The Forensic Autopsy The Pathophysiology of Death The Establishment of Identity of Human Remains The Pathology of Wounds Head and Spinal Injuries Chest and Abdominal Injuries Self-Inflicted Injury Gunshot and Explosion Deaths Transportation Injuries Abuse of Human Rights: Deaths in Custody Burns and Scalds Electrical Fatalities Complications of Injury Suffocation and 'Asphyxia' Fatal Pressure on the Neck Immersion Deaths Neglect, Starvation and Hypothermia Deaths Associated with Sexual offences Deaths Associated with Pregnancy Child Homicide Sudden Death in Infancy Fatal Child Abuse Deaths Associated with Surgical Procedures Dysbaric Fatalities and Barotrauma The Pathology of Sudden Death Forensic Dentistry for the Pathologist Poisoning and the Pathologist Forensic Aspects of Alcohol Carbon Monoxide Poisoning Organophosphorus Poisoning Poisoning by Medicines Death from Narcotic and Hallucinogenic Drugs Corrosive and Metallic Poisoning Deaths from Organic Solvents Appendix
Background: Recent advances in mRNA vaccine technology, accelerated by the global COVID-19 pandemic, have generated significant interest in their applications beyond infectious diseases. Dentistry has emerged as a promising field for exploring the potential of mRNA-based therapies in preventing and treating oral diseases. Objectives: This narrative review aims to evaluate the current status of mRNA vaccine development and its preclinical applications in oral health, focusing on periodontal disease, dental caries, regenerative medicine, implantology, and oral cancer. Methods: The review synthesizes findings from preclinical studies, including research conducted in animal models and in vitro, to assess the potential of mRNA-based therapies to modulate immune responses and promote tissue regeneration in the oral cavity. Clinical trials were only mentioned in the context of broader areas of mRNA vaccine implementation such as oncology and immunotherapy. Results: The preclinical studies highlight the capacity of mRNA vaccines to enhance the body’s immune response and facilitate tissue repair processes. Despite these promising results, challenges persist in delivering mRNA vaccines effectively within the complex oral environment. These challenges include vaccine stability, delivery mechanisms, and the modulation of immune responses. Conclusions: While mRNA vaccines offer significant promise for revolutionizing oral health care, they face notable limitations concerning safety, efficacy, and clinical feasibility. Overcoming these obstacles through further research is essential to unlock their full translational potential and ensure their safe and effective integration into dental practice.
Achieving a stable passive fit is important in implant treatment, especially for restorations of screw-retained superstructures. A passive fit is often evaluated by tactile sensing of tightening a fixing screw; however, tactile sensing is a subjective procedure. Objective and quantitative assessment of passive fits can be performed by measuring the tightening torque on prosthetic screws. In this clinical case, accumulative screw tightening torques for passive fit and misfit superstructures were calculated to examine the usefulness of the proposed method. The results suggested that accumulative torques and time slopes of torques may be potentially useful parameters for quantitatively evaluating passive fits; further laboratory and/or clinical trials are necessary.
R. S. Basavanna, Ishaan Adhaulia, N. M. Dhanyakumar
et al.
Background:
The integration of artificial intelligence in dentistry has seen remarkable advancements, especially in diagnostic imaging. This study evaluates and compares the accuracy of deep learning models with that of dental postgraduate students in determining working length on intraoral periapical radiographs.
Materials and Methods:
One hundred anonymized radiographs of single-rooted teeth with files at working length were obtained. The images were preprocessed and used to train a deep learning model. Five dental postgraduates visually estimated the working length after receiving training. Pixel counting in image processing software provided the gold standard measurement. Accuracy comparisons were performed using a t-test.
Results:
The deep learning model demonstrated significantly higher accuracy (85%) compared to human estimations (mean accuracy 75.4%). The t-test yielded P = 0.0374 (P < 0.05), rejecting the null hypothesis.
Conclusion:
Deep learning models show great potential in enhancing precision and reliability for working length determination in endodontics. With further refinement, these models can effectively complement human expertise in dental radiographic interpretation.
Rim Bourgi, Naji Kharouf, Carlos Enrique Cuevas-Suárez
et al.
The central aim of adhesive dentistry is to improve the compatibility between current adhesives and a range of substrates by employing diverse application techniques. Therefore, the overarching objective of this review is to offer a comprehensive analysis of dentin bonding systems, starting with an introduction to adhesion and a detailed overview of enamel and dentin structures, their histology, and the impact of dentin structure on resin–dentin bonding. It covers the mechanisms of resin–dentin bonding, including resin adhesive application, bonding mechanisms, and factors influencing efficacy. Further, this review explores the composition of resin adhesive systems, including acidic components, cross-linking monomers, solvents, and other critical elements. It also examines various adhesive strategies—etch-and-rinse, self-etch, and universal adhesives—highlighting their applications and advantages. The review extends to clinical applications of dental adhesion, including direct restorations, indirect restorations, and immediate dentin sealing (IDS), demonstrating the practical implications of adhesive systems in enhancing restoration longevity and performance. In conclusion, despite significant advancements, no gold-standard method for optimal adhesion exists. Each adhesive system has distinct strengths and limitations. The review emphasizes the importance of evaluating methods for achieving durable adhesion and staying current with technological advancements in adhesive systems. <b>Summary:</b> This review provides a thorough analysis of dentin bonding systems, delving into the structures and bonding mechanisms of both enamel and dentin. By exploring various adhesive systems and their components, it highlights the ongoing challenges in achieving optimal resin–dentin adhesion. The review also addresses the clinical applications of dental adhesion, including direct restorations, indirect restorations, and immediate dentin sealing (IDS), illustrating how different adhesive techniques impact clinical outcomes. It underscores the necessity for continuous innovation and assessment of adhesive systems to enhance long-term bonding effectiveness in clinical practice.
The various strains of influenza virus cause respiratory symptoms in humans every year and annual vaccinations are recommended. Due to its RNA-type genes and segmented state, it belongs to a virus that mutates frequently with antigenic drift and shift, giving rise to various strains. Each year, the World Health Organization identifies the epidemic strains and operates a global surveillance system to suggest the viral composition for the influenza vaccine. Influenza viruses, which have multiple viral strains, are produced in the format of multivalent vaccine. However, the multivalent vaccine has a possibility of causing immune interference by introducing multiple strain-specific antigens in a single injection. Therefore, evaluating immune interference phenomena is essential when assessing multivalent vaccines. In this study, the protective ability and immunogenicity of multivalent and monovalent vaccines were evaluated in mice to assess immune interference in the multivalent vaccine. Monovalent and multivalent vaccines were manufactured using the latest strain of the 2022–2023 seasonal influenza virus selected by the World Health Organization. The protective abilities of both types of vaccines were tested through hemagglutination inhibition test. The immunogenicity of multivalent and monovalent vaccines were tested through enzyme-linked immunosorbent assay to measure the cellular and humoral immunity expression rates. As a result of the protective ability and immunogenicity test, higher level of virus neutralizing ability and greater amount of antibodies in both IgG1 and IgG2 were confirmed in the multivalent vaccine. No immune interference was found to affect the protective capacity and immune responses of the multivalent vaccines.
Nanomaterials (NMs) have increasingly been used for the diagnosis and treatment of head and neck cancers (HNCs) over the past decade. HNCs can easily infiltrate surrounding tissues and form distant metastases, meaning that most patients with HNC are diagnosed at an advanced stage and often have a poor prognosis. Since NMs can be used to deliver various agents, including imaging agents, drugs, genes, vaccines, radiosensitisers, and photosensitisers, they play a crucial role in the development of novel technologies for the diagnosis and treatment of HNCs. Indeed, NMs have been reported to enhance delivery efficiency and improve the prognosis of patients with HNC by allowing targeted delivery, controlled release, responses to stimuli, and the delivery of multiple agents. In this review, we consider recent advances in NMs that could be used to improve the diagnosis, treatment, and prognosis of patients with HNC and the potential for future research.
Materials of engineering and construction. Mechanics of materials, Biology (General)
Nasser M. Assery, Carlos A. Jurado, Mansour K. Assery
et al.
Peri-implantitis is an inflammatory condition induced by bacterial biofilm that affects the soft and hard tissues surrounding dental implants, compromising the success of implant therapy. Recent studies have highlighted the potential links between peri-implant health and systemic inflammation, including uncontrolled diabetes mellitus, psychological stress, cardiovascular disease, obesity, and infectious diseases such as COVID-19. As an inflammatory disease, peri-implantitis may trigger systemic inflammation by elevating circulating levels of pro-inflammatory cytokines, which could have unknown impacts on overall health. While the relationship between periodontal health and systemic conditions is better understood, the association between peri-implant disease and systemic inflammation remains unclear. Therefore, this comprehensive review aims to summarize the most recent evidence on the relationship between peri-implantitis and systemic inflammation, focusing on biological complications, microbiology, and biomarkers. This review aims to enhance our understanding of the links between peri-implantitis and systemic inflammation and promote further research in this field by discussing the latest insights and clinical implications.
Francesco Coccia, Angelo Pietrobelli, Thomas Zoller
et al.
Osteogenesis Imperfecta (OI) is a heterogeneous group of inherited skeletal dysplasias characterized by bone fragility. The study of bone metabolism, in these disease, is problematic in terms of clinical and genetic variability. The aims of our study were to evaluate the importance of Vitamin D levels in OI bone metabolism, reviewing studies performed on this topic and providing advice reflecting our experience using vitamin D supplementation. A comprehensive review on all English-language articles was conducted in order to analyze the influence of vitamin D in OI bone metabolism in pediatric patients. Reviewing the studies, contradictory data were found on the relationship between 25OH vitamin D levels and bone parameters in OI, and in several studies the baseline levels of 25OH D were below the threshold value of 75 nmol/L. In conclusion, according to the literature and to our experience, we highlight the importance of adequate vitamin D supplementation in children with OI.
Yuri N. Perlamutrov, Svetlana B. Volkova, Kira B. Olhovskaya
et al.
The article is devoted to ParryRomberg syndrome, one of the rare diseases. Here we declare contemporary views on predisposing factors, pathogenesis and character of clinical performance. We describe the methods of differential diagnostics, the criteria of diagnostics as well as contemporary treatment methods. We also describe a case history of the disease.
Background/Aim: The objective of this study was to evaluate the stress distribution on implants and supporting bone tissue in All-on-Four and conventional designs in edentulous mandible by using 3D finite element analysis.
Azam Valian, Zahra Jaber Ansari, Mohammad Moien Rezaie
et al.
Abstract Background Esthetic dental restorations have gained increasing popularity. The surface of restorations should be smooth enough to achieve maximum esthetics and prevent the adhesion of microorganisms and food particles. This study aimed to assess the surface roughness and color change of composite specimens following airflow usage. Methods In this in vitro, experimental study, 30 Tokuyama composite discs were fabricated and randomly divided into three groups (n = 10) for the use of airflow with calcium carbonate/bicarbonate powder and conventional polishing with FlexiDisc. The surface roughness of the specimens was measured by profilometry while the color change was assessed by measuring the L*, a* and b* color parameters using spectrophotometry before polishing (T1). The composite specimens were then polished for stain removal, and their surface roughness as well as color parameters were remeasured after polishing (T2). Paired t-test and Tukey’s test were applied for within-group and between-group comparisons. Results Significant differences were noted in roughness average (Ra) between airflow with calcium carbonate (0.251 ± 0.014 μm) and airflow with sodium bicarbonate (0.421 ± 0.208 μm), and between airflow with sodium bicarbonate and FlexiDisc (0.207 ± 0.076 μm) groups after polishing (P < 0.05). Regarding the correlation of change in surface roughness and color parameters at T1 and T2, an inverse correlation was noted between the change in surface roughness and all color parameters except for L*. In other words, reduction in surface roughness decreased the a* and b* color parameters. Conclusions Within the limitations of this study, the results showed that the airflow device used in this study had no significant difference with conventional polishing in terms of reduction in surface roughness and staining. Considering the cost and maintenance of the airflow device, it is not suggested as a suitable alternative to the conventional polishing procedures. Trial Registration Number: This study does not involve human subjects.
Suliman Y. Shahin, Amr S. Bugshan, Khalid S. Almulhim
et al.
Abstract Background This study aimed to assess the knowledge of dental professionals in Saudi Arabia regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19). Methods A questionnaire was developed to assess various dental professionals from both governmental and private sectors through online and social media outlets. Results A total of 1,033 questionnaires were collected (273 dental students, 193 dental auxiliary personnel, 544 dentists). In all, 63.4% of the respondents worked in hospitals. Of all the respondents, 44.9%, 33.4%, and 21.7% worked in governmental clinics, academia, and the private sector, respectively. Overall knowledge of the incubation period and route of transmission of SARS-CoV-2 was consistent across all dental professions. Knowledge of hand-soap cleaning time was significantly different among dental professionals (p < 0.001). Dental professionals displayed significant disagreement on the survival of SARS-CoV-2 outside the host (p < 0.001). Furthermore, 75.1% of the respondents were reluctant to treat a suspected COVID-19 patient, and 92% of the participants believed that the mode of transmission was droplet inhalation. Fever, coughing, and shortness of breath were identified as the most common symptoms of COVID-19. Most standard methods of prevention in the dental office were selected by at least 50% of the participants. Conclusions Dental professionals seem to be consistent regarding their knowledge of the incubation period of SARS-CoV-2. However, knowledge of viral survivability and recommended hand-soap washing time was significantly variable among the professionals. A high degree of apprehension toward suspected COVID-19 patients existed among all dental professionals. Pandemic-awareness campaigns are essential among healthcare providers.