Hasil untuk "By period"

Ninad Kishor Honwadkar, Eknath Deosing Pawar, Abhiram T V et al.

Introduction: Osteochondromas (OCs) are benign hamartomatous lesions composed of cartilage and bone, arising from aberrant growth-plate cartilage. They characteristically project from the bone surface through the cortex and grow by endochondral ossification beneath the periosteum. Lesion growth usually parallels skeletal growth and typically ceases after physeal closure, although minimal growth of the cartilage cap may persist and generally stops by the third decade of life. This developmental mechanism explains the predilection for involvement of the distal femur, proximal tibia, and proximal humerus. Most OCs are asymptomatic and do not require surgical intervention. However, intra-articular or atypically located lesions may produce pain, restricted joint movement, or compression of adjacent neurovascular structures, necessitating operative management. Case Report: A 39-year-old male presented to the outpatient department with complaints of left-sided hip pain associated with restricted range of motion and radiating pain along the posterior aspect of the left thigh, accompanied by buttock pain for 6 months. The symptoms had gradually progressed and were aggravated by activity. The patient also reported mild paresthesia over the anteromedial aspect of the left knee and the dorsum of the left foot. He noticed a gradually enlarging, ill-defined mass in the left gluteal region during the same period. On clinical examination, a firm, immobile mass measuring approximately 10 × 6 cm was palpated in the left buttock. Left hip flexion was limited to 60° due to pain. Neurological examination revealed weakness of both plantar flexion and dorsiflexion of the left ankle. The patient had previously received conservative treatment, including rest, non-steroidal anti-inflammatory drugs, and physiotherapy at another institution, with no improvement in symptoms. Results: The lesion was excised through a posterior approach with the patient positioned in the right lateral decubitus position, as described by Yu et al. The sciatic nerve was identified, carefully dissected, and protected throughout the procedure. The OCs were excised using an osteotome. Intraoperative assessment of the femoral neck revealed no cortical defects or fractures, and no fixation was required. Histopathological examination confirmed the diagnosis of OCs with a cartilaginous cap measuring <1 cm. Conclusion: Sciatic nerve compression symptoms in non-traumatic cases in young adults may result due to intra or extraspinal causes, depending on the anatomical site of involvement. Lumbar intervertebral disc prolapse and spinal canal stenosis constitute the most frequent intraspinal causes. Extraspinal etiologies are comparatively rare and include conditions such as piriformis syndrome and pelvic bone lesions. Benign bone tumors, particularly OCs, though uncommon, should be considered as a potential source of sciatic nerve compression. OCs arising from the femoral neck with intra-articular or posterior extension are rare, particularly in adults, and may present with pain, mechanical restriction of movement, and neurological symptoms due to mass effect. Awareness of such atypical presentations is essential to avoid misdiagnosis and delays in appropriate management.

Donata Bulotta

The precariousness of the health situation in England from the 14th century onwards led to the use of any curative means, whether scientific, religious or ritual-magical. In this context, healing charms were seen as accessible and practicable methods. They were often added to medical prescriptions and herbal remedies in medical or pseudo-pharmacological compilations, as they were considered an alternative form of therapy equally valid in the treatment of ailments. Many charms created during this period were a mixture of magic, religion and folklore, but some received new cultural stimulus, by incorporating original elements and symbolism from Arabic, Greek and Hebrew magical texts introduced to the island. This work will focus on a selection of 15th century healing charms. The analysis aims to demonstrate that the principles of the new occult and esoteric doctrines, circulating in the intellectual and cultural centers of the island, influenced the magical healing ritual. The study of pseudo-Solomonic texts, although strongly censored by the Church, however contributed to the creation of new textual amulets, which were used in addition to the pre-existing charms so becoming a further alternative medium in the therapeutic procedure.

samaneh kakavand

Each King in their respective reigns attempted to shape visual culture according to their intellectual and ideological foundations. In some periods, these changes were explicit and evident, while in others, they were implicit and gradual. The Zand era also possesses distinctive artistic characteristics, including a particular type of Mihrab design. In other words, one of the identifying components of Zand-era visual culture is a type of "Mihrab" design. The Zand Mihrab design exhibits unique visual elements that serve as an iconic representation of the visual culture of that period, along with other visual components, forming the artistic characteristics of the era. The art of the Zand era is full of innovative designs, among which the repetition of a type of frame similar to the types of altars is thought-provoking. Introducing the mentioned frame as an identity identifier and searching for its frequency and how it is manifested in the Zand heritage is the concern of this article. The design of a mihrab with a corrugation, which is often seen in the art of the Zand, is a combination of two crescent and pointed arches, which has brought the upper part, especially the crown of the arch, to the fore in a new form. The mentioned design is an innovative frame in the Zend era and has a hybrid form that is inspired by two crescent and pointed arches in the crown part. The discovery of such distinctive markers necessitates research in this field, as the lack of attention to the study framework may result in misattributing artworks to the Zand era or the early years of the Qajar period without proper identification. The adoption of Mihrab designs imprinted on dateless artifacts and handicrafts of the Zand era will serve as an identity marker of that period. While motifs inspired by arches and muqarnas are prominent in Islamic art, the present study argues that the "Mihrab" design discussed here, is a distinguished visual characteristic of Zand-era art.Research Objective: The primary objective is to introduce, classify, and study the form of the "Mihrab" frame in Zand-era artworks to define one of its visual elements and cultural markers. The secondary objective is to establish the "Zand Mihrab" as an identity marker.Research Questions: How can the unique work of the "Zand Frame" be explained as an identity marker in artworks from the second half of the 12th century and the first half of the 13th century AH? How is the identity marker of the "Zand motif" interpreted in terms of innovation in the design of the Mihrab?In terms of the hypothesis it is assumed that the "Mihrab" design is an identity marker of the art in the Zand era.Research Methodology: This research is primarily theoretical, as it aims to explore the visual phenomenon known as the "Zand Mihrab" design and to elucidate its characteristics and qualities. The research employs a descriptive-analytical approach, utilizing library research, document analysis, virtual observations, and field visits to collect information and concepts. Data was gathered through written texts and images, focusing on 19 samples of visual arts from the Zand period, including tiles of Vakil mosque, the pavilion, the Haft-Tanan mansion, as well as objects and artifacts such as carpets, tombstones, a wooden door located in the Qazvin Museum, and a fabric piece containing a "Mihrab" frame.Results: The quantitative findings of this research indicate a prevalence of the "Mihrab" design in the Vakil mosque compared to other architectural structures and artistic works of the mentioned period. The study of the chronological evolution of the "Zand Mihrab" design demonstrates its invention and flourishing in the second half of the 12th century AH and persisted during the first half of the 13th century AH.Another significant finding of this research is that, although the studied design carries spiritual meanings, it has been transformed in usage during the Zand period and manifested in non-religious architectural structures and artifacts. The "Mihrab" design is found in works such as the Vakil mosque (religious), the pavilion, and the Abdul Razzaq Khan mansion (palace), as well as in Vakil School (educational) and the decoration of objects and tombstones. The Zand-era artists, through innovation in the design and modern visual composition of the Mihrab arch by iterating and harmonizing the application of the motif, and ultimately the utilization of the principle of diversity, transformed the "Mihrab" design into an identity element of the Zand period. Thus, in addition to its original invention, the repetition and diverse application of this form in various arts and architectures have turned the spiritual figure of Mihrab design into a symbol of Zand's identity and an integral part of the visual culture.

Catiane Cinelli, Solange Struwka

This text is based on a postdoctoral research entitled "O protagonismo das mulheres no curso de Licenciatura em Educação do Campo (LEDOC) da Universidade Federal de Rondônia (UNIR)". The objectives were: to historicize the context of research in Rural Education in Brazil; and to understand the process of constitution the Bachelor's Degree in Rural Education course in different Brazilian institutions, with attention to the challenges faced by female teachers in the Northern Region. Historical-Dialectical Materialism was the method that answered the research objectives. The methodology used was bibliographic research, with search terms in Brazilian digital repositories, without a specific period, and subsequent analysis based on the research objectives. As results, we have the categories of Rural Education, Rural Education Public Policy, and Bachelor's Degree in Rural Education. Rural Education has been present in the spaces of struggle of rural people since 1998, achieving the right of rural people to study at all levels of education, with specific legislation that determines who are the subjects and schools of the rural area and, for a teacher training policy, it is the LEDOC that brings several constructions and makes formal spaces accessible, welcoming, and dialogical.

M. Hughes, H. Diaz

P. Fuhr, R. Agostino, M. Hallett

George J Watase, Yukiko M Yamashita

Ribosomal DNA (rDNA), which encodes ribosomal RNA, is an essential but unstable genomic element due to its tandemly repeated nature. rDNA's repetitive nature causes spontaneous intrachromatid recombination, leading to copy number (CN) reduction, which must be counteracted by a mechanism that recovers CN to sustain cells' viability. Akin to telomere maintenance, rDNA maintenance is particularly important in cell types that proliferate for an extended time period, most notably in the germline that passes the genome through generations. In Drosophila, the process of rDNA CN recovery, known as 'rDNA magnification', has been studied extensively. rDNA magnification is mediated by unequal sister chromatid exchange (USCE), which generates a sister chromatid that gains the rDNA CN by stealing copies from its sister. However, much remains elusive regarding how germ cells sense rDNA CN to decide when to initiate magnification, and how germ cells balance between the need to generate DNA double-strand breaks (DSBs) to trigger USCE vs. avoiding harmful DSBs. Recently, we identified an rDNA-binding Zinc-finger protein Indra as a factor required for rDNA magnification, however, the underlying mechanism of action remains unknown. Here we show that Indra is a negative regulator of rDNA magnification, balancing the need of rDNA magnification and repression of dangerous DSBs. Mechanistically, we show that Indra is a repressor of RNA polymerase II (Pol II)-dependent transcription of rDNA: Under low rDNA CN conditions, Indra protein amount is downregulated, leading to Pol II-mediated transcription of rDNA. This results in the expression of rDNA-specific retrotransposon, R2, which we have shown to facilitate rDNA magnification via generation of DBSs at rDNA. We propose that differential use of Pol I and Pol II plays a critical role in regulating rDNA CN expansion only when it is necessary.

P. Brenchley, J. Marshall, G. Carden et al.

H. Chugani

Elena Martín-González, Manuela Olmedo-Córdoba, Ángeles Prados-Pardo et al.

IntroductionCompulsive behavior has been proposed as a transdiagnostic trait observed in different neuropsychiatric disorders, such as obsessive-compulsive disorder, autism, and schizophrenia. Research Domain Criteria (RDoC) strategy could help to disentangle the neuropsychological basis of compulsivity for developing new therapeutic and preventive approaches. In preclinical research, the selection of high-drinker (HD) vs. low-drinker (LD) animals by schedule-induced polydipsia (SIP) is considered a putative model of compulsivity, which includes a well-differentiated behavioral pattern.MethodsThe purpose of this research was to assess the cognitive control and the negative valence system domains in a phenotype of compulsive HD rats. After the selection of animals as HD or LD, we assessed behavioral inflexibility by probabilistic spatial reversal learning (PSRL), motor and cognitive impulsivity by variable delay-to-signal (VDS), and risky decision-making by rodent gambling task (rGT).ResultsHD rats performed fewer reversals and showed less probability of pressing the same lever that was previously reinforced on PSRL, more premature responses after the exposure to longer delays on VDS, and more disadvantageous risky choices on rGT. Moreover, HD animals performed more perseverative responses under the punishment period on rGT.DiscussionThese results highlight that HD compulsive phenotype exhibits behavioral inflexibility, insensitivity to positive feedback, waiting impulsivity, risky decision-making, and frustrative non-reward responsiveness. Moreover, these findings demonstrate the importance of mapping different behavioral domains to prevent, treat, and diagnose compulsive spectrum disorders correctly.

U. Nanni, U. Nanni, D. Scherler et al.

<p>Accurate measurements of ice flow are essential to predict future changes in glaciers and ice caps. Glacier displacement can in principle be measured on the large scale by cross-correlation of satellite images. At weekly to monthly scales, the expected displacement is often of the same order as the noise for the commonly used satellite images, complicating the retrieval of accurate glacier velocity. Assessments of velocity changes on short timescales and over complex areas such as mountain ranges are therefore still lacking but are essential to better understand how glacier dynamics are driven by internal and external factors. In this study, we take advantage of the wide availability and redundancy of satellite imagery over the western Pamirs to retrieve glacier velocity changes over 10 d intervals for 7 years and for a wide range of glacier geometry and dynamics. Our results reveal strong seasonal trends. In spring/summer, we observe velocity increases of up to 300 % compared to a slow winter period. These accelerations clearly migrate upglacier throughout the melt season, which we link to changes in subglacial hydrology efficiency. In autumn, we observe glacier accelerations that have rarely been observed before. These episodes are primarily confined to the upper ablation zone with a clear downglacier migration. We suggest that they result from glacier instabilities caused by sudden subglacial pressurization in response to (1) supraglacial pond drainage and/or (2) gradual closure of the hydrological system. Our 10 d resolved measurements allow us to characterize the short-term response of glaciers to changing meteorological and climatic conditions.</p>

V. Bhatia

Photoinduced long-period gratings are shown as versatile sensors for temperature, axial strain and index of refraction measurements. The principle of operation of such devices is discussed and the application to simultaneous temperature and strain is demonstrated.

L. Remontet, J. Estève, A. Bouvier et al.

Ivana Drvenica, Milica Stojić, Natalija Fratrić et al.

Redox imbalance in peripartum period influences health of dairy cows and their foetus and, through the colostrum, health of new-born calves. Oxidative stress in cattle can be suppressed by dietary supplementation with natural minerals, and we investigated the effect of supplementation with organically modified clinoptilolite on redox status parameters in healthy pregnant primiparous dairy cows. Holstein cows were randomly assigned to receive daily oral drenching, with 1 L of water containing either 0 g/L (n = 14; control group) or 150 g/L of clinoptilolite (n = 17; supplemented group). Treatment lasted from 24 ± 4 days prior to parturition until 2 days postpartum (pp). Blood samples were collected on days 24 ± 4 (–24 D) and 4 ± 2 (–4 D) prior to parturition and on days 1 (+1 D), 2 (+2 D), and 7 (+7 D) pp, and colostrum were collected at 2, 12, 24 and 36 h pp. Total antioxidant capacity, lipid peroxides, and advanced oxidation protein products (AOPP) levels were determined in peripheral blood plasma, erythrocytes, and colostrum whey. The concentration of antioxidants in the peripheral blood of supplemented cows was increased by 41% and 19% on (+2 D) and (+7 D), respectively, while the concentration of lipid peroxides on (+7 D) was lowered by 57% compared with the control group. In addition, this supplementation increased erythrocyte AOPP level on (–4 D) 61%) and colostral lipid peroxides level (90%) at 24 h pp. The results of this study showed that applied short-term supplementation with clinoptilolite influences redox homeostasis and may contribute to effective adaptation of primiparous cows to redox imbalance in the peripartum period. Highlights Short-term dietary supplementation with clinoptilolite in the prepartum period modulates redox homeostasis of the dairy cows’ blood plasma. Short-term dietary supplementation with clinoptilolite contributes to adaptation of dairy cows to redox imbalance in the peripartum period. Short-term dietary supplementation with clinoptilolite increase the level of lipid peroxides in colostrum of dairy cows.

Agnes Magyar, Eva Racz, Clara Matesz et al.

Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements, posture and vegetative functions. After a shorter or longer period of time, the vestibular function is partially or completely restored via a series of processes such as modification in the efficacy of synaptic inputs. As the plasticity of adult central nervous system is associated with the alteration of extracellular matrix, including its condensed form, the perineuronal net, we studied the changes of brevican expression in the perineuronal nets of the superior vestibular nucleus after unilateral labyrinth lesion. Our results demonstrated that the unilateral labyrinth lesion and subsequent compensation are accompanied by the changing of brevican staining pattern in the perineuronal nets of superior vestibular nucleus of the rat. The reduction of brevican in the perineuronal nets of superior vestibular nucleus may contribute to the vestibular plasticity by suspending the non-permissive role of brevican in the restoration of perineuronal net assembly. After a transitory decrease, the brevican expression restored to the control level parallel to the partial restoration of impaired vestibular function. The bilateral changing in the brevican expression supports the involvement of commissural vestibular fibers in the vestibular compensation. All experimental procedures were approved by the ‘University of Debrecen – Committee of Animal Welfare’ (approval No. 6/2017/DEMAB) and the ‘Scientific Ethics Committee of Animal Experimentation’ (approval No. HB/06/ÉLB/2270-10/2017; approved on June 6, 2017).

Md. Jamal Hossain, Foyez Ahmmed, Md. Robin Khan et al.

ObjectivesThis current study aims to assess the prevalence and factors associated with body mass index (BMI), dietary patterns, and the extent of physical activities among university students following the prolonged coronavirus disease 2019 (COVID-19) lockdown in Bangladesh.MethodsA cross-sectional web-based survey was conducted between July 10 to August 10, 2021, through a pre-designed Google Form to collect the data from Bangladeshi university students (age: ≥18 years). Informed consent was electronically obtained from each participant, and a simple snowball technique was employed during the sampling. Frequency and percentage distribution, paired t-test, chi-square [χ2] test, and multinomial and binary logistic regression analyses were consecutively applied to analyze the collected data.ResultsAmong the total participants (n = 1,602), 45.1% were female and 55.6% were 22–25 years' age group students. The BMI (mean ± standard deviation, SD) during the COVID-19 lockdown was 23.52 ± 7.68 kg/m2, which was 22.77 ± 4.11 kg/m2 during the pre-lockdown period (mean difference = 0.753; p &lt; 0.001). The multinomial logistic regression analysis found a significant impact of gender [male vs. female: adjusted relative risk ratio (RRR) = 1.448; 95% confidence interval (CI) = 1.022, 2.053; p = 0.037], age (years) (&lt;22 vs. &gt;25: RRR =0.389, 95% CI = 0.213,0.710; p = 0.002, and 22–25 vs. &gt;25: RRR = 0.473, 95% CI = 0.290, 0.772; p = 0.003), monthly family income (BDT) (&lt;25,000 vs. &gt;50,000: RRR = 0.525, 95% CI = 0.334,0.826; p = 0.005), university type (public vs. private: RRR = 0.540, 95% CI = 0.369, 0.791; p = 0.002), eating larger meals/snacks (increased vs. unchanged: RRR = 2.401, 95% CI = 1.597, 3.610; p &lt; 0.001 and decreased vs. unchanged: RRR = 1.893, 95% CI = 1.218, 2.942; p = 0.005), and verbally or physically abuse (yes vs. no: RRR = 1.438, 95% CI = 0.977, 2.116; p = 0.066) on obesity during COVID-19 pandemic. Besides, the female students and those who have constant eating habits, were more likely to be underweight. Additionally, the binary logistic regression analysis found that the students from private universities [others vs. private: adjusted odds ratio (AOR) = 0.461, 95% CI = 0.313, 0.680; p &lt; 0.001], urban areas (urban vs. rural: AOR = 1.451, 95% CI = 1.165, 1.806; p = 0.001), wealthier families (&lt;25,000 BDT vs. &gt;50,000 BDT: AOR = 0.727, 95% CI = 0.540, 0.979; p = 0.036), and who were taking larger meals/snacks (increased vs. unchanged: AOR = 2.806, 95% CI = 2.190, 3.596; p &lt; 0.001) and had conflicts/arguments with others (no vs. yes: AOR = 0.524, 95% CI = 0.418, 0.657; p &lt; 0.001), were significantly more physically inactive. Finally, the level of education and smoking habits significantly influenced the eating habits of university students during the extended strict lockdown in Bangladesh.ConclusionThe current findings would be helpful tools and evidence for local and international public health experts and policymakers to reverse these worsening effects on students mediated by the prolonged lockdown. Several effective plans, programs, and combined attempts must be earnestly implemented to promote a smooth academic and daily life.

Ayush Aniket, Arpan Chattopadhyay

We study learning in periodic Markov Decision Process(MDP), a special type of non-stationary MDP where both the state transition probabilities and reward functions vary periodically, under the average reward maximization setting. We formulate the problem as a stationary MDP by augmenting the state space with the period index, and propose a periodic upper confidence bound reinforcement learning-2 (PUCRL2) algorithm. We show that the regret of PUCRL2 varies linearly with the period and as sub-linear with the horizon length. Numerical results demonstrate the efficacy of PUCRL2.

G. Csörnyei, L. Szabados, L. Molnár et al.

Investigating period changes of classical Cepheids through the framework of $O-C$ diagrams provides a unique insight to the evolution and nature of these variable stars. In this work, the new or extended $O-C$ diagrams for 148 Galactic classical Cepheids are presented. By correlating the calculated period change rates with the Gaia EDR3 colours, we obtain observational indications for the non-negligible dependence of the period change rate on the horizontal position within the instability strip. We find period fluctuations in 59 Cepheids with a confidence level of 99%, which are distributed uniformly over the inspected period range. Correlating the fluctuation amplitude with the pulsation period yields a clear dependence, similar to the one valid for longer period pulsating variable stars. The non-negligible amount of Cepheids showing changes in their $O-C$ diagrams that are not or not only of evolutionary origin points toward the need for further studies for the complete understanding of these effects. One such peculiar behaviour is the large amplitude period fluctuation in short period Cepheids, which occurs in a significant fraction of the investigated stars. The period dependence of the fluctuation strength and its minimum at the bump Cepheid region suggests a stability enhancing mechanism for this period range, which agrees with current pulsation models.

C. Drake, M. Jones, C. Baruch

Sofia I. H. Godinho, E. Maywood, L. Shaw et al.