Hasil untuk "History of Italy"

R. McCrae, P. Costa, Margarida Pedroso de Lima et al.

Gianluca Nicolai, Francesco Campanella, Sergio Alexandre Gehrke et al.

ABSTRACT Cutaneous squamous cell carcinoma (cSCC) is a malignant epithelial tumor of the skin, classified as a nonmelanoma skin cancer. It may develop from precancerous conditions such as chronic inflammatory dermatoses, actinic keratosis, or actinic cheilitis, but can also arise de novo. The aim of this case report is to describe the clinical management and therapeutic outcome of a patient with infraorbital squamous cell carcinoma who was deemed inoperable due to poor general health conditions, and was therefore treated with electrochemotherapy (ECT) as an alternative local therapy. A 73‐year‐old male patient with a complex medical history, including untreated chronic kidney disease, untreated diabetes mellitus, left leg lymphedema, right leg thrombosis, previous lobectomy for lung cancer, and amputation of the left big toe due to squamous cell carcinoma (SCC), presented with a new lesion diagnosed as SCC located in the infraorbital region. Electrochemotherapy is a minimally invasive oncologic treatment that combines electroporation with the administration of chemotherapeutic agents to enhance their cytotoxic efficacy. Bleomycin, 15 μ/m2 (Bleomycin Nippon Kayaku, Sanofi Aventis, Milan, Italy), was administered intralesional before applying the electric pulses. After three sessions spaced two months apart, complete tumor remission was observed, as confirmed by PET‐CT. Given the patient's complex comorbidities and inoperability, this report highlights the feasibility, safety, and effectiveness of ECT as a palliative and potentially curative local treatment option in anatomically and clinically challenging cases.

Daniele Zambelli, Giulia Ballotta, Dina Guerra et al.

Ovarian remnant syndrome (ORS) is a recognized postoperative complication in spayed dogs and cats, resulting from incomplete excision or inadvertent revascularisation of ovarian tissue during gonadectomy. Affected animals typically exhibit recurrent oestrous behaviour and may develop serious sequelae, including stump pyometra, mammary neoplasia, and granulosa cell tumours. This retrospective study evaluated 93 cases (70 dogs, 23 cats) diagnosed with ORS referred to the University Veterinary Hospital of Bologna, Italy, focusing on signalment, clinical presentation, diagnostic protocols, and treatment outcomes. Diagnosis relied on a multimodal approach combining clinical history, vaginal cytology, serum progesterone assays, ultrasonography, and histopathological examination of excised tissue. Surgical excision of residual ovarian tissue was the only curative treatment, with improved outcomes when performed during hormonally active phases of the oestrous cycle to optimize remnant localisation. Histopathology confirmed ovarian tissue in the majority of cases, with neoplastic transformation identified in 10% of dogs. Bilateral ovarian remnants were more prevalent than previously reported. Surgical revision was complicated by adhesions involving vital abdominal structures, emphasizing the need for meticulous technique. These findings highlight the critical importance of precise surgical technique during initial gonadectomy, early recognition of ORS, and comprehensive surgical management to prevent severe complications and promote companion animal welfare.

Laura Orsolini, Imran Gokcen Yılmaz-Karaman, Matteo Bottaro et al.

Abstract Background Depression occurring during the perinatal period (PND) could affect both future mother and father. PND may lead to several adverse physical and mental health outcomes for the whole family. Several psychopathological determinants have been identified, even though few studies investigated the role of paternal mental health in the onset of maternal perinatal depression (MPND). Hence, a retrospective cohort study was carried out in order to investigate the relationship between paternal mental health and the occurrence of antenatal maternal depression as well as identifying potential sociodemographic, clinical and obstetrical predictors in the development of MPND. Methods All pregnant women afferent to the Perinatal Mental Health Outpatient Service of the Unit of Clinical Psychiatry at the University Hospital of Marche, Polytechnic University of Marche, Ancona, Italy, between April 2021 to February 2022, were consecutively recruited and longitudinally screened for antenatal depression. The sample was divided in two groups, based on the screening by using the Edinburgh Postpartum Depression Scale (EPDS) for PND. A stepwise binary logistic regression analysis was performed in order to evaluate the predictors associated with the presence of antenatal depression (vs. the absence of antenatal depression). Results A total of 106 participants among all 460 screened from April 2021 to February 2022, were retrospectively included. In our sample, a prevalence of 13.2% in antenatal depression was found. The binary logistic regression model showed that the higher maternal age (OR = 1.320; p = 0.005), gestational comorbidity (OR = 10.931; p = 0.010), pregnant women’s (OR = 19.001; p = 0,001) and their partner’s positive history (OR = 16.536; p = 0.004) for mental disorder significantly predicted the presence of antenatal depression in our sample. Conclusions Our study suggests the need to investigate the pre-existing psychopathology of the pregnant woman’s partner as a potential risk factor for MPND, particularly for antenatal depression. Overall, a better understanding and investigation of all potential risk and/or protective factors for the onset and/or maintenance and/or worsening of MPND could help clinicians in early identifying treatment strategies to improve maternal mental health as well as future father’s mental health.

Maria Daghmehchi, Chiara Coletti, Dong Hyeok Moon et al.

L. Bottazzi, A. Lusardi

Abstract We examine gender differences in financial literacy among high school students in Italy using data from the 2012 Programme for International Student Assessment (PISA). Gender differences in financial literacy are large among the young in Italy. They are present in all regions and are particularly severe in the South and the Islands. Combining the rich PISA data with a variety of other indicators, we provide a thorough analysis of the potential determinants of the gender gap in financial literacy. We find that parental background, in particular the role of mothers, matters for the financial knowledge of girls. Moreover, we show that the social and cultural environment in which girls and boys live plays a crucial role in explaining gender differences. We also show that history matters: Medieval commercial hubs and the nuclear family structure created conditions favorable to the transformation of the role of women in society, and shaped gender differences in financial literacy as well. We discuss the changes that are needed to close the gap in financial knowledge among the young.

R. Omori, R. Matsuyama, Y. Nakata

Among Italy, Spain, and Japan, the age distributions of COVID-19 mortality show only small variation even though the number of deaths per country shows large variation. To understand the determinant for this situation, we constructed a mathematical model describing the transmission dynamics and natural history of COVID-19 and analyzed the dataset of mortality in Italy, Spain, and Japan. We estimated the parameter which describes the age-dependency of susceptibility by fitting the model to reported data, including the effect of change in contact patterns during the epidemics of COVID-19, and the fraction of symptomatic infections. Our study revealed that if the mortality rate or the fraction of symptomatic infections among all COVID-19 cases does not depend on age, then unrealistically different age-dependencies of susceptibilities against COVID-19 infections between Italy, Japan, and Spain are required to explain the similar age distribution of mortality but different basic reproduction numbers (R0). Variation of susceptibility by age itself cannot explain the robust age distribution in mortality by COVID-19 infections in those three countries, however it does suggest that the age-dependencies of (i) the mortality rate and (ii) the fraction of symptomatic infections among all COVID-19 cases determine the age distribution of mortality by COVID-19.

Kyle Franson, Brendan P. Bowler, Mariangela Bonavita et al.

Benchmark brown dwarf companions with well-determined ages and model-independent masses are powerful tools to test substellar evolutionary models and probe the formation of giant planets and brown dwarfs. Here, we report the independent discovery of HIP 21152 B, the first imaged brown dwarf companion in the Hyades, and conduct a comprehensive orbital and atmospheric characterization of the system. HIP 21152 was targeted in an ongoing high-contrast imaging campaign of stars exhibiting proper-motion changes between Hipparcos and Gaia, and was also recently identified by Bonavita et al. (2022) and Kuzuhara et al. (2022). Our Keck/NIRC2 and SCExAO/CHARIS imaging of HIP 21152 revealed a comoving companion at a separation of 0.″37 (16 au). We perform a joint orbit fit of all available relative astrometry and radial velocities together with the Hipparcos-Gaia proper motions, yielding a dynamical mass of ${24}_{-4}^{+6}\,{M}_{\mathrm{Jup}}$ , which is 1–2 σ lower than evolutionary model predictions. Hybrid grids that include the evolution of cloud properties best reproduce the dynamical mass. We also identify a comoving wide-separation (1837″ or 7.9 × 10 ^4 au) early-L dwarf with an inferred mass near the hydrogen-burning limit. Finally, we analyze the spectra and photometry of HIP 21152 B using the Saumon & Marley (2008) atmospheric models and a suite of retrievals. The best-fit grid-based models have f _sed = 2, indicating the presence of clouds, T _eff = 1400 K, and $\mathrm{log}g=4.5\,\mathrm{dex}$ . These results are consistent with the object’s spectral type of T0 ± 1. As the first benchmark brown dwarf companion in the Hyades, HIP 21152 B joins the small but growing number of substellar companions with well-determined ages and dynamical masses.

Gabriella Di Giuseppe, Silvia Angelillo, Aida Bianco et al.

Background: This survey investigated the knowledge, attitudes, and behaviors towards HPV preventive measures among university students in Italy and their associated factors. Methods: The cross-sectional survey was conducted between November 2022 and April 2023. Results: Only 41.7% knew about HPV infection and the main preventive measures. Multilevel mixed-effects logistic regression analysis showed that females, those aged 25–30 years, those who have had oral sex, those who had received information about HPV infection and preventive measures from physicians, and those who needed additional information about HPV infection and preventive measures were more knowledgeable. Only 39.1% have received at least one HPV vaccination dose, whereas 29.2% and 31.7% had not been vaccinated or did not remember. Multilevel mixed-effects logistic regression analysis identified that female students enrolled in the field of health sciences, those who did not report a prior history of a sexually transmitted infection, and those with a higher knowledge about HPV infection and preventive measures were more willing to receive the HPV vaccination. Conclusions: Despite some limitations, this was the first detailed survey on this topic conducted in the post-acute phase of COVID-19 among university students in Italy. The survey underlined the need to develop and to implement comprehensive educational programs and health interventions among students, to enhance their knowledge and modify their attitudes and improve the HPV vaccine uptake.

V. Carelli, M. Carbonelli, Irenaeus F. M. de Coo et al.

Marine Cotte, Victor Gonzalez, Frederik Vanmeert et al.

The European Synchrotron Radiation Facility (ESRF) has recently commissioned the new Extremely Brilliant Source (EBS). The gain in brightness as well as the continuous development of beamline instruments boosts the beamline performances, in particular in terms of accelerated data acquisition. This has motivated the development of new access modes as an alternative to standard proposals for access to beamtime, in particular via the “block allocation group” (BAG) mode. Here, we present the recently implemented “historical materials BAG”: a community proposal giving to 10 European institutes the opportunity for guaranteed beamtime at two X-ray powder diffraction (XRPD) beamlines—ID13, for 2D high lateral resolution XRPD mapping, and ID22 for high angular resolution XRPD bulk analyses—with a particular focus on applications to cultural heritage. The capabilities offered by these instruments, the specific hardware and software developments to facilitate and speed-up data acquisition and data processing are detailed, and the first results from this new access are illustrated with recent applications to pigments, paintings, ceramics and wood.

Emanuele Sansone, Carlo Bonfanti, Emma Sala et al.

Objectives: This is a longitudinal prospective study which was designed to assess the trend of anti-SARS-CoV-2 antibodies targeting the Spike (anti-S) and Nucleocapside protein (anti-N) viral antigens over a 9-month period after the administration of an anti-SARS-CoV-2 vaccine in a big COVID-19 hospital located in Northern Italy. Participants: 7411 vaccinated workers were included in a linear mixed-effect model analysis performed to model the anti-S decay over the 9 months following the vaccination, during serological screening performed approximately 2, 4, and 9 months following the first jab administration. Serological tests performed in the 9 months preceding vaccine administration were retrospectively analysed to identify the burden of infections occurring before vaccination. Results: The serological assays were used for monitoring the antibody titres during the observational period. Vaccination significantly reduced the rate of infection and elicited a specific humoral response, which lasted during the whole observational period (9 months). A decay was observed in all considered subgroups. At 35 weeks, workers with no history of pre-vaccine infection showed a significantly lower anti-S titre (−2522 U/mL on average (−2589.7 to −2445.7)); younger workers showed significantly higher anti-S titres (140.2 U/mL on average (82.4 to 201.3)). Only seven immunocompromised workers did not show significant levels of anti-S antibodies; three of them, all females, showed a specific T-cell response. Conclusions: Comparing the 9-month periods before and after the first vaccine dose, a significant reduction in infection rate was observed (1708 cases vs. 156). Pre-vaccine infection, especially if contracted during the first pandemic wave, greatly enhanced the response to vaccination, which was significantly affected also by age both in extent and duration (inversely related). A gender effect on the T-cell immune response was observed in a small group of workers who did not produce antibodies after vaccine administration.

M. Curzi, A. Caracausi, F. Rossetti et al.

Abstract Post‐orogenic back‐arc magmatism is accompanied by hydrothermal ore deposits and mineralizations derived from mantle and crustal sources. We investigate Zannone Island (ZI), back‐arc Tyrrhenian basin, Italy, to define the source(s) of mineralizing hydrothermal fluids and their relationships with the regional petrological‐tectonic setting. On ZI, early Miocene thrusting was overprinted by late Miocene post‐orogenic extension and related hydrothermal alteration. Since active submarine hydrothermal outflow is reported close to the island, Zannone provides an ideal site to determine the P‐T‐X evolution of the long‐lived hydrothermal system. We combined field work with microstructural analyses on syn‐tectonic quartz veins and carbonate mineralizations, X‐ray diffraction analysis, microthermometry and element mapping of fluid inclusions (FIs), C, O, and clumped isotopes, and analyses of noble gases (He‐Ne‐Ar) and CO2 content in FIs. Our results document the evolution of a fluid system of magmatic origin with increasing mixing of meteoric fluids. Magmatic fluids were responsible for quartz veins precipitation at ∼125 to 150 MPa and ∼300°C–350°C. With the onset of extensional faulting, magmatic fluids progressively interacted with carbonate rocks and mixed with meteoric fluids, leading to (a) host rock alteration with associated carbonate and minor ore mineral precipitation, (b) progressive fluid neutralization, (c) cooling of the hydrothermal system (from ∼320°C to ∼86°C), and (d) embrittlement and fracturing of the host rocks. Both quartz and carbonate mineralizations show noble gases values lower than those from the adjacent active volcanic areas and submarine hydrothermal systems, indicating that the fossil‐to‐active hydrothermal history is associated with the emplacement of multiple magmatic intrusions.

E. Tinti, L. Scognamiglio, Alberto Michelini et al.

Cariad J. Williams, Martino Pani, Andrea Bucchi et al.

Summary: Azhdarchid pterosaurs, the largest flying vertebrates, remain poorly understood, with fundamental aspects of their palaeobiology unknown. X-ray computed tomography reveals a complex internal micro-architecture for three-dimensionally preserved, hyper-elongate cervical vertebrae of the Cretaceous azhdarchid pterosaur, Alanqa sp. Incorporation of the neural canal within the body of the vertebra and elongation of the centrum result in a “tube within a tube” supported by helically distributed trabeculae. Linear elastic static analysis and linearized buckling analysis, accompanied with a finite element model, reveal that as few as 50 trabeculae increase the buckling load by up to 90%, implying that a vertebra without the trabeculae is more prone to elastic instability due to axial loads. Subsuming the neural tube into the centrum tube adds considerable stiffness to the cervical series, permitting the uptake of heavy prey items without risking damage to the cervical series, while at the same time allowing considerable skeletal mass reduction.

Luca Battioni

A few years after the arrival of sound cinema in Italy, the technology of dubbing emerged as an optimal solution to transfer films across national borders. This seemingly simple artifice had enormous cultural and political ramifications transnationally. For example, in the early 1930s, dubbing became the only way to screen foreign films in Italy, and the fascist government transformed the technology into a filter to bolster national identity and limit internal and external "threats" such as local dialects, foreign words, and music. Thus, under Mussolini’s regime, a film’s soundtrack (including music, sounds, and noises) underwent significant manipulation once it crossed the Italian border. This article examines Italian dubbing in the 1930s through the lenses of national cinema and local production. Additionally, it aims to explore early soundtrack manipulations before the establishment of dubbing as a practice, as well as the nationalist roots of dubbing itself. Finally, by analysing archival documents, this study posits that dubbing was not merely a matter of mechanical translation, but also a locus of sound experimentation in a time of stagnation for Italian cinema. Investigating dubbing, a phenomenon so profoundly ingrained in Italian society, opens up new interpretations of Italian culture, political history, and film production from the 1930s throughout the twentieth century.

Hilary Fraser

Federica Genovese

This paper investigates Italy's position on global climate change politics in order to explore the larger question of why this country, like similar middle powers, may adopt ambiguous positions on global public policy issues. I start from the observation that in recent history Italy has taken a rather mild posi-tion on international climate cooperation and climate policy more broadly. To explain this, I propose an argument in divergence with those who claim Italy has low salience in the issue or lack of interest in international climate leadership. I put forward a political economy perspective and claim that different salient concerns motivate the domestic actors that shape the country’s international position. I main-tain that these different concerns offset each other, resulting in overall mild preferences. I present support for my theory, zooming in on the motivations of two domestic sources of international posi-tions: economic sectors and public opinion. The empirical data largely corroborates the theory.

Liviana Gazzetta

The textbook remains a fundamental tool in schoolwork. In Italy they reflect the contradictory data that look after the debate on gender studies, between misunderstanding and politically correct narration. Some innovations are considered as necessary and the publishers give rhapsodic answers, fearing however that their books are too different from the school rule. Starting from the study of some recent textbooks, this essay analyzes the problems of the examination of the gender history in the twentieth century, and so it shows some proposals and didactic tools from the Società Italiana delle Storiche. Due to the small size of sample, this survey does not allow conclusions, but contribute to the debate.

Elena Liberatoscioli, Giancarlo Boscaino, Silvano Agostini et al.

Majella National Park is located in the central Apennines (Italy), in a vast mountainous area of about 740 km2. Owing to the complex geological history of the Majella Massif and surrounding areas, it features many different landforms. Woodlands rich in water characterize the wide tectonic depression of Caramanico, which separates the rounded gentle profile of the Majella to the east from the impervious steep slope of the Morrone Mt. to the west. Bare pitted highlands, like lunar landforms, characterize the top of the Majella (i.e., Femmina Morta Valley) shaped by flowing ice that long ago covered the higher parts of the massif. Sedimentary structures and fossil content recovered in carbonates attest to a long period of sedimentation in warm, shallow-marine environments, revealing that the Majella and the surrounding carbonate mountains looked, approximately from 140 to 7 Ma, like the present-day Bahamas and Persian Gulf. The Park hosts at least 95 geosites, some of which (22) are well-known in the international literature because of their scientific relevance. In addition, its natural and cultural wealth, deeply fused together with geoheritage, preserves several features of national and world rarity. Therefore, the Park Authority decided to put forward its territory as a candidate to become part of the United Nations Educational, Scientific and Cultural Organization (UNESCO) Global Geoparks Network.