously stable headache pattern, headache that abruptly reaches the peak level, headache that changes with posture, headache awakening the patient, or precipitated by physical activity or Valsalva manoeuvre, first onset of headache ≥50 years of age, neurological symptoms or signs, trauma, fever, seizures, history of malignancy, history of HIV or active infections, and prior history of stroke or intracranial bleeding. All national headache societies and the European Headache Alliance invited to review and comment the consensus before the final draft. The consensus recommends brain MRI for the case of migraine with aura that persists on one side or in brainstem aura. Persistent aura without infarction and migrainous infarction require brain MRI, MRA and MRV. Brain MRI with detailed study of the pituitary area and cavernous sinus, is recommended for all TACs. For primary cough headache, exercise headache, headache associated with sexual activity, thunderclap headache and hypnic headache apart from brain MRI additional tests may be required. Because there is little and no good evidence the committee constructed a consensus based on the opinion of experts, and should be treated as imperfect.
A literary work is most often characterised by formal, thematic and stylistic features. The distinction between these is never obvious, though. In a Petrarchan sonnet, for instance, the form is closely tied to the theme (tension in the octet and relief in the sestet). Similarly, the traditional ballad generally tells a tragic story in local history or legend in quatrains where the second and fourth lines usually rhyme. Stylistically, a ballad will tend to use simple language and occasional vivid dialogue. However, throughout history, many literary genres have undergone changes that would often free them from formal constraints, so much so that a modern reader might wonder why W. C. Williams’s “This is just to say” should not be taken as prose or Martin Luther King’s “I have a dream” as verse. Genre assignment has thus grown increasingly complex, an operation that will need to take into consideration the dynamicity of the creative literary mind and its resistance to submissive alignment with generic standards. In this context, the following paper will consult recent views on genre and genre modelling in an effort to elucidate how W. B. Yeats’s “September 1913”, by embodying prominent generic features of poetry and elegy, can be read as a model of compound generic deviations. This makes the work a modelled piece that resists generic categorization and testifies to the poet’s strategic unwillingness to irretrievably engage with the nationalist cause.
Arts in general, History of scholarship and learning. The humanities