Patient-Specific Computational Hemodynamic Modeling of the Right Pulmonary Artery Using CardioMEMS Data: Validation, Simplification, and Sensitivity Analysis
Angélica Casero, Laura G. Sánchez, Felicia Alfano
et al.
This study investigates the application of computational hemodynamic modeling, involving both FSI and CFD models, using SimVascular to simulate blood flow in the right pulmonary artery for patient-specific cardiovascular assessment. The artery’s three-dimensional geometry was reconstructed from a computed tomography (CT) image, and pressure measurements from a CardioMEMS™ device were used as clinical ground truth for validation. To represent the arterial hemodynamics, we initially formulated a fluid–structure interaction (FSI) approach to capture wall mechanics. However, given the high computational cost of fully patient-specific FSI simulations for routine clinical decision-making, we evaluated the validity of key simplifications by assuming rigid vessel walls coupled with a three-element Windkessel (3WK) model and applying a half-sine inflow waveform derived from the patient’s cardiac output. These simplifications yielded results with minimal error: the rigid-wall assumption introduced a 1.1% deviation, while the idealized waveform resulted in a 0.56 mmHg offset. Crucially, while wall rigidity was acceptable, we found that arterial compliance in the boundary conditions is non-negotiable; reducing the model to a pure resistance approach resulted in non-physiological pressures (130 mmHg). A subsequent parametric analysis examined how varying resistance (R) and compliance (C) distinctively alter the pressure waveform morphology. The results underscore the potential of combining remote monitoring data with validated computational simulations to deepen the understanding of cardiovascular dynamics and enhance diagnostic and therapeutic approaches for cardiovascular diseases.
Thermodynamics, Descriptive and experimental mechanics
Flow Evolution in Magmatic Conduits: A Constructal Law Analysis of Stochastic Basaltic and Felsic Lava Dynamics
Antonio F. Miguel, Vinícius R. Pepe, Luiz A. O. Rocha
This study probabilistically assesses magma ascent by modeling dike propagation as a fully coupled fluid-flow, thermo-mechanical problem, explicitly accounting for the stochastic heterogeneity of the crustal host rock. We study felsic (rhyolite) lava flow and two distinct basaltic feeding regimes that correspond to the conditions necessary to produce the contrasting pāhoehoe and ʻaʻā surface morphologies. Basaltic dikes demonstrate high propagation efficiency to the surface (pāhoehoe-feeding regime 99.5%; ʻaʻā-feeding regime 97.5%), whereas rhyolite dikes have an 89% failure rate, attributed to significant friction. Both regimes represent distinct constructal approaches aimed at maximizing flow persistence. The pāhoehoe-feeding regime is a thermally regulated, stable design characterized by low-velocity, cooling-dominated dynamics. Its slow, persistent flow allows for significant conductive heating of the surrounding rock wall, creating an efficient, pre-heated thermal conduit. In contrast, the ʻaʻā-feeding regime is a mechanically dominated design governed by high-velocity, stochastic dynamics. This morphology is driven by forceful flow, and its thermal budget is supplemented by intense viscous dissipation (internal friction). Rhyolite magma flow fails upon losing constructal viability, driven by a coupled mechanical–thermal cascade. The sequence begins when a mechanical barrier halts the magma velocity, which triggers a freezing event and leads to permanent arrest.
Thermodynamics, Descriptive and experimental mechanics
Extended URDF: Accounting for parallel mechanism in robot description
Virgile Batto, Ludovic de Matteis, Nicolas Mansard
Robotic designs played an important role in recent advances by providing powerful robots with complex mechanics. Many recent systems rely on parallel actuation to provide lighter limbs and allow more complex motion. However, these emerging architectures fall outside the scope of most used description formats, leading to difficulties when designing, storing, and sharing the models of these systems. This paper introduces an extension to the widely used Unified Robot Description Format (URDF) to support closed-loop kinematic structures. Our approach relies on augmenting URDF with minimal additional information to allow more efficient modeling of complex robotic systems while maintaining compatibility with existing design and simulation frameworks. This method sets the basic requirement for a description format to handle parallel mechanisms efficiently. We demonstrate the applicability of our approach by providing an open-source collection of parallel robots, along with tools for generating and parsing this extended description format. The proposed extension simplifies robot modeling, reduces redundancy, and improves usability for advanced robotic applications.
Numerical Study on the Impact Pressure of Droplets on Wind Turbine Blades Using a Whirling Arm Rain Erosion Tester
Nobuyuki Fujisawa, Hirokazu Kawabata
The leading-edge erosion of a wind turbine blade was tested using a whirling arm rain erosion tester, whose rotation rate is considerably higher than that of a full-scale wind turbine owing to the scale effect. In this study, we assessed the impact pressure of droplets on a wet surface of wind turbine blades using numerical simulation of liquid droplet impact by solving the Navier–Stokes equations combined with the volume-of-fluid method. This was conducted in combination with an estimation of liquid film thickness on the rotating blade using an approximate solution of Navier–Stokes equations considering the centrifugal and Coriolis forces. Our study revealed that the impact pressure on the rain erosion tester exceeded that on the wind turbine blade, attributed to the thinner liquid film on the rain erosion tester than on the wind turbine blade caused by the influence of centrifugal and Coriolis forces. This indicates the importance of correcting the influence of liquid-film thickness in estimating the impact velocity of droplets on the wind turbine blade. Furthermore, we demonstrated the correction procedure when estimating the impact velocity of droplets on the wind turbine blade.
Thermodynamics, Descriptive and experimental mechanics
Calibration and Validation of a Phase-Field Model of Brittle Fracture within the Damage Mechanics Challenge
Jonas Heinzmann, Pietro Carrara, Chenyi Luo
et al.
In the context of the Damage Mechanics Challenge, we adopt a phase-field model of brittle fracture to blindly predict the behavior up to failure of a notched three-point-bending specimen loaded under mixed-mode conditions. The beam is additively manufactured using a geo-architected gypsum based on the combination of bassanite and a water-based binder. The calibration of the material parameters involved in the model is based on a set of available independent experimental tests and on a two-stage procedure. In the first stage an estimate of most of the elastic parameters is obtained, whereas the remaining parameters are optimized in the second stage so as to minimize the discrepancy between the numerical predictions and a set of experimental results on notched three-point-bending beams. The good agreement between numerical predictions and experimental results in terms of load-displacement curves and crack paths demonstrates the predictive ability of the model and the reliability of the calibration procedure.
Extended invariant cones as Nonlinear Normal Modes of inhomogeneous piecewise linear systems
A. Yassine Karoui, Remco I. Leine
The aim of this paper is to explore the relationship between invariant cones and nonlinear normal modes in piecewise linear mechanical systems. As a key result, we extend the invariant cone concept, originally established for homogeneous piecewise linear systems, to a class of inhomogeneous continuous piecewise linear systems. The inhomogeneous terms can be constant and/or time-dependent, modeling nonsmooth mechanical systems with a clearance gap and external harmonic forcing, respectively. Using an augmented state vector, a modified invariant cone problem is formulated and solved to compute the nonlinear normal modes, understood as periodic solutions of the underlying conservative dynamics. An important contribution is that invariant cones of the underlying homogeneous system can be regarded as a singularity in the theory of nonlinear normal modes of continuous piecewise linear systems. In addition, we use a similar methodology to take external harmonic forcing into account. We illustrate our approach using numerical examples of mechanical oscillators with a unilateral elastic contact. The resulting backbone curves and frequency response diagrams are compared to the results obtained using the shooting method and brute force time integration.
Surrogate Models for Heat Transfer in Oscillating Flow with a Local Heat Source
Simon Knecht, Denislav Zdravkov, Albert Albers
Simulative optimization methods often build on an iterative scheme, where a simulation model is solved in each iteration. To reduce the time needed for an optimization, finding the right balance between simulation model quality, and simulation time is essential. This is especially true for transient problems, such as fluid flow within a hydromechanical system. Therefore, we present an approach to building steady-state surrogate models for oscillating flow in a pipe with a local heat source. The main aspect is to model the fluid as a solid with an orthotropic heat transfer coefficient. The values of this coefficient are fitted to reproduce the temperature distribution of the transient case by parametric optimization. It is shown that the presented approach is feasible for different sets of parameters and creates suitable surrogate models for oscillating flow within a pipe with a local heat source. In future works, the presented approach will be transferred from the simplified geometry under investigation to industrial problems.
Thermodynamics, Descriptive and experimental mechanics
Deformation Decomposition versus Energy Decomposition for Chemo- and Poro- Mechanics
Janel Chua, Mina Karimi, Patrick Kozlowski
et al.
We briefly compare the structure of two classes of popular models used to describe poro- and chemo- mechanics wherein a fluid phase is transported within a solid phase. The multiplicative deformation decomposition has been successfully used to model permanent inelastic shape change in plasticity, solid-solid phase transformation, and thermal expansion, which has motivated its application to poro- and chemo- mechanics. However, the energetic decomposition provides a more transparent structure and advantages, such as to couple to phase-field fracture, for models of poro- and chemo- mechanics.
Experimental study of developing free-falling annular flow in a large-scale vertical pipe
Yunpeng Xue, Colin Stewart, David Kelly
et al.
Annular flow is the primary characteristic of unsteady wastewater flow, which initiates entrained air and sets up the air pressure regime within the system - an important design consideration. This paper reports on an experimental investigation of free-falling annular flow in a vertical pipe with different inlets at extended flow ranges up to Re = 3 x 10e4, similar to those in Building Drainage Systems (BDS). In the experimental setup, a vertical pipe system (5 m) was used to record velocity profiles and film thickness in the developing region through Particle Image Velocimetry (PIV) measurements. Entrained droplets were collected through a separator, and the entrainment fraction was calculated at different flow conditions. The study reports on the development process of the film velocity and thickness along the vertical pipe, which agrees well with empirical predictions. The results of the droplet entrainment of a vertical annular flow show the development process to the steady state. Additionally, a Tee-junction inlet in drainage system generates a higher and different entrainment profile.
PENGGUNAAN METODE EKSPERIMEN TERHADAP HASIL BELAJAR FISIKA SISWA PADA MATERI POKOK GELOMBANG MEKANIK DI KELAS XII SMA NEGERI
Sari Wahyuni Rozi Nasution, Unita Sukma Zuliani
The aims of this research wa to know whether there was a significent influence of using experiment method on physics achievement in mechanic waves subject at the twelfth grade students of SMA Negeri 1 Pangaribuan. The approach of this research was experimental method. The population of this research was all the twelfth grade students of IPA majors SMA Negeri 1 Pangaribuan. They were consist of 3 classes which include 120 students. This research use cluster random sumpling technique to take sample, so the total sample 40 students. In collecting the data, the writer used test and questionnaire. The data was analyzed two ways. They are descriptive analysis and inferential statistic. Based on descriptive analysis, the average of using experiment method was 2.85. It was categorized “good”. Physics achievement in mechanic waves subject before using experiment methode had average 63.50, it was categorized “enough”. While physics achievement in mechanic waves subject after using experiment method had average 80.38, it was categorized “very good”. Based on inferential statistics, it could be gotten that tcaunt = 17,39 and ttable = 1,68 at confidence level 95% or error level 5%, df = N - 1 = 40 - 1 = 39. It could be seen that tcaunt was greater than ttable (17,39 1,68). The hypothesis was accepted. In the other words, there was a significant influence between using experiment method on physics achievement in mechanics waves subject at the twelfth grade students of SMA Negeri 1 Pangaribuan.
Effects of Computer-Mediated Instruction (Cmi) on Student-Teachers’ Misconceptions and Achievement in Physics
Onyukwu Chima Onyedineke, Mangut Mankilik
Physics is one of the natural sciences taught in Colleges of Education in Nigeria as a teaching subject with course units in line with the branches of physics, such as mechanics, thermodynamics, electromagnetism, optics, acoustics, astronomy and electronics. These course units are generally taught using the traditional lecture approach which neither give students opportunity to participate actively in the learning process nor co-construct knowledge as required in a science classroom. Consequently, students struggle with misconceptions which lead to poor academic achievement in physics. This study investigated the effects of computer-mediated instruction (CMI) on physics student-teachers’ misconceptions and achievement in Federal Colleges of Education, South-South Zone, Nigeria. The study adopted pretest-posttest one control group quasi-experimental design with intact classes. The study population comprised 51 physics student-teachers from the three federal colleges of education in the South-South zone of Nigeria who registered for Mechanics and Properties of Matter II during the 2018/2019 academic session. Simple random sampling technique was use to select the two federal colleges of education that participated in the study. Data were collected using Mechanics and Properties of Matter Misconceptions and Achievement Test (MPMMAT). Descriptive and inferential statistics were used for analysis with the assistance of Statistical Package for Social Sciences (SPSS) version 23.0 software. Result findings showed that Physics students hold a number of misconceptions on Mechanics and Properties of Matter II. Results equally revealed that CMI can improve students’ achievement in Mechanics and Properties of Matter II and can also reduce their misconceptions in the course. The study concluded that computer-mediated instruction (CMI) is an effective teaching approach which can reduce physics student-teachers’ misconceptions in mechanics and improve their academic achievement.
Multiphysics and multiscale modeling of microthrombosis in COVID-19
He Li, Yixiang Deng, Z. Li
et al.
Emerging clinical evidence suggests that thrombosis in the microvasculature of patients with Coronavirus disease 2019 (COVID-19) plays an essential role in dictating the disease progression. Because of the infectious nature of SARS-CoV-2, patients’ fresh blood samples are limited to access for in vitro experimental investigations. Herein, we employ a novel multiscale and multiphysics computational framework to perform predictive modeling of the pathological thrombus formation in the microvasculature using data from patients with COVID-19. This framework seamlessly integrates the key components in the process of blood clotting, including hemodynamics, transport of coagulation factors and coagulation kinetics, blood cell mechanics and adhesive dynamics, and thus allows us to quantify the contributions of many prothrombotic factors reported in the literature, such as stasis, the derangement in blood coagulation factor levels and activities, inflammatory responses of endothelial cells and leukocytes to the microthrombus formation in COVID-19. Our simulation results show that among the coagulation factors considered, antithrombin and factor V play more prominent roles in promoting thrombosis. Our simulations also suggest that recruitment of WBCs to the endothelial cells exacerbates thrombogenesis and contributes to the blockage of the blood flow. Additionally, we show that the recent identification of flowing blood cell clusters could be a result of detachment of WBCs from thrombogenic sites, which may serve as a nidus for new clot formation. These findings point to potential targets that should be further evaluated, and prioritized in the anti-thrombotic treatment of patients with COVID-19. Altogether, our computational framework provides a powerful tool for quantitative understanding of the mechanism of pathological thrombus formation and offers insights into new therapeutic approaches for treating COVID-19 associated thrombosis.
Robust, strong form mechanics on an adaptive structured grid: efficiently solving variable-geometry near-singular problems with diffuse interfaces
Vinamra Agrawal, Brandon Runnels
Many solid mechanics problems on complex geometries are conventionally solved using discrete boundary methods. However, such an approach can be cumbersome for problems involving evolving domain boundaries due to the need to track boundaries and constant remeshing. In this work, we employ a robust smooth boundary method (SBM) that represents complex geometry implicitly, in a larger and simpler computational domain, as the support of a smooth indicator function. We present the resulting equations for mechanical equilibrium, in which inhomogeneous boundary conditions are replaced by source terms. The resulting mechanical equilibrium problem is semidefinite, making it difficult to solve. In this work, we present a computational strategy for efficiently solving near-singular SBM elasticity problems. We use the block-structured adaptive mesh refinement (BSAMR) method for resolving evolving boundaries appropriately, coupled with a geometric multigrid solver for an efficient solution of mechanical equilibrium. We discuss some of the practical numerical strategies for implementing this method, notably including the importance of grid versus node-centered fields. We demonstrate the solver's accuracy and performance for three representative examples: a) plastic strain evolution around a void, b) crack nucleation and propagation in brittle materials, and c) structural topology optimization. In each case, we show that very good convergence of the solver is achieved, even with large near-singular areas, and that any convergence issues arise from other complexities, such as stress concentrations. We present this framework as a versatile tool for studying a wide variety of solid mechanics problems involving variable geometry.
Hydraulic fracture propagation and interaction with natural fractures by coupled hydro-mechanical modeling
Yu Hu, Q. Gan, A. Hurst
et al.
An Analysis of Acoustic Cavitation Thresholds of Water Based on the Incubation Time Criterion Approach
Ivan Smirnov, Natalia Mikhailova
Researchers are still working on the development of models that facilitate the accurate estimation of acoustic cavitation threshold. In this paper, we have analyzed the possibility of using the incubation time criterion to calculate the threshold of the onset of acoustic cavitation depending on the ultrasound frequency, hydrostatic pressure, and temperature of a liquid. This criterion has been successfully used by earlier studies to calculate the dynamic strength of solids and has recently been proposed in an adapted version for calculating the cavitation threshold. The analysis is carried out for various experimental data for water presented in the literature. Although the criterion assumes the use of macroparameters of a liquid, we also considered the possibility of taking into account the size of cavitation nuclei and its influence on the calculation result. We compared the results of cavitation threshold calculations done using the incubation time criterion of cavitation and the classical nucleation theory. Our results showed that the incubation time criterion more qualitatively models the results of experiments using only three parameters of the liquid. We then discussed a possible relationship between the parameters of the two approaches. The results of our study showed that the criterion under consideration has a good potential and can be conveniently used for applications where there are special requirements for ultrasound parameters, maximum negative pressure, and liquid temperature.
Thermodynamics, Descriptive and experimental mechanics
Інтелектуальна мультисенсорна система для ідентифікації та оцінки технічного стану електротехнічного обладнання
Stefan Zaichenko, Natalia Jukova, Dmitro Yakovlev
et al.
Сучасний етап розвитку енергетики характеризується широким використанням альтернативних та відновлюваних джерел енергії, вітрогенератори сонячні панелі. Такі системи, як правило, мають надскладну структуру і мають високу питому вартість електроенергії. Наявність поновлюваних джерел енергії дозволяє використовувати їх як окремі, але ефективність та надійність повністю залежать від добових ритмів та пори року. Ці особливості істотно обмежують використання альтернативних джерел енергії як надійного автономного джерела енергії. Наявність надійного резервного джерела живлення на сучасному підприємстві - запорука безпечної та якісної роботи.
Technological innovations. Automation, Mechanical industries
Triple Decomposition of Velocity Gradient Tensor in Compressible Turbulence
Radouan Boukharfane, Aimad Er-raiy, Linda Alzaben
et al.
The decomposition of the local motion of a fluid into straining, shearing, and rigid-body rotation is examined in this work for a compressible isotropic turbulence by means of direct numerical simulations. The triple decomposition is closely associated with a basic reference frame (BRF), in which the extraction of the biasing effect of shear is maximized. In this study, a new computational and inexpensive procedure is proposed to identify the BRF for a three-dimensional flow field. In addition, the influence of compressibility effects on some statistical properties of the turbulent structures is addressed. The direct numerical simulations are carried out with a Reynolds number that is based on the Taylor micro-scale of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>Re</mi><mi>λ</mi></msub><mo>=</mo><mn>100</mn></mrow></semantics></math></inline-formula> for various turbulent Mach numbers that range from <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>Ma</mi><mi>t</mi></msub><mo>=</mo><mn>0.12</mn></mrow></semantics></math></inline-formula> to <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>Ma</mi><mi>t</mi></msub><mo>=</mo><mn>0.89</mn></mrow></semantics></math></inline-formula>. The DNS database is generated with an improved seventh-order accurate weighted essentially non-oscillatory scheme to discretize the non-linear advective terms, and an eighth-order accurate centered finite difference scheme is retained for the diffusive terms. One of the major findings of this analysis is that regions featuring strong rigid-body rotations or straining motions are highly spatially intermittent, while most of the flow regions exhibit moderately strong shearing motions in the absence of rigid-body rotations and straining motions. The majority of compressibility effects can be estimated if the scaling laws in the case of compressible turbulence are rescaled by only considering the solenoidal contributions.
Thermodynamics, Descriptive and experimental mechanics
Numerical Computation of Dufour and Soret Effects on Radiated Material on a Porous Stretching Surface with Temperature-Dependent Thermal Conductivity
Tahir Naseem, Umar Nazir, Essam R. El-Zahar
et al.
The current research is prepared to address the transport phenomenon in a hydro-magnetized flow model on a porous stretching sheet. Mass and heat transport are modeled via temperature dependent models of thermal conductivity and diffusion coefficients. Accordingly, the involvement of radiation, chemical reaction, the Dufour effect, and the Soret effect are involved. The flow presenting expression has been modeled via boundary layer approximation and the flow is produced due to the experimental stretching sheet. The governing equations have been approximated numerically via shooting method. The efficiency of the scheme is established by including the comparative study. Moreover, a decline in the velocity field is recorded against the escalating values of the porosity parameter and the magnetic parameter.
Thermodynamics, Descriptive and experimental mechanics
Perceptual-cognitive expertise in sport: some considerations when applying the expert performance approach.
A. Williams, K. Anders Ericsson
481 sitasi
en
Computer Science, Medicine
The antisecretory peptide AF-16 may modulate tissue edema but not inflammation in experimental peritonitis induced sepsis
Annelie Barrueta Tenhunen, Jaap van der Heijden, I. Blokhin
et al.
Sepsis is a life-threatening condition due to a dysregulated immunological response to infection. Apart from source control and broad-spectrum antibiotics, management is based on fluid resuscitation and vasoactive drugs. Fluid resuscitation implicates the risk of volume overload, which in turn is associated with longer stay in intensive care, prolonged use of mechanical ventilation and increased mortality. Antisecretory factor (AF), an endogenous protein, is detectable in most tissues and in plasma. The biologically active site of the protein is located in an 8-peptide sequence, contained in a synthetic 16-peptide fragment, named AF-16. The protein as well as the peptide AF-16 has multiple modulatory effects on abnormal fluid transport and edema formation/resolution as well as in a variety of inflammatory conditions. Apart from its’ anti-secretory and anti-inflammatory characteristics, AF is an inhibitor of capillary leakage in intestine. It is not known whether the protein AF or the peptide AF-16 can ameliorate symptoms in sepsis. We hypothesized that AF-16 decreases the degree of hemodynamic instability, the need of fluid resuscitation, vasopressor dose and tissue edema in fecal peritonitis. To test the hypothesis, we induced peritonitis and sepsis by injecting autologous fecal solution into abdominal cavity of anesthetized pigs, and randomized (in a blind manner) the animals to intervention (AF-16, n = 8) or control (saline, n = 8) group. After the onset of hemodynamic instability (defined as mean arterial pressure 5 minutes), intervention with AF-16 (20 mg/kg (50 mg/ml) in 0.9% saline) intravenously (only the vehicle in the control group) and a protocolized resuscitation was started. We recorded respiratory and hemodynamic parameters hourly for twenty hours or until the animal died and collected post mortem tissue samples at the end of the experiment. No differences between the groups were observed regarding hemodynamics, overall fluid balance, lung mechanics, gas exchange or histology. However, liver wet-to-dry ratio remained lower in AF-16 treated animals as compared to controls, 3.1 ± 0.4, (2.7–3.5, 95% CI, n = 8) vs 4.0 ± 0.6 (3.4–4.5, 95% CI, n = 8), p = 0.006, respectively. Bearing in mind the limited sample size, this experimental pilot study suggests that AF-16 may inhibit sepsis induced liver edema in peritonitis-sepsis.