This study investigates the relationship between gender and self-concept among high school students enrolled in sports-oriented programs. In addition, it examines the interconnections among self-concept, motivation, and the satisfaction of basic psychological needs. The sample comprises 215 high school students aged 16 to 18 years. Three standardized instruments were employed: the brief version of the Five-Factor Self-Concept Questionnaire, the Basic Psychological Needs in Exercise Scale, and the Sport Motivation Scale (SMS-II). Statistical analyses were conducted using IBM SPSS (version 28.0) and AMOS (version 29). As anticipated, no significant differences emerged in overall self-concept between male and female students, a finding consistent with prior research. However, a significant positive association was observed between gender and emotional self-concept, with female students scoring higher than their male counterparts. Regarding the relationship between self-concept and motivation, academic self-concept demonstrated a significant positive association with intrinsic motivation and a negative correlation with amotivation. Furthermore, academic self-concept was positively related to the basic psychological needs of autonomy, competence, and relatedness, with autonomy showing the strongest link. The study highlights the complex interplay among gender, self-concept, motivational orientations, and psychological needs. Emotional self-concept was positively correlated with less autonomous forms of motivation—introjected regulation, external regulation, and amotivation—suggesting a potential connection between emotional sensitivity and motivational vulnerability. Family self-concept emerged as a strong predictor of autonomous motivation, while social self-concept was significantly associated with the need for relatedness. In summary, the findings underscore the complex and multidimensional nature of self-concept and its significant implications for motivational processes.
Annette Alstadsæter, Martin Jacob, Wojciech Kopczuk
et al.
Abstract Using linked individual and firm administrative data from Norway, we look through layers of holding companies and attribute corporate profits to the ultimate personal owner as the profits accrue rather than when income is realized. We show that our accrual-based measure of income inequality changes the level and trend of income inequality over time and eliminates the sensitivity of measures of inequality and income persistence to changing payout policies in response to tax reforms. After a tax reform in 2005 that incentivized retention of earnings within businesses, the total income share of the top 0.1% more than doubled in some years, compared with ordinary realization-based income measures. We further utilize rich data to show that (1) using our accrual-based measure of personal income reduces the estimated tax elasticity of income, and (2) observed capital income in individuals’ tax returns does not proxy well for overall corporate profits, so that an imputation method based on realized dividends, which is commonly used in the literature, performs poorly. We discuss implications for top income inequality measures in other countries. We also document the importance of indirect ownership as a mechanism behind our findings and its relevance in other developed countries and discuss implications for debates on capital income and wealth taxation.
I kjølvannet av asylforliket i 2015 ble det gjort en rekke innstramninger i innvandreres tilgang til norske trygdeordninger, og dette er den første gangen den norske folketrygdloven er blitt endret utelukkende av innvandringspolitiske hensyn. I denne artikkelen analyserer vi disse politiske prosessene og spør hvordan problemforståelser og logikker fra innvandringsfeltet har påvirket trygdepolitikken. Datamaterialet består av politiske dokumenter, og vi benytter Carol Lee Bacchis WPR-tilnærming til policyanalyse. Analysene viser hvordan innvandringspolitiske kategorier blir vevet inn i trygderegelverket og fører til at noen grupper nykommere blir ekskludert fra trygdeordningene. Dette fører til en differensiering av grupper og rettigheter som er langt mer kompleks enn analytiske begreper som «dualisering» og «tosporet velferdsmodell» gir inntrykk av. Nykommere som blir ekskludert fra de universelle ordningene, blir gjort mer avhengige av arbeidsmarkedet eller familien. På denne måten dreier politikken bort fra prinsipper om likestilling og universalisme og uavhengighet fra familien og markedet, som har ligget til grunn for den nordiske velferdsmodellen i trekvart århundre.
Jia Xin Tang, Alfredo Cabrera-Orefice, Jana Meisterknecht
et al.
The mitochondrial protein COA5 was previously reported as a complex IV assembly factor. Studying a further case of COA5-related mitochondrial disease, the authors delineate an essential role of this protein in the early stage of complex IV assembly. Pathogenic variants in cytochrome c oxidase assembly factor 5 (COA5), a proposed complex IV (CIV) assembly factor, have been shown to cause clinical mitochondrial disease with two siblings affected by neonatal hypertrophic cardiomyopathy manifesting a rare, homozygous COA5 missense variant (NM_001008215.3: c.157G>C, p.Ala53Pro). The most striking observation in the affected individuals was an isolated impairment in the early stage of mitochondrial CIV assembly. In this study, we report an unrelated family in whom we have identified the same COA5 variant with patient-derived fibroblasts and skeletal muscle biopsies replicating an isolated CIV deficiency. A CRISPR/Cas9-edited homozygous COA5 knockout U2OS cell line with a similar biochemical profile was generated to interrogate the functional role of the human COA5 protein. Mitochondrial complexome profiling pinpointed a role of COA5 in early CIV assembly, more specifically, its involvement in the stage between MTCO1 maturation and the incorporation of MTCO2. We therefore propose that the COA5 protein plays an essential role in the biogenesis of MTCO2 and its integration into the early CIV assembly intermediate for downstream assembly of the functional holocomplex.
It has long been stated that children have the rights to protection from, e.g., abuse and to the provision of age-appropriate leisure, play, and recreational activities along with participation in all matters that concerns them. Yet, the full range of children’s rights to and in sport has not yet been explored in detail. To do so, it is relevant to turn to the Scandinavian countries, which are praised for promoting children’s rights and well-being, with organized sport forming part of the daily lives of many children and youths. In this paper, we examine the organizational policies in Scandinavian sport in order to develop foundational knowledge about how the range of children’s rights to and in sport may be supported. Comparing key policy documents of the major sports confederations in Denmark, Norway, and Sweden, these analyses identify great variety in the following: 1. when and how children’s rights to and in sport have been made explicit in the three countries; 2. whether the emphasis is on protection and/or provision of sport to children and youths or their participation in shaping sporting activities; 3. the degree to and ways in which such rights are regulated. In sum, our findings reflect a disparity between organizational policies in the three countries, with a more liberal and individualistic approach to public policy in the Danish context, providing some explanation of the only recent development in and scattered enaction of regulations to support children’s rights to and in sports. Furthermore, we identify that political attention has mainly been drawn to the protection and provision of sports to children and youths, while their participation in shaping sport is a shared challenge for sport confederations in the Scandinavian countries and beyond.
Abstract Background Evidence has accumulated to demonstrate that intestinal microbiome can inhibit viral infection. However, our knowledge of the signaling pathways and identity of specific commensal microbes that mediate the antiviral response is limited. Zebrafish have emerged as a powerful animal model for study of vertebrate-microbiota interactions. Here, a rhabdoviral infection model in zebrafish allows us to investigate the modes of action of microbiome-mediated antiviral effect. Results We observed that oral antibiotics-treated and germ-free zebrafish exhibited greater spring viremia of carp virus (SVCV) infection. Mechanistically, depletion of the intestinal microbiome alters TLR2-Myd88 signaling and blunts neutrophil response and type I interferon (IFN) antiviral innate immunity. Through 16S rRNA sequencing of the intestinal contents from control and antibiotic(s)-treated fish, we identified a single commensal bacterial species, Cetobacterium somerae, that can restore the TLR2- and neutrophil-dependent type I IFN response to restrict SVCV infection in gnotobiotic zebrafish. Furthermore, we found that C. somerae exopolysaccharides (CsEPS) was the effector molecule that engaged TLR2 to mediate the type I IFN-dependent antiviral function. Conclusions Together, our results suggest a conserved role of intestinal microbiome in regulating type I IFN antiviral response among vertebrates and reveal that the intestinal microbiome inhibits viral infection through a CsEPS-TLR2-type I IFN signaling axis in zebrafish. Video Abstract
Jessica Lage Fernandez, Sara Årbogen, Mohammad Javad Sadeghinia
et al.
Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new strategies to improve the delivery of drugs and therapeutic response. Relevant preclinical tumour models are needed to test potential treatments. This paper compared orthotopic and subcutaneous PDAC tumour models and their suitability for drug delivery studies. A novel aspect was the broad range of tumour properties that were studied, including tumour growth, histopathology, functional vasculature, perfusion, immune cell infiltration, biomechanical characteristics, and especially the extensive analysis of the structure and the orientation of the collagen fibres in the two tumour models. The study unveiled new insights into how these factors impact the uptake of a fluorescent model drug, the macromolecule called 800CW. While the orthotopic model offered a more clinically relevant microenvironment, the subcutaneous model offered advantages for drug delivery studies, primarily due to its reproducibility, and it was characterised by a more efficient drug uptake facilitated by its collagen organisation and well-perfused vasculature. The tumour uptake seemed to be influenced mainly by the structural organisation and the alignment of the collagen fibres and perfusion. Recognising the diverse characteristics of these models and their multifaceted impacts on drug delivery is crucial for designing clinically relevant experiments and improving our understanding of pancreatic cancer biology.
Nora Berz Slapø, Stener Nerland, Kjetil Nordbø Jørgensen
et al.
Abstract Background and Hypothesis The auditory cortex (AC) may play a central role in the pathophysiology of schizophrenia and auditory hallucinations (AH). Previous schizophrenia studies report thinner AC and impaired AC function, as indicated by decreased N100 amplitude of the auditory evoked potential. However, whether these structural and functional alterations link to AH in schizophrenia remain poorly understood. Study Design Patients with a schizophrenia spectrum disorder (SCZspect), including patients with a lifetime experience of AH (AH+), without (AH−), and healthy controls underwent magnetic resonance imaging (39 SCZspect, 22 AH+, 17 AH−, and 146 HC) and electroencephalography (33 SCZspect, 17 AH+, 16 AH−, and 144 HC). Cortical thickness of the primary (AC1, Heschl’s gyrus) and secondary (AC2, Heschl’s sulcus, and the planum temporale) AC was compared between SCZspect and controls and between AH+, AH−, and controls. To examine if the association between AC thickness and N100 amplitude differed between groups, we used regression models with interaction terms. Study Results N100 amplitude was nominally smaller in SCZspect (P = .03, d = 0.42) and in AH− (P = .020, d = 0.61), while AC2 was nominally thinner in AH+ (P = .02, d = 0.53) compared with controls. AC1 thickness was positively associated with N100 amplitude in SCZspect (t = 2.56, P = .016) and AH− (t = 3.18, P = .008), while AC2 thickness was positively associated with N100 amplitude in SCZspect (t = 2.37, P = .024) and in AH+ (t = 2.68, P = .019). Conclusions The novel findings of positive associations between AC thickness and N100 amplitude in SCZspect, suggest that a common neural substrate may underlie AC thickness and N100 amplitude alterations.
Fredrik Håkonsholm, Marit A. K. Hetland, Iren H. Löhr
et al.
Abstract Klebsiella pneumoniae is an opportunistic pathogen frequently associated with antibiotic resistance and present in a wide range of environments, including marine habitats. However, little is known about the development, persistence, and spread of antibiotic resistance in such environments. This study aimed to obtain the complete genome sequences of antibiotic‐resistant K. pneumoniae isolated from marine bivalves in order to determine the genetic context of antibiotic‐ and heavy metal resistance genes in these isolates. Five antibiotic‐resistant K. pneumoniae isolates, of which four also carried heavy metal resistance genes, were selected for complete genome sequencing using the Illumina MiSeq platform and the Oxford Nanopore Technologies GridION device. Conjugation experiments were conducted to examine the transfer potential of selected plasmids. The average length of the complete genomes was 5.48 Mbp with a mean chromosome size of 5.27 Mbp. Seven plasmids were detected in the antibiotic‐resistant isolates. Three IncFIB, one IncFIB/IncFII, and one IncFIB/IncHIB plasmid, respectively, carried antibiotic resistance genes such as qnrS1, aph(6)‐Id and aph(3′)‐Ia, aadA1, and aadA2. Four of these plasmids also carried genes encoding resistance to copper (pco), silver (sil), and arsenic (ars). One plasmid carrying tet(D) and blaSHV‐1 as well as pco, sil, and ars genes was transferred to Escherichia coli by conjugation. We show the co‐occurrence of antibiotic‐ and heavy metal resistance genes on a conjugative IncFIB plasmid from K. pneumoniae from marine bivalves. Our study highlights the importance of the marine environment and seafood as a possible dissemination route for antimicrobial resistance and provides insights into the potential for co‐selection of antibiotic resistance genes by heavy metals.
Digital innovation (DIN) is crucial for managing the growth of resource use in the hospital sector and for providing citizens with services aligned with the requirements of the modern world. DIN includes the co-creation of novel services, such as digital remote care (DRC) solutions. The healthcare sector, with a plethora of applications, is an example of a large digital infrastructure. Our study aims to explore how DRC initiatives can be integrated in large-scale digital infrastructures. Our in-depth case study, which explores 72 different DRC trajectories at 9 hospital health trusts in Norway, reveals the dynamic interplay among 3 key mechanisms – idealistic entrepreneurship, anchoring and remote infrastructure. Our contribution to the DIN literature is a model that shows the interplay among these key mechanisms, which increases the innovation pace, improves the innovations’ scalability and provides a robust organisation that constantly implements innovations. As a contributions to DRC practice, lessons learned to speed up the innovation pace are offered: (1) Create a DRC organisational structure. (2) Ensure financial predictability. (3) secure anchoring upward in the governance structure. (4) Make the remote infrastructure appropriate for integration with the current digital infrastructure. (5) Advocate the success across the organisation to spur others to innovate.
Syftet med denna studie är att bidra med kunskap om läsförståelseundervisning i svenskämnet i mellanstadiet. Material från en observationsstudie i två klasser i årskurs 6 analyseras för att förstå och beskriva hur lärare undervisar i läsförståelse utifrån skönlitterära böcker som eleverna valt själva, så kallade tystläsningsböcker, respektive ett läromedel i svenskämnet. Genom innehållsanalys synliggörs vad som kan vara undervisning för att förstå ett specifikt textinnehåll respektive förståelsestrategier. Trots olika utgångspunkter vad gäller texter och läsaktiviteter ställer båda lärarna frågor och genererar diskussioner på hög nivå. De utmanar även eleverna att tänka om textens innehåll, form och budskap, men undervisar i låg grad om strategier för att förstå och komma ihåg textinnehåll. Ingen av lärarna påpekar explicit för eleverna att det sätt som de tar sig an läsaktiviteterna hjälper dem att förstå textinnehåll och att liknande strategier kan användas vid all läsning. En slutsats är att lärare behöver bli medvetna om att det inte räcker med att låta elever träna på att synliggöra textinnehåll eller att knyta textinnehåll till sig själva, utan det behövs också direkt undervisning om det. Potential att undervisa explicit om när och hur olika strategier kan användas för att stötta elever att bli självständiga läsare diskuteras.
English abstract
Teaching Reading Comprehension in Grade 6 Using Fiction and a Textbook in Swedish
This article aims to contribute to knowledge about the teaching of reading comprehension in the subject Swedish in middle school. Material from an observational study in two grade six classes is analysed to learn about and describe how teachers teach reading comprehension using fiction books chosen by students (so-called silent reading books) and a Swedish textbook, respectively. A content analysis makes visible teaching that supports students in understanding the content of a text, as well as teaching that provides students with reading strategies. Despite differences in their use of texts and reading activities, the teachers in both classrooms ask questions and initiate high-level discussions. They also challenge students to think about the content, form, and message of texts. However, strategies for understanding and remembering text content are taught to a low degree. None of the teachers explicitly point out to students that the way they approach reading activities can help them understand text content and that similar strategies can be used for all reading. One conclusion is that teachers need to become aware that it is not enough to let students practice making text content visible or to connect text content to themselves; explicit teaching about comprehension strategies is also needed. The article also discusses when and how different strategies can be used to support students to become independent readers.
Education (General), Language. Linguistic theory. Comparative grammar
Raúl M. Pérez-García, Patrick J. Riss, Patrick J. Riss
et al.
A tris(pentafluorophenyl)borane catalysed method for the synthesis of boronic acid esters from aromatic amines in yields of up to 93% was devised. Mild conditions, benign reagents, short reaction times, low temperatures and a wide substrate scope characterize the method. The reaction was found applicable to the synthesis of boronic acid ester derivatives of complex drug molecules in up to 86% isolated yield and high purity suitable for labelling. These boronates were subsequently labelled with [18F]fluoride ion in radiochemical yields of up to 55% with and even without isolation of the boronate-intermediate.
Jan-Magnus Kvamme, Sveinung Sørbye, Jon Florholmen
et al.
Abstract The impact of a gluten-free diet (GFD) on screen-detected celiac disease (CD) is currently ambiguous. We aimed to identify the population-based prevalence of undiagnosed adult CD and examine the impact of a GFD on screen-detected CD. In total, 12,981 adults participated in a population-based health study in Tromsø, Norway. Participants with increased levels of anti-tissue transglutaminase-2 IgA or anti-deamidated gliadin peptide IgG were invited to undergo gastroduodenoscopy with both histological and immunohistochemical examination of small-bowel biopsies. The prevalence of previously diagnosed CD was 0.37%. Additionally, the prevalence of previously undiagnosed CD was 1.10%. Thus, 1.47% of the population had CD, of whom 75% were previously undiagnosed. A GFD resulted in significant improvements in overall gastrointestinal symptoms, diarrhea, and health-related quality of life, with reduced abdominal discomfort (76%) and improved levels of energy (58%). The large majority of patients with adult CD were undiagnosed and benefited from a GFD with reduced gastrointestinal symptoms and improved health-related quality of life. In clinical practice, there should be a low threshold for CD testing even in the absence of abdominal complaints because most adult patients appear to consider their symptoms a part of their normal state and therefore remain untested and undiagnosed. Trial registration: Clinical Trials. Gov Identifier: NCT01695681.
V. O. Kashparov, D. M. Holiaka, S. E. Levchuk
et al.
The radiological zoning of Chornobyl contaminated areas was one of the essential elements of social and radiation protection. The zoning was based on estimates of annual committed effective doses to members of the public and on the levels of radionuclide deposition density. In 1991, 86 settlements were classified as associated with the zone of unconditional (mandatory) resettlement, and 841 settlements were assigned to the zone of guaranteed voluntary resettlement. The status of these settlements has been preserved until now. The assessments showed that as of 2022, for all settlements located outside the Chornobyl Exclusion Zone the radiological conditions do not exceed the current legislative criteria for inclusion in the zone of unconditional (mandatory) resettlement. It is also shown that in 2022, the zone of guaranteed voluntary resettlement can be assigned for: only 38 settlements, according to the legislative criterion "90Sr density of contamination" and only 17 settlements, according to the legislative criterion "137Cs density of contamination". The work also indicates and analyses the provisions of current legislation that require clarification.
Atomic physics. Constitution and properties of matter
Maria Sandhaug, Iines Palmu, Sarah Jakobsen
et al.
The compulsory educational context and school systems within the Nordic countries Sweden, Finland, Denmark, and Norway share fundamental similarities, facilitating comparison across these countries. In this study, we describe and compare existing practices of recording, reporting, and utilizing school attendance data in four countries. In Sweden, Finland, and Norway there is a lack of national guidelines and agreements of how to record, report, and use school attendance data. Municipal autonomy has led to a variety of recording and reporting practices, which then lead to lack of comparable data and wider use of the data gathered. Denmark has a national registry of attendance data, and schools are required to report the data to municipal level. There are more specific guidelines regarding recording and reporting in Denmark compared to Sweden, Finland, and Norway. Problems with school non-attendance are well recognized in the North, but ways of recording and responding to absenteeism are still versatile. This leads to inconsistencies both within and between the countries. Due to variations of the way attendance is recorded, the quality of the national registry of data in Denmark can be questioned. A unified approach to inform research and practice to include formalized definitions of school absence in the Nordic Education Acts are suggested. It requires schools to record and report attendance data within a national register and finding a reliable way to differentiate problematic from non-problematic absenteeism.
During the last decade numerous review articles have been published on how concurrent strength and endurance training affect cycling performance. However, none of these have reviewed if there are any sex differences in the effects of concurrent training on cycling performance, and most research in this area has been performed with male cyclists. Thus, the aim of the current paper is to review the scientific literature on the effect of concurrent training on cycling performance in male and female cyclists with a special emphasis on potential sex differences. The results indicate that both male and female cyclists experience a similar beneficial effect from concurrent training on cycling performance and its physiological determinants compared to normal endurance training only. Some data indicate that women have a larger effect on cycling economy, but more studies are needed to explore this further. Furthermore, the adaptations to strength training thought to be responsible for the beneficial effects on cycling performance seem to be very similar between men and women. Interestingly, increased muscle cross-sectional area in the main locomotor muscles seems to be an important adaptation for improved performance, and, contrary to popular belief, cyclists should aim for increased muscle cross-sectional area when adding strength training to their normal training. We conclude that both male and female cyclists can improve their cycling performance by adding strength training to their normal training.
<p>Gas flares are a regionally and globally significant source of atmospheric pollutants.
They can be detected by satellite remote sensing.
We calculate the global flared gas volume and black carbon emissions in 2017 by applying (1) a previously developed hot spot detection and characterisation algorithm to all observations of the Sea and Land Surface Temperature Radiometer (SLSTR) instrument on board the Copernicus satellite Sentinel-3A and (2) newly developed filters for identifying gas flares and corrections for calculating both flared gas volumes (billion cubic metres, BCM) and black carbon (BC) emissions (g).
The filter to discriminate gas flares from other hot spots uses the observed hot spot characteristics in terms of temperature and persistence.
A regression function is used to correct for the variability of detection opportunities. A total of
6232 flaring sites are identified worldwide.
The best estimates of the annual flared gas volume and the BC emissions are 129 BCM with a confidence interval of [35, 419 BCM] and 73 Gg with a confidence interval of [20, 239 Gg], respectively.
Comparison of our activity (i.e. BCM) results with those of the Visible Infrared Imaging Radiometer Suite (VIIRS) Nightfire data set and SWIR-based calculations show general agreement but distinct differences in several details.
The calculation of black carbon emissions using our gas flaring data set with a newly developed dynamic assignment of emission factors lie in the range of recently published black carbon inventories, albeit towards the lower end.
The data presented here can therefore be used e.g. in atmospheric dispersion simulations.
The advantage of using our algorithm with Sentinel-3 data lies in the previously demonstrated ability to detect and quantify small flares, the long-term data availability from the Copernicus programme, and the increased detection opportunity of global gas flare monitoring when used in conjunction with the VIIRS instruments.
The flaring activity and related black carbon emissions are available as “GFlaringS3” on the Emissions of atmospheric Compounds and Compilation of Ancillary Data (ECCAD) website
(<a href="https://doi.org/10.25326/19">https://doi.org/10.25326/19</a>, <span class="cit" id="xref_altparen.1"><a href="#bib1.bibx11">Caseiro and Kaiser</a>, <a href="#bib1.bibx11">2019</a></span>).</p>
Decision-making in ship investment is a complex and difficult process with trade-offs. The purpose of this study is to guide the decisions on the purchase of dry bulk carriers based on a Fuzzy Technique for Order Preference by Similarity to Ideal Solution (Fuzzy TOPSIS) multi-criteria decision analysis algorithm. A set of criteria and a set of alternatives based on various characteristics are developed and evaluated with expert questionnaires. The proposed method provides weights for a given criteria to provide ranked alternatives, identifying the optimal solution. The alternatives among the multiple suppliers are ranked in the context of the shipping investment. This study reveals that shipowners are rather acting with a holistic perspective in ship purchase; however, we prove a detailed analysis is required.
Siden januar-revolutionen 2011 har kopternes position som medborgere i Egypten været usikker, hvilket har ført til både koptiske protester og varierende opbakning til siddende regimer. Spørgsmålet er, hvordan kopterne har forsøgt at navigere i dette politiske landskab, der har været omskifteligt og uforudsigeligt.