Hasil untuk "cs.SC"

Zhaoheng Guo, Taran Driver, Sandra Beauvarlet et al.

Jiayi Fu, Shizhong Liu, Weiqing Zheng et al.

Juan David Mesa

Reseña del libro:Guerrero, Mauricio (ed.) (2014). Objetos públicos, espacios privados. Usuarios y relaciones sociales en tres centros comerciales de Santiago de Cali. Cali: Universidad Icesi, pp. 158.

NE Udeh, SO Onoja, E Orji et al.

This study evaluated the safety of the ethnomedicinal plant, Combretum. dolichopetalum methanol extract (CDME) in Wistar rats using the sub-acute toxicity model. Twenty-four adult male Wistar rats were randomly divided into 4 groups of 6 rats each. Group A (control) received 5% dimethylsulfoxide (DMSO) at 5 ml/kg, while groups B -D received CDME at 50, 100 and 200 mg/kg, respectively. All treatments were administered orally and once daily for 28 consecutive days. The haematological profile, liver and kidney function tests, lipid profile as well as antioxidant status were evaluated. The 50 mg/kg extract significantly (P<0.05) reduced the red blood cell count, packed cell volume, haemoglobin, but had no effect on leucocytic profile of rats. There was no significant difference (P>0.05) in leucocyte profile between the control and groups given the extract. At 200 mg/kg, CDME significantly (P<0.05) increased total protein, alkaline phosphatase (ALP) and aspartate transaminase (AST) compared to the control group. Triglyceride, high density lipoprotein (HDL-C) and very low density lipoprotein (VLDL-C) were significantly (P<0.05) increased by the extract at both 100 and 200 mg/kg while low density lipoprotein (LDL-C) was significantly (P<0.05) decreased by the extract at those doses compared to the control. Urea level was significantly higher (P<0.05) in rats dosed at 100mg/kg while creatinine levels was not increased by the extract. The antioxidants Superoxide dismutase and glutathione reductase were significantly (P<0.05) higher in rats at all doses of the extract while serum catalase level was significantly lower (P<0.05). We conclude that Combretum dolichopetalum could cause a reduction in erythrocyte parameters and should be administered with caution in anaemic conditions as well as in liver diseases.

Ozum Ozsaygili

Bruce Ronald McCart

Rekha Lalwani, SunitaA Athavale, Ketu Chauhan et al.

María Del Pilar Carmona Suárez

Yee Liang Thian, Albert SC Low, Pierce KH Chow et al.

Introduction: The 2005 American Association for Study of Liver Diseases (AASLD) diagnostic criteria allow non-invasive diagnosis of hepatocellular carcinoma (HCC) based on their enhancement pattern but we have observed a high incidence of atypical enhancement characteristics in HCC associated with portal vein thrombosis. This study seeks to examine the radiological features of this particular subgroup. Materials and Methods: Patients with HCC and portal vein thrombosis who underwent pre-treatment multiphasic CT imaging were drawn from a surgical database. The arterial, portal venous and delayed phase images were assessed qualitatively and quantitatively (with region of interest [ROI] analysis) for lesion hypervascularity and washout. The background enhancement of the left and right lobes of the liver was also quantified by ROI analysis. Results: Twenty-five lesions in 25 patients were selected for analysis. Qualitative analysis showed that 10/25 (40%) lesions demonstrated arterial hypervascularity while 16/25 (64%) lesions showed washout. Ten out of 25 (40%) lesions demonstrated both arterial hypervascularity and washout. Quantitative analysis showed that the average absolute lesion enhancement from precontrast to arterial phases was 49.1 (±17.1) HU for hypervascular lesions compared to 23.8 (±16.6) HU for non-hypervascular lesions (P <0.01). The mean absolute enhancement of the background liver parenchyma in the arterial phase was 13.79 (±7.9) HU for hypervascular lesions compared to 36.6 (±30.6) HU for non-hypervascular lesions (P = 0.03). Conclusion: A large proportion of HCC with portal vein thrombosis lack characteristic arterial hypervascularity, which may be secondary to compensatory increased arterial supply to the background liver. This is a potential pitfall when applying imaging criteria for diagnosis of HCC. Key words: HCC, Hypervascular, Pitfall, Wash-out

K. Nagaraj