Globalization is not a new phenomenon; nor is it irreversible. In Globalization and History, Kevin O'Rourke and Jeffrey Williamson present a coherent picture of trade, migration, and international capital flows in the Atlantic economy in the century prior to 1914--the first great globalization boom. The book's originality lies in its application of the tools of open-economy economics to this critical historical period--differentiating it from most previous work, which has been based on closed-economy or single-sector models. The authors also keep a close eye on globalization debates of the 1990s, using history to inform the present and vice versa.
The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced expression of a few embryonic transcription factors. This discovery has raised fundamental questions about the mechanisms by which transcription factors influence the epigenetic conformation and differentiation potential of cells during reprogramming and normal development. In addition, iPSC technology has provided researchers with a unique tool to derive disease-specific stem cells for the study and possible treatment of degenerative disorders with autologous cells. In this review, we summarize the progress that has been made in the iPSC field over the last 4 years, with an emphasis on understanding the mechanisms of cellular reprogramming and its potential applications in cell therapy.
We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over the drafts of 2002. Tested against a nonredundant collection of 19,079 full-length cDNAs, 97.7% of the genes are aligned, without fragmentation, to the mapped super-scaffolds of one or the other genome. We introduce a gene identification procedure for plants that does not rely on similarity to known genes to remove erroneous predictions resulting from transposable elements. Using the available EST data to adjust for residual errors in the predictions, the estimated gene count is at least 38,000–40,000. Only 2%–3% of the genes are unique to any one subspecies, comparable to the amount of sequence that might still be missing. Despite this lack of variation in gene content, there is enormous variation in the intergenic regions. At least a quarter of the two sequences could not be aligned, and where they could be aligned, single nucleotide polymorphism (SNP) rates varied from as little as 3.0 SNP/kb in the coding regions to 27.6 SNP/kb in the transposable elements. A more inclusive new approach for analyzing duplication history is introduced here. It reveals an ancient whole-genome duplication, a recent segmental duplication on Chromosomes 11 and 12, and massive ongoing individual gene duplications. We find 18 distinct pairs of duplicated segments that cover 65.7% of the genome; 17 of these pairs date back to a common time before the divergence of the grasses. More important, ongoing individual gene duplications provide a never-ending source of raw material for gene genesis and are major contributors to the differences between members of the grass family.
ABSTRACT Appealing to history, rather than to God, to provide an ultimate judgment about human actions can have a justificatory or consolatory function. The former grants proleptic absolution for acts that may be morally dubious because of their benign consequences, while the latter enables victims in the present to gain a measure of relief by imagining they will be honored by posterity. In both cases, problematic assumptions about “history” and “judgment” call into question the belief that future generations will vindicate present‐day struggles. The first of these assumptions is that “history” conveys worth by what might be called “victors’ justice,” in which success proves that the winner was morally superior. The second is that “history” is an impersonal process that can be recounted in a single metanarrative rather than an ongoing series of different narratives that are themselves variable depending on who is doing the narrating. When “history” means the community of historians who recount and analyze the past, there is rarely, if ever, a grand consensus agreed upon by all. Finally, whereas the judgment of God is assumed to be qualitative and individualized, and thus perfect for each case, human judgment depends either on deontological rules, which may not be universal, or on analogies that are only roughly equivalent. In either case, the judgment can never transcend the fallibilities of those doing the judging and approach the perfection of a divine Last Judgment. Perhaps the most plausible version of “history will judge” is the realization that we are judged in the present by the still admirable aspirations of the past, which have yet to be realized.