Hasil untuk "Evolution"

S. Baca, D. Prandi, M. Lawrence et al.

The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes, but the spectrum of genome-wide alterations has not been profiled extensively in this disease. We sequenced the genomes of 57 prostate tumors and matched normal tissues to characterize somatic alterations and to study how they accumulate during oncogenesis and progression. By modeling the genesis of genomic rearrangements, we identified abundant DNA translocations and deletions that arise in a highly interdependent manner. This phenomenon, which we term "chromoplexy," frequently accounts for the dysregulation of prostate cancer genes and appears to disrupt multiple cancer genes coordinately. Our modeling suggests that chromoplexy may induce considerable genomic derangement over relatively few events in prostate cancer and other neoplasms, supporting a model of punctuated cancer evolution. By characterizing the clonal hierarchy of genomic lesions in prostate tumors, we charted a path of oncogenic events along which chromoplexy may drive prostate carcinogenesis.

J. Salk

M. Nowak, C. Tarnita, E. Wilson

Kevin C. Chen, N. Rajewsky

W. Maddison, D. Maddison

A. Dickson

D. Bramble, D. Lieberman

Geoff A. Parker

S. Gould, N. Eldredge

J. Kormendy, R. Kennicutt

▪ Abstract The Universe is in transition. At early times, galactic evolution was dominated by hierarchical clustering and merging, processes that are violent and rapid. In the far future, evolution will mostly be secular—the slow rearrangement of energy and mass that results from interactions involving collective phenomena such as bars, oval disks, spiral structure, and triaxial dark halos. Both processes are important now. This review discusses internal secular evolution, concentrating on one important consequence, the buildup of dense central components in disk galaxies that look like classical, merger-built bulges but that were made slowly out of disk gas. We call these pseudobulges. We begin with an “existence proof”—a review of how bars rearrange disk gas into outer rings, inner rings, and stuff dumped onto the center. The results of numerical simulations correspond closely to the morphology of barred galaxies. In the simulations, gas is transported to small radii, where it reaches high densities and...

J. Wendel

N. Barton

R. Alexander

Ravi Kumar, Jasmine Novak, A. Tomkins

C. Ray, M. Hoopes, I. Hanski et al.

C. Dobson

M. Nowak, K. Sigmund

A. Agrawal

P. Falkowski, M. Katz, A. Knoll et al.

The community structure and ecological function of contemporary marine ecosystems are critically dependent on eukaryotic phytoplankton. Although numerically inferior to cyanobacteria, these organisms are responsible for the majority of the flux of organic matter to higher trophic levels and the ocean interior. Photosynthetic eukaryotes evolved more than 1.5 billion years ago in the Proterozoic oceans. However, it was not until the Mesozoic Era (251 to 65 million years ago) that the three principal phytoplankton clades that would come to dominate the modern seas rose to ecological prominence. In contrast to their pioneering predecessors, the dinoflagellates, coccolithophores, and diatoms all contain plastids derived from an ancestral red alga by secondary symbiosis. Here we examine the geological, geochemical, and biological processes that contributed to the rise of these three, distantly related, phytoplankton groups.

R. Hudson, M. Kreitman, M. Aguadé