J. Apfelbaum, Carin A. Hagberg, Richard T. Connis
et al.
The American Society of Anesthesiologists; All India Difficult Airway Association; European Airway Management Society; European Society of Anaesthesiology and Intensive Care; Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care, Learning, Teaching and Investigation Difficult Airway Group; Society for Airway Management; Society for Ambulatory Anesthesia; Society for Head and Neck Anesthesia; Society for Pediatric Anesthesia; Society of Critical Care Anesthesiologists; and the Trauma Anesthesiology Society present an updated report of the Practice Guidelines for Management of the Difficult Airway.
ObjectivesTo assess the accuracy of Advanced Pediatric Life Support (APLS) and Neonatal Resuscitation Program (NRP) formulas for predicting oral endotracheal tube (ETT) depth in Chinese infants undergoing elective surgery, and to develop a flexible intubating video endoscope (FIVE)-verified predictive formula for this population.MethodsIn this prospective study, 189 infants (including term neonates and infants aged 1–12 months) who required oral intubation for elective surgery were enrolled. Demographics were recorded, and ETT depths were calculated using APLS and NRP formulas. A reference insertion depth was determined using FIVE, with the tube tip positioned 1 cm above the carina (a pragmatic reference position rather than a universal “ideal”). Correlations between patient characteristics and optimal depth were assessed, and new formulas were developed by linear regression.ResultsIn neonates, FIVE-confirmed depth correlated with height (r = 0.670, P < 0.001), weight (r = 0.488, P < 0.001), and body surface area (BSA) (r = 0.536, P < 0.001). In infants aged 1–12 months, stronger correlations were found with height (r = 0.952, P < 0.001), weight (r = 0.895, P < 0.001), BSA (r = 0.926, P < 0.001), and age in months (r = 0.871, P < 0.001). APLS and NRP formulas produced deeper predicted depths than the FIVE-referenced depth in 12.5% of neonates and 30.1% of older infants. New predictive formulas were: infants 1–12 months: depth (cm) = 4.5 + 0.1 × height (cm).ConclusionThe weight-based APLS formula may be less applicable to Chinese infants undergoing elective surgery. A height-based formula demonstrated closer agreement with the FIVE-referenced depth. Because the model was developed and assessed in the same cohort, it should be considered preliminary and requires independent external validation (preferably multicenter) before widespread clinical use, particularly in non-elective or critically ill populations.
Niklas Giesa, Maria Sekutowicz, Kerstin Rubarth
et al.
Abstract Background Patients who experienced postoperative delirium (POD) are at higher risk of poor outcomes like dementia or death. Previous machine learning models predicting POD mostly relied on time-aggregated features. We aimed to assess the potential of temporal patterns in clinical parameters during surgeries to predict POD. Methods Long short-term memory (LSTM) and transformer models, directly consuming time series, were compared to multi-layer perceptrons (MLPs) trained on time-aggregated features. We also fitted hybrid models, fusing either LSTM or transformer models with MLPs. Univariate Spearman’s rank correlations and linear mixed-effect models establish the importance of individual features that we compared to transformers’ attention weights. Results Best performance is achieved by a transformer architecture ingesting 30 min of intraoperative parameter sequences. Systolic invasive blood pressure and given opioids mark the most important input variables, in line with univariate feature importances. Conclusions Intraoperative temporal dynamics of clinical parameters, exploited by a transformer architecture named TRAPOD, are critical for the accurate prediction of POD.
Eric R. Bain, Bistees George, Syed H. Jafri
et al.
Abstract Background Patients with severe aortic stenosis (AS) and left ventricular (LV) dysfunction demonstrate improvement in left ventricular injection fraction (LVEF) after aortic valve replacement (AVR). The timing and magnitude of recovery in patients with very low LVEF (≤ 25%) in surgical or transcatheter AVR is not well studied. Objective Determine clinical outcomes following transcatheter aortic valve replacement (TAVR) and surgical aortic valve repair (SAVR) in the subset of patients with severely reduced EF ≤ 25%. Methods Single-center, retrospective study with primary endpoint of LVEF 1-week following either procedure. Secondary outcomes included 30-day mortality and delayed postprocedural LVEF. T-test was used to compare variables and linear regression was used to adjust differences among baseline variables. Results 83 patients were enrolled (TAVR = 56 and SAVR = 27). TAVR patients were older at the time of procedure (TAVR 77.29 ± 8.69 vs. SAVR 65.41 ± 10.05, p < 0.001). One week post procedure, all patients had improved LVEF after both procedures (p < 0.001). There was no significant difference in LVEF between either group (TAVR 33.5 ± 11.77 vs. SAVR 35.3 ± 13.57, p = 0.60). Average LVEF continued to rise and increased by 101% at final follow-up (41.26 ± 13.70). 30-day mortality rates in SAVR and TAVR were similar (7.4% vs. 7.1%, p = 0.91). Conclusion Patients with severe AS and LVEF ≤ 25% have a significant recovery in post-procedural EF following AVR regardless of method. LVEF doubled at two years post-procedure. There was no significant difference in 30-day mortality or mean EF recovery between TAVR and SAVR. Trial registration Indiana University institutional review board granted approval for above study numbered 15,322.
Background and aimsGastrointestinal microbial metabolomics is closely related to the state of the organism and has significant interaction with the pathogenesis of many diseases. Based on the publications in Web of Science Core Collection(WoSCC) from 2004 to 2022, this study conducted a bibliometric analysis of this field, aiming to understand its development trend and frontier, and provide basic information and potential points for in-depth exploration of this field.MethodsAll articles on gastrointestinal flora and metabolism published from 2004 to 2022 were collected and identified in WoCSS. CiteSpace v.6.1 and VOSviewer v.1.6.15.0 were used to calculate bibliometric indicators, including number of publications and citations, study categories, countries/institutions, authors/co-cited authors, journals/co-cited journals, co-cited references, and keywords. A map was drawn to visualize the data based on the analysis results for a more intuitive view.ResultsThere were 3811 articles in WoSCC that met our criteria. Analysis results show that the number of publications and citations in this field are increasing year by year. China is the country with the highest number of publications and USA owns the highest total link strength and citations. Chinese Acad Sci rank first for the number of institutional publications and total link strength. Journal of Proteome Research has the most publications. Nicholson, Jeremy K. is one of the most important scholars in this field. The most cited reference is “Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease”. Burst detection indicates that Urine, spectroscopy, metabonomic and gut microflora are long-standing hot topics in this field, while autism spectrum disorder and omics are likely to be at the forefront of research. The study of related metabolic small molecules and the application of gastrointestinal microbiome metabolomics in various diseases are currently emerging research directions and frontier in this field.ConclusionThis study is the first to make a bibliometric analysis of the studies related to gastrointestinal microbial metabolomics and reveal the development trends and current research hotspots in this field. This can contribute to the development of the field by providing relevant scholars with valuable and effective information about the current state of the field.
Background. Workplace-based assessment (WPBA) is a new technology for evaluating medical residents that is believed to be more effective than traditional multiple-choice tests or exam-based assessment methods. The aim of the study was to investigate the WPBA efficacy in final-year medical residents: multi-source feedback (360°) assessment, direct procedure assessment (Anaesthesia-Clinical Evaluation Exercise (A-CEX)) and clinical case-based assessment, and to identify difficult competencies, which graduate residents acquire the least successfully. Materials and methods. From April 1 to June 15, 2023, 36 residents were evaluated at the workplace: the multi-source feedback 360°-evaluation form was filled out by three representatives of the medical team where the resident worked during the on-site part of the residency (1 anesthesiologist, 1 nurse and 1 other specialist); the form of direct procedure assessment was filled out by the teacher on face-to-face bases directly during the resident’s performance of the general anesthesia in low-risk patients (American Society of Anesthesiologists (ASA) I or II), preoperative examination of low-risk patients (ASA I or II) and neuraxial anesthesia in low-risk patients (ASA I or II) with the following feedback; assessment based on a clinical case was carried out by teachers during the conference of residents, where each of them presented a clinical case of anesthetic management or treatment of a critically ill patient. Results. According to the results of the multi-source feedback (360°) evaluation, most of the residents have received 7 or more points out of 10 possible. Communication with the medical team (odds ratio (OR) 1.9 [1.05–3.5], p = 0.048) and management in a critical situation (OR 2 [1.14–3.83], p = 0.024) were most difficult competencies during the multi-source feedback (360°) assessment. During direct procedure of general anesthesia, the most difficult competencies were: 1) management in a critical situation — knowledge/recognition of risks and how to avoid and treat them (OR 5.29 [1.9–14.4], p = 0.001 compared to documentation); 2) solving problems, making decisions (OR 12.6 [1.5–10,4], p = 0.007 compared to documentation); 3) interaction in the team (OR 2.7 [1.1–6.5], p = 0.049). No problematic competencies were identified during the assessment of neuraxial anesthesia competencies and preoperative examination. Conclusions. WPBA techniques such as multi-source feedback (360°) assessment, direct procedure evaluation (A-CEX) and clinical case-based assessment are effective in final year residents, improving their communication skills, readiness to work independently, help identify skill deficiencies. Communication with the medical team and management in a critical situation were difficult competencies during the multi-source feedback (360°) evaluation. Difficult competences during the direct evaluation of general anesthesia turned out to be the management in a critical situation; solving problems, making decisions; interaction in the team. No problematic competencies were identified during the assessment of neuraxial anesthesia competencies and preoperative examination.
Medical emergencies. Critical care. Intensive care. First aid
Background: Sleep deprivation reduced the time to induce anesthesia by propofol and isoflurane and prolonged the time to recovery. However, it is unknown whether sleep deprivation affects the potency of inhaled anesthetics. In this study, the effect of sleep deprivation on sevoflurane anesthetic potency was explored. Methods: Ten animals received the following behavioral interventions in turn (ad libitum activity, 24 h sleep deprivation, 48 h sleep deprivation, 72 h sleep deprivation). After each behavioral intervention, the 50% effective dose for loss of righting reflex (LORR ED50) was determined to evaluate the potency of sevoflurane in inducing unconsciousness in mice. Repeated-measures analysis of variance was used to compare our behavioral interventions statistically, post hoc multiple comparisons were made using the Bonferroni test. Results: Sleep deprivation decreased the sevoflurane LORR ED50 significantly (p = 0.0003). However, the effect of duration of sleep deprivation on LORR ED50 was not statistically significant (p > 0.9999). Conclusions: Sleep deprivation can increase the anesthetic potency of sevoflurane regardless of duration of sleep deprivation.
Behiye Deniz Kosovalı, Gül Meral Kocabeyoğlu, Nevzat Mehmet Mutlu
et al.
Objective: The patients admitted to coronavirus disease-2019 (COVID-19) intensive care units (ICUs) with the suspicion of COVID-19 in the first four months of the pandemic were evaluated both in diagnostics and according to periods of the pandemic.
Materials and Methods: The data of 1,430 patients admitted to the COVID-19 ICUs were recorded with the same algorithm in a single-center retrospectively. Patients were classified as COVID-19 and non-COVID-19 patients according to polymerase chain reaction results, radiological and clinical findings. Also, COVID-19 patients were compared as dying and surviving. Additionally, the data of patients admitted to COVID-19 ICUs during the onset of the pandemic and during the normalization period were also compared.
Results: Of 1,430 patients, 630 were included in the COVID-19 group and 800 in the non-COVID-19 group. While there was a significant difference in the mean age of the groups, there was no difference between the genders (p=0.001, p=0.262 respectively). The age in the COVID-19 and deceased group was higher than that in the survivors (p<0.001). The most common presenting symptom was dyspnea (51.2%), while hypertension’s most common comorbidity (51.2%). During the normalization period, the rate of patients admitted to the ICU with the diagnosis of COVID-19 and the mortality rates in the ICU was higher.
Conclusion: The initial period of the pandemic was spent understanding COVID-19, which entered our lives as a mystery at the same time. It was a guiding period for us to treat patients more effectively while protecting the community and healthcare professionals.
Maxime Nguyen, Maxime Nguyen, Maxime Nguyen
et al.
IntroductionDuring peritonitis, lipopolysaccharides (LPS) cross the peritoneum and pass through the liver before reaching the central compartment. The aim of the present study was to investigate the role of lipoproteins and phospholipid transfer protein (PLTP) in the early stages of LPS detoxification.Material and MethodsPeritonitis was induced by intra-peritoneal injection of LPS in mice. We analyzed peritoneal fluid, portal and central blood. Lipoprotein fractions were obtained by ultracentrifugation and fast protein liquid chromatography. LPS concentration and activity were measured by liquid chromatography coupled with mass spectrometry and limulus amoebocyte lysate. Wild-type mice were compared to mice knocked out for PLTP.ResultsIn mice expressing PLTP, LPS was able to bind to HDL in the peritoneal compartment, and this was maintained in plasma from portal and central blood. A hepatic first-pass effect of HDL-bound LPS was observed in wild-type mice. LPS binding to HDL resulted in an early arrival of inactive LPS in the central blood of wild-type mice.ConclusionPLTP promotes LPS peritoneal clearance and neutralization in a model of peritonitis. This mechanism involves the early binding of LPS to lipoproteins inside the peritoneal cavity, which promotes LPS translocation through the peritoneum and its uptake by the liver.
David Alexander Christian Messerer, David Alexander Christian Messerer, Laura Vidoni
et al.
Studying innate immunity in humans is crucial for understanding its role in the pathophysiology of systemic inflammation, particularly in the complex setting of sepsis. Therefore, we standardized a step-by-step process from the venipuncture to the transfer in a human model system, while closely monitoring the inflammatory response for up to three hours. We designed an animal-free, human whole blood sepsis model using a commercially available, simple to use, tubing system. First, we analyzed routine clinical parameters, including cell count and blood gas analysis. Second, we demonstrated that extracellular activation markers (e.g., CD11b and CD62l) as well as intracellular metabolic (intracellular pH) and functional (generation of radical oxygen species) features remained stable after incubation in the whole blood model. Third, we mimicked systemic inflammation during early sepsis by exposure of whole blood to pathogen-associated molecular patterns. Stimulation with lipopolysaccharide revealed the capability of the model system to evoke a sepsis-like inflammatory phenotype of innate immunity. In summary, the presented model serves as a convenient, economic, and reliable platform to study innate immunity in human whole blood, which may yield clinically important insights.
JungHyun Park, Jueun Kwak, Sukyung Chung, Hyo Ju Hong, Jin Young Chon, Ho Sik Moon Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaCorrespondence: Ho Sik MoonDepartment of Anesthesiology and Pain Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 1021, Tongil-ro, Eunpyeong-gu, Seoul 03312, Republic of KoreaTel +822-2030-3864Fax +822-2030-3861Email mhsjshgma@gmail.comPurpose: Endocrinological complications of an epidural steroid injection (ESI) are rare but dangerous. Nevertheless, despite the associated risks, repeated long-term ESIs are indispensable in some clinical situations. However, only a few reports to date have assessed the safety of this procedure. In this study, we evaluate the incidence of adrenal insufficiency (AI) and Cushing’s syndrome after long-term ESIs.Methods: This clinical observational study enrolled herniated nucleus pulposus or spinal stenosis patients who had received ESIs over a period of six months or longer. The adrenocorticotropic hormone (ACTH) stimulation test was performed to confirm AI and the late-night salivary cortisol (LNSC) test was performed to diagnose Cushing’s syndrome. To evaluate the hypothalamus pituitary adrenal axis suppression, salivary cortisol (SC) levels were measured on days 0, 1, 7, 21, 28, 35, and 42.Results: This study included 17 patients. Among these, two patients (11.8%) developed AI, but no cases of Cushing’s syndrome were reported. There was no predictor for the development of AI. The SC levels tended to increase with time after an ESI (β = 0.003). The slope of the mixed effect model between the AI and non-AI groups showed a significant difference (p value = 0.015). However, the differences in mean SC levels at each time point between the two groups were not significant (adjusted p value = 0.053).Conclusion: Long-term ESI use may be associated with AI development. An unexpected adrenal crisis due to AI could be life threatening. Therefore, regular monitoring of adrenal function in patients who have received long-term ESIs may be prudent.Keywords: epidural, glucocorticoid, salivary cortisol, adrenal insufficiency, long-term
S.M. Verst, P.H.P. de Aguiar, M.A.S. Joaquim
et al.
Objectives: To determine whether high-frequency 250–500 Hz monopolar stimulation is effective for mapping cortical and subcortical language structures during brain tumor resection. Methods: Using high-frequency monopolar stimulation, we mapped the speech areas of 41 awake patients undergoing brain tumor resection in the dominant hemisphere, subject to risk of lesions in the cortical and subcortical speech tracts. Patients were tested for object naming, semantic and other language tasks. Results: Mapping was positive in 22 out of 41 patients. Nine patients presented clinical worsening immediately after surgery. Only one patient did not recover after the 30-day follow-up. Nineteen patients showed negative mapping for language tracts, none of whom exhibited worsening of symptoms at the final evaluation. The applied method showed 89% sensitivity and 56% specificity rates. Conclusions: The applied method was effective in identifying cortical and subcortical speech areas during the surgical resection of brain tumors. Significance: Determining whether monopolar high-frequency stimulation is effective for language mapping is important, since it may be very effective in infiltrating tumor areas and nearby edema region. Keywords: Awake craniotomy, Cortical stimulation, Glioma, Language mapping, Motor evoked potentials, Subcortical mapping, Motor mapping
Paurush Ambesh, Melissa Hirsch, Aviva Tobin-Hess
et al.
Although most intracardiac defects are congenital, a small fraction may be acquired during life. The Gerbode defect is an abnormal anatomical connection between the left ventricle and the right atrium. We describe herein a patient who initially underwent repair of tetralogy of Fallot (TOF). Years after TOF repair, he developed severe dyspnea. Extensive evaluation revealed that he had developed a Gerbode defect. Very few cases of acquired Gerbode defect have been previously reported. Management options are predominantly surgical interventions.
Anesthesiology, Diseases of the circulatory (Cardiovascular) system
Background Perioperative magnesium sulfate (MgSO4) is used for analgesic, anti-arrhythmic, and obstetric purposes. The effects of MgSO4 on the neuromuscular blockade (NMB) induced by rocuronium, and the sugammadex reversal thereof, have not been clearly quantified. We investigated the effect of various MgSO4 concentrations on the NMB by rocuronium, and sugammadex reversal, in isolated left phrenic nerve hemi-diaphragm (PNHD) preparations from the rat. Methods Rat PNHD preparations were randomly allocated to one of four groups varying in terms of MgSO4 concentration (1, 2, 3, and 4 mM, each n = 10, in Krebs solution). The train-of-four (TOF) and twitch height responses were recorded mechanomyographically. The preparations were treated with incrementally increasing doses of rocuronium and each group’s effective concentration (EC)50, EC90, and EC95 of rocuronium were calculated via nonlinear regression. Then, sugammadex was administered in doses equimolar to rocuronium. The recovery index, time to T1 height > 95% of control, and the time to a TOF ratio > 0.9 after sugammadex administration were measured. Results The EC50, EC90, and EC95 of rocuronium fell significantly as the magnesium level increased. The EC50, EC90, and EC95 of rocuronium did not differ between the 3 and 4 mM groups. The recovery index, time to T1 height > 95% of control, and time to a TOF ratio > 0.9 after sugammadex administration did not differ among the four groups. Conclusions Increases in the magnesium concentration in rat PNHD preparations proportionally enhanced the NMB induced by rocuronium but did not affect reversal by equimolar amounts of sugammadex.