Maureen Watt, Inmaculada Martinez-Saguer, Angela Simon
et al.
Abstract Background Hereditary angioedema (HAE) is a rare genetic disease manifesting as recurrent painful, burdensome, and potentially life-threatening swelling attacks. This noninterventional, cross-sectional, web-based survey of adult (aged ≥ 18 years) participants with HAE from Argentina, Brazil, Colombia, Croatia, Denmark, Germany, Hungary, Ireland, Norway, Poland, Portugal, Romania, and Sweden sought to deepen the understanding of HAE burden. Individuals were eligible if they had a self-reported physician diagnosis of HAE, ≥ 1 HAE attack or prodromal symptom within the last year, and received HAE medications within the last 2 years. Data were collected on participant demographics, clinical characteristics, and patient-reported outcomes using validated questionnaires; these included disease control (Angioedema Control Test [AECT]), health-related quality of life (HRQoL; Angioedema Quality of Life [AE-QoL]), general health status (12-Item Short Form Survey [SF-12 v2]), anxiety and depression (Hospital Anxiety and Depression Scale [HADS]), and work productivity impairment (Work Productivity and Activity Impairment: General Health [WPAI:GH]). Results Overall, 260 participants were included; age (mean ± SD) was 43.3 ± 13.5 years; 72.7% of participants were female, 89.6% had HAE due to C1 inhibitor deficiency, and 78.5% reported family history of HAE. Participants reported 11.5 ± 14.2 (mean ± SD) HAE attacks in the 6 months before the survey, with 68.5% reporting their most recent attack occurring within the last 4 weeks. Of 260 participants, 153 (58.8%) reported currently using any medication for long-term prophylaxis, but only 56/153 (36.6%) reported using a first-line LTP option per international guidelines. Patient-reported disease burden included, on average, moderate to large HRQoL impairment (AE-QoL total score [mean ± SD] 42.9 ± 23.2), poor disease control (AECT score [mean ± SD] 7.4 ± 3.1), and work productivity impairment (WPAI:GH overall work productivity loss score [mean ± SD] 26.9% ± 32.2). Participants with a lower versus higher number of HAE attacks in the past 6 months reported better disease control, less HRQoL impairment, and less work productivity loss. Conclusion Results of this large multinational survey highlight that patients included in this study, most of whom were not using first-line LTP, reported being burdened by their disease, including frequent HAE attacks, HRQoL impairment, poor disease control, and work productivity impairment.
Daniel Buquet , Ariadna Gallo , Nataly Viviana Vargas Gamboa
et al.
This issue presents a first approach to the study of open and simultaneous presidential primary elections (PAS) carried out in several Latin American countries during the last 25 years. It includes brief articles that offer different approaches to presidential primary elections in several Latin American countries, with an analysis of their particularities, adaptations, exceptions and regulations, within the different contexts in which this system has been incorporated and implemented throughout multiple electoral processes.
<b>Background and Aims</b>: Colon capsule endoscopy (CCE) provides a non-invasive alternative to traditional colonoscopy. This study evaluated the feasibility, safety, diagnostic yield (DY), and patient satisfaction of the OMOM CC100 CCE system, with special focus on fully remote (n = 30) and partially remote (n = 89) administration across four centres to advance decentralised models. <b>Methods:</b> This prospective, investigator-initiated, international multicentre feasibility study enrolled 119 patients aged 18–75 years at centres in Denmark, Sweden, Portugal, and Poland from July 2024 to May 2025. Indications included rectal bleeding, iron-deficiency anaemia, a positive faecal immunochemical test, changes in bowel habit, suspected inflammatory bowel disease (IBD), post-polypectomy or colorectal cancer (CRC) surgery surveillance, and a family history of CRC. The OMOM CC100 capsule was employed with a standardised bowel preparation regimen. Administration was fully remote in Denmark using the IntelliGI™ platform and partially remote (clinic ingestion, home completion) at the other sites. Primary outcomes encompassed procedure feasibility, completion rate (capsule excretion or anal verge visualisation), bowel cleanliness (Leighton-Rex scale ≥ 3), diagnostic yield, and patient satisfaction. Secondary measures included transit times, adverse events, and technical failures. <b>Results</b>: Median age was 55.7 years (65 males, 54 females). Overall completion rate was 79%, varying by centre: Sweden (90%), Portugal (81%), Denmark (80%), and Poland (63%). Adequate bowel cleanliness was achieved in 71% of cases. Diagnostic findings included polyps (25 patients), angioectasia (20), diverticulosis (17), and mucosal inflammation (17); 42% were normal. Fully remote administration yielded 80% completion and 89.7% satisfaction. No serious adverse events occurred; overall satisfaction was 81%, with 87% preferring home-based procedures. <b>Conclusions:</b> The OMOM CC100 CCE system is feasible, safe, with DY comparable to established systems. IntelliGI™-enabled remote administration promotes decentralised care, enhancing accessibility.
Sandee Oster, Jerome P. Reynard, Hayley C. Cawthra
et al.
Archaeological deposits from Waterfall Bluff Rock Shelter (Eastern Cape) span from Marine Isotope Stage 3 (~39–29 ka) to the mid-Holocene (~8 ka), showing persistent human occupations. The site’s consistent proximity to the shoreline and stable coastline over millennia makes it key for exploring human settlement patterns. This study reports on preliminary results of identifiable fauna from Marine Isotope Stage 3 to the Early Holocene layers at Waterfall Bluff. The identified species may suggest a mosaic environment, although caution is warranted given the small sample size. Furthermore, leopard seal remains were recovered in layers dating to the Last Glacial Maximum. This is the first direct evidence of a leopard seal recovered from Pleistocene and Holocene archaeo-faunal assemblages along the South African coast.
Significance:
Last Glacial Maximum (LGM) sites are rare in southern Africa. Waterfall Bluff in the Eastern Cape shows that human occupation persisted there from Marine Isotope Stage 3 to the mid-Holocene. A leopard seal tooth was identified in the LGM layers, making it the first evidence of this species recovered off South Africa’s coast.
This study discusses Portuguese and Brazilian history magazines in circulation for the last 20 years. Understanding the History magazines as potential educational media products, what elements distinguish them from a dialogical perspective with the concepts and meanings of textbooks? In this article we seek to understand the history magazines
in Portugal, identifying their pedagogical purpose, besides of their sense of disseminating historical knowledge and their commercial interests. We aim to raise questions from a panoramic view of the Portuguese editorial projects in circulation nowadays. To do so, we’ll use the Brazilian cases as reference, both because of the theoretical contributions already consolidated around this topic, and the potential cultural dialogs in Portuguese language in the publishing and historiographical production fields. What relationship or distinction can be drawn between these printed materials and school textbooks? This is thus an attempt to analyze the existence of strategies to meet the needs of history teaching, official curricula and the readership ideally
formed by education professionals.
History (General) and history of Europe, History (General)
Constraints on the Higgs boson self-coupling are set by combining double-Higgs boson analyses in the bb¯bb¯, bb¯τ+τ− and bb¯γγ decay channels with single-Higgs boson analyses targeting the γγ, ZZ⁎, WW⁎, τ+τ− and bb¯ decay channels. The data used in these analyses were recorded by the ATLAS detector at the LHC in proton–proton collisions at s=13 TeV and correspond to an integrated luminosity of 126–139 fb−1. The combination of the double-Higgs analyses sets an upper limit of μHH<2.4 at 95% confidence level on the double-Higgs production cross-section normalised to its Standard Model prediction. Combining the single-Higgs and double-Higgs analyses, with the assumption that new physics affects only the Higgs boson self-coupling (λHHH), values outside the interval −0.4<κλ=(λHHH/λHHHSM)<6.3 are excluded at 95% confidence level. The combined single-Higgs and double-Higgs analyses provide results with fewer assumptions, by adding in the fit more coupling modifiers introduced to account for the Higgs boson interactions with the other Standard Model particles. In this relaxed scenario, the constraint becomes −1.4<κλ<6.1 at 95% CL.
Abstract Approximately five centuries of the involvement of Portugal in Antarctic regions is described. Discoveries, the sealing and whaling industries, and modern developments are discussed.
Abstract The Portuguese elections of early 2022 took place during the most severe wave of COVID-19 infections in Portugal. Nevertheless, the pandemic was not the most important issue in the campaign. Although opinion polls forecast a narrow election, the Socialists gained their second absolute majority in history. The electoral results marked a breakthrough for the radical right and Liberals. Every other traditional party had its worst electoral night in democratic history. The Christian Democrats and the Greens ended up exiting the parliament. The 2022 general elections saw the Socialists rise to dominance and the end of the Portuguese exceptionalism in keeping the radical right at arm’s length.
Having built much of their wealth, power, and identities on imperial expansion, how did the Portuguese and, by extension, Europeans deal with the end of empire? Postcolonial People explores the processes and consequences of decolonization through the histories of over half a million Portuguese settlers who 'returned' following the 1974 Carnation Revolution from Angola, Mozambique, and other parts of Portugal's crumbling empire to their country of origin and citizenship, itself undergoing significant upheaval. Looking comprehensively at the returnees' history and memory for the first time, this book contributes to debates about colonial racism and its afterlives. It studies migration, 'refugeeness,' and integration to expose an apparent paradox: The end of empire and the return migrations it triggered belong to a global history of the twentieth century and are shaped by transnational dynamics. However, they have done nothing to dethrone the primacy of the nation-state. If anything, they have reinforced it.
Ximene Rêgo, Maria João R. Oliveira, Catarina Lameira
et al.
Portugal decriminalized the public and private use, acquisition, and possession of all drugs in 2000; adopting an approach focused on public health rather than public-order priorities. Arguing that the Portuguese Drug Policy Model has not proven influential enough to emancipate drug use from the stigma that associates it either with crime or pathology, this article critically discusses the developments and current challenges the Portuguese drug policy confronts, namely the growing diversity of drug use patterns observed in Portugal as well as in Europe. To this end, international and national legal instruments concerning drugs and official local data were analysed. Despite encouraging results, conclusions indicate that these policies are marked by contradictions and ambiguities that have permeated its history since the very beginning, and modest ambitions, particularly regarding the implementation of harm reduction measures. Moreover, the polemical Supreme Court judgment that reestablished, in 2008, drug use as a crime when the quantities at play exceeded those required for an average individual’s use for 10 days, might have impacted the landscape of drug use penalization. The last decade saw an increase of punitiveness targeted at drug users, including criminal sentences of jail terms. We finish with some suggestions that could be employed in the practical application of drug policy.
Este artigo defende que o conceito de archii limes (limiar arquivístico) do jus archivi, em que o registo de documentos por um arquivo serve para autenticar esses documentos, se inverte no contexto dos dados abertos governamentais e das tecnologias cívicas. Estas tecnologias geram uma expetativa de transparência que inverte a função do limiar arquivístico. Somente com a difusão dos dados a partir dos arquivos para o espaço público é que se pode verificar a autenticidade. Na era das informações falsas e dos denominados factos alternativos, esta dinâmica revela-se problemática e suscita questões sobre a participação nos sistemas de informação estatais.
BACKGROUND Many different types of oral overuse behaviors occur frequently in adult populations with painful temporomandibular disorders (TMDs). Less is known regarding these behaviors and their associations with TMDs in university students. OBJECTIVES Test the association between frequency of different oral overuse behaviors evaluated by the Oral Behavior Checklist (OBC) and the severity of painful TMDs. METHODS In this cross-sectional study, 1,381 students from 19 universities in the Oporto District, Portugal, completed the Research Diagnostic Criteria for TMD (RDC/TMD) Personal History Questionnaire and the OBC, and they received an RDC/TMD clinical examination. The OBC sum score (ranging from 0-84 points) was classified as normal (0≤16 points), low overuse (17≤24) or high overuse (≥25). Painful TMD subtypes (myalgia, arthralgia, or combined) were identified. Associations were tested using multivariable binary logistic regression models (α=.05), adjusted for age and sex, and referencing the normal parafunction group. RESULTS University students with high overuse were more likely to have a painful TMD: myalgia (OR=1.9, 95%CL:1.3-3.0); arthralgia (OR=2.2; 95%CL:1.4-3.4), combined (OR=5.0; 95%CL3.1-8.1). Students with low overuse were more likely to have only the combined painful TMD (OR=2.4; 95%CI:1.4-4.0) but not the individual painful disorders. Of the 21 different behaviors, 13 were reported at least 50% of the time. CONCLUSIONS In this university student sample, oral overuse behaviors are widespread, and their overall extent exhibited a dose-response relationship with respect to severity of painful TMDs based on pain and chronicity. Only some behaviors were independently associated with painful TMDs, suggesting the value of further OBC instrument development.
Young people represent a powerful force for social change, and they have an important role to play in climate change responses. However, empowering young people to be “systems changers” is not straightforward. It is particularly challenging within educational systems that prioritize instrumental learning over critical thinking and creative actions. History has shown that by creating novel spaces for reflexivity and experimentation, the arts have played a role in shifting mindsets and opening up new political horizons. In this paper, we explore the role of art as a driver for societal transformation in a changing climate and consider how an experiment with change can facilitate reflection on relationships between individual change and systems change. Following a review of the literature on transformations, transformative learning and the role of art, we describe an experiment with change carried out with students at an Art High School in Lisbon, Portugal, which involved choosing one sustainable behavior and adopting it for 30 days. A transformative program encouraged regular reflection and group discussions. During the experiment, students started developing an art project about his or her experience with change. The results show that a transformative learning approach that engages students with art can support critical thinking and climate change awareness, new perspectives and a sense of empowerment. Experiential, arts-based approaches also have the potential to create direct and indirect effects beyond the involved participants. We conclude that climate-related art projects can serve as more than a form of science communication. They represent a process of opening up imaginative spaces where audiences can move more freely and reconsider the role of humans as responsible beings with agency and a stake in sustainability transformations.
A Revista Portuguesa de História (RPH) cumpre este ano 80 anos de publicação ininterrupta de artigos e recensões críticas. No ano em que se completam oito décadas de publicação, decidimos dedicar o editorial aos princípios fundadores desta publicação científica e enlaçar esta celebração com uma evocação breve da obra do Prof. Doutor António de Oliveira, que nos deixou no dia 1 de janeiro de 2021.
The Francophile tradition in Latin American urban planning evolved in the sixties and seventies. In France, the State created not only new public but also parapublic organisms in charge of developing urban analysis and planning. One of the most important, which oversaw the Paris region, also developed many missions in Latin America. The study of the first missions in Argentina, Brazil, and Bolivia shows that they were at the conjunction of two movements: the policy of soft power and economic expansion of the French government and the new “developmentalist” economic planning policies of the Latin American governments.
The sexual abuse of animals has persisted prehistoric times and is currently studied in the disciplines of history, medicine, psychiatry, veterinary medicine and law. The Portuguese legislation has no explicit reference to sexual contact with animals and the Spanish legislation had recently added “sexual exploitation of animals” which could be interpreted as implying the element of profit. The principal aim of this thesis is to prove that cases of animal sexual abuse in Portugal and Spain are not so infrequent as we may believe. We aim to establish the incidence and frequency of cases of sexual abuse detected by veterinarians in Portugal and Spain and to show that people are actively searching for zoophilic content online in these two countries. An online survey was made and directed to Spanish and Portuguese veterinarians. Our results left no doubt about the existence of such abuses in Portugal and Spain (8.2% of veterinarians in our study had encountered or at least suspected of cases of sexual abuse). Moreover, our analyses via Google Trends proved that people are currently looking for zoophilic content online. With that said, we hope to authenticate the urgent need to change legislation to protect the victims of these abuses and to encourage other investigators to focus on this neglected subject.
Animal culture, Law in general. Comparative and uniform law. Jurisprudence
Leonor Freire Costa, Pedro Lains, Susana Münch Miranda
This book offers a fascinating exploration of the evolution of the Portuguese economy over the course of eight centuries, from the foundation of the kingdom in 1143, when political boundaries began to take shape in the midst of the Christian Reconquista of the Iberian Peninsula, and the formation of an empire, to the integration of the nation into the European Communities and the Economic and Monetary Union. Through six chapters, the authors provide a vibrant history of Portugal's past with a focus ranging from the medieval economy and the age of globalization, to war and recovery, the Atlantic economy, the rise of liberalism and patterns of convergence. The book provides a unique long-term perspective of change in a southern European country and its empire, which responds to the fundamental broader questions about when, how and why economies expand, stagnate or contract.