Ramya Ramasubramanian, Helen C. S. Meier, Sithara Vivek
et al.
AbstractBackgroundCellular changes in adaptive immune system accompany the process of aging and contribute to an aging-related immune phenotype (ARIP) characterized by decrease in naïve T-cells (TN) and increase in memory T-cells (TM). A population-representative marker of ARIP and its associations with biological aging and age-related chronic conditions have not been studied previously.MethodsWe developed two ARIP indicators based on well understood age-related changes in T cell distribution: TN/(TCM(Central Memory) + TEM(Effector Memory) + TEFF(Effector)) (referred as TN/TM) in CD4 + and CD8 + T-cells. We compared them with existing ARIP measures including CD4/CD8 ratio and CD8 + TN cells by evaluating associations with chronological age and the Klemera Doubal measure of biological age (measured in years) using linear regression, multimorbidity using multinomial logistic regression and two-year mortality using logistic regression.ResultsCD8 + TNand CD8 + TN/TMhad the strongest inverse association with chronological age (beta estimates: -3.41 and -3.61 respectively;p-value < 0.0001) after adjustment for sex, race/ethnicity and CMV status. CD4 + TN/TMand CD4 + TN had the strongest inverse association with biological age (β = -0.23;p = 0.003 and β = -0.24;p = 0.004 respectively) after adjustment for age, sex, race/ethnicity and CMV serostatus. CD4/CD8 ratio was not associated with chronological age or biological age. CD4 + TN/TMand CD4 + TNwas inversely associated with multimorbidity. For CD4 + TN/TM, people with 2 chronic conditions had an odds ratio of for 0.74 (95%CI: 0.63–0.86p = 0.0003) compared to those without any chronic conditions while those with 3 chronic conditions had an odds ratio of 0.75 (95% CI: 0.63–0.90;p = 0.003) after adjustment for age, sex, race/ethnicity, CMV serostatus, smoking, and BMI. The results for the CD4 + TNsubset were very similar to the associations seen with the CD4 + TN/TM. CD4 + TN/TMand CD4 + TNwere both associated with two-year mortality (OR = 0.80 (95% CI: 0.67–0.95;p = 0.01) and 0.81 (0.70–0.94;p = 0.01), respectively).ConclusionCD4 + TN/TMand CD4 + TNhad a stronger association with biological age, age-related morbidity and mortality compared to other ARIP measures. Future longitudinal studies are needed to evaluate the utility of the CD4 + subsets in predicting the risk of aging-related outcomes.
In this paper we show that a nodal complete intersection threefold $X$ in $\mathbb{P}^{3+c}$ with defect, but without induced defect, has at least $\sum_{i\leq j} (d_i-1)(d_j-1)$ nodes, provided either $c=2$ or $d_c>\sum_{i=1}^{c-1} d_i$ holds.
Suruchi Mishra, Tamara B. Harris, Trisha Hue
et al.
Background. Abdominal adiposity and serum leptin increase with age as does risk of metabolic syndrome. This study investigates the prospective association between leptin and metabolic syndrome risk in relation to adiposity and cytokines.Methods. The Health, Aging, and Body Composition study is a prospective cohort of older adults aged 70 to 79 years. Baseline measurements included leptin, cytokines, BMI, total percent fat, and visceral and subcutaneous fat. Multivariate logistic regression was used to determine the association between leptin and metabolic syndrome (defined per NCEP ATP III) incidence after 6 years of follow-up among 1,120 men and women.Results. Leptin predicted metabolic syndrome in men (Pfor trend = 0.0002) and women (Pfor trend = 0.0001). In women, risk of metabolic syndrome increased with higher levels of leptin (compared with quintile 1, quintile 2 RR = 3.29, CI = 1.36, 7.95; quintile 3 RR = 3.25, CI = 1.33, 7.93; quintile 4 RR = 5.21, CI = 2.16, 12.56; and quintile 5 RR = 7.97, CI = 3.30, 19.24) after adjusting for potential confounders. Leptin remained independently associated with metabolic syndrome risk after additional adjustment for adiposity, cytokines, and CRP. Among men, this association was no longer significant after controlling for adiposity.Conclusion. Among older women, elevated concentrations of leptin may increase the risk of metabolic syndrome independent of adiposity and cytokines.
We continue the study of Lagrangian-invariant objects (LI-objects for short) in the derived category $D^b(A)$ of coherent sheaves on an abelian variety, initiated in arXiv:1109.0527. For every element of the complexified ample cone $D_A$ we construct a natural phase function on the set of LI-objects, which in the case $\dim A=2$ gives the phases with respect to the corresponding Bridgeland stability (see math.AG/0307164). The construction is based on the relation between endofunctors of $D^b(A)$ and a certain natural central extension of groups, associated with $D_A$ viewed as a hermitian symmetric space. In the case when $A$ is a power of an elliptic curve, we show that our phase function has a natural interpretation in terms of the Fukaya category of the mirror dual abelian variety. As a byproduct of our study of LI-objects we show that the Bridgeland's component of the stability space of an abelian surface contains all full stabilities.
The paper is a second step in the study of $\overline{M}_{0,n}$ started in arXiv:1006.0987 [math.AG]. We study fiber type morphisms of this moduli space via Kapranov's beautiful description. Our final goal is to understand if any dominant morphism $f: \overline{M}_{0,n} \to X$ with positive dimensional fibers factors through forgetful morphisms. We prove that this is true if either $n \leq 7$ or $\rm {dim} X \leq 2$ or the rational map induced on $P^{n-3}$ has linear general fibers. Along the way we give examples of forgetful morphisms whose fibers are connected curves of arbitrarily high positive genus, for $n>>0$.
This is a continuation of math.AG/0609741. Let Y be an affine symplectic variety with a C^*-action with positive weights, and let π: X -> Y be its crepant resolution. Then πinduces a natural map PDef(X) -> PDef(Y) of Kuranishi spaces for the Poisson deformations of X and Y. In the Part I, we proved that PDef(X) and PDef(Y) are both non-singular, and this map is a finite surjective map. In this paper (Part II), we prove that it is a Galois covering. Markman already obtained a similar result in the compact case, which was a motivation of this paper. As an application, we shall construct explicitly the universal Poisson deformation of the normalization \tilde{O} of a nilpotent orbit closure \bar{O} in a complex simple Lie algebra when \tilde{O} has a crepant resolution.
We introduce and study kernel algebras, i.e., algebras in the category of sheaves on a square of a scheme, where the latter category is equipped with a monoidal structure via a natural convolution operation. We show that many interesting categories, such as D-modules, equivariant sheaves and their twisted versions, arise as categories of modules over kernel algebras. We develop the techniques of constructing derived equivalences between these module categories. As one application we generalize the results of math.AG/9901009 concerning modules over algebras of twisted differential operators on abelian varieties. As another application we recover and generalize the results of Laumon in alg-geom/9603004 concerning an analog of the Fourier transform for derived categories of quasicoherent sheaves on a dual pair of generalized 1-motives.
A principal toric bundle $M$ is a complex manifold equipped with a free holomorphic action of a compact complex torus $T$. Such a manifold is fibered over $M/T$, with fiber $T$. We discuss the notion of positivity in fiber bundles and define positive toric bundles. Given an irreducible complex subvariety $X\subset M$ of a positive principal toric bundle, we show that either $X$ is $T$-invariant, or it lies in an orbit of $T$-action. For principal elliptic bundles, this theorem is known (math.AG/0403430). As follows from Borel-Remmert-Tits theorem, any compact simply connected homogeneous complex manifold is a principal toric bundle. We show that compact Lie groups with left-invariant complex structure $I$ are positive toric bundles, if $I$ is generic. Other examples of positive toric bundles are discussed.
Let g be a differential graded Lie algebra and suppose given a contraction of chain complexes of g onto a general chain complex M. We show that the data determine an sh-Lie algebra structure on M, that is, a coalgebra perturbation of the coalgebra differential on the cofree coaugmented differential graded cocommutative coalgebra S' on the suspension of M, a Lie algebra twisting cochain from the perturbed coalgebra S" to the given Lie algebra g, and an extension of this Lie algebra twisting cochain to a contraction of chain complexes from the Cartan-Chevalley-Eilenberg coalgebra on g onto S" which is natural in the data. This extends a result established in a joint paper of the author with J. Stashef [Forum math. 14 (2002), 847-868, math.AG/9906036] where only the particular where M is the homology of g has been explored.
In math.AG/0005152 a certain $t$-structure on the derived category of equivariant coherent sheaves on the nil-cone of a simple complex algebraic group was introduced (the so-called perverse $t$-structure corresponding to the middle perversity). In the present note we show that the same $t$-structure can be obtained from a natural quasi-exceptional set generating this derived category. As a consequence we obtain a bijection between the sets of dominant weights and pairs consisting of a nilpotent orbit, and an irreducible representation of the centralizer of this element, conjectured by Lusztig and Vogan (and obtained by other means in math.RT/0010089).
Let X be a complex-projective contact manifold whose second Betti-number is one. It has long been conjectured that X should then be rational-homogeneous, or equivalently, that there exists an embedding of X into a projective space whose image contains lines. Using methods introduced in math.AG/0206193, we show that X is covered by a compact family of rational curves, called "contact lines" that behave very much like the lines on the rational homogeneous examples: if x in X is a general point, then all contact lines through x are smooth, no two of them share a common tangent direction at x, and the union of all contact lines through x forms a cone over an irreducible, smooth base. As a corollary, we obtain that the tangent bundle of X is stable.
Assume that there exists a hypersurface singularity which cannot be resolved by iterated monoidal transformations in positive characteristic. We show that in the set of defining functions of hypersurface singularities which cannot be resolved, we can find a function satisfying very strong conditions. By these conditions we may be able to deduce a contradiction under the above assumption. Besides, we introduce fundamental concepts for the study of resolution of singularities of germs such as space germs, iterated analytic monoidal transforms with a normal crossing, Weierstrass representations, reduction sequences, and so forth. This is a revised version of a part of contents of my previous manuscript "Resolution of Singularities of Germs in Characteristic Positive associated with Valuation Rings of Iterated Divisor Type" at math.AG/9901048.
Nicole Lemire, Vladimir L. Popov, Zinovy Reichstein
A connected linear algebraic group G is called a Cayley group if the Lie algebra of G endowed with the adjoint G-action and the group variety of G endowed with the conjugation G-action are birationally G-isomorphic. In particular, the classical Cayley map, X \mapsto (I_n-X)/(I_n+X), between the special orthogonal group SO_n and its Lie algebra so_n, shows that SO_n is a Cayley group. In an earlier paper (see math.AG/0409004) we classified the simple Cayley groups defined over an algebraically closed field of characteristic zero. Here we consider a new numerical invariant of G, the Cayley degree, which "measures" how far G is from being Cayley, and prove upper bounds on Cayley degrees of some groups.
Let X be a smooth projective curve of genus g>1 defined over an algebraically closed field k of characteristic p>0. Let M_X(r) be the moduli space of semi-stable rank r vector bundles with fixed trivial determinant. The relative Frobenius map F : X \to X_1 induces by pull-back a rational map V: M_{X_1}(r) \to M_X(r). We determine the equations of V in the following two cases (1) (g,r,p) = (2,2,2) and X non-ordinary with Hasse-Witt invariant equal to 1 (see math.AG/0005044 for the case X ordinary), and (2) (g,r,p) = (2,2,3). We also show, for any triple (g,r,p), the existence of base points of V, i.e., semi-stable bundles E such that F^* E is not semi-stable.
We construct an explicit equivalence between a category of complexes over the exterior algebra, which we call HT-complexes, and the stable category of vector bundles on the corresponding projective space, and establish a relation between HT-complexes and the Tate resolutions over the exterior algebra, which had been described by D. Eisenbud, G. Floystad, F.O. Schreyer in math.AG/0104203. The correspondence between HT-complexes and stable classes of vector bundles essentially translates into more fancy terms former results of Trautmann on representing Koszul complexes, which, in turn, were influenced by ideas of Horrocks. However, the relation between the Tate resolutions over the exterior algebra and HT-complexes might be new, although, perhaps, not a surprise to experts.
This is a sequel to the paper "Frobenius amplitude and strong vanishing theorems for vector bundles" (math.AG/0202129). We introduce a more elementary variant of the notion of F-amplitude from the earlier paper which we call amplitude. This provides another measure of positivity of a vector bundle which is related to a number of preexisting positivity notions such as k-ampleness or q-convexity. We use this to refine the estimates of F-amplitude from the first paper, and to deduce some further vanishing theorems as a consequence. We also give some new proofs of some known vanishing theorems for Abelian and toric varieties by analogous methods. For technical reasons, we need to develop a theory of partial Castelnuovo-Mumford regularity which provides a rough measure of the cohomological complexity of a sheaf. Since this material may have independent interest, it is contained in a section which can be read on its own.
In their paper Livné and Yui (math.AG/0304497) discuss several examples of non-rigid Calabi-Yau varieties which admit semi-stable K3-fibrations with 6 singular fibres over a base which is a rational modular curve. They also establish the modularity of the L-function of these examples. The purpose of this note is to point out that the examples which were listed in their paper, but which do not lead to semi-stable fibrations, are still modular in the sense that their L-function is associated to modular forms. We treat the case associated to the group Gamma_1(7) in detail, but our technique also applies to many other cases. We further make some comments concerning the Kummer construction for fibre products of elliptic surfaces in general.