Hasil untuk "Office management"

Ricardo Ricardo, R. Meilani

Learning outcomes are influenced by many factors; among others are students’ learning interest and motivation. This article discusses the findings of a study on the impacts of students’ learning interest and motivation on learning outcomes in the subject of office equipment management at a private vocational high school in Bandung Regency. The study adopted explanatory survey method, where data were gathered using Likert scale questionnaire distributed to a population of 47 tenth grade students of the Office Administration Program. The findings show that learning interest and learning motivation had positive and significant effects on students’ learning outcomes, both simultaneously and partially. This article emphasizes the importance of learning interest and motivation to increase students’ learning outcomes.  ABSTRAK Hasil belajar siswa dipengaruhi oleh banyak faktor, diantaranya adalah minat dan motivasi belajar siswa. Artikel ini membahas hasil penelitian tentang pengaruh minat dan motivasi belajar siswa terhadap hasil belajar pada mata pelajaran mengelola peralatan kantor di sebuah SMK swasta di Kabupaten Bandung. Penelitian dilakukan dengan menggunakan metode explanatory survey , dimana data dikumpulkan dengan menggunakan angket model likert scale yang diberikan kepada populasi sejumlah 47 orang siswa kelas X program Administrasi Perkantoran. Hasil penelitian yang dilakukan menunjukkan adanya pengaruh yang positif dan signifikan dari minat belajar dan motivasi belajar terhadap hasil belajar siswa baik secara simultan maupun parsial. Artikel ini menekankan pentingnya kedua variabel tersebut dalam usaha meningkatkan hasil belajar siswa.

T. G. Pickering, J. Hall, Lawrence J. Appel et al.

D. Bisias, Mark D. Flood, Andrew W. Lo et al.

B. Spear, S. Barlow, Christopher Ervin et al.

Louis Anthony (Tony)Cox

J. Hirsh, V. Fuster, J. Ansell et al.

S. Khajavi, Naser Hossein Motlagh, Alireza Jaribion et al.

The concept of a digital twin has been used in some industries where an accurate digital model of the equipment can be used for predictive maintenance. The use of a digital twin for performance is critical, and for capital-intensive equipment such as jet engines it proved to be successful in terms of cost savings and reliability improvements. In this paper, we aim to study the expansion of the digital twin in including building life cycle management and explore the benefits and shortcomings of such implementation. In four rounds of experimentation, more than 25,000 sensor reading instances were collected, analyzed, and utilized to create and test a limited digital twin of an office building facade element. This is performed to point out the method of implementation, highlight the benefits gained from digital twin, and to uncover some of the technical shortcomings of the current Internet of Things systems for this purpose.

B. Ayyub

R. Phidd, J. Boston, John Martin et al.

A. Schutte, A. Kollias, G. Stergiou

Current hypertension guidelines recommend using the average values of several blood pressure (BP) readings obtained both in and out of the office for the diagnosis and management of hypertension. In-office BP measurement using an upper-arm cuff constitutes the evidence-based reference method for current BP classification and treatment targets. However, out-of-office BP evaluation using 24 h ambulatory or home BP monitoring is recommended by all major medical associations for obtaining further insights into the BP profile of an individual and how it relates to their daily activities. Importantly, the highly variable nature of office and out-of-office BP readings has been widely acknowledged, including the association of BP variability with cardiovascular outcomes. However, to date, the implications of BP variability on cardiovascular outcomes have largely been ignored, with limited application in clinical practice. Novel cuffless wearable technologies might provide a detailed assessment of the 24 h BP profile and behaviour over weeks or months. These devices offer many advantages for researchers and patients compared with traditional BP monitors, but their accuracy and utility remain uncertain. In this Review, we outline and compare conventional and novel methods and techniques for assessing average BP levels and BP variability, and reflect on the utility and potential of these methods for improving the treatment and management of patients with hypertension. The most commonly available blood pressure (BP) monitoring devices are useful for capturing a snapshot BP value, but most have limited utility in measuring BP variability. In this Review, Schutte and colleagues outline the advantages and disadvantages of conventional and novel techniques to measure average BP levels and BP variability. Although the dynamic nature of blood pressure (BP) is well-known, hypertension guidelines recommend using the average values of static BP readings (office or out-of-office), specifically aiming to level the fluctuations and peaks in BP readings. All current BP measurement methods have imperfect reproducibility owing to the continuous fluctuation in BP readings, making it difficult to accurately diagnose hypertension. Accumulating evidence from clinical trials, large registries and meta-analyses shows that increased BP variability predicts cardiovascular outcome, independently of the average BP values. To date, BP variability is overlooked, with limited application in clinical practice, probably owing to a variety of complex non-standardized BP variability assessment methods and indices, and uncertain thresholds and clinical usefulness. Novel cuffless wearable BP technologies can provide very large numbers of readings for days and months without the discomfort of traditional BP monitoring devices, and have the potential to replace current BP methods, once accuracy issues are resolved and their clinical usefulness is proved. Although the dynamic nature of blood pressure (BP) is well-known, hypertension guidelines recommend using the average values of static BP readings (office or out-of-office), specifically aiming to level the fluctuations and peaks in BP readings. All current BP measurement methods have imperfect reproducibility owing to the continuous fluctuation in BP readings, making it difficult to accurately diagnose hypertension. Accumulating evidence from clinical trials, large registries and meta-analyses shows that increased BP variability predicts cardiovascular outcome, independently of the average BP values. To date, BP variability is overlooked, with limited application in clinical practice, probably owing to a variety of complex non-standardized BP variability assessment methods and indices, and uncertain thresholds and clinical usefulness. Novel cuffless wearable BP technologies can provide very large numbers of readings for days and months without the discomfort of traditional BP monitoring devices, and have the potential to replace current BP methods, once accuracy issues are resolved and their clinical usefulness is proved.

Joseph S. Friedman, Jonathan Silberman

G. Newsome

M. Tsechkovski

Koh K, Nogami K, Kakuda H et al.

Katsuyoshi Koh,1 Keiji Nogami,2 Harumi Kakuda,3 Yuri Okimoto,3 Moeko Hino,4 Yusuke Tanigawara,5,6 Zhaoyang Li,7 Chihiro Suzuki,8 Souhei Terashio,8 Hitoshi Ueda,9 Shouichi Ohga10 1Department of Hematology/Oncology, Saitama Children’s Medical Center, Saitama City, Saitama, Japan; 2Department of Pediatrics, Nara Medical University, Kashihara City, Nara, Japan; 3Department of Hematology/Oncology, Chiba Children’s Hospital, Chiba City, Chiba, Japan; 4Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan; 5Laboratory of Pharmacometrics and Systems Pharmacology, K-FRECS at Tonomachi, Keio University, Kawasaki City, Kanagawa, Japan; 6Quantitative Clinical Pharmacology, Takeda Development Center, Osaka City, Osaka, Japan; 7Clinical & Translational Sciences, PDT Business Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA; 8Plasma-Derived Therapies Strategy Unit, PDT R&D, Takeda Pharmaceutical Company Limited, Osaka City, Osaka, Japan; 9Japan Medical Office, Takeda Pharmaceutical Company Limited, Chuo-ku, Tokyo, Japan; 10Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Fukuoka, JapanCorrespondence: Katsuyoshi Koh, Department of Hematology/Oncology, Saitama Children’s Medical Center, 1-2, Shintoshin, Chuo-ku, Saitama, 330-8777, Japan, Email ko.katsuyoshi@saitama-pho.jpPurpose: Severe congenital protein C deficiency (SCPCD) is a rare, life-threatening disorder. Plasma-derived protein C concentrate is recommended for the acute and long-term management of SCPCD; however, data in Japanese patients are lacking. In this study, the pharmacokinetics (PK) and safety of protein C concentrate were investigated in a Japanese population.Patients and Methods: This study was an open-label, phase 1/2, nonrandomized, noncontrolled, multicenter clinical trial in Japanese patients with SCPCD (ClinicalTrials.gov: NCT04984889). Patients received a single intravenous dose (80 IU/kg) of human plasma-derived protein C concentrate. The primary endpoints were plasma protein C activity levels and PK parameters. Secondary endpoints for safety included adverse events (AEs).Results: All five enrolled patients (mean age, 15.2 years; mean weight, 34.0 kg) received the predefined dose of protein C concentrate and were included in PK and safety analyses. The geometric mean (coefficient of variation [CV]%) maximum concentration (Cmax) was 1.679 IU/mL (31.7%) and the geometric mean (CV%) area under the curve (AUCinf) was 21.88 IU·h/mL (47.1%). The median (range) half-life for protein C in plasma was 10.7 (7.35– 12.4) hours. Cmax and AUCinf tended to be higher in older patients (≥ 20 years old) than in younger patients (< 20 years old), whereas half-life was similar regardless of age. One patient had a mild treatment-related AE of pyrexia. No serious AEs or deaths were reported.Conclusion: PK parameters for protein C concentrate in Japanese patients with SCPCD were determined to be comparable to studies in western populations. A single intravenous 80 IU/kg dose was well tolerated, with no serious treatment-related AEs.Keywords: pharmacokinetics, phase 1/2 clinical trials, protein C concentrate, protein C deficiency, SCPCD, thrombotic disorders

Holly M. English, Patricia Romero, Lorraine Bull et al.

ABSTRACT Wildlife species are often captured in ecological studies to take morphometric measurements, collect biological samples and/or fit animal‐attached tags to collect data on movement and behaviour. Capture may be difficult depending on the target species, with implications for the effort required by field teams, overall capture success and study goals. Though routine practice, wildlife captures have important welfare implications which should be carefully considered prior to each study. Full details on capture protocols are rarely shared with the international community, often limited to short descriptions in the methods sections of papers. More detailed information sharing can improve knowledge on methods that lead to increased or reduced capture success, saving researcher time and resources and, most importantly, boosting animal welfare. Here, we share detailed capture protocols for improving trapping success and optimising welfare protocols for our trap‐shy target species, the red fox (Vulpes vulpes). We report on the methodological refinements used to successfully trap urban red foxes in Dublin, Ireland (n = 16 captures), as well as related efforts as part of a pilot study in rural Tuscany, Italy (n = 3). We recommend setting multiple capture sites but caution against prolonged time spent in traps for foxes. Remote transmission camera traps and remote trap alert systems are highly recommended, wherever possible, to remotely monitor multiple trapping sites at once with reduced disturbance and to facilitate quick arrival at capture sites. We discuss a cheap, lightweight collar drop‐off solution to negate the need for a second capture for collar retrieval. In Dublin, we found the likelihood of capturing a fox was significantly affected by rainfall but not temperature. We conclude with an easy‐to‐consult checklist, providing advice on trap setting, pre‐baiting, collar drop‐offs and weather conditions to aid researchers embarking on the capture of foxes and other difficult‐to‐trap species, particularly in urban areas with high levels of human activity.

Adrianne P. Smits, Ed K. Hall, Bridget R. Deemer et al.

Abstract Evaluating progress toward achieving freshwater conservation and sustainability goals requires transforming diverse types of data into useful information for scientists, managers, and other interest groups. Despite substantial increases in the volume of freshwater data collected worldwide, many regions and ecosystems still lack sufficient data collection and/or data access. We illustrate how these data challenges result from a diverse set of underlying mechanisms and propose solutions that can be applied by individuals or organizations. We discuss creative approaches to address data scarcity, including the use of community science, remote‐sensing, environmental sensors, and legacy datasets. We highlight the importance of coordinated data collection efforts among groups and training programs to improve data access. At the institutional level, we emphasize the power of prioritizing data curation, incentivizing data publication, and promoting research that enhances data coverage and representativeness. Some of these strategies involve technological and analytical approaches, but many necessitate shifting the priorities and incentives of organizations such as academic and government research institutions, monitoring groups, journals, and funding agencies. Our overarching goal is to stimulate discussion to narrow the data disparities hindering the understanding of freshwater processes and their change across spatial scales.

Cao X, Li X, Song Z et al.

Xiaolong Cao,1,2,&ast; Xinyue Li,1,3,&ast; Zexuan Song,4 Ping He,5 Ruiqing Zhang,1,3 Chong Teng,6 Qian Sun,2 Xue Wang,2 Bing Zhao,3 Zhiguo Zhang,7 Yanlin Zhao3 1National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People’s Republic of China; 2Outpatient Department, Beijing Changping Institute for Tuberculosis Prevention and Treatment, Beijing, 102200, People’s Republic of China; 3National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing, 102206, People’s Republic of China; 4Department of Clinical Laboratory, Children’s Hospital, Capital Institute of Pediatrics, Beijing, 100020, People’s Republic of China; 5Center for Infection Biology, School of Medicine, Tsinghua University, Beijing, 100084, People’s Republic of China; 6Tuberculosis Prevention and Control Department, Beijing Dongcheng District Center for Disease Control and Prevention, Beijing, 100050, People’s Republic of China; 7Hospital Management Office, Beijing Changping Mental Health Care Hospital, Beijing, 102202, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhiguo Zhang, Beijing Changping Mental Health Care Hospital, Changping District, Beijing, 102202, People’s Republic of China, Email zhgzh8689@126.com Yanlin Zhao, National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Changping District, Beijing, 102206, People’s Republic of China, Email zhaoyl@chinacdc.cnBackground: College students are a crucial link in curbing the epidemic. The aim of this study is to analyze the genetic diversity and drug resistance of Mycobacterium tuberculosis strains in college students with tuberculosis in Beijing, revealing the lineage structure and transmission patterns specific to this group.Methods: This study used the hospital’s electronic management system to screen for tuberculosis among college students in Changping District, Beijing, from January 2004 to December 2023. Socio-demographic and clinical data were collected, and whole-genome sequencing was performed on culture-positive isolates. Isolates with a genetic distance of less than 12 SNPs were grouped into the same genomic cluster. The TB Profiler software predicted drug resistance mutations, and categorical data were analyzed using Chi-square or Fisher’s exact tests.Results: Among the 1436 college students with tuberculosis, a total of 153 isolates successfully underwent whole-genome sequencing. The results showed that about one-third (49/153) of the isolates carried one or more drug resistance genes, with more than half (26/49) associated with first-line anti-tuberculosis drugs. However, encouragingly, the incidence of drug-resistant tuberculosis showed a significant downward trend, with statistical significance (p< 0.05). Lineage 2 (86.3%, 132/153) was the predominant genotype, with the Beijing genotype (90.1%, 120/153) being the most common, while the isolation of Lineage 3 in a student from Xinjiang. Sixteen college student isolates clustered, and all of which were Beijing genotype. Transmission within the same campus showed characteristics of short clustering time.Conclusion: The drug resistance rate among college students is relatively high, however it shows a declining trend. School tuberculosis infections could stem not only from within-campus transmission but also necessitate consideration of spatial and cross-regional spread possibilities.Keywords: Mycobacterium tuberculosis, whole genome sequencing, lineage, transmission, drug resistance, college students

Mohammad Izdiyan Muttaqin, Yon Machmudi, S. Salahudin Suyurno et al.

KH. Abdullah Syafi'i (1910–1985) was a central Betawi scholar whose influence on Islamic education and urban da'wah in Jakarta remains understudied, particularly in relation to how his institutions navigated the intersection of pesantren traditions and educational modernization. Previous scholarship has largely focused on his biography or community activism, leaving a gap in explaining the structural transformation of Betawi-based Islamic schools and their contribution to the development of urban pesantren in Indonesia. This study addresses that gap by analyzingAbdullah Syafi'i’s educational initiatives, socio-religious leadership, and da'wah strategies within the broader evolution of modern Indonesian Islamic education. Employing a qualitative historical-sociological approach, the study draws on archival documents, institutional records, and selective interviews to trace the development of the As-Syafi'iyah educational network. The findings reveal that Abdullah Syafi'i introduced an integrated religious–general curriculum, strengthened mass da'wah through organized majelis taklim, utilized radio as a pioneering medium for Islamic outreach, and established orphan-based boarding schools as a model of urban social empowerment. The study argues that Abdullah Syafi'i represents a distinctive model of urban ulama who simultaneously preserved tradition and advanced modernization. His contributions expand the scholarly understanding of Indonesian Islamic education, offering an urban-based perspective on pesantren reform that challenges dominant rural and Java-centric frameworks.

Abu Bakkar Siddique, A S M Nasim, Nishrita Devnath et al.

Objectives This study aims to evaluate the prevalence and associated factors of lower back pain (LBP) among farmers, rickshaw pullers and office workers in Bangladesh, while also investigating potential contributors within these occupational groups.Design This cross-sectional study aimed to determine the prevalence of LBP, associated factors and management procedures among farmers, rickshaw pullers and office workers in Bangladesh through face-to-face interviews.Setting The study was conducted in different parts of the Bogura district in Bangladesh.Participants A total of 396 participants were included in the final analysis, all the participants were men and adult in age.Main outcome measurements Data were collected using a semi-structured questionnaire based on previous research. Bivariate and multivariable logistic regression analyses were performed to identify significant associations.Results The prevalence of LBP was found to be 42.7% among the participants. Farmers and rickshaw pullers had approximately four-times and three-times higher odds of experiencing LBP compared with office workers. Other significant factors associated with LBP included living in a nuclear family, having a normal body weight, lacking professional training, having a chronic disease, having a family history of LBP and experiencing numbness in the legs or feet. The majority of respondents sought medical attention and took medication for their LBP.Conclusion The study underscores occupational differences in LBP prevalence, emphasising the necessity for tailored interventions and occupational health policies. Identifying specific risk factors and management practices in these professions can aid in developing effective prevention strategies and enhancing healthcare services.

Lakshmi Rao, Arjun Chadha, Anila Rao et al.

Abstract Background Myocardial bridging (MB) is a known congenital anomaly in which a segment of the coronary artery transverses from the epicardium through the myocardium. MB may clinically manifest as recurrent angina, acute coronary syndrome, ventricular dysrhythmia, and even sudden cardiac death. On electrocardiogram (EKG), MB can present with findings consistent with significant ST-segment changes. The AngelMed Guardian System (the Guardian device) was developed in an effort to optimize the time from the onset of myocardial ischemia to intervention. The device analyzes myocardial electrical changes and alerts the patient to seek emergent medical evaluation if an acute ST-segment deviation is detected. We describe the first documented case of the Guardian device detecting acute ST-segment changes secondary to myocardial bridging. Case Presentation A 50-year-old male, with a history of percutaneous coronary intervention of the proximal left anterior descending (LAD) artery, presented to his cardiologist’s office with reports of recurrent, atypical chest pain. The Guardian device was implanted. One month after implantation, the patient experienced chest pain and was alerted by the Guardian device to seek emergent medical evaluation. Initial EKG and high-sensitivity troponins were negative for acute ischemia. Guardian device interrogation revealed significant ST depressions, encouraging further ischemic evaluation. The exercise myocardial perfusion imaging revealed an apical reversible defect. Left heart catheterization revealed a large segment of mid-LAD MB with the patient’s previous LAD stent noted to be widely patent along with no evidence of new obstructive coronary disease. Following the identification of the MB, medication regimen adjusted and the patient denied recurrence of chest pain or Guardian alerts. Conclusions We describe the first documented case of the Guardian device detecting acute ST-segment changes that were secondary to myocardial bridging. The Guardian device appropriately documented an ischemic event not appreciated with initial EKG or troponin testing. With the assistance of the Guardian device, we were able to rapidly identify MB as the cause for the ischemic EKG changes and subsequent abnormal stress test, optimize medical management, and prevent recurrent atypical chest pain along with office and hospital visits.